Abstract:
The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in which A, R 3 , R 4 , R 5 R 6 and R 7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivaties can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases.
Abstract translation:本发明涉及式(I)的新的1,3-二氢吲哚-2-酮(羟吲哚)衍生物,其中A,R 3,R 4,R 5 R 6和R 5, 7>根据权利要求1定义,并且含有它们用于治疗疾病的药物。 特别地,新羟吲哚衍生物可用于控制和/或预防各种加压素依赖性或催产素依赖性疾病。
Abstract:
Poly(bis-9,9'-fluorenes) are disclosed with identical or different recurring structural elements of formula (I), in which the two R1 groups independently of one another stand for H, C1-C18-alkyl, C6-C14-aryl, C7-C15-aralkyl, C1-C18-alkoxy, R2-(O-CnH2n)m-O-, C1-C18 alkylthio, C1-C18-dialkylamino, -C(O)OH, -C(O)O-C1-C18-alkyl, -C(O)-N(C1-C18-alkyl)2, SO3H, -SO3-C1-C18-alkyl, -SO2-N(C1-C18-alkyl)2, C1-C17-alkyl-C(O)-O- or C1-C17-alkyl-C(O)-, R2 stands for H or C1-C12-alkyl, n is a number between 2 and 6 and m is a number between 1 and 12. The polymers can be used on their own or mixed with at least one additional fluorophore whose absorption band overlaps with the emission band (fluorescence emission) of the polymer of formula (I), as an active radiating layer for light-emitting diodes, screens and display elements.
Abstract:
The description relates to bicyclene derivatives of formula (I) in which A, B, D, E, G, K, L, R , R , Z and Z have the meanings given in the description, and their production. These compounds are suitable for treating diseases.
Abstract:
The present invention relates to a method for the replication of a patterned surface relief microstructure, comprising the steps of generation of a first layer with a patterned surface relief microstructure, generation of a master, by copying the microstructure of the first layer into a second layer, thereby involving at least one dry or wet etching step, characterized by an additional step, in which the microstructure of the master is brought into contact with a replica material, such that the microstructure of the master is reproduced in the replica. The invention further relates to the elements made as a replica according to the method. The surface relief microstructures are suitable to display images with a positive- negative and/or color image flip. The elements according to the invention are particularly useful for securing documents and articles against counterfeiting and falsification.
Abstract:
Die vorliegende Erfindung betrifft neue substituierte Oxindol-Derivate der Formel (I), diese enthaltende pharmazeutische Mittel und ihre Verwendung zur Behandlung von Vasopressin-abhängigen Erkrankungen.
Abstract:
Die vorliegende Erfindung betrifft neue 5,6-disubstituierte Oxindol-Derivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung zur Herstellung eines Medikaments.
Abstract:
The present invention relates to novel quinoline compounds of the formula (I) and to the salts thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT 6 receptor. In formula (I) R is a moiety of the formula (R) wherein * indicates the binding site to the quinolinyl radical and wherein A, B, X', Y, Q, R 1 , R 2 , R 3 , R 4 , R 5 , m, n, p, q, R a , R b , X and Ar are as defined in claim 1.
Abstract:
The present invention relates to compounds of the general formula (I) in which A, B, R 1 , R 2 and Het have the meaning given in claim 1; Y is a bivalent group of the formula (II) in which D is C 1 -C 3 -alkylene, where D may have a substituent R 5 ; R 3 is hydrogen, C 1 -C 8 -alkyl or together with R 4 is C 1 -C 3 -alkylene which may have a radical R 5a , or together with R 5 is C 1 -C 3 -alkylene, and R 4 is hydrogen, C 1 -C 8 -alkyI or together with R 3 is C 1 -C 3 -alkylene which may have a radical R 5a , or together with R 5 is C 1 -C 3 -alkylene, where R 5 together with R 5a , where present, are a bond or C 1 -C 3 -alkylene; and where one of the following conditions is satisfied: R 3 together with R 4 is C 1 -C 3 -alkylene which may have a radical R 5a ; or R 3 together with R 5 is C 1 -C 3 -alkylene; or R 4 together with R 5 is C 1 -C 3 -alkylene where the radical A is different from phenyl when the radical B is phenyl or naphthyl; and medicaments which comprise such compounds and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.
Abstract:
The present invention relates to novel oxindole derivatives of the formula (I) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin dependent.
Abstract:
The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R 1 , R 2 , R 3 , A 1 , A 2 , and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.