公开(公告)号：US5856301A

公开(公告)日：1999-01-05

申请号：US450905

申请日：1995-05-26

Applicant: Stewart Craig ,  Michael George Hunter ,  Richard Mark Edwards ,  Lloyd George Czaplewski ,  Richard James Gilbert

Inventor： Stewart Craig ,  Michael George Hunter ,  Richard Mark Edwards ,  Lloyd George Czaplewski ,  Richard James Gilbert

IPC: C12N15/09 ,  A61K38/00 ,  C07K14/52 ,  C12N1/19 ,  C12N1/21 ,  C12N15/19 ,  C12N15/67 ,  C12N15/81 ,  C12P21/02 ,  C12R1/84 ,  A61K38/19

CPC classification number: C07K14/523 ,  C12N15/67 ,  C12N15/815 ,  A61K38/00

Abstract: Proteinaceous molecules with stem cell inhibition activity are analogues of LD78 or MIP-1.alpha. which have mutations to prevent or reduce multimer formation beyond certain stages (for example a dodecamer). Aggregate formation is therefore inhibited, and the resulting low molecular weight monomers (or oligomers) have improved solution properties leading to enhanced productivity and greater therapeutic utility as stem cell protective agents, which are useful in tumour therapy.

Abstract translation: 具有干细胞抑制活性的蛋白质分子是LD78或MIP-1α的类似物，其具有预防或减少超过某些阶段（例如十二聚体）的多聚体形成的突变。 因此，聚集体形成被抑制，并且所得到的低分子量单体（或低聚物）具有改善的溶液性质，导致提高的生产率和作为干细胞保护剂的更大的治疗效用，其可用于肿瘤治疗。