公开(公告)号：CA3116561A1

公开(公告)日：2020-04-23

申请号：CA3116561

申请日：2019-10-17

Applicant: ARRAY BIOPHARMA INC

Inventor： BLAKE JAMES F ,  BOYS MARK LAURENCE ,  CHICARELLI MARK JOSEPH ,  COOK ADAM ,  ELSAYED MOHAMED S A ,  FELL JAY B ,  FISCHER JOHN P ,  HINKLIN RONALD JAY ,  MCNULTY OREN T ,  MEJIA MACEDONIO J ,  RODRIGUEZ MARTHA E ,  WONG CHRISTINA E

IPC: C07D401/04 ,  A61K31/498 ,  A61K31/4985 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

Abstract: Compounds of Formula la or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases in the view of their ability to inhibit SHP2. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.