公开(公告)号：KR100761549B1

公开(公告)日：2007-10-04

申请号：KR1020060029439

申请日：2006-03-31

Applicant: 재단법인서울대학교산학협력재단

Inventor： 조명행 ,  조종수

IPC: A61K48/00 ,  A61K47/36 ,  A61K47/48

CPC classification number: A61K48/005 ,  A61K47/36

Abstract: A carrier/DNA complex is provided to promote the apoptosis and suppress an important path of the cell cycle and the angiogenesis by PDCD4, thereby acting as an inhibitor of lung cancer. And an anti-cancer composition comprising the same and a method for delivering the same to cancer cells are provided to be usefully used for preventing and treating lung cancer. In a carrier/DNA complex used for gene therapy of preventing and treating lung cancer, the carrier is UAC(Urocanic Acid modified-Chitosan), the DNA molecule is a nucleic acid coding a protein having the anti-cancer activity and the protein is PDCD4. The pharmaceutical composition for treating lung cancer comprises the complex as an effective ingredient. The method for inhibiting the proliferation of lung cancer cells comprises a step of delivering the complex to the lung cancer cells.

Abstract translation: 提供载体/ DNA复合物以促进细胞凋亡，并通过PDCD4抑制细胞周期和血管生成的重要途径，从而作为肺癌的抑制剂。 提供包含其的抗癌组合物和将其递送至癌细胞的方法可用于预防和治疗肺癌。 在用于预防和治疗肺癌的基因治疗的载体/ DNA复合物中，载体是UAC（Urocanic Acid modified-Chitosan），DNA分子是编码具有抗癌活性的蛋白质的核酸，蛋白质是PDCD4 。 用于治疗肺癌的药物组合物包含该复合物作为有效成分。 抑制肺癌细胞增殖的方法包括将复合物递送至肺癌细胞的步骤。