公开(公告)号：US07625921B2

公开(公告)日：2009-12-01

申请号：US11034822

申请日：2005-01-13

Applicant: Jingwu Duan ,  James Sheppeck ,  Bin Jiang ,  John L. Gilmore

Inventor： Jingwu Duan ,  James Sheppeck ,  Bin Jiang ,  John L. Gilmore

IPC: A61K31/4748 ,  C07D401/14 ,  C07D417/12

CPC classification number: C07D471/08 ,  C07D401/12 ,  C07D401/14 ,  C07D417/12 ,  C07D417/14

Abstract: A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR1R2 or CH2NR1R2 and where at least one of X1-X8 is N, and R, Ra, Rb, Rc and Rd are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

Abstract translation: 提供了一类新型非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性的调节相关的疾病，包括肥胖症，糖尿病，炎症和免疫疾病，并且具有 式（I）其立体异构体，或其溶剂合物或其前药，或其药学上可接受的盐，其中Z为CONR1R2或CH2NR1R2，并且其中X1-X8中的至少一个为N，R，Ra，Rb， Rc和Rd在本文中定义。 还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

公开(公告)号：US07592461B2

公开(公告)日：2009-09-22

申请号：US11642508

申请日：2006-12-20

Applicant: Jingwu Duan ,  Bin Jiang

Inventor： Jingwu Duan ,  Bin Jiang

IPC: A61K31/426 ,  A61K31/433 ,  C07D277/46 ,  C07D285/135

CPC classification number: C07D285/135 ,  C07D233/76 ,  C07D249/12 ,  C07D277/46 ,  C07D285/08

Abstract: Novel non-steroidal compounds are provided that are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases having the structure of formula (I): or enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, where X is -A1QA2-; Q is a bond, —C(═O)—, —OC(O)—, —C(═O)NR5—, —SOp—, —SOpNR5—, —C(O)O—, —NR5C(O)—, —OC(O)NR5—, —NR5C(O)O—, —S(O)pNR5C(O)—, —C(O)NR5S(O)p— —NR5S(O)p—, or —NR5C(═O)NR6—. Y is selected from hydrogen, C1-6alkyl, OR16, substituted C1-6alkyl, cycloalkyl, aryl, heterocyclo and heteroaryl. A1 and A2 are independently selected from a bond, C1-3alkylene, or C1-3alkenylene, and R1-R11 are defined herein. Also provided are pharmaceutical compositions, combinations, and methods of treating obesity, diabetes and inflammatory- or immune-associated diseases comprising said compounds.

Abstract translation: 提供了新型非甾体化合物，其可用于治疗与调节糖皮质激素受体，AP-1和/或NF-κB活性相关的疾病，包括具有式（I）结构的肥胖症，糖尿病，炎症和免疫疾病： 或对映异构体，非对映异构体或其药学上可接受的盐或水合物，其中X为-A1QA2-; Q是键，-C（-O） - ， - OC（O） - ， - C（-O）NR5-，-SOp-，-SOpNR5-，-C（O） - （O）NR 5 - ， - NR 5 C（O）O-，-S（O）p NR 15 C（O） - ， - C（O）NR 5 S（O）p - ， - -NR 5 C（-O）NR 6 - 。 Y选自氢，C 1-6烷基，OR 16，取代的C 1-6烷基，环烷基，芳基，杂环和杂芳基。 A1和A2独立地选自键，C1-3亚烷基或C1-3亚烯基，R1-R11在本文中定义。 还提供了治疗包含所述化合物的肥胖症，糖尿病和炎性或免疫相关疾病的药物组合物，组合和方法。

公开(公告)号：US07579873B1

公开(公告)日：2009-08-25

申请号：US11985706

申请日：2007-11-16

Applicant: Bin Jiang ,  Sang Kong Chan

Inventor： Bin Jiang ,  Sang Kong Chan

IPC: H03K19/0175 ,  H03K3/00

CPC classification number: H03K5/01 ,  H03K5/06

Abstract: An interface driver circuit comprises N cascaded delay cells, each including a data bit input, a delayed data bit output that communicates with the data bit input of an adjacent one of the N cascaded delay cells, and a delay time input that sets delay values between receiving data at the data bit input and generating the delayed data bit output. N predrivers receive an output enable signal that is independent of the data, receive a corresponding one of the N delayed data bit outputs and generate a predriver output signal based on the output enable signal and the corresponding one of the N delayed data bit outputs.

