公开(公告)号：US08124094B2

公开(公告)日：2012-02-28

申请号：US11910962

申请日：2005-04-28

Applicant: Young Min Kim ,  Sung Min Bae ,  Dae Jin Kim ,  Dae Hae Song ,  Chang Ki Lim ,  Se Chang Kwon ,  Gwan Sun Lee

Inventor： Young Min Kim ,  Sung Min Bae ,  Dae Jin Kim ,  Dae Hae Song ,  Chang Ki Lim ,  Se Chang Kwon ,  Gwan Sun Lee

IPC: A61K39/00

CPC classification number: A61K47/6835 ,  A61K47/6811 ,  A61K47/6813 ,  C07K2317/52 ,  C07K2319/30

Abstract: Disclosed are an Fc fragment modified by a non-peptide polymer, a pharmaceutical composition comprising the Fc fragment modified by the non-peptide polymer as a carrier, a complex of the Fc fragment and a drug via a linker and a pharmaceutical composition comprising such a complex. The Fc fragment modified by a non-peptide peptide according to the present invention lacks immunogenicity and effector functions. Due to these properties, the Fc fragment maintains the in vivo activity of a drug conjugated thereto in high levels, remarkably increases the serum half-life of the drug, and remarkably reduces the risk of inducing immune responses.

Abstract translation: 公开了由非肽聚合物修饰的Fc片段，包含由作为载体的非肽聚合物修饰的Fc片段的药物组合物，Fc片段的复合物和通过接头的药物和包含这样的 复杂。 由本发明的非肽肽修饰的Fc片段缺乏免疫原性和效应子功能。 由于这些性质，Fc片段以高水平维持与其结合的药物的体内活性，显着增加了药物的血清半衰期，并显着降低了诱导免疫应答的风险。

公开(公告)号：US20080064066A1

公开(公告)日：2008-03-13

申请号：US11975541

申请日：2007-10-19

Applicant: Se-Chang Kwon ,  Sung-Youb Jung ,  Sung-Min Bae ,  Gwan-Sun Lee

Inventor： Se-Chang Kwon ,  Sung-Youb Jung ,  Sung-Min Bae ,  Gwan-Sun Lee

IPC: C12P21/04 ,  C07K14/00 ,  C12N1/20 ,  C12N15/00 ,  C12N15/11

CPC classification number: C07K14/535 ,  C07K2319/034 ,  C07K2319/75 ,  C12N15/625 ,  C12N15/70

Abstract: A modified human granulocyte-colony stimulating factor (hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to produce and secrete the modified hG-CSF to periplasm, said modified hG-CSF being obtained by replacing at least one of the 1st, 2nd, 3rd and 17th amino acids of wild-type hG-CSF (SEQ ID NO: 2) with other amino acid

Abstract translation: 通过培养用包含编码修饰的hG-CSF的基因的表达载体转化的微生物来产生修饰的人粒细胞集落刺激因子（hG-CSF），以产生和分泌经修饰的hG-CSF至周质，所述修饰的hG-CSF 通过将野生型hG-CSF（SEQ ID NO：2）的第1，第2，第3和第17氨基酸中的至少一个替换为其他氨基酸而获得