Abstract:
The present invention provides a device useful for supporting underground mine/ tunnels. The device continuously monitors the roof load coming over the canopy and correspondingly yielding/convergence indicated by the pointer on graduate scale. The roof load coming on the canopy is transmitted to the prop via a set of steel disc springs to increase the yielding and longevity of the present device. The present invention has mechanism for preloading upto the desired load. It is a simple, easily transportable and user friendly device having quick release mechanism from a safe distance.
Abstract:
The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof.
Abstract:
The invention relates to telecommunication systems and in particular to a method and system for efficient connection setup procedure for mobile terminated calls. A method of connection setup for mobile terminated calls is proposed in which a page message originating from the access network contains one access sequence along with access terminal identity or unicast access terminal identifier (UATI) of the paged access terminal. When more than one access terminal uses the same access sequence for sending their access probe at the same time a collision may occur. Access network selects access sequences from a reserved pool to direct the paged access terminal for performing access attempt to avoid collisions during access attempts. With this resource pooling, there is no need to send bind request and hence connection setup time reduces.
Abstract:
There are provided derivatives having PPAR agonist activity. The derivatives include compounds and/or their pharmaceutically acceptable salts; the compounds having the formula (I) wherein A has the structure (II) or (III); X is chosen from -CH 2 -, -O-, -NH-, and -S-; Y is chosen from -O-, -NH-, and -S-; Z, which may be located in any position of substitution, is hydrogen or halogen; R 1 and R 2 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl, or R 1 and R 2 together form a carbocyclic ring having from 4 to 6 carbon atoms; R 3 is chosen from hydrogen and C 1 -C 8 alkyl; R 4 , R 5 , and R 6 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl; and n is 1 to 6. Various embodiments and variants are provided. In accordance with other aspects, the invention also provides methods of producing a PPARa agonist activity in a mammal, the methods including administering to the mammal an effective amount of certain derivative(s) of the first aspect of the invention, a method of producing a PPARa agonist activity and a PPARa agonist activity in a mammal, the method including administering to the mammal an effective amount of certain derivative(s); and a pharmaceutical composition that includes the derivative(s) of the first aspect of the invention and one or more pharmaceutically-acceptable excipients. Various embodiments and variants are provided.
Abstract:
There are provided derivatives having PPAR agonist activity. The derivatives include compounds and/or their pharmaceutically acceptable salts; the compounds having the formula (I) wherein A has the structure (II) or (III); X is chosen from -CH 2 -, -O-, -NH-, and -S-; Y is chosen from -O-, -NH-, and -S-; Z, which may be located in any position of substitution, is hydrogen or halogen; R 1 and R 2 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl, or R 1 and R 2 together form a carbocyclic ring having from 4 to 6 carbon atoms; R 3 is chosen from hydrogen and C 1 -C 8 alkyl; R 4 , R 5 , and R 6 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl; and n is 1 to 6. Various embodiments and variants are provided. In accordance with other aspects, the invention also provides methods of producing a PPARa agonist activity in a mammal, the methods including administering to the mammal an effective amount of certain derivative(s) of the first aspect of the invention, a method of producing a PPARa agonist activity and a PPARa agonist activity in a mammal, the method including administering to the mammal an effective amount of certain derivative(s); and a pharmaceutical composition that includes the derivative(s) of the first aspect of the invention and one or more pharmaceutically-acceptable excipients. Various embodiments and variants are provided.
Abstract translation:提供具有PPAR激动剂活性的衍生物。 衍生物包括化合物和/或其药学上可接受的盐; 具有式(I)的化合物其中A具有结构(II)或(III); X选自-CH 2 - , - O - , - N - 和-S-; Y选自-O - , - NH-和-S-; 可以位于任何取代位置的Z是氢或卤素; R 1和R 2可以相同或不同,独立地选自氢和C 1 -C 8烷基, 或者R 1和R 2一起形成具有4至6个碳原子的碳环; R 3选自氢和C 1 -C 8烷基; R 4,R 5,R 5和R 6可以相同或不同,独立地选自氢和C 1 C 8 -C 14烷基; 并且n为1至6.提供了各种实施方案和变体。 根据其它方面,本发明还提供了在哺乳动物中产生PPARα激动剂活性的方法,所述方法包括向哺乳动物施用有效量的本发明第一方面的某些衍生物, PPARα激动剂活性和PPARα激动剂活性,所述方法包括向哺乳动物施用有效量的某些衍生物; 和包含本发明第一方面的衍生物和一种或多种药学上可接受的赋形剂的药物组合物。 提供了各种实施例和变型。
Abstract:
The present invention relates to novel hypolipidemic, antiobesity, hypocholesterolemic and antidiabetic compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general formula (I), their stereoisomers, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing them where all symbols are as defined in the description.
Abstract:
Air is separated in a single fractionation column (116) to produce a top nitrogen gaseous fraction (142) and a bottom liquid fraction (120) containing less than (80) mole per cent of oxygen. A liquid nitrogen product (136) is also produced. The necessary refrigeration is created by expansion with the performance of external work of firstly a stream of compressed air in an expansion turbine (114) and of secondly a stream of vaporised bottom fraction in an expansion turbine (128). At least part of the feed to the column (116) comes from the turbine (114). The outlet pressure of the turbine (114) is essentially the gaseous nitrogen product pressure. A double fractionation column may be used instead of the single fractionation column (116).
Abstract:
Some aspects described herein relate to determining, by a transmitter user equipment (UE) in sidelink communications with a receiver UE, a feedback forwarding timing capability based at least in part on a first timing for receiving and processing feedback from the receiver UE, and indicating, to an access point, the feedback forwarding timing capability. Other aspects relate to determining, by a transmitter UE in sidelink communications with a receiver UE, a timing capability for the receiver UE to at least one of receive sidelink communications from the transmitter UE or report feedback for the sidelink communications to the transmitter UE.
Abstract:
Techniques for handling sidelink feedback signaling in situations where collisions would otherwise be experienced in a network communication link are shown and described. For example, sidelink feedback signaling handling techniques may provide for collision handling when sidelink HARQ is to be simultaneously transmitted with network communication radio interface uplink channel information (e.g., Uu HARQ, SR, CSI, etc. ) on one or more Uu channel (e.g., PUCCH, PUSCH, etc. ). In operation of sidelink feedback handling, a transmitter or intermediary UE of a sidelink communication link may decide whether and how to forward the sidelink HARQ to a corresponding base station. Other aspects and features are also claimed and described.
Abstract:
The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula (I) and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).