公开(公告)号：KR100747640B1

公开(公告)日：2007-08-08

申请号：KR1020050114469

申请日：2005-11-29

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  정유정 ,  임순성

IPC: A61K36/62

Abstract: 본 발명은 연수 (
Nelumbo

nucifera stamen) 추출물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 당뇨병성 합병증의 예방 및 치료용 조성물에 관한 것으로, 본 발명의 연수 추출물 또는 이로부터 분리된 화합물은 알도즈 환원효소에 대한 강력한 억제 활성을 나타내므로, 상기 조성물은 당뇨병성 합병증 예방 또는 치료용 약학조성물 및 건강기능식품으로 유용하게 이용될 수 있다.
연수, 알도즈 환원효소, 당뇨병성 합병증, 약학 조성물, 건강기능식품

公开(公告)号：KR1020140016217A

公开(公告)日：2014-02-07

申请号：KR1020130161917

申请日：2013-12-23

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  정현아

IPC: A61K31/7048 ,  A61K36/28 ,  A61K31/7042 ,  A61P29/00

CPC classification number: A61K31/7048 ,  A61K36/28 ,  A61K2236/333 ,  A61K2236/39 ,  A61K2236/50 ,  Y10S514/886

Abstract: The present invention relates to a pharmaceutical composition and a health functional food containing raw extract and non polar solvent-soluble extract of Cirsium maackii, or a compound of luteolin 5-O-β-D-glucopyranoside for preventing or treating inflammatory diseases. An active ingredient has an anti-inflammatory activity in lipopolysaccharides-induced nitrogen oxide generation of RAW 264.7 macrophage and right leg edema in carrageenan-induced mice. Thus, the Cirsium maackii extract has a strong preventive activity against the inflammatory diseases and secures the safety as a natural medicinal herb, thereby being able to be useful as the pharmaceutical composition and health functional food for preventing or treating the inflammatory diseases.

Abstract translation: 本发明涉及药用组合物和含有生姜提取物的非极性溶剂可溶性提取物，或用于预防或治疗炎性疾病的木犀草素5-O-β-D-吡喃葡萄糖苷的化合物的保健功能食品。 活性成分在角叉菜胶诱导的小鼠中脂多糖诱导的RAW 264.7巨噬细胞和右腿水肿的氮氧化物产生中具有抗炎活性。 因此，马鞭草提取物对炎性疾病具有很强的预防作用，确保了作为天然药草的安全性，从而能够用作预防或治疗炎性疾病的药物组合物和保健功能食品。

公开(公告)号：KR1020120111813A

公开(公告)日：2012-10-11

申请号：KR1020110030402

申请日：2011-04-01

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  이민섭 ,  신태선 ,  변대석 ,  최재수

IPC: A61K8/97 ,  A61K36/03 ,  A61Q19/02 ,  A61P17/00

CPC classification number: A61K8/9706 ,  A61K9/0014 ,  A61K36/03 ,  A61Q19/02

Abstract: PURPOSE: A composition containing Ecklonia stolonifera or Ecklonia cava spirit extract is provided to suppress tyrosinase expression and melanogenesis. CONSTITUTION: A composition with a whitening effect contains Ecklonia stolonifera spirit extract as an active ingredient. The Ecklonia stolonifera spirit extract is used as a material for a cosmetic product for skin whitening, a pharmaceutical product for treating hyperpigmentary dermatitis, and a functional food for whitening. The composition also contains Ecklonia cava spirit extract as an active ingredient. The composition additionally contains dieckol or phlorofucofuroeckol A as an active ingredient. [Reference numerals] (AA) Ecklonia stolonifera/Ecklonia cava; (BB) Drying in the shade; (CC) Powder; (DD) - reflux condensing extraction(repeat three times) - using spirit; (EE) Extraction; (FF) Filtering by reduced pressure; (GG) - vacuum rotary concentration - 40°C(removing organic solvent); (HH) Ecklonia stolonifera/Ecklonia cava crude extract; (II) Organic solvent soluble fraction(repeat 3-4 times); (JJ) N-hexane soluble extract; (KK) Water soluble fraction; (LL) Dichloromethane soluble extract; (MM) Water soluble fraction; (NN) Ethyl acetate soluble extract; (OO) Water soluble fraction

