公开(公告)号：US10851404B2

公开(公告)日：2020-12-01

申请号：US15533688

申请日：2015-12-04

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Hongying Jiang ,  Masayuki Nakamura ,  Xuan Jiang ,  Catherine A. Bothof

IPC: C07D277/68 ,  C07D417/04 ,  C12Q1/66 ,  B01L3/00

Abstract: Luciferin-containing substrates are provided including a substrate and luciferin dried on the substrate. The luciferin-containing substrate is free of a detectable amount of reactive luciferase. The substrate is optionally a nonwoven substrate. Monitoring devices are also provided. The monitoring devices include a test element having a test portion, a detection reagent comprising luciferase, a luciferin-containing substrate, and a container having a first end with an opening and a second end opposite the first end. The container is configured to receive the test portion and configured to be operationally coupled to an analytical instrument. The detection reagent and the luciferin each are capable of participating in one or more chemical reaction that results in the formation of a detectable product.

公开(公告)号：US10471398B2

公开(公告)日：2019-11-12

申请号：US15444565

申请日：2017-02-28

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Catherine A. Bothof ,  George W. Griesgraber ,  James I. Hembre ,  Jerald K. Rasmussen

IPC: B01D71/78 ,  B01J20/32 ,  B01D71/40 ,  B01D71/56 ,  B01D71/76 ,  C09D179/02 ,  G01N33/543 ,  C09D177/04 ,  C08F255/02 ,  C08G69/48 ,  B01J20/26 ,  C08F283/04 ,  C08J7/18 ,  G01N33/545 ,  C08G69/10 ,  C08G73/02

Abstract: Guanidinyl ligand-functionalized polymers, methods of making the same, and substrates bearing a grafted coating of the ligand-functional polymers are described. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, endotoxins and proteins, at pH's near or below the pI's of the biomaterials.

公开(公告)号：US10352835B2

公开(公告)日：2019-07-16

申请号：US15936767

申请日：2018-03-27

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jerald K. Rasmussen ,  Catherine A. Bothof ,  George W. Griesgraber ,  Semra Colak Atan ,  James I. Hembre ,  Robert T. Fitzsimons, Jr.

IPC: B01D71/44 ,  G01N1/40 ,  C07K1/34 ,  C08J7/18 ,  C07F9/38 ,  G01N33/544 ,  C07K1/18 ,  B01D67/00 ,  B01D71/52 ,  B01D71/56 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32

Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.

公开(公告)号：US20190062369A1

公开(公告)日：2019-02-28

申请号：US16174373

申请日：2018-10-30

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jerald K. Rasmussen ,  Catherine A. Bothof ,  Kannan Seshadri ,  James I. Hembre ,  Robert T. Fitzsimons, JR. ,  George W. Griesgraber ,  Yi He

IPC: C07K1/22 ,  C09D179/02 ,  B01D71/56 ,  C07K14/765 ,  B01D67/00 ,  C07H1/08

Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.

公开(公告)号：US09650470B2

公开(公告)日：2017-05-16

申请号：US14467651

申请日：2014-08-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Catherine A. Bothof ,  Yi He ,  Jerald K. Rasmussen ,  Kannan Seshadri ,  Clinton P. Waller, Jr. ,  Douglas E. Weiss

IPC: B32B27/00 ,  C08G69/48 ,  B01J20/285 ,  C07C279/12 ,  C07C281/16 ,  C08J7/18 ,  C08J9/28 ,  C08J9/42 ,  B01D39/16 ,  C07K1/34 ,  C12N7/00 ,  C07C277/08 ,  C07C279/14 ,  C08F259/08

CPC classification number: C07C279/12 ,  B01D39/1676 ,  B01J20/285 ,  C07C277/08 ,  C07C279/14 ,  C07C281/16 ,  C07K1/34 ,  C08F259/08 ,  C08F283/04 ,  C08G69/48 ,  C08J7/18 ,  C08J9/283 ,  C08J9/42 ,  C08J2327/16 ,  C08J2377/00 ,  C12N7/00 ,  Y02C10/08 ,  Y10T428/31855

Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.

公开(公告)号：US20160152662A1

公开(公告)日：2016-06-02

申请号：US15018129

申请日：2016-02-08

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jerald K. Rasmussen ,  Catherine A. Bothof ,  Kannan Seshadri ,  James I. Hembre ,  Robert T. Fitzsimons, JR. ,  George W. Griesgraber ,  Yi He

IPC: C07K1/22 ,  C07H1/08 ,  C07K14/765

CPC classification number: C07K1/22 ,  B01D67/0093 ,  B01D71/56 ,  B01D2323/30 ,  B01D2323/385 ,  C07H1/08 ,  C07K14/765 ,  C09D179/02 ,  Y10T428/31663 ,  Y10T428/31721 ,  Y10T428/31725 ,  Y10T428/31855 ,  Y10T428/31928

Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.

