公开(公告)号：WO2007096375A1

公开(公告)日：2007-08-30

申请号：PCT/EP2007/051651

申请日：2007-02-21

Applicant: DSM IP ASSETS B.V. ,  STARK, Jacobus ,  DE RIJK, Angelique

Inventor： STARK, Jacobus ,  DE RIJK, Angelique

IPC: C12Q1/18

CPC classification number: C12Q1/18 ,  G01N2333/245

Abstract: The present invention relates to a novel method for the rapid detection of the presence or absence of antimicrobial drug residues belonging to the class of the quinolones in liquid samples such as milk, meat juice, serum, urine, blood, eggs or extracts obtained from animal tissues or food products.

Abstract translation: 本发明涉及一种快速检测液体样品如牛奶，肉汁，血清，尿液，血液，卵或从动物获得的提取物中属于喹诺酮类的抗微生物药物残留物的存在或不存在的新方法 组织或食品。

公开(公告)号：WO2007063043A1

公开(公告)日：2007-06-07

申请号：PCT/EP2006/068932

申请日：2006-11-27

Applicant: DSM IP ASSETS B.V. ,  STARK, Jacobus ,  DUTREUX, Nicole Liliane

Inventor： STARK, Jacobus ,  DUTREUX, Nicole Liliane

IPC: A61K31/195 ,  A23L3/3517 ,  A23L3/3526 ,  A23K1/16 ,  A61K47/48 ,  A23L1/305

CPC classification number: A23K20/195 ,  A23K20/10 ,  A23K20/105 ,  A23K20/111 ,  A23K20/147 ,  A23L3/3517 ,  A23L3/3526 ,  A23L33/175 ,  A23L33/195 ,  A61K31/19 ,  A61K31/195 ,  A61K31/7048 ,  A61K2300/00

Abstract: The present invention describes a composition comprising epsilon-poly-L-lysine and an anti-fungal agent. The composition has improved anti-microbial activity. Also covered are methods for preserving foodstuffs, agricultural products, adhesives, paints, inks, cosmetics and pharmaceutical products by applying the composition of the invention. The composition of the invention is stable and effective against a broad-spectrum of microbe.

Abstract translation: 本发明描述了包含ε-聚-L-赖氨酸和抗真菌剂的组合物。 该组合物具有改善的抗微生物活性。 还涉及通过应用本发明的组合物来保存食品，农产品，粘合剂，油漆，油墨，化妆品和药品的方法。 本发明的组合物对于广谱的微生物是稳定和有效的。

公开(公告)号：WO2006032646A1

公开(公告)日：2006-03-30

申请号：PCT/EP2005/054663

申请日：2005-09-19

Applicant: DSM IP Assets B.V. ,  DUTREUX, Nicole Liliane ,  HAAN, DE, Ben Rudolf ,  STARK, Jacobus

Inventor： DUTREUX, Nicole Liliane ,  HAAN, DE, Ben Rudolf ,  STARK, Jacobus

IPC: A23L3/3463 ,  A23B4/22

CPC classification number: A01N43/90 ,  A23B4/22 ,  A23L3/3463 ,  A23L3/34635

Abstract: The present invention describes a process to preserve a water-containing product such as a foodstuff, which comprises adding natamycin and nisin to the product, whereby at least 90% (w/v) of natamycin is dissolved and/or less than 10% (w/v) of natamycin is present in crystal form.

Abstract translation: 本发明描述了一种保存含水产品如食品的方法，其包括将游霉素和乳链菌肽加入到产品中，由此至少90％（w / v）的游霉素溶解和/或少于10％ w / v）的游霉素以晶体形式存在。

公开(公告)号：WO2005118838A3

公开(公告)日：2006-02-02

申请号：PCT/EP2005052529

申请日：2005-06-02

Applicant: DSM IP ASSETS BV ,  ES VAN REMCO MARIA ,  LANGEVELD PIETER CORNELIS ,  STARK JACOBUS ,  BLANKWATER IJSBRAND JOHAN ,  FRANSE MAARTJE MARIA

Inventor： ES VAN REMCO MARIA ,  LANGEVELD PIETER CORNELIS ,  STARK JACOBUS ,  BLANKWATER IJSBRAND JOHAN ,  FRANSE MAARTJE MARIA

IPC: C12Q1/18

CPC classification number: C12Q1/18

Abstract: The present invention provides a test system, a test method and a test kit for the determination of the presence of an antibiotic in a fluid based on a test medium comprising a component that binds to an antibiotic. Preferably the component that binds to an antibiotic is an antibody or a penicillin binding protein.

