公开(公告)号：KR1020130106454A

公开(公告)日：2013-09-30

申请号：KR1020110016764

申请日：2011-02-24

Applicant: 아주대학교산학협력단 ,  주식회사 한국인삼공사

Inventor： 정연훈 ,  진,슝위엔 ,  백인호 ,  서재현

IPC: A61K36/258 ,  A61P27/16

CPC classification number: A61K31/704 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/30 ,  A61K36/258 ,  Y10S514/956

Abstract: PURPOSE: A composition for preventing or treating ototoxic drug-induced hearing loss is provided to reduce side effects using a red ginseng extract, thereby treating infectious diseases by stably administering antibiotics when long-term administration of ototoxic aminoglycoside-based antibiotics is necessary. CONSTITUTION: A pharmaceutical composition for preventing or treating hearing loss contains a red ginseng extract as an active ingredient. The extract is prepared from red ginseng using water, C1-C4 alcohols, and a mixture thereof. Red ginseng is Korean red ginseng. The red ginseng extract contains ginsenoside Rb1 and/or ginsenoside Rb2. Hearing loss is induced by an ototoxic drug.

Abstract translation: 目的：提供一种用于预防或治疗耳毒性药物诱发的听力损失的组合物，以减少使用红参提取物的副作用，从而在需要长期施用基于耳毒素的氨基糖苷类抗生素时，通过稳定地施用抗生素来治疗感染性疾病。 构成：用于预防或治疗听力损失的药物组合物含有红参提取物作为活性成分。 采用水，C1-C4醇及其混合物从红参制备提取物。 红参是韩国红参。 红参提取物含有人参皂苷Rb1和/或人参皂甙Rb2。 听力损失是由耳毒性药物引起的。

公开(公告)号：KR101118331B1

公开(公告)日：2012-06-14

申请号：KR1020100010784

申请日：2010-02-05

Applicant: 아주대학교산학협력단

Inventor： 정연훈 ,  정종훈

IPC: A01K67/027 ,  G01N33/15 ,  A61P27/16

Abstract: PURPOSE: An animal models for chronic tympanic membrane perforations is provided to screen a medicine for chronic tympanic membrane perforations and an otitis media. CONSTITUTION: The device is comprised of steps: making an ear drum damaged by heat in punching the ear drum of an animal; processing mitomycin on the punched region; and processing dexmethasone on the processed era drum. A heat-treated tool is used in punching the ear drum to make the ear drum damaged. .

公开(公告)号：KR1020110091115A

公开(公告)日：2011-08-11

申请号：KR1020100010784

申请日：2010-02-05

Applicant: 아주대학교산학협력단

Inventor： 정연훈 ,  정종훈

IPC: A01K67/027 ,  G01N33/15 ,  A61P27/16

CPC classification number: A01K67/027 ,  A01K2227/105 ,  A01K2267/03 ,  G01N33/15

Abstract: PURPOSE: An animal models for chronic tympanic membrane perforations is provided to screen a medicine for chronic tympanic membrane perforations and an otitis media. CONSTITUTION: The device is comprised of steps: making an ear drum damaged by heat in punching the ear drum of an animal; processing mitomycin on the punched region; and processing dexmethasone on the processed era drum. A heat-treated tool is used in punching the ear drum to make the ear drum damaged. .

Abstract translation: 目的：提供用于慢性鼓膜穿孔的动物模型，以筛选用于慢性鼓膜穿孔和中耳炎的药物。 规定：该装置包括以下步骤：在冲压动物耳鼓时使耳鼓受热破坏; 在冲孔区加工丝裂霉素; 并在加工时代的鼓上加工地塞米松。 使用热处理工具冲压耳鼓，使耳鼓损坏。 。

公开(公告)号：KR101381108B1

公开(公告)日：2014-04-11

申请号：KR1020110006785

申请日：2011-01-24

Applicant: 서울대학교산학협력단

Inventor： 정종훈 ,  백수정 ,  정연훈 ,  정필훈

IPC: A61L24/00 ,  A61L27/36 ,  A61L27/38 ,  A61L27/56 ,  A61F2/28

Abstract: 본 발명은 나노 동물뼈 분말을 함유하는 나노 세라믹 골시멘트 및 이의 제조 방법, 나노 말뼈 분말을 함유하는 다공성 골지지체에 관한 것이다. 본 발명의 나노 동물뼈 분말을 함유하는 나노 세라믹 골시멘트는 실제 뼈와 유사한 수산화인회석 성분으로 강한 강도, 빠른 경화 시간, 생체적합성, 뼈 조직 재생을 촉진 시키는 우수한 특성을 가진다.

