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    INQUIRY SKILLS TUTORING SYSTEM
    31.
    发明申请
    INQUIRY SKILLS TUTORING SYSTEM 审中-公开
    查询技能指导系统

    公开(公告)号：WO2014120780A1

    公开(公告)日：2014-08-07

    申请号：PCT/US2014/013615

    申请日：2014-01-29

    Applicant: WORCESTER POLYTECHNIC INSTITUTE

    Inventor： GOBERT, Janice, D. ,  BAKER, Ryan, S. ,  SAO PEDRO, Michael, A.

    IPC: G09B5/00

    CPC classification number: G09B19/00 ,  G06N5/022 ,  G06N5/025 ,  G06Q10/06398 ,  G09B5/00 ,  G09B5/02 ,  G09B7/02

    Abstract: An assessment engine includes a definition of inquiry skills being assessed. Assessment models are used to infer skill demonstration as one or more students engage in inquiry within computerized simulations and/or microworlds. A pedagogical agent and/or help system provides real-time feedback to one or more students based on the assessment model outputs, and/or based on additional models that track one or more students developing proficiency across inquiry tasks over time. A pedagogical agent and/or help system for science inquiry tutoring responds in real-time on the basis of knowledge-engineered and data-mined assessment and/or tracking models.

    Abstract translation: 评估引擎包括正在评估的查询技能的定义。 评估模型用于推测技能演示，因为一个或多个学生在计算机化模拟和/或微世界中进行查询。 教学代理和/或帮助系统基于评估模型输出，和/或基于跟踪一个或多个学生在一段时间内跨查询任务熟练度的附加模型来向一个或多个学生提供实时反馈。 用于科学咨询辅导的教学代理和/或帮助系统在知识设计和数据挖掘评估和/或跟踪模型的基础上实时响应。

    FIRST RESPONDER PROTECTIVE UNIFORM
    32.
    发明申请
    FIRST RESPONDER PROTECTIVE UNIFORM 审中-公开
    第一反应者保护统一

    公开(公告)号：WO2014036136A1

    公开(公告)日：2014-03-06

    申请号：PCT/US2013/057076

    申请日：2013-08-28

    Applicant: WORCESTER POLYTECHNIC INSTITUTE ,  FOFANA, Mustapha S. ,  BLAKINGTON, Neil ,  HAYNES, Steven

    Inventor： FOFANA, Mustapha S. ,  BLAKINGTON, Neil ,  HAYNES, Steven

    IPC: A41D13/00 ,  F41H1/02 ,  G21F3/02

    CPC classification number: A62B17/006 ,  A41D31/0061 ,  A41D2400/60 ,  F41H1/02

    Abstract: A protective garment comprising a plurality of layers integrated or bonded in a complementary manner protects wearers such as emergency responders against multiple hazards often present in a response area. The layers include a toxicity barrier adapted for visual contrast with toxic substances, such that the toxicity is barrier responsive to toxic substances by varying a response to an optical signal such as a UV light. An impact layer is responsive to projectiles by controlled deformation, such that the controlled deformation prevents passage of the projectile, as EMT response areas are often unsecured crime scenes where firearms may be present. Also, an absorbent layer is responsive to expelled fluids of the wearer such as perspiration, in which the absorbent layer is adapted for unidirectional diffusion of fluids so that moisture does not remain in contact with the skin of the wearer and cause discomfort, irritation, and thermal imbalance.

    Abstract translation: 包含以互补方式集成或结合的多个层的防护服保护了诸如应急响应者之类的穿着者，以防止经常存在于响应区域中的多种危险。 这些层包括适于与有毒物质的视觉对比的毒性屏障，使得毒性是通过改变对诸如UV光的光学信号的响应而对有毒物质产生的屏障。 碰撞层通过受控的变形对射弹作出反应，使受控变形防止弹丸的通过，因为EMT响应区域通常是不可靠的犯罪现场，其中可能存在火器。 此外，吸收层对穿着者排出的流体例如排汗有响应，其中吸收层适于使流体单向扩散，使得水分不会与穿着者的皮肤保持接触并引起不适，刺激和 热不平衡。

    COMPOSITIONS AND METHODS FOR IDENTIFYING VIRULENCE FACTORS AND ANTI-FUNGAL AGENTS
    33.
    发明申请
    COMPOSITIONS AND METHODS FOR IDENTIFYING VIRULENCE FACTORS AND ANTI-FUNGAL AGENTS 审中-公开
    用于鉴定病毒因子和抗真菌剂的组合物和方法