Abstract translation: 目的：提供含有Ecklonia stolonifera或Ecklonia cava spirit提取物的组合物，以抑制酪氨酸酶的表达和黑素生成。 构成：具有美白作用的组合物含有Ecklonia stolonifera精神提取物作为活性成分。 Ecklonia stolonifera精油提取物用作皮肤美白化妆品的材料，用于治疗色素性皮炎的药物和美白功能性食品。 该组合物还含有Ecklonia cava精华提取物作为活性成分。 该组合物另外含有甲羟戊酸或间苯三酚甲醇作为活性成分。 （AA）Ecklonia stolonifera / Ecklonia cava; （BB）在树荫下干燥; （CC）粉; （DD） - 回流冷凝提取（重复三次） - 使用精神; （EE）提取; （FF）减压过滤; （GG） - 真空旋转浓度-40℃（去除有机溶剂）; （HH）Ecklonia stolonifera / Ecklonia cava粗提物; （二）有机溶剂可溶成分（重复3-4次）; （JJ）N-己烷可溶提取物; （KK）水溶性成分; （LL）二氯甲烷可溶提取物; （MM）水溶性成分; （NN）乙酸乙酯可溶提取物; （OO）水溶性成分

公开(公告)号：KR1020110055771A

公开(公告)日：2011-05-26

申请号：KR1020090112323

申请日：2009-11-20

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  정현아

IPC: A61K31/37 ,  A23L1/30 ,  A61P3/10 ,  A61K31/7048

Abstract: PURPOSE: A composition containing Cirsium japonicum extract or compound isolated from the extract is provided to suppress aldose reductase and to prevent and treat diabetes or diabetes complication. CONSTITUTION: A composition for preventing or treating diabetes or diabetes compliation contains luteolin compound of chemical formula 1 or leuteolin 5-O-beta-D-glucopyranoside compound of chemical formula 2 as an active ingredient. The compounds are derived from Cirsium japonicum. The composition contains Cirsium japonicum crude extract or non-polar solvent soluble extract as an active ingredient. The crude extract of Cirsium japonicum is isolated using methanol, ethanol, propanol, isopropanol, n-butanol, or mixture solvent thereof.

Abstract translation: 目的：提供含有蓟马提取物或从提取物中分离的化合物的组合物以抑制醛糖还原酶并预防和治疗糖尿病或糖尿病并发症。 构成：用于预防或治疗糖尿病或糖尿病并发症的组合物含有化学式1的木犀草素化合物或化学式2的木犀草素5-O-β-D-吡喃葡萄糖苷化合物作为活性成分。 化合物衍生自日本蓟马。 该组合物含有日本蓟马提取物或非极性溶剂可溶性提取物作为活性成分。 使用甲醇，乙醇，丙醇，异丙醇，正丁醇或其混合溶剂分离日本蓟马的粗提物。

公开(公告)号：KR1020110035127A

公开(公告)日：2011-04-06

申请号：KR1020090092697

申请日：2009-09-29

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  김아름 ,  권미성 ,  최재수 ,  신태선 ,  변대석 ,  우희철

IPC: A61K36/03 ,  A61P29/00 ,  A23L1/30 ,  A61K31/357

CPC classification number: A61K36/03 ,  A23L29/035 ,  A61K31/357 ,  A61K2236/30 ,  Y10S514/886

Abstract: PURPOSE: A composition containing Ecklonia stolonifera OKAMURA and ecklonia cava extract is provided to suppress iNOS and COX-2 expression. CONSTITUTION: A composition for suppressing inflammation contains Ecklonia stolonifera OKAMURA and ecklonia cava extract. The composition contains hexane extract of Ecklonia stolonifera OKAMURA and ecklonia cava using water, low alcohol or mixture solvent. A pharmaceutical composition or functional food composition for suppressing inflammation contains phlorotannin isolated and purified from crude extract or non-polar solvent soluble extract of Ecklonia stolonifera OKAMURA and ecklonia cava. A pharmaceutical composition contains phlorofucofuroeckol A compound as an active ingredient.

