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公开(公告)号：DE2639192B2
公开(公告)日：1979-12-20
申请号：DE2639192
申请日：1976-08-31
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公开(公告)号：US12234408B2
公开(公告)日：2025-02-25
申请号：US17272616
申请日：2019-08-30
Inventor： Emily Rose Adams , David John Adams
IPC: G02F1/1516 , C07D471/06 , C09K9/02
Abstract: Provided are novel naphthalene diimide (NDI) compound of Formula 1. The compounds may exhibit colour change from substantially transparent to substantially black upon electrochemical or photochemical stimulus and may be useful in smart windows.
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公开(公告)号：US20240373849A1
公开(公告)日：2024-11-14
申请号：US18007513
申请日：2021-06-04
Inventor： Shireen A. Davies , Robert M.J. Liskamp , Julian A.T. Dow
IPC: A01N37/46 , A01N47/44 , A01P7/04 , C07K14/435
Abstract: The present invention relates to analogues of insect neuropeptides having activity against hemipteran and dipteran insects, such as aphids and fruit flies, and their use as insect control agents (e.g. insecticides) and plant protection agents.
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公开(公告)号：US12129235B2
公开(公告)日：2024-10-29
申请号：US17251712
申请日：2019-06-21
Applicant: The University Court of the University of Glasgow , The University Court of the University of Edinburgh
Inventor： Andrew Sutherland , Sally Pimlott , Adriana Tavares , Christoph Lucatelli
IPC: C07D215/48 , A61K51/04
CPC classification number: C07D215/48 , A61K51/04 , C07B2200/05
Abstract: The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.
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公开(公告)号：US20240350162A1
公开(公告)日：2024-10-24
申请号：US18292766
申请日：2022-07-29
Inventor： Nicola Giuseppe FENU , Sandy COCHRAN , Margaret LUCAS , Rupert SHINGLETON , Rebecca Shirley CLEARY
CPC classification number: A61B17/320068 , A61B2017/00137 , A61B2017/320074
Abstract: An ultrasonic transducer for surgical applications is disclosed. The ultrasonic transducer comprises: a back mass; a front mass; an ultrasonic actuator arrangement held between the back mass and the front mass; and an ultrasonic horn arrangement forward of the front mass. The back mass, ultrasonic actuator arrangement, front mass and ultrasonic horn arrangement are arranged along a longitudinal axis of the transducer. Vibrations generated by the ultrasonic actuator arrangement are conducted into the front mass and into the ultrasonic horn arrangement along a vibrational energy transfer path and are amplitude amplified by the ultrasonic horn arrangement. One or more of the back mass, front mass and ultrasonic horn arrangement includes a plurality of openings opening towards the longitudinal axis and intersecting the vibrational energy transfer path and configured to provide an increased mechanical compliance in a direction along the vibrational energy transfer path.
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Patent Agency Ranking
36.发明公开公开(公告)号：US20240344149A1
公开(公告)日：2024-10-17
申请号：US18290974
申请日：2022-07-15
Inventor： Ralf Dieter HOFFMAN , George BAILLIE
IPC: C12Q1/6888 , G16H20/40
CPC classification number: C12Q1/6888 , G16H20/40 , C12Q2600/106 , C12Q2600/158
Abstract: The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of three or more PDE4D7 knockdown differentially expressed genes selected from the group consisting of: ACPP, AR, CDH1, EHF, ETV1, FOLH1, FOXA1, HOXB13, KLK2, KLK3, MAOA, MLH1, MME, MYO6, NAALADL2, NKX3-1, NQO1, NRP1, SLC45A3, SPDEF, ATM, ATR, BRCA1, BR-CA2, CDK12, FANCA, MRE11 and PALB2, said gene expression profiles being determined in a biological sample obtained from the subject, and determining the prediction of the radiotherapy response based on the gene expression profiles for the three or more PDE4D7 knockdown genes, wherein the radiotherapy is radical radiotherapy or salvage radiotherapy.