Abstract translation: 一个接口驱动电路包括N个级联延迟单元，每个包括数据位输入，与N个级联延迟单元相邻的数据位输入通信的延迟数据位输出，以及延迟时间输入， 在数据位输入端接收数据并产生延迟的数据位输出。 N个预取器接收独立于数据的输出使能信号，接收N个延迟的数据位输出中的相应一个，并且基于输出使能信号和N个延迟的数据位输出中的相应一个产生预驱动输出信号。

公开(公告)号：US07569689B2

公开(公告)日：2009-08-04

申请号：US11034652

申请日：2005-01-13

Applicant: Jingwu Duan ,  Bin Jiang ,  James Sheppeck ,  John L. Gilmore

Inventor： Jingwu Duan ,  Bin Jiang ,  James Sheppeck ,  John L. Gilmore

IPC: A61K31/498 ,  C07D417/14

CPC classification number: C07D403/12 ,  C07D241/36 ,  C07D417/12 ,  C07D417/14

Abstract: A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR1R2 or CH2NR1R2 and where at least two of X1-X4 and/or X5-X8 is N or NR18, and R, Ra, Rb, Rc, Rd, R1, R2 and R18 are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

Abstract translation: 提供了一类新型非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性的调节相关的疾病，包括肥胖症，糖尿病，炎症和免疫疾病，并且具有 式（I）其立体异构体，或其溶剂合物，或其前药，或其药学上可接受的盐，其中Z为CONR1R2或CH2NR1R2，并且其中X1-X4和/或X5-X8中的至少两个为N或NR18 ，R，R a，R b，R c，R d，R 1，R 2和R 18如本文所定义。 还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

公开(公告)号：US20090075995A1

公开(公告)日：2009-03-19

申请号：US11835438

申请日：2007-08-08

Applicant: David S. Weinstein ,  Ping Chen ,  T.G. Murali Dhar ,  Jingwu Duan ,  Hua Gong ,  Bin Jiang ,  Bingwei Vera Yang ,  Arthur M. Doweyko

Inventor： David S. Weinstein ,  Ping Chen ,  T.G. Murali Dhar ,  Jingwu Duan ,  Hua Gong ,  Bin Jiang ,  Bingwei Vera Yang ,  Arthur M. Doweyko

IPC: A61K31/5377 ,  A61K31/436 ,  C07D491/052 ,  A61P31/12 ,  A61K31/427 ,  C07D417/12

CPC classification number: C07D417/12 ,  C07D277/46 ,  C07D405/12 ,  C07D417/14 ,  C07D491/04

Abstract: Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; A is a 5- to 8-membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B is a cycloalkyl, cycloalkenyl, aryl, heterocyclo, or heteroaryl ring, wherein each ring is fused to the A ring on adjacent atoms and optionally substituted by one to four groups which are the same or different and are independently selected from R5, R6, R7, and R8; J1, J2, and J3 are at each occurrence the same or different and are independently -A1QA2-; Q is a bond, O, S, S(O), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3alkylene, substituted C1-3alkylene, C2-4alkenylene, and substituted C2-4alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.

Abstract translation: 提供了新的非甾体化合物，其可用于治疗与式（I）结构的糖皮质激素受体，AP-1和/或NF-κB活性（包括炎症和免疫疾病）调节相关的疾病：对映异构体 ，非对映异构体或其互变异构体，或其前药酯或其药学上可接受的盐，其中：Z是杂环或杂芳基; A是5至8元碳环或5至8元杂环; B是环烷基，环烯基，芳基，杂环基或杂芳基环，其中每个环与相邻原子上的A环稠合并任选地被一至四个相同或不同的基团取代，并且独立地选自R5，R6， R7和R8; J1，J2和J3各自出现相同或不同，独立地为-A1QA2-; Q是键，O，S，S（O）或S（O）2; A1和A2相同或不同，并且在每次出现时独立地选自键，C1-3亚烷基，取代的C1-3亚烷基，C2-4亚烯基和取代的C2-4亚烯基，条件是选择A1和A2使得环A为 5-至8-元碳环或杂环; R1至R11如本文所定义。 还提供了使用所述化合物治疗炎性或免疫相关疾病和肥胖症和糖尿病的药物组合物和方法。

