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公开(公告)号：US20210098076A1
公开(公告)日：2021-04-01
申请号：US16864744
申请日：2020-05-01
Applicant: California Institute of Technology
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G16B25/00 , G16B5/00 , C12Q1/6851 , G16B25/20 , G16B40/10 , C12Q1/68 , G01N21/64 , C12Q1/6825
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US10376146B2
公开(公告)日：2019-08-13
申请号：US14174827
申请日：2014-02-06
Applicant: California Institute of Technology
Inventor： Muhammad Mujeeb-U-Rahman , Axel Scherer
IPC: A61B5/00 , A61B5/1473 , A61B5/145 , A61B5/1486
Abstract: An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.
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公开(公告)号：US10368788B2
公开(公告)日：2019-08-06
申请号：US15216675
申请日：2016-07-21
Inventor： Axel Scherer , Meisam Honarvar Nazari , Muhammad Mujeeb-U-Rahman , Mehmet Sencan , Arti Gaur
IPC: A61M5/142 , A61M5/172 , A61B5/1473 , A61B17/34 , A61B5/145 , A61B5/1486 , A61B5/00 , A61B5/1459 , A61B5/07
Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
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公开(公告)号：US20190034583A1
公开(公告)日：2019-01-31
申请号：US15914356
申请日：2018-03-07
Applicant: California Institute of Technology
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G06F19/20 , G01N21/64 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G06F19/12 , G06F17/10 , G06F17/11 , G06F19/24
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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35.发明授权公开(公告)号：US10189001B2
公开(公告)日：2019-01-29
申请号：US15967543
申请日：2018-04-30
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Sameer Walavalkar , Axel Scherer
Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.
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Patent Agency Ranking
公开(公告)号：US10081844B2
公开(公告)日：2018-09-25
申请号：US15675048
申请日：2017-08-11
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
IPC: C12P19/34 , C12Q1/70 , C12Q1/6851 , C12Q1/68
CPC classification number: C12Q1/701 , C12Q1/68 , C12Q1/6851 , C12Q1/703 , Y10T436/143333 , C12Q2561/113 , C12Q2565/101 , C12Q2527/101 , C12Q2565/1015 , C12Q2565/133
Abstract: Methods of detecting at least one genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, the first primer and the second primer are specific for the polynucleotide analyte. A signal generated by the fluorophore and quencher is measured. PCR is performed with the first primer and the second primer using the polynucleotide analyte as a template, thereby amplifying the template. A signal generated by the fluorophore and quencher from