Abstract translation: 提供了包含交联聚合物底漆层并接枝到配体官能化聚合物上的底物。 在接近或低于生物材料的pI的pH值下，接枝聚合物对结合中性或带负电荷的生物材料如细胞，细胞碎片，细菌，孢子​​，病毒，核酸和蛋白质具有必要的亲和力。

公开(公告)号：US09018267B2

公开(公告)日：2015-04-28

申请号：US14254247

申请日：2014-04-16

Applicant: 3M Innovative Properties Company

Inventor： Simon K. Shannon ,  Catherine A. Bothof ,  Babu N. Gaddam ,  Jerald K. Rasmussen ,  Richard B. Ross

IPC: B01D15/08 ,  B01J39/18 ,  C08F20/56 ,  C08F271/02 ,  B01J20/286 ,  B01J20/32 ,  B01J39/16 ,  B01J41/12 ,  B01J20/26 ,  B01J20/287 ,  C07K1/22 ,  B01J39/20 ,  B01J41/14 ,  B01D15/38

CPC classification number: C07K17/08 ,  B01D15/08 ,  B01D15/3804 ,  B01D15/3809 ,  B01J20/264 ,  B01J20/286 ,  B01J20/287 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3255 ,  B01J20/3276 ,  B01J20/3278 ,  B01J20/328 ,  B01J39/17 ,  B01J39/18 ,  B01J39/20 ,  B01J41/12 ,  B01J41/14 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/62 ,  C07K1/22 ,  C08F271/02

Abstract: Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample.

Abstract translation: 描述了含有从固体支持物延伸的接枝链的固体支持物的制品，制造这些制品的方法以及制品的各种用途。 更具体地，接枝链具有可与目标化合物反应或与其相互作用的官能团。 或者，接枝链上的官能团可以与改性剂反应，以提供可与目标化合物反应或与目标化合物相互作用的另一个基团。 接枝的链通过开环的吖内酯基团连接到固体支持物上。 该制品可用于纯化目标化合物或将目标化合物与样品中的其它分子分离。

公开(公告)号：US08945896B2

公开(公告)日：2015-02-03

申请号：US13748373

申请日：2013-01-23

Applicant: 3M Innovative Properties Company

Inventor： Jerald K. Rasmussen ,  Catherine A. Bothof ,  Kannan Seshadri ,  Erin A. Satterwhite ,  Robert T. Fitzsimons, Jr. ,  James L. Hembre ,  Mahfuza B. Ali

IPC: C08F26/02 ,  C08F220/56 ,  C08F20/00 ,  B01D15/00 ,  C08F220/60 ,  G01N33/543

CPC classification number: C08F220/56 ,  B01D15/00 ,  C08F20/00 ,  C08F26/02 ,  C08F220/60 ,  G01N33/54393 ,  Y10T428/12264 ,  Y10T428/249991

Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.

Abstract translation: 配体功能化底物，制备配体官能化底物的方法，以及使用官能化底物的方法。

公开(公告)号：US20130137158A1

公开(公告)日：2013-05-30

申请号：US13748373

申请日：2013-01-23

Applicant: 3M Innovative Properties Company

Inventor： Jerald K. Rasmussen ,  Catherine A. Bothof ,  Kannan Seshadri ,  Erin A. Satterwhite ,  Robert T. Fitzsimons, JR. ,  James L. Hembre ,  Mahfuza B. Ali

IPC: C08F220/56

CPC classification number: C08F220/56 ,  B01D15/00 ,  C08F20/00 ,  C08F26/02 ,  C08F220/60 ,  G01N33/54393 ,  Y10T428/12264 ,  Y10T428/249991

Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.

公开(公告)号：US20180265542A1

公开(公告)日：2018-09-20

申请号：US15987441

申请日：2018-05-23

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jerald K. Rasmussen ,  Kannan Seshadri ,  Robert T. Fitzimons, JR. ,  James I. Hembre ,  Catherine A. Bothof ,  Erin A. Satterwhite ,  George W. Griesgraber ,  Yi He ,  Louis C. Haddad

IPC: C07K1/14 ,  B01D21/01 ,  C08F120/60 ,  C08G73/02 ,  C12N11/08 ,  C08F126/02

CPC classification number: C07K1/14 ,  B01D21/01 ,  C08F120/60 ,  C08F126/02 ,  C08G69/10 ,  C08G73/0206 ,  C08G73/022 ,  C08G73/028 ,  C08L77/04 ,  C08L79/02 ,  C08L83/08 ,  C12N7/02 ,  C12N11/08 ,  G01N33/54393 ,  G01N33/545 ,  Y10T428/249978 ,  Y10T428/249991 ,  Y10T428/2935 ,  Y10T428/2998 ,  Y10T442/20

Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.