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公开(公告)号：KR100950428B1
公开(公告)日：2010-04-02
申请号：KR1020090048521
申请日：2009-06-02
Applicant: 주식회사 알바이오
IPC: A61K31/12 , A61P31/16 , A61K31/7028 , A61K31/70
CPC classification number: A61K31/7032 , A61K31/12 , A61K31/7028
Abstract: 본 발명은 바이러스 활성 억제를 위한, 하기 화학식 (I)의 디아릴헵타노이드계(diarylheptanoid) 화합물의 용도에 관한 것이다.
상기 화학식의 화합물은 바이러스 활성 억제 효능이 우수하므로 바이러스와 관련된 질환에 대한 치료제로서 유용하게 사용될 수 있다.
디아릴헵타노이드, 바이러스, 조류 인플루엔자-
公开(公告)号：KR100930480B1
公开(公告)日：2009-12-09
申请号：KR1020090048522
申请日：2009-06-02
Applicant: 주식회사 알바이오
IPC: C07C49/24 , C07C49/172 , A61K31/121 , A61P31/16
CPC classification number: C07C49/248 , A61K31/12 , C07B2200/07 , C07C49/245
Abstract: PURPOSE: A diaryl heptanoid-based compound is provided to be used for the treatment and prevention of disease by virus activity, especially to be useful for activity inhibition of avian influenza virus. CONSTITUTION: A diaryl heptanoid-based compound, its isomer or its pharmaceutically acceptable salts has a structure represented by chemical formula 1. In the chemical formula 1, Z is hydrogen or hydroxy and a dotted line is an arbitrary double bond. The virus is influenza virus or avian influenza virus. A pharmaceutical composition for the treatment of diseases according to infection and/or prevention of virus comprises the diaryl heptanoid-based compound and pharmaceutically acceptable carrier.
Abstract translation: 目的：提供二芳基庚酮类化合物，用于通过病毒活性治疗和预防疾病，特别是可用于禽流感病毒的活性抑制。 构成：二芳基庚酮类化合物，其异构体或其药学上可接受的盐具有由化学式1表示的结构。在化学式1中，Z是氢或羟基，虚线是任意的双键。 病毒是流感病毒或禽流感病毒。 根据感染和/或预防病毒治疗疾病的药物组合物包括二芳基庚酮类化合物和药学上可接受的载体。
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公开(公告)号：KR100904396B1
公开(公告)日：2009-06-26
申请号：KR1020070107341
申请日：2007-10-24
Applicant: 주식회사 알바이오
CPC classification number: A61K36/282 , A23K10/12 , A23K50/10 , A23L33/105
Abstract: 본 발명은 인진쑥을 유효성분으로 함유하는 가축의 산유량 증가용 조성물에 관한 것으로, 더욱 자세하게는 인진쑥을 유효성분으로 함유하는 가축의 산유량 증가용 조성물과 사료첨가제 및 인진쑥을 유효성분으로 함유하는 가축 젖의 체세포 감소용 조성물과 사료첨가제에 관한 것이다.
본 발명의 조성물을 사용하면, 인간을 포함하는 동물이 생산하는 젖의 생산량을 증가시킬 수 있을 뿐만아니라, 생산되는 젖에 포함되는 체세포의 수를 감소시켜 양질의 젖을 생산할 수 있다.
산유량 증가, 인진쑥, 발효 인진쑥, 젖소, 원유, 체세포 감소-
公开(公告)号：KR1020090041694A
公开(公告)日：2009-04-29
申请号：KR1020070107341
申请日：2007-10-24
Applicant: 주식회사 알바이오
CPC classification number: A61K36/282 , A23K10/12 , A23K50/10 , A23L33/105
Abstract: A composition for increasing milk yield containing artemisia capillaries is provided to increase milk yield of animals including human and to decrease the content of somatic cells of the milk produced effectively. Artemisia capillaries are contained as valid components of a feed admixture for decreasing somatic cells and promoting milk yield. The artemisia capillaries are selected from a group consisting of fermentation Artemisia capillaries and Artemisia capillaries extract. The artemisia capillaries extract is dry powder gained by extracting the artemisia capillaries powder with ethanol.