公开(公告)号：US20080310542A1

公开(公告)日：2008-12-18

申请号：US12095194

申请日：2006-11-24

Applicant: Xiqi Gao ,  Xiaohu You ,  Bin Jiang ,  Zhiwen Pan ,  Yuan Zhang

Inventor： Xiqi Gao ,  Xiaohu You ,  Bin Jiang ,  Zhiwen Pan ,  Yuan Zhang

IPC: H04L27/28

CPC classification number: H04L1/0028 ,  H04B7/0413 ,  H04B7/0456 ,  H04B7/0617 ,  H04B7/0621 ,  H04B7/0636 ,  H04L1/0003 ,  H04L1/0009 ,  H04L1/0625 ,  H04L1/0631 ,  H04L25/0204 ,  H04L25/0228 ,  H04L25/03955 ,  Y02D70/444

Abstract: An adaptive transmission scheme of the channel environment in the multi-antenna wireless transmission system can raise the spectrum use rate and power efficiency of the communication system in fast. Comparing with the traditional single antenna input and single antenna output, the channel environment in MIMO wireless communication system is more complex. When the terminal is moving, the different types of channels between terminal and base station can be gone through and then its capacity can be changed more largely. It is characterized in: at first, obtaining the statistical channel information at the receiving end using the result of channel estimation; then, quantizing and encoding the obtained statistical channel information to get feedback bit information and send the feedback bit information to the transmitting end through a feedback channel; thereby using statistical information, the sending end calculates link self-adapting control parameters, which are used for controlling coding modulation and sending the pre-code; the sending end obtains the digital base band transmission signal using a characteristic mode transmission method and a random virtual space selection transmission method, and the receiving end carries out self-adapting receiving by the same parameters.

Abstract translation: 多天线无线传输系统中的信道环境的自适应传输方案可以快速提高通信系统的频谱利用率和功率效率。 与传统的单天线输入和单天线输出相比，MIMO无线通信系统中的信道环境更加复杂。 当终端移动时，终端和基站之间的不同类型的信道可以通过，其容量可以更大地改变。 其特征在于：首先，使用信道估计结果在接收端获取统计信道信息; 然后对获得的统计信道信息进行量化和编码以获得反馈比特信息，并通过反馈信道将反馈比特信息发送到发送端; 从而使用统计信息，发送端计算用于控制编码调制和发送预编码的链路自适应控制参数; 发送端使用特征模式发送方法和随机虚拟空间选择发送方法获得数字基带发送信号，接收端通过相同的参数进行自适应接收。

公开(公告)号：US09971830B2

公开(公告)日：2018-05-15

申请号：US13605999

申请日：2012-09-06

Applicant: Todd Christopher Jackson ,  William Russell Maschmeyer ,  Bin Jiang ,  Kenneth M. Lau ,  Michael Novati

Inventor： Todd Christopher Jackson ,  William Russell Maschmeyer ,  Bin Jiang ,  Kenneth M. Lau ,  Michael Novati

IPC: G06F17/30 ,  G06Q50/00

CPC classification number: G06F17/30699 ,  G06F17/30702 ,  G06F17/30867 ,  G06Q50/01

Abstract: Based on information associated with users, a social networking system recommends one or more groups for a target user to join or to create. Characteristics of the target user, characteristics of users connected to the target user, characteristics of candidate groups in the social networking system may be used to identify groups for recommendation. The social networking system may provide questions to the target user and recommend a group to the target user based on received answers to the questions. For example, the answers to the provided question identify one or more characteristics of the target user, which are used to select a group for recommendation. Additionally, the social networking system may recommend additional users for the target user to add or invite to a group based on characteristics of the target user, the additional users, and/or the group.

公开(公告)号：US08654879B2

公开(公告)日：2014-02-18

申请号：US13387308

申请日：2010-11-02

Applicant: Xiqi Gao ,  Wenjin Wang ,  Ting Li ,  Meili Zhou ,  Bin Jiang ,  Wen Zhong ,  Long Qin

Inventor： Xiqi Gao ,  Wenjin Wang ,  Ting Li ,  Meili Zhou ,  Bin Jiang ,  Wen Zhong ,  Long Qin

IPC: H04B7/02

CPC classification number: H04L25/0204 ,  H04B7/0413 ,  H04L25/0232 ,  H04L27/2647

Abstract: A multi-antenna channel estimation method based on polyphase decomposition includes: receiving frequency domain received signals transformed using discrete fourier transformation (DFT) in pilot symbols; performing phase correction on the frequency domain received signals; performing polyphase decomposition on the frequency domain received signals which are corrected using phase correction and acquiring polyphase signals; performing interpolation on the polyphase signals and acquiring the estimation values of the multi-antenna channel parameters with various linear combinations on each frequency; acquiring decorrelation array based on the pilot structure of the transmission antenna and decorrelating the estimation values of the multi-antenna channel parameters with various linear combination on each frequency using the decorrelation array and acquiring channel parameters of the pilot symbols on each frequency; acquiring channel parameters of data symbols based on the channel parameters of the pilot symbols. With the present invention, the inversion problem in multi-antenna channel estimation is avoided with lower complexity, and results of the multi-antenna channel estimation method become more accurate since the DFT and filtering are performed in the interpolation after polyphase decomposition.