Abstract translation: 本发明提供了一种用于基于包含与抗生素结合的成分的测试培养基测定流体中抗生素的存在的测试系统，测试方法和测试试剂盒。 优选结合抗生素的成分是抗体或青霉素结合蛋白。

公开(公告)号：WO2005074687A1

公开(公告)日：2005-08-18

申请号：PCT/EP2005/001052

申请日：2005-01-31

Applicant: DSM IP ASSETS B.V. ,  DEKKER, Angelina ,  DUTREUX, Nicole, Liliane ,  STARK, Jacobus

Inventor： DEKKER, Angelina ,  DUTREUX, Nicole, Liliane ,  STARK, Jacobus

IPC: A01N43/90

CPC classification number: A01N43/90

Abstract: The present invention relates to a process to treat banana plants against disease wherein a polyene antibiotic is applied on the plant. In particular a process is described to protect banana crops from the devastating Sigatoka and Panama diseases. To that effect, banana plants are treated with a preparation comprising an amount of a polyene antibiotic effective to prevent or inhibit mould growth, especially M. fijensis and Fusarium oxysporum f sp. cubense.

Abstract translation: 本发明涉及一种治疗香蕉植物抗病的方法，其中将多烯抗生素施用于植物。 特别是描述了一个过程，以保护香蕉作物不受破坏性的Sigatoka和巴拿马疾病的影响。 为此，香蕉植物用包含有效预防或抑制霉菌生长的一定量的多烯抗生素的制剂进行处理，特别是M. fijensis和尖孢镰刀菌（Fusarium oxysporum） 香蕉枯萎病。

公开(公告)号：WO2005024048A1

公开(公告)日：2005-03-17

申请号：PCT/EP2004/009948

申请日：2004-09-06

Applicant: DSM IP ASSETS B.V. ,  GEIJP, Edith, Magda, Lucia ,  STARK, Jacobus

Inventor： GEIJP, Edith, Magda, Lucia ,  STARK, Jacobus

IPC: C12Q1/18

CPC classification number: C12Q1/18

Abstract: The present invention provides a test medium comprising a test microorganism, an indicator and a metal in ionized form, wherein the valence of said metal is at least 2 and the concentration of said metal is between 0.001 M and 1 M. Furthermore, there is provided a method for the determination of the presence of an antibiotic characterized in that a metal salt is added to said test medium and/or to said sample of fluid. Finally, there is provided a kit suitable for the determination of an antibiotic in a fluid.

Abstract translation: 本发明提供了包含测试微生物，指示剂和电离形式的金属的测试介质，其中所述金属的化合价至少为2，所述金属的浓度为0.001M至1M。此外，提供了 用于测定抗生素存在的方法，其特征在于向所述测试介质和/或所述流体样品中加入金属盐。 最后，提供了适于测定流体中抗生素的试剂盒。

公开(公告)号：WO2005005655A1

公开(公告)日：2005-01-20

申请号：PCT/EP2004/007288

申请日：2004-07-01

Applicant: DSM IP ASSETS B.V. ,  DEKKER, Angelina ,  BOUWKNECHT, Cornelis, Jacobus ,  PELT, Van, Johannes, Theodorus, Arie ,  RIJK, De, Angelique ,  STARK, Jacobus ,  LANGEVELD, Pieter, Cornelis

Inventor： DEKKER, Angelina ,  BOUWKNECHT, Cornelis, Jacobus ,  PELT, Van, Johannes, Theodorus, Arie ,  RIJK, De, Angelique ,  STARK, Jacobus ,  LANGEVELD, Pieter, Cornelis

IPC: C12Q1/18

CPC classification number: C12Q1/18

Abstract: Provided is a test system, a test method and a test kit based on a test medium comprising Bromothymol Blue or a structurally related indicator.