Abstract translation: 提供了一种用于增加含有毛蒿的产奶量的组合物，以增加包括人在内的动物的产奶量，并有效降低产生的牛奶体细胞的含量。 作为用于减少体细胞和促进产奶量的饲料混合物的有效组分，含有艾蒿毛细血管。 艾蒿毛细血管选自发酵蒿毛细血管和艾蒿毛细血管提取物。 艾蒿毛细血管提取物是通过用乙醇提取青蒿素粉末而获得的干粉。
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公开(公告)号：KR1020080097593A
公开(公告)日：2008-11-06
申请号：KR1020070042645
申请日：2007-05-02
Inventor： 라정찬
CPC classification number: A61K35/28 , A61K35/36 , A61K38/1774
Abstract: A cellular therapeutic agent for inducing hair growth is provided to cure depilation and atrichia by using a human fatty tissue derived from adult stem cell and a scalp tissue derived follicular cell as an active ingredient. A cellular therapeutic agent for inducing hair growth has a human fatty tissue derived from adult stem cell and a scalp tissue derived follicular cell as an active ingredient. The scalp tissue derived follicular cell contains a CD34 negative cell and/or a CD34 positive cell. The human fatty tissue derived from adult stem cell and the scalp tissue derived follicular cell are mixed to a rate of 100:1 - 1:100.
Abstract translation: 提供用于诱导毛发生长的细胞治疗剂，通过使用源自成体干细胞和头皮组织来源的滤泡细胞的人体脂肪组织作为活性成分来治愈脱毛和无毛。 用于诱导毛发生长的细胞治疗剂具有来自成体干细胞和头皮组织来源的滤泡细胞作为活性成分的人体脂肪组织。 头皮组织衍生的滤泡细胞含有CD34阴性细胞和/或CD34阳性细胞。 将来自成体干细胞和头皮组织来源的滤泡细胞的人体脂肪组合物混合至100:1-1:100的比例。
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Patent Agency Ranking
公开(公告)号：KR100795708B1
公开(公告)日：2008-01-17
申请号：KR1020070114451
申请日：2007-11-09
Applicant: 주식회사 알바이오
Abstract: A method for isolating and culturing adult stem cells derived from human amniotic epithelium is provided to improve collection convenience as compared to therapeutic stem cells of umbilical cord blood and bone marrow, and increase yield and growth rates by DTT(dithiothreitol) treatment, ROCK(Rho-associated kinase) inhibitor addition or medium exchange. A method for isolating and culturing adult stem cells derived from human amniotic epithelium comprises the steps of: treating the human amniotic tissue with 5-50 mM of DTT; treating the DTT-treated human amniotic tissue with 0.025-0.125% of trypsin to isolate human amniotic epithelial cell; culturing the isolated human amniotic epithelial cell in DMEM(Dulbecco Modified Eagle Medium) or K-SFM(keratinocyte serum free medium) containing 10nM to 100muM of ROCK inhibitor; and recovering the stem cells from the cultured medium.