    公开(公告)号：WO2012122298A2

    公开(公告)日：2012-09-13

    申请号：PCT/US2012/028116

    申请日：2012-03-07

    Applicant: WORCESTER POLYTECHNIC INSTITUTE ,  RAO, Reeta, Prusty

    Inventor： RAO, Reeta, Prusty

    IPC: A01K67/027 ,  C12N5/07 ,  C12N1/14 ,  C12N5/10 ,  C12N1/15 ,  A01N63/04

    CPC classification number: F25B49/022 ,  A01N63/02 ,  G01N33/5085

    Abstract: The present invention is based on the discovery of a two- or three-organism model system that can be used to identify virulence factors involved in fungal infection and to screen for agents that attenuate the activity of those factors. The system includes a model eukaryote, the nematode, Caenorhabditis elegans, and one or more species of Candida, a fungal pathogen that infects humans, e.g., Candida albicans, C. dubliniensis, C. krusei, C. tropicalis, C. parapsilosis, or C. glabrata. The system also includes a food source for the C. elegans; the food source can be a live or attenuated bacterium, e.g., Escherichia coli.

    Abstract translation: 本发明基于发现可用于鉴定真菌感染中涉及的毒力因子并筛选减弱这些因子的活性的试剂的二体或三体模型系统。 该系统包括模型真核生物，线虫，秀丽隐杆线虫以及一种或多种假丝酵母，一种感染人类的​​真菌病原体，例如白色念珠菌，都柏林白蜡菌，克氏梭菌，热带假丝酵母，副伤寒杆菌或 C. glabrata。 该系统还包括线虫的食物来源; 食物来源可以是活的或减毒的细菌，例如大肠杆菌。

    NOVEL USE OF BASIC FIBROBLAST GROWTH FACTOR IN THE DE-DIFFERENTIATION OF ANIMAL CONNECTIVE TISSUE CELLS
    35.
    发明申请
    NOVEL USE OF BASIC FIBROBLAST GROWTH FACTOR IN THE DE-DIFFERENTIATION OF ANIMAL CONNECTIVE TISSUE CELLS 审中-公开
    基础成纤维细胞生长因子在动物连接组织细胞鉴定中的新用途

    公开(公告)号：WO2009111087A1

    公开(公告)日：2009-09-11

    申请号：PCT/US2009/001517

    申请日：2009-03-09

    Applicant: WORCESTER POLYTECHNIC INSTITUTE ,  PAGE, Raymond, L. ,  DOMINKO, Tanja

    Inventor： PAGE, Raymond, L. ,  DOMINKO, Tanja

    IPC: C12N5/08

    CPC classification number: C12N5/0662 ,  C12N2500/02 ,  C12N2501/115 ,  C12N2506/1307

    Abstract: De-differentiation protocols are described herein for generating progenitor cells from adult connective tissue, in particular adult human fibroblasts. The de- differentiation protocols described herein comprise culturing the differentiated cells with an amount of FGF2 to de-differentiate the cells. These de-differentiated cells may then be cultured and used for experimentation, amplification and clinical applications. The clinical applications include the use of the cells for tissue and cell based therapies.

    Abstract translation: 本文描述了去分化方案用于从成人结缔组织，特别是成人人成纤维细胞产生祖细胞。 本文描述的去分化方案包括用一定量的FGF2培养分化的细胞以使细胞去分化。 然后可以将这些去分化的细胞培养并用于实验，扩增和临床应用。 临床应用包括使用细胞进行组织和基于细胞的疗法。

    FREE-HAND THREE-DIMENSIONAL ULTRASOUND DIAGNOSTIC IMAGING WITH POSITION AND ANGLE DETERMINATION SENSORS
    37.
    发明申请
    FREE-HAND THREE-DIMENSIONAL ULTRASOUND DIAGNOSTIC IMAGING WITH POSITION AND ANGLE DETERMINATION SENSORS 审中-公开
    具有位置和角度测量传感器的自由三维超声诊断成像

    公开(公告)号：WO2006127142A2

    公开(公告)日：2006-11-30

    申请号：PCT/US2006/012327

    申请日：2006-03-30

    Applicant: WORCESTER POLYTECHNIC INSTITUTE ,  PEDERSEN, Peder, C. ,  SZABO, Thomas, L.

    Inventor： PEDERSEN, Peder, C. ,  SZABO, Thomas, L.

    IPC: G09G3/36

    CPC classification number: A61B8/14 ,  A61B8/4227 ,  A61B8/4254 ,  A61B8/483 ,  A61B34/20 ,  A61B2034/2048 ,  A61B2034/2055 ,  A61B2090/067 ,  A61B2090/367 ,  A61B2090/378 ,  G01S15/8936 ,  G01S15/8993

    Abstract: A freehand 3-D imaging system includes an integrated sensor configuration that provides position and orientation of each 2D imaging plane used for 3-D reconstruction without the need for external references. The position sensors communicate with the imaging system using either wired and wireless means. At least one translational and one angular sensor or three translational sensors acquire data utilized to compute position tags associated with 2D ultrasound image scan frames. The sensors can be built into the ultrasound transducer or can be reversibly connected and therefore retrofitted to existing imaging probes for freehand 3D imaging.

