페노피브레이트를 함유하는 패혈증 예방용 약학 조성물
    31.
    发明公开
    페노피브레이트를 함유하는 패혈증 예방용 약학 조성물 有权
    含有防腐剂的防腐剂的药物组合物

    公开(公告)号:KR1020120095170A

    公开(公告)日:2012-08-28

    申请号:KR1020110014674

    申请日:2011-02-18

    CPC classification number: A61K31/216

    Abstract: PURPOSE: A pharmaceutical composition containing fenofibrate for preventing septicemia is provided to suppress secretion of cytokine and drastically increase survival rate. CONSTITUTION: A pharmaceutical composition for preventing septicemia containes fenofibrate as an active ingredient. The sepsis is caused by infection of the gram-negative bacteria. The fenofibrate is formed into a formulation of powder, granule, tablet, capsule or injection by mixing with a pharmaceutically allowed carrier, a forming agent, and diluent. The fenobrate dose is 1-100mg per 1kg per day and is divided into 1 time-several times to be administrated.

    Abstract translation: 目的:提供含有非诺贝特预防败血症的药物组合物,以抑制细胞因子的分泌,大大提高存活率。 构成:用于预防败血症的药物组合物含有非诺贝特作为活性成分。 败血症是由革兰氏阴性细菌感染引起的。 通过与药学上允许的载体,成形剂和稀释剂混合,将非诺贝特形成为粉末,颗粒,片剂,胶囊或注射剂的制剂。 fenobrate剂量为每天1kg 1-100mg,分1次给药。

    면역질환 치료용 제약 조성물
    32.
    发明公开
    면역질환 치료용 제약 조성물 有权
    用于治疗免疫疾病和癌症的药物组合物

    公开(公告)号:KR1020100050198A

    公开(公告)日:2010-05-13

    申请号:KR1020080109371

    申请日:2008-11-05

    CPC classification number: A61K38/1793 C07K14/4713 C07K2319/00

    Abstract: PURPOSE: A pharmaceutical composition containing tat-ret-1 fusion protein is provided to effectively prevent and treat autoimmune diseases and cancer by controlling the development of HMGB1(high-mobility group box 1). CONSTITUTION: A pharmaceutical composition for treating autoimmune diseases and cancer contains tat-ref-1 fusion protein with the sequence number 1 as an active ingredient. The Tat-ref-1 fusion protein is produced by E.coli transformant BL 21(DE3)/pTat-ref-1 transformed as a development vector. The autoimmune disease includes sepsis, Churg-Strauss syndrome, Sjogren's syndrome, Systemic lupus erythematosus, or Rheumatoid arthritis. The cancer includes breast cancer, colon cancer, melanoma, prostate cancer, lung cancer or pancreatic cancer. The amount of each dose is 0.1~10 nM per day.

    Abstract translation: 目的:提供含有tat-ret-1融合蛋白的药物组合物,通过控制HMGB1(高迁移率组盒1)的发展来有效预防和治疗自身免疫性疾病和癌症。 构成:用于治疗自身免疫疾病和癌症的药物组合物含有序列号1的tat-ref-1融合蛋白作为活性成分。 Tat-ref-1融合蛋白由作为显影载体转化的大肠杆菌转化株BL21(DE3)/ pTat-ref-1产生。 自身免疫性疾病包括败血症,Churg-Strauss综合征,干燥综合征,系统性红斑狼疮或类风湿关节炎。 癌症包括乳腺癌,结肠癌,黑素瘤,前列腺癌,肺癌或胰腺癌。 每剂量为0.1〜10nM /天。

    신규한 인터루킨-6 결합 폴리펩타이드 및 이의 용도
    37.
    发明公开
    신규한 인터루킨-6 결합 폴리펩타이드 및 이의 용도 有权
    新型多糖与白蛋白-6的结合及其用途

    公开(公告)号:KR1020140094837A

    公开(公告)日:2014-07-31

    申请号:KR1020130007380

    申请日:2013-01-23

    Abstract: The present invention relates to a method, for preventing or treating a cancer, which includes: a novel polypeptide which is able to suppress a biological activation through a specific binding with an interleukin-6; a polynucleotide which codes the polypeptide; a vector which includes the polynucleotide; a transformant to which the vector is adopted; a method for producing the polypeptide by using the transformant; a composition, for preventing or treating a cancer, which includes the polypeptide; and an injection of the composition, for preventing or treating a cancer, which includes the polypeptide. The polypeptide of the present invention can be widely used as a substance for preventing or treating an IL-6-related disease by significantly decreasing the activation of an STAT3 and the concentration of an interleukin-6.

    Abstract translation: 本发明涉及一种预防或治疗癌症的方法,其包括:能够通过与白介素-6的特异性结合抑制生物活化的新型多肽; 编码该多肽的多核苷酸; 包含多核苷酸的载体; 采用载体的转化体 通过使用转化体生产多肽的方法; 用于预防或治疗癌症的组合物,其包括所述多肽; 以及注射组合物,用于预防或治疗包括多肽的癌症。 通过显着降低STAT3的活化和白细胞介素-6的浓度,本发明的多肽可以广泛用作预防或治疗IL-6相关疾病的物质。

    면역질환 치료용 제약 조성물
    38.
    发明授权
    면역질환 치료용 제약 조성물 有权
    用于治疗免疫疾病的药物组合物

    公开(公告)号:KR101056346B1

    公开(公告)日:2011-08-12

    申请号:KR1020080109371

    申请日:2008-11-05

    Abstract: 본 발명은 융합단백질을 유효성분으로 함유하는 제약 조성물에 관한 것으로, 보다 상세하게는 서열번호 1의 Tat-ref-1 융합단백질을 유효성분으로 함유하는 면역질환과 암의 치료에 유용한 제약 조성물에 관한 것이다.
    본 발명의 Tat-ret-1 융합단백질을 유효성분으로 함유하는 제약 조성물은 HMGB1의 발현을 효과적으로 억제하여 HMGB1의 발현과 관련한 면역질환, 자가면역질환 및 암의 예방 및 치료에 유용하게 이용될 수 있다.
    산화환원인자-1, 세포투과, 융합단백질, HMGB1, 면역질환, 암

    Abstract translation: 本发明涉及含有融合蛋白作为活性成分的药物组合物,更具体地涉及用于治疗免疫疾病的药物组合物和含有SEQ ID NO:1的Tat-ref-1融合蛋白作为活性成分的癌症 会的。

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