Abstract translation: 基于多相分解的多天线信道估计方法包括：在导频符号中接收使用离散傅立叶变换（DFT）变换的频域接收信号; 对频域接收信号进行相位校正; 对使用相位校正和获取多相信号校正的频域接收信号执行多相分解; 对所述多相信号执行插值，并且在每个频率上以各种线性组合获取所述多天线信道参数的估计值; 基于发射天线的导频结构获取解相关阵列，并使用解相关阵列在每个频率上用各种线性组合去除多个天线信道参数的估计值，并获取每个频率上的导频符号的信道参数; 基于导频符号的信道参数获取数据符号的信道参数。 利用本发明，以更低的复杂度避免了多天线信道估计中的反转问题，并且由于在多相分解之后的内插中执行DFT和滤波，所以多天线信道估计方法的结果变得更加精确。

公开(公告)号：US20140005146A1

公开(公告)日：2014-01-02

申请号：US14005572

申请日：2012-03-16

Applicant: Stephen T. Wrobleski ,  Jagabandhu Das ,  Lidia M. Doweyko ,  Junqing Guo ,  John Hynes ,  Bin Jiang ,  James Kempson ,  Shuqun Lin ,  Steven H. Spergel ,  John S. Tokarski ,  Hong Wu ,  Bingwei Vera Yang

Inventor： Stephen T. Wrobleski ,  Jagabandhu Das ,  Lidia M. Doweyko ,  Junqing Guo ,  John Hynes ,  Bin Jiang ,  James Kempson ,  Shuqun Lin ,  Steven H. Spergel ,  John S. Tokarski ,  Hong Wu ,  Bingwei Vera Yang

IPC: C07D487/04 ,  C07F9/6561

CPC classification number: C07D487/04 ,  C07F9/6561

Abstract: Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

Abstract translation: 公开了式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。

公开(公告)号：US20130076130A1

公开(公告)日：2013-03-28

申请号：US13414279

申请日：2012-03-07

Applicant: Huaguang ZHANG ,  Qiuye Sun ,  Jun Yang ,  Bin Jiang ,  Lianzhi Wang ,  Dazhong Ma ,  Zhenwei Liu ,  Fei Teng ,  Zhiqiang He ,  Xintong Li

Inventor： Huaguang ZHANG ,  Qiuye Sun ,  Jun Yang ,  Bin Jiang ,  Lianzhi Wang ,  Dazhong Ma ,  Zhenwei Liu ,  Fei Teng ,  Zhiqiang He ,  Xintong Li

IPC: H02J3/00

CPC classification number: H02J3/16 ,  H02J3/1878 ,  H02P13/06 ,  Y02E40/34 ,  Y10T307/297

Abstract: Disclosed is a transformer control device and method based on a three-dimensional zone diagram policy. The method includes: setting transformers, including a transformer A and a transformer B; collecting three-phase voltage data and three-phase current data in a power system; rectifying the collected three-phase voltage data and the three-phase current data; transferring the data to the latches in a time-transfer method; transferring the data to an A/D converter of a processor to convert analog signals to digital signals; constructing a three-dimensional zone diagram in the processor; determining transformer operating conditions according to positions of points formed by voltage, reactive power factor and substation load; and adjusting the transformers. This invention adopts a simple, easy and clear three-parameter control policy including voltage, power factors and substation loads, so as to simplify analysis of transformer operating conditions, realize optimal substation operation, reduce transformer loss, and increase economic benefits.

Abstract translation: 公开了一种基于三维区域图策略的变压器控制装置和方法。 该方法包括：设置变压器，包括变压器A和变压器B; 在电力系统中收集三相电压数据和三相电流数据; 整流收集的三相电压数据和三相电流数据; 以时间传送方式将数据传送到锁存器; 将数据传送到处理器的A / D转换器，以将模拟信号转换为数字信号; 在处理器中构建三维区域图; 根据由电压，无功功率因数和变电站负载形成的点的位置确定变压器工作条件; 并调整变压器。 本发明采用简单，简单，明确的三参数控制策略，包括电压，功率因数和变电站负载，简化变压器运行状况分析，实现最佳变电站运行，减少变压器损耗，增加经济效益。