公开(公告)号：KR101473447B1

公开(公告)日：2014-12-24

申请号：KR1020140030553

申请日：2014-03-14

Applicant: 서울대학교산학협력단

Inventor： 정종훈 ,  백수정 ,  정연훈 ,  정필훈

IPC: A61L24/00 ,  A61L27/36 ,  A61L27/56 ,  A61F2/28

Abstract: 본 발명은 나노 동물뼈 분말을 함유하는 나노 세라믹 골시멘트 및 이의 제조 방법, 나노 말뼈 분말을 함유하는 다공성 골지지체에 관한 것이다. 본 발명의 나노 동물뼈 분말을 함유하는 나노 세라믹 골시멘트는 실제 뼈와 유사한 수산화인회석 성분으로 강한 강도, 빠른 경화 시간, 생체적합성, 뼈 조직 재생을 촉진 시키는 우수한 특성을 가진다.

公开(公告)号：KR1020140041664A

公开(公告)日：2014-04-04

申请号：KR1020140030553

申请日：2014-03-14

Applicant: 서울대학교산학협력단

Inventor： 정종훈 ,  백수정 ,  정연훈 ,  정필훈

IPC: A61L24/00 ,  A61L27/36 ,  A61L27/56 ,  A61F2/28

CPC classification number: A61L24/0084 ,  A61F2/28 ,  A61L24/0005 ,  A61L27/3608 ,  A61L27/56

Abstract: The present invention relates to nanoceramic bone cement containing animal bone powder and a preparation method thereof, and a porous bone support containing nanohorse bone powder. The nanoceramic bone cement containing animal bone powder of the present invention is a hydroxyapatite component similar to a real bone and has a strong strength, fast curing time, biocompatibility, and excellent characteristics for promoting bone tissue regeneration.

Abstract translation: 本发明涉及含有动物骨粉的纳米陶瓷骨水泥及其制备方法，以及含有纳米骨粉末的多孔骨架。 本发明的含有动物骨粉的纳米陶瓷骨粘固剂是与实骨相似的羟基磷灰石成分，具有强度高，固化时间快，生物相容性好，促进骨组织再生的优异特性。

公开(公告)号：KR1020120094547A

公开(公告)日：2012-08-27

申请号：KR1020110006785

申请日：2011-01-24

Applicant: 서울대학교산학협력단

Inventor： 정종훈 ,  백수정 ,  정연훈 ,  정필훈

IPC: A61L24/00 ,  A61L27/36 ,  A61L27/38 ,  A61L27/56 ,  A61F2/28

CPC classification number: A61L24/0084 ,  A61F2/28 ,  A61L27/3608 ,  A61L27/38 ,  A61L27/56

Abstract: PURPOSE: Nano ceramic bone cement using animal bone is provided to have strong strength, quick curing time, bio-compatibility, and excellent accelerating effect of bone tissue regeneration by a hydroxyapatite component which is similar with rear bone. CONSTITUTION: A manufacturing method of nano ceramic bone cement using animal bone comprises: a step of removing blood and organic material in animal bone; a step of sintering dried animal bone; a step of pulverizing the sintered animal bone; a step of manufacturing micro animal bone powder; a step of sintering the pulverized animal bone powder 1 times to 5 times; a step of grinding the animal bone powder to manufacture a nano animal bone powder; and a step of mixing the nano animal bone powder with chitosan solution.

Abstract translation: 目的：提供使用动物骨骼的纳米陶瓷骨水泥，具有强度高，固化时间快，生物相容性好，骨组织再生由于与后骨相似的羟基磷灰石组分的优异加速作用。 构成：使用动物骨的纳米陶瓷骨水泥的制造方法包括：去除动物骨骼中的血液和有机物质的步骤; 烧结干燥动物骨的步骤; 粉碎烧结的动物骨的步骤; 制造微型动物骨粉的一步; 将粉碎的动物骨粉烧结1次至5次的步骤; 研磨动物骨粉以制造纳米动物骨粉的步骤; 以及将纳米动物骨粉与壳聚糖溶液混合的步骤。