Abstract translation: 目的：提供含有Ecklonia stolonifera OKAMURA和ecklonia cava提取物以抑制iNOS和COX-2表达的组合物。 构成：用于抑制炎症的组合物含有Ecklonia stolonifera OKAMURA和ecklonia cava提取物。 该组合物含有水，低醇或混合溶剂的Ecklonia stolonifera OKAMURA和ecklonia cava的己烷提取物。 用于抑制炎症的药物组合物或功能性食品组合物包含从粗提物或Ecllonia stolonifera OKAMURA和ecklonia cava的非极性溶剂可溶性提取物中分离和纯化的氯氰青霉素。 药物组合物含有作为活性成分的间苯二酚甲醇A化合物。

公开(公告)号：KR1020090084439A

公开(公告)日：2009-08-05

申请号：KR1020080010638

申请日：2008-02-01

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  윤나영 ,  정현아

IPC: A61K31/35 ,  A61K31/352 ,  A61K36/489 ,  A61P3/10

Abstract: A composition for preventing and treating diabetic complication is provided to drastically suppress generation activity of rat lens aldose reductase, recombinant human aldose reductase and advanced glycation endproducts (AGEs). A composition for preventing and treating diabetic complication comprises a Sophora flavescens extract or prenylated flavonoid compound isolated from the extract as an active ingredient. The prenylated flavonoid compound is denoted by the structural formula (1) to (14). The diabetic complication is artery scleroma, hypertension, intracerbroventricular infarction, stroke, myocardial infarction, angina, nephropathy, neuropathy, diabetic retinopathy, cataract or the glaucoma. The Sophora flavescens extract or prenylated flavonoid compound isolated from the extract is contained in 0.1-50 %weight based on total weight.

Abstract translation: 提供了用于预防和治疗糖尿病并发症的组合物，以显着抑制大鼠晶状体醛糖还原酶，重组人醛糖还原酶和晚期糖基化终末产物（AGEs）的产生活性。 用于预防和治疗糖尿病并发症的组合物包括从提取物中分离的苦参提取物或异戊烯醛化的类黄酮化合物作为活性成分。 异戊烯酮化合物由结构式（1）〜（14）表示。 糖尿病并发症是动脉硬化，高血压，脑室内梗死，中风，心肌梗死，心绞痛，肾病，神经病，糖尿病性视网膜病，白内障或青光眼。 从提取物中分离的苦参提取物或异戊烯酮化黄酮化合物的含量占总重量的0.1-50％。

公开(公告)号：KR1020070056172A

公开(公告)日：2007-06-04

申请号：KR1020050114469

申请日：2005-11-29

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  정유정 ,  임순성

IPC: A61K36/62

CPC classification number: A61K36/62 ,  A23V2200/328 ,  A61K2236/331 ,  A61K2236/333 ,  Y10S514/866

Abstract: A composition comprising an extract of Nelumbo nucifera stamen or a compound isolated therefrom is provided to show strong inhibition activity on an aldose reductase, thereby being usefully used as pharmaceutical compositions and health functional foods for preventing or treating diabetic complication. The pharmaceutical composition for preventing and treating diabetic complication comprises an extract of Nelumbo nucifera stamen or a compound represented by the formula(I) isolated therefrom as an effective ingredient, and a pharmaceutically acceptable carrier or an excipient. In the formula(I), R1 is H, galactosyl, glucosyl, glucuronyl, rhamnose-(1->6)-glucosyl, rhamnose-(1->2)-glucuronyl, rhamnose-(1->2)-glucosyl and glucuron-methyl, R2 is H or glucosyl, and each R3 and R4 is independently H, OH or OR'(where R' is H or lower alkyl).