Abstract translation: 提供了一种分离培养源自人羊膜上皮的成体干细胞的方法，以提高与脐带血和骨髓的治疗性干细胞相比的收集方便性，并通过DTT（二硫苏糖醇）治疗ROCK（Rho）提高产量和生长速率 - 相关激酶）抑制剂添加或中等交换。 用于分离和培养源自人羊膜上皮的成体干细胞的方法包括以下步骤：用5-50mM DTT处理人羊膜组织; 用0.025-0.125％的胰蛋白酶处理DTT处理的人羊膜组织以分离人羊膜上皮细胞; 在含有10nM至100mMM的ROCK抑制剂的DMEM（Dulbecco Modified Eagle Medium）或K-SFM（角质细胞无血清培养基）中培养分离的人羊膜上皮细胞; 并从培养基中回收干细胞。
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公开(公告)号：KR100762149B1
公开(公告)日：2007-10-04
申请号：KR1020060059185
申请日：2006-06-29
Applicant: 주식회사 알바이오
IPC: A23L1/29
CPC classification number: A23L33/105 , A23L33/00 , A23L33/30 , A23L33/40
Abstract: An antiviral composition containing an extract of Acer ginnala(Amur Maple) as an active component is provided to secure excellent antiviral effect and low toxicity against chorioallantoic cells as a normal cell and be used in treatment and prevention of influenza virus disease. A food composition contains Acer ginnala extract and a food acceptable auxiliary-additive. Fruits, stems and leaves of Acer ginnala are dried at room temperature for 24hr, cut and ground. The Acer ginnala powder is reflux-extracted with 99.9% methanol at room temperature for 2hr, filtered under reduced pressure and dried at room temperature for 24hr.
Abstract translation: 提供含有Acer ginnala（Amur Maple）提取物作为活性组分的抗病毒组合物，以确保优良的抗病毒作用和对绒毛尿囊细胞作为正常细胞的低毒性，并用于治疗和预防流感病毒病。 食物组合物含有宏碁提取物和可食用的辅助添加剂。 水果，茎和叶子的Acer ginnala在室温下干燥24小时，切割并研磨。 将Acer ginnala粉末用99.9％甲醇在室温下回流提取2小时，在减压下过滤并在室温下干燥24小时。
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公开(公告)号：KR100757712B1
公开(公告)日：2007-09-13
申请号：KR1020060059191
申请日：2006-06-29
Applicant: 주식회사 알바이오
CPC classification number: A61K36/185 , A23L33/105
Abstract: An antiviral composition containing alder wood(Alnus pendula Matsumura) extract is provided to prevent and treat influenza virus disease by using alder wood extract which shows low toxicity to chorioallantoic cells but excellent antiviral effect. An avian antiviral composition for prevention and treatment of human influenza virus disease, swine influenza virus disease, equine influenza virus disease and avian influenza virus disease contains alder wood extract and food acceptable additives. The avian influenza virus is KBNP-0028(KCTC10866BP). Stems and leaves of alder wood are dried at room temperature for 24hr, crushed, extracted at room temperature for 24hr and filtered under reduced pressure to obtain the alder wood extract.
Abstract translation: 提供含有der木（Alnus pendula Matsumura）提取物的抗病毒组合物，以通过使用对绒毛尿囊细胞毒性低而具有优异抗病毒作用的al木提取物来预防和治疗流感病毒病。 用于预防和治疗人流感病毒病，猪流感病毒病，马流感病毒病和禽流感病毒病的禽类抗病毒组合物含有檀香木提取物和食品可接受的添加剂。 禽流感病毒是KBNP-0028（KCTC10866BP）。 al木的茎和叶在室温下干燥24小时，粉碎，在室温下萃取24小时，并在减压下过滤得到al木提取物。
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公开(公告)号：KR101763343B1
公开(公告)日：2017-08-01
申请号：KR1020100012425
申请日：2010-02-10
Applicant: 서울대학교산학협력단 , 주식회사 알바이오
IPC: C12N15/873 , C12N5/075 , C12N5/074 , A01K67/027
Abstract: 본발명은개과 () 동물의체세포또는줄기세포를이용한, 새로운핵 이식산자생산방법에관한것이다. 보다구체적으로본 발명은개의감수분열말기의탈핵된난모세포로부터핵을제거하여탈핵난자에, 유사분열 G2/M단계의체세포또는줄기세포의핵 공여세포를이식하여융합시키는단계를포함하는, 복제개 생산용핵이식란을제조하는방법및 이를이용한복제개 생산방법에관한것이다. 본발명에따른방법은개과동물을고효율로복제할수 있게함으로써복제된개과동물을이용한우량품종의번식, 이종이식, 질환모델동물등 수의학, 인류학및 의학연구분야의발달에기여할수 있다.
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