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公开(公告)号：US20240165270A1
公开(公告)日：2024-05-23
申请号：US18503439
申请日：2023-11-07
Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
Inventor： Adrian BIRD , Rebekah TILLOTSON , Stuart Robert COBB , Ralph David HECTOR
CPC classification number: A61K48/0066 , A61K9/0019 , A61K9/0085 , A61P25/14 , C07K14/001 , C07K14/4703 , C12N7/00 , C12N15/86 , A61K38/00 , C12N2750/14143
Abstract: MECP2 EXPRESSION CASSETTES. The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5′ to 3′: a 5′ transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3′ untranslated region (3′UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes. The nucleic acid molecules and viral vectors disclosed herein provide novel tools for expressing MeCP2 and are of particular value in the treatment of disorders associated with reduced MeCP2 activity, including Rett syndrome.
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公开(公告)号：US20230296645A1
公开(公告)日：2023-09-21
申请号：US18014715
申请日：2021-07-05
Inventor： Thomas McMullen , Richard Bates
CPC classification number: G01R1/06744 , C23F4/00 , G01R1/06755 , G01R3/00
Abstract: The present invention relates primarily to a method of fabrication of one or more free-standing micromachined parts. The method includes performing reactive ion etching of photoresist and tungsten-based layers supported on a carrier substrate to thereby define one or more micromachined parts, followed by separating the resulting one or more micromachined parts from the carrier substrate such that the parts are free-standing. The invention also relates to tungsten-based microprobe obtainable by such a method, wherein the microprobe has a substantially square or rectangular cross-section in a direction perpendicular to a longitudinal axis of the microprobe, and to probe cards comprising a plurality of such microprobes.
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公开(公告)号：US20230184924A1
公开(公告)日：2023-06-15
申请号：US17766760
申请日：2020-10-07
Applicant: ECOLE NATIONALE SUPERIEURE DE L'ELECTRONIQUE ET DE SES APPLICATIONS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , CY CERGY PARIS UNIVERSITÉ
Inventor： Olivier ROMAIN , Julien LEKERNEC , Jordane LORANDEL , Francesco FIORANELLI
IPC: G01S13/89 , G06V10/764 , G08B21/04
CPC classification number: G01S13/89 , G06V10/764 , G08B21/0446
Abstract: The invention discloses a device (1) for characterizing in real time the actimetry of a subject, having: a radar (2) emitting and receiving radar signals, and having a software interface for configuring the shape of the signal emitted; processing and computing means (3) coupled to the radar (2), having a trained classifier (3a) using a database, said processing and computing means (3) being configured to perform in real time: —a capture of color micro-Doppler images (6) having several color channels (R, V, B), each having micro-Doppler signatures (6a) with color pixels the value of which is a function of a reflectivity and a speed of the subject; —a processing of the micro-Doppler images (6) for: computing a so-called monochromatic image having monochromatic pixels, each having a given monochromatic intensity, on the basis of the color pixels of each color micro-Doppler image; transforming the monochromatic image into a binary image by segmentation, according to a binary luminous intensity threshold, of the monochromatic pixels, producing binary pixels, the value of which is dependent on the chromatic intensity of the monochromatic pixel associated with the binary pixel, with respect to the threshold.
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公开(公告)号：US20230183868A1
公开(公告)日：2023-06-15
申请号：US18086364
申请日：2022-12-21
Inventor： Leroy Cronin , Mark Symes , Jia-Jia Chen
Abstract: A method is disclosed of manufacturing a semiconductor structure comprising an (001) oriented zincblende structure group III-nitride layer, such as GaN. The layer is formed on a 3C-SiC layer on a silicon substrate. A nucleation layer is formed, recrystallized and then the zincblende structure group III-nitride layer is formed by MOVPE at temperature T3 in the range 750-1000° C., to a thickness of at least 0.5μ. There is also disclosed a corresponding semiconductor structure comprising a zincblende structure group III-nitride layer which, when characterized by XRD, shows that the substantial majority, or all, of the layer is formed of zincblende structure group III-nitride in preference to wurtzite structure group III-nitride.
The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons. A method of the invention comprises the steps of reducing a mediator by four or more electrons to yield a reduced mediator, and oxidising a reduced mediator to yield a mediator, and reducing protons to yield hydrogen.
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