公开(公告)号：DK1318138T3

公开(公告)日：2004-10-25

申请号：DK02025292

申请日：2002-11-13

Applicant: BASF AG

Inventor： ERHARDT MELANIE ,  KLATT MARTIN JOCHEN ,  NIEBEL MARKUS

IPC: C07D339/04 ,  C07C67/30 ,  C07C67/31 ,  C07C67/317 ,  C07C67/32 ,  C07C69/66 ,  C07C69/675

Abstract: Production of dihydroxycarboxylic acid esters, by reaction of hydroxycarboxylic acid diesters with complex hydrides, is conducted in the absence of a solvent. Production of dihydroxycarboxylic acid esters of formula (I) by reaction of hydroxycarboxylic acid diesters of formula (II) with complex hydrides is conducted in the absence of a solvent. n = 1, 2, 3, 4, 5, 6 or 7; and R and R = optionally substituted 1-20C alkyl, 2-20C alkenyl or alkynyl, 3-8C cycloalkyl, aralkyl, aryl, hetarylalkyl or hetaryl An Independent claim is included for production of R-(+)- alpha -lipoic acid of formula (III) from (I) obtained as above (i.e. in the absence of solvent) by: (1) converting (I) to its bis-sulfonic ester by reaction in an organic solvent with a sulfonic acid chloride and a tertiary nitrogen base; (2) converting the ester thus obtained to R- alpha -lipoic acid ester by reaction in a polar solvent with sulfur and an alkali metal disulfide; and then (3) converting the ester to the required product.

公开(公告)号：AU2002358612A1

公开(公告)日：2003-06-17

申请号：AU2002358612

申请日：2002-12-05

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS

IPC: C07B53/00 ,  C07B61/00 ,  C07C67/31 ,  C07C69/675 ,  C07D339/04

公开(公告)号：ES2184475T3

公开(公告)日：2003-04-01

申请号：ES99932864

申请日：1999-07-12

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM ,  RIEGER JENS

IPC: A61K31/385 ,  C07B57/00 ,  C07D339/04 ,  A23L1/30

Abstract: In the 2 &THgr; diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 &THgr;=23°.

公开(公告)号：CZ2001381A3

公开(公告)日：2001-05-16

申请号：CZ2001381

申请日：1999-07-12

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM ,  RIEGER JENS

IPC: A23L33/115 ,  A61K31/385 ,  C07D339/04 ,  A23L1/30

公开(公告)号：CZ20010381A3

公开(公告)日：2001-05-16

申请号：CZ20010381

申请日：1999-07-12

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM ,  RIEGER JENS

IPC: A23L33/115 ,  A61K31/385 ,  C07D339/04 ,  A23L1/30

公开(公告)号：NO20010516L

公开(公告)日：2001-01-30

申请号：NO20010516

申请日：2001-01-30

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM ,  RIEGER JENS

IPC: A61K31/385 ,  C07B57/00 ,  C07D339/04 ,  A23L1/30

Abstract: In the 2 &THgr; diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 &THgr;=23°.

公开(公告)号：NO20010516D0

公开(公告)日：2001-01-30

申请号：NO20010516

申请日：2001-01-30

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM ,  RIEGER JENS

IPC: A61K31/385 ,  A23L1/30 ,  C07B57/00 ,  C07D339/04 ,  C07D

Abstract: In the 2 &THgr; diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 &THgr;=23°.