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公开(公告)号：US10901128B2
公开(公告)日：2021-01-26
申请号：US15739680
申请日：2016-06-24
Inventor： Stanley Pau , Russell Chipman , Wei-Liang Hsu
IPC: G02B5/30 , G02F1/1335
Abstract: Compound dichroic polarizers (CDPs) include multiple component dichroic polarizers based on different dichroic dyes and oriented to have different eigenpolarization directions. The component dichroic polarizers can be fixed to each other or to a substrate such as an eyeglass lens. Selection of eigenpolarization orientation and spectrum in a CDP permits color encoding of different SOPs.
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公开(公告)号：US10793595B2
公开(公告)日：2020-10-06
申请号：US16150496
申请日：2018-10-03
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , UNIVERSITY OF SOUTH FLORIDA
Inventor： David L. Morse , Josef Vagner , Mark McLaughlin , Robert Gillies , Amanda Huynh , Michael Doligalski
Abstract: Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.
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公开(公告)号：US10772722B2
公开(公告)日：2020-09-15
申请号：US15492227
申请日：2017-04-20
Applicant: The Research Foundation for The State University of New York , The Arizona Board of Regents on Behalf of the University of Arizona
Inventor： Danny Bluestein , Thomas E. Claiborne , Marvin J. Slepian
IPC: A61F2/24
Abstract: A polymeric valve which may include a heart valve, and also may include a trileaflet heart valve includes a stent having a base and a plurality of outwardly extending posts from the base and equidistant from each other. A plurality of leaflets each connected to a corresponding one of the posts at one end, and each of the leaflets connected to the base. Each of the leaflets having an operative end opposite the end connected to the post, and the operative ends of the leaflets being biased in a closed position such that the operative ends abut each other. The operative ends are configured to rhythmically open and close in relation to each other, and the leaflets include multiple cross sectional thicknesses at different portions of the leaflets.
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34.发明授权公开(公告)号：US10718889B2
公开(公告)日：2020-07-21
申请号：US16299066
申请日：2019-03-11
Inventor： Stanley Pau , Wei-Liang Hsu
IPC: G02B5/30 , G01J4/04 , C09K19/38 , C09K19/56 , G02F1/1337 , G02F1/1335 , G01J4/00
Abstract: Exemplary thin-film optical devices have first and second layer groups disposed as a layer stack on a substrate. The first layer group comprises a first PPN layer, a first LCP layer, and a first barrier layer all superposed. The second layer group is superposed relative to the first layer group, and includes a second PPN layer, a second LCP layer, and a second barrier layer all superposed. The first and second layer groups cooperate to polarize multiple wavelengths of an incident light flux in a broadband and/or wide-angle manner Each of the layer groups has an alignment layer, a respective liquid-crystal polymer layer, and a barrier layer.
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公开(公告)号：US20200163605A1
公开(公告)日：2020-05-28
申请号：US16691637
申请日：2019-11-22
Inventor： Joseph S. Valacich , Jeffrey L. Jenkins
Abstract: The present invention provides a system and a method for eliciting information to sensitive questions and reliably detecting whether one is being deceptive, concealing information, or experiencing a heightened emotional response to the question. In particular, the system and the method of the invention are based on analyzing the user behavioral biometric of using one or more input device(s).
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Patent Agency Ranking
公开(公告)号：US10551089B2
公开(公告)日：2020-02-04
申请号：US15748792
申请日：2016-08-03
Inventor： Justin J Hyatt , Brian M Wheelwright , Roger P Angel
IPC: F24S23/77 , H01L31/054 , F24S23/70 , F24S20/20 , F24S25/13 , F24S30/452 , F24S30/00
Abstract: A solar concentrator may have a horizontal circular track on the ground, a tower centered on a vertical axis of the track, and a rotatable structure around the track having an upper, concave mounting surface approximating the shape of part of a sphere centered on the top of the tower. Articulated concave mirrors are attached to the rotatable structure, and the mirrors have a focal length approximately equal to the radius of a sphere portion formed by the concave mounting surface. Sunlight is focused at a receiver mounted atop the tower, and the receiver may convert sunlight into thermal or electrical energy. As the position of the Sun changes, sunlight is maintained on the receiver by turning the rotatable structure toward the Sun, turning the receiver about said vertical axis to face the mirrors, and articulating the mirrors toward the receiver in response to the changing elevation of the Sun.
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公开(公告)号：US10514485B2
公开(公告)日：2019-12-24
申请号：US14072443
申请日：2013-11-05
Inventor： Raymond K. Kostuk , Shelby D. Vorndran , Deming Zhang , Juan Manuel Russo , Michael Gordon
IPC: G02B5/32 , H01L31/052 , A01G33/00 , G02B19/00 , G02B27/10 , A01H3/02 , C12N1/12 , C12N13/00 , C12M1/00 , H02S40/22 , H01L31/054 , F24S23/00
Abstract: An apparatus for obtaining energy from a polychromatic energy source that emits radiation in a first and a second wavelength band comprises a reflector or an energy receiver having an aperture therein; and a holographic lens that diffracts and focuses the radiation within the first wavelength band from the energy source through said aperture towards a first energy receiver, and transmits the radiation within the second wavelength band from the energy source to the reflector or energy receiver. If a reflector is used, the reflector reflects the radiation transmitted by the holographic lens towards a second energy receiver.
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公开(公告)号：US20190314561A1
公开(公告)日：2019-10-17
申请号：US16346840
申请日：2017-11-03
Inventor： Peter RHEE , Andrew TANG , Kevin OKARSKI
Abstract: A needle assembly includes an outer cannula having a distal end portion, the distal end portion comprising a sharp bevel facilitating insertion of the needle assembly into a subject. The needle assembly further includes an inner cannula slidably disposed coaxially in the lumen of the outer cannula and movable between an extended position and a retracted position, the inner cannula having a blunt distal end portion extending beyond the sharp bevel of the outer cannula whenever the inner cannula is in the extended position. The needle assembly further includes a bias coupled to the inner cannula in a manner favoring automatic positioning of the inner cannula at the extended position. The needle assembly includes a valve located in fluid communication with the lumen of the inner cannula to allow fluid to exit the subject through the inner cannula, and to prevent ingress of fluid into the subject.
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39.发明授权公开(公告)号：US10428115B2
公开(公告)日：2019-10-01
申请号：US14893800
申请日：2014-05-23
Inventor： Yeon Sun Lee , Victor J. Hruby , Frank Porreca , Josephine Lai
Abstract: Described are Dynorphin A analog compounds and uses thereof for treating pain in humans and lower animals by administering to a human or lower animal in need of treatment. The compounds interact with the bradykinin receptor to relieve pain. Preferred compounds are amphipathic [Des-Arg7]-dynorphin A peptide analogs and specific cyclic dynorphin A peptide analogs.
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公开(公告)号：US20190263857A1
公开(公告)日：2019-08-29
申请号：US16150496
申请日：2018-10-03
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , UNIVERSITY OF SOUTH FLORIDA
Inventor： David L. Morse , Josef Vagner , Mark McLaughlin , Robert Gillies , Amanda Huynh , Michael Doligalski
Abstract: Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.
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