Abstract translation: 提供了基于包含溴百里酚蓝或结构相关指示剂的测试培养基的测试系统，测试方法和测试试剂盒。

公开(公告)号：WO2003033728A1

公开(公告)日：2003-04-24

申请号：PCT/EP2002/011369

申请日：2002-10-10

Applicant: DSM N.V. ,  LANGEVELD, Pieter, Cornelis ,  HEMERT, VAN, Karl, Heinrich ,  KERKHOF, Johannes, Hendrik, Pieter, Machiel ,  STARK, Jacobus

Inventor： LANGEVELD, Pieter, Cornelis ,  HEMERT, VAN, Karl, Heinrich ,  KERKHOF, Johannes, Hendrik, Pieter, Machiel ,  STARK, Jacobus

IPC: C12Q1/18

CPC classification number: G01J3/52 ,  G01J3/46 ,  G01J3/462 ,  G01J2003/466 ,  G01N31/221 ,  G01N33/04 ,  G01N33/49 ,  G01N33/493 ,  G01N2201/0484 ,  G01N2201/102

Abstract: Detection arrangement and method for detecting presence of a residue in a sample by determining color values of the sample, associated with the L*a*b color model, where a value of a composite parameter Z is calculated as follows: Z = w L + w a a + w b b where w L , w a , and w b are weighting factors having a value depending on said residue and said sample, and a determination is made whether or not said sample comprises more or less than a predetermined amount of said residue in dependence on said value of said composite parameter Z. In a preferred embodiment, the arrangement is used to detect antibiotic residues, e.g. penicillin-G, in food products, e.g. milk, or body fluids, e.g. blood, urine.

Abstract translation: 用于通过确定与L * a * b颜色模型相关联的样品的颜色值来检测样品中残留物的检测装置和方法，其中复合参数Z的值如下计算：Z = wL + waa + wbb其中wL，wa和wb是具有取决于所述残基和所述样品的值的加权因子，并且根据所述残基和所述样品的值是否确定所述样品是否包含大于或小于预定量的所述残基 所述复合参数Z。在优选实施方案中，该装置用于检测抗生素残留物，例如， 青霉素G，在食品中，例如 牛奶或体液，例如， 血，尿。

公开(公告)号：WO1996023901A1

公开(公告)日：1996-08-08

申请号：PCT/EP1996000488

申请日：1996-02-01

Applicant: GIST-BROCADES B.V. ,  LANGEVELD, Pieter, Cornelis ,  BEUKERS, Robert ,  BOMMELE, Michiel, Wilhelmus, Cristianus ,  STARK, Jacobus

Inventor： GIST-BROCADES B.V.

IPC: C12Q01/18

CPC classification number: C12Q1/18

Abstract: The present invention relates to a microbiological test method for detecting antibacterial compounds in liquid samples such as milk, meat juice, serum and urine. The method employs an acid-base or redox indicator to detect growth of a test organism and is characterised in that a thermophilic strain of Bacillus or Streptococcus, e.g. Bacillus stearothermophilus var. calidolactis C953, is employed at a concentration of above 10 CFU/ml, preferably between 2 x 10 and 3 x 10 CFU/ml.

Abstract translation: 本发明涉及一种用于检测牛奶，肉汁，血清和尿液等液体样品中抗菌化合物的微生物检测方法。 该方法使用酸碱或氧化还原指示剂来检测测试生物的生长，其特征在于芽孢杆菌或链球菌的嗜热菌株，例如， 嗜热脂肪芽孢杆菌变种 calidolactis C953以高于10 7 CFU / ml，优选2×10 7至3×10 8 CFU / ml的浓度使用。

公开(公告)号：WO1995008918A1

公开(公告)日：1995-04-06

申请号：PCT/EP1994003245

申请日：1994-09-28

Applicant: GIST-BROCADES N.V. ,  VAN RIJN, Ferdinand, Theodorus, Joseph ,  STARK, Jacobus ,  TAN, Hong, Sheng ,  VAN ZOEST, Willem, Johan ,  BARENDSE, Nicolaas, Cornelis, Maria, Emanuel

Inventor： GIST-BROCADES N.V.

IPC: A01N43/90

CPC classification number: C12Q1/18 ,  A01N25/02 ,  A01N43/90 ,  A01N63/02 ,  A23C19/11 ,  A23C19/16 ,  A23C19/163 ,  A23L3/34635 ,  A61K31/70 ,  C07H17/08 ,  G01N33/56961 ,  A01N25/08 ,  A01N25/04 ,  A01N2300/00

Abstract: The present invention provides a method of preparing an improved antifungal composition containing an antifungal compound of the polyene type such as natamycin wherein the antifungal compound is incorporated into the composition in a form which shows an enhanced activity, e.g. in the form of a solution and/or being in a modified polymorphic form.

Abstract translation: 本发明提供一种制备改进的抗真菌组合物的方法，所述抗真菌组合物含有多烯类抗真菌化合物，例如那他霉素，其中抗真菌化合物以显示增强活性的形式，例如， 以溶液的形式和/或处于修饰的多晶形式。