    Abstract translation: 独立的三维成像系统包括集成的传感器配置，其提供用于3-D重建的每个2D成像平面的位置和取向，而不需要外部参考。 位置传感器使用有线和无线方式与成像系统进行通信。 至少一个平移和一个角度传感器或三个平移传感器获取用于计算与2D超声图像扫描帧相关联的位置标签的数据。 传感器可以内置在超声波传感器中，也可以被可逆地连接，因此可以用于现有的成像探头，用于手绘3D成像。

    IMAGE-BASED COMPUTATIONAL MECHANICAL ANALYSIS AND INDEXING FOR CARDIOVASCULAR DISEASES
    38.
    发明申请
    IMAGE-BASED COMPUTATIONAL MECHANICAL ANALYSIS AND INDEXING FOR CARDIOVASCULAR DISEASES 审中-公开
    基于图像的计算机械分析和心血管疾病指数

    公开(公告)号：WO2006062958A2

    公开(公告)日：2006-06-15

    申请号：PCT/US2005/044085

    申请日：2005-12-07

    Applicant: WORCESTER POLYTECHNIC INSTITUTE ,  TANG, Dalin

    Inventor： TANG, Dalin

    IPC: G06F19/00

    CPC classification number: G06F19/321 ,  G06F19/00 ,  G16H50/50 ,  Y02A90/26

    Abstract: A method and a computer system, for providing an assessment for disease status of a disease, such as a cardiovascular disease, employ construction of image-based 3D computational model of an organ representative of the disease status; computationally obtaining a certain mechanical distribution using the 3D-organ model; and computational, quantitative analysis of the mechanical distribution to provide an assessment for disease status of a disease. The image-based 3D computational model includes a fluid-structure interaction and multiple components within the organ.

    Abstract translation: 用于提供诸如心血管疾病的疾病的疾病状况的评估的方法和计算机系统采用代表疾病状态的器官的基于图像的3D计算模型的构建; 使用3D器官模型计算获得一定的机械分布; 以及机械分布的计算，定量分析，以提供疾病疾病状况的评估。 基于图像的3D计算模型包括器官内的流体结构相互作用和多个成分。

    COMPOSITE GAS SEPARATIONS MODULES HAVING INTERMEDIATE METAL LAYERS
    39.
    发明申请
    COMPOSITE GAS SEPARATIONS MODULES HAVING INTERMEDIATE METAL LAYERS 审中-公开
    具有中间金属层的复合气体分离模块

    公开(公告)号：WO2004085034A2

    公开(公告)日：2004-10-07

    申请号：PCT/US2004/008382

    申请日：2004-03-19

    Applicant: WORCESTER POLYTECHNIC INSTITUTE ,  MA, Yi, Hua ,  ENGWALL, Erik, E. ,  MARDILOVICH, Ivan, P.

    Inventor： MA, Yi, Hua ,  ENGWALL, Erik, E. ,  MARDILOVICH, Ivan, P.

    IPC: B01D53/00

    CPC classification number: B01D69/141 ,  B01D53/228 ,  B01D67/0069 ,  B01D67/0072 ,  B01D67/0086 ,  B01D69/10 ,  B01D69/12 ,  B01D71/022 ,  B01D71/028 ,  B01D2325/04 ,  B01D2325/20 ,  C01B3/505 ,  C01B2203/041 ,  C01B2203/0475

    Abstract: The present invention relates to a composite gas separation module and to methods for fabricating a composite gas separation module. The present invention also relates to methods for selectively separating hydrogen gas from a hydrogen gas containing gaseous stream. In one embodiment, the composite gas separation module includes a porous metal substrate; an intermediate porous metal layer, wherein the intermediate porous metal layer overlies the porous metal substrate; and a dense hydrogen-selective membrane, wherein the dense hydrogen-selective membrane overlies the intermediate porous metal layer. The intermediate porous metal layer can include can include palladium and a Group IB metal. For example, the intermediate porous metal layer can contain alternating layers of palladium and a Group IB metal.

    Abstract translation: 本发明涉及一种复合气体分离模块及其制造方法。 本发明还涉及从含有氢气的气流中选择性分离氢气的方法。 在一个实施例中，复合气体分离模块包括多孔金属基底; 中间多孔金属层，其中所述中间多孔金属层覆盖在所述多孔金属基板上; 和致密的氢选择性膜，其中致密的氢选择性膜覆盖在中间多孔金属层上。 中间多孔金属层可以包括钯和IB族金属。 例如，中间多孔金属层可以包含钯和IB族金属的交替层。

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