Abstract translation: 提供包含Nelumbo nucifera雄蕊提取物或从其分离的化合物的组合物，以显示对醛糖还原酶的强抑制活性，从而可用作预防或治疗糖尿病并发症的药物组合物和健康功能食品。 用于预防和治疗糖尿病并发症的药物组合物包含Nelumbo nucifera雄蕊的提取物或由其分离的式（I）表示的化合物作为有效成分，以及药学上可接受的载体或赋形剂。 在式（I）中，R1是H，半乳糖基，葡糖基，葡糖醛酸，鼠李糖 - （1-> 6） - 葡糖基，鼠李糖 - （1-> 2） - 葡萄糖醛酸，鼠李糖 - （1-> 2） - 葡糖基和 葡萄糖醛酸甲基，R2为H或葡糖基，R3和R4独立地为H，OH或OR'（其中R'为H或低级烷基）。

公开(公告)号：KR1020040095124A

公开(公告)日：2004-11-12

申请号：KR1020030028736

申请日：2003-05-06

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  강혜숙 ,  손병화

IPC: A61K8/97 ,  A61Q19/02

CPC classification number: A61K8/97 ,  A23B7/14 ,  A23L33/105 ,  A61K8/498 ,  A61K2800/782 ,  A61Q5/02 ,  A61Q19/02 ,  A61Q19/10

Abstract: PURPOSE: Provided are a composition for whitening the skin or preventing food browning which contains the Ecklonia stolonifera extract having tyrosinase inhibiting activity or phlorotannin isolated from the extract. As inhibiting tyrosinase activity, overelaborates is prevented to whiten the skin and to prevent food browning. CONSTITUTION: The skin whitening composition is characterized by containing the crude extract or nonpolar solvent soluble extract of Ecklonia stolonifera. The crude extract is obtained by using, as an extraction solvent, water, methanol, ethanol, butanol or their mixture, and the nonpolar solvent soluble extract is obtained by using, as an extraction solvent, n-hexane, dichloromethane, chloroform or ethylacetate.

Abstract translation: 目的：提供含有从提取物中分离的具有酪氨酸酶抑制活性或氯光亮苷的Ecklonia stolonifera提取物的美白皮肤或防止食物褐变的组合物。 作为抑制酪氨酸酶活性，可以防止大戟素酯使皮肤变白并防止食物变褐。 构成：皮肤美白组合物的特征在于含有Ecklonia stolonifera的粗提取物或非极性溶剂可溶性提取物。 通过使用水，甲醇，乙醇，丁醇或其混合物作为萃取溶剂，得到粗提物，通过使用正己烷，二氯甲烷，氯仿或乙酸乙酯作为萃取溶剂，得到非极性溶剂可溶性提取物。

公开(公告)号：KR102242342B1

公开(公告)日：2021-04-19

申请号：KR1020190061651

申请日：2019-05-27

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  성수희

IPC: A61K31/357 ,  A61K36/03 ,  A61P25/00 ,  A23L33/10

Abstract: 본발명은플로로푸코푸로엑콜-A 또는디엑콜을유효성분으로포함하는신경질환의예방또는치료용약학조성물에관한것으로서, 상기플로로푸코푸로엑콜-A 또는디엑콜은 MAO-A (monoamine oxidase A) 또는 MAO-B (monoamine oxidase B) 활성을비경쟁적으로저해하고, 도파민 D3 수용체또는도파민 D4 수용체에의한신호전달을촉진시키고, 도파민 D1 수용체에의한신호전달을저해함으로써신경질환의예방또는치료에유용하게사용될수 있다.

公开(公告)号：KR1020200136085A

公开(公告)日：2020-12-07

申请号：KR1020190061651

申请日：2019-05-27

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  성수희

IPC: A61K31/357 ,  A61K36/03 ,  A61P25/00 ,  A23L33/10

Abstract: 본발명은플로로푸코푸로엑콜-A 또는디엑콜을유효성분으로포함하는신경질환의예방또는치료용약학조성물에관한것으로서, 상기플로로푸코푸로엑콜-A 또는디엑콜은 MAO-A (monoamine oxidase A) 또는 MAO-B (monoamine oxidase B) 활성을비경쟁적으로저해하고, 도파민 D3 수용체또는도파민 D4 수용체에의한신호전달을촉진시키고, 도파민 D1 수용체에의한신호전달을저해함으로써신경질환의예방또는치료에유용하게사용될수 있다.