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    Method employing bispecific antibodies
    31.
    发明授权
    Method employing bispecific antibodies 有权

    公开(公告)号：US10829566B2

    公开(公告)日：2020-11-10

    申请号：US15779426

    申请日：2016-12-01

    Applicant: UCB BIOPHARMA SPRL

    Inventor： Stephen Edward Rapecki

    IPC: C07K14/39 ,  C07K16/00 ,  G01N33/68 ,  C07K16/14 ,  C07K16/46

    Abstract: The present invention relates to a method of identifying, separating and characterizing a cell or a population of cells, by capturing at the cell surface, secreted soluble substances (such as an immunoglobulin) that cell or population of cell secrete. This is achieved by combing on a heterodimerically-tethered multispecific protein complex combining a binding specificity for the secreted molecule and a binding specificity for a surface antigen specific for that cell or population of cells. This method may be used in research and experimental purposes, such as patients' stratification in preparation of clinical trials or personalized therapies by identifying cell populations relevant to a pathology and/or prognosis.

    Multispecific antibodies
    32.
    发明授权
    Multispecific antibodies 有权

    公开(公告)号：US10774157B2

    公开(公告)日：2020-09-15

    申请号：US15779424

    申请日：2016-12-01

    Applicant: UCB BIOPHARMA SPRL

    Inventor： Michael John Wright

    IPC: C07K16/28 ,  C07K16/00 ,  C07K16/46 ,  C07K16/14 ,  C07K14/39

    Abstract: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A(A1)n-X:Y-B(B1)m and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets. Such complexes may be used to capture soluble molecules secreted from a particular cell, in therapy, in research and for experimental purposes such as in assays to characterise patient populations by identifying cell populations relevant to a pathology or prognosis.

    Single linker FabFv antibodies and methods of producing same
    36.
    发明授权
    Single linker FabFv antibodies and methods of producing same 有权

    公开(公告)号：US10457748B2

    公开(公告)日：2019-10-29

    申请号：US14654240

    申请日：2013-12-20

    Applicant: UCB Biopharma SPRL

    Inventor： Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys

    IPC: C07K16/18 ,  C07K16/46 ,  C07K16/28

    Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I): (Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III): V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.

    Sequence symmetric modified IGG4 bispecific antibodies
    40.
    发明授权
    Sequence symmetric modified IGG4 bispecific antibodies 有权

    公开(公告)号：US10221251B2

    公开(公告)日：2019-03-05

    申请号：US14380309

    申请日：2013-02-22

    Applicant: UCB Biopharma SPRL

    Inventor： David Paul Humphreys ,  Shirley Jane Peters

    IPC: C07K16/00 ,  C07K16/46

    Abstract: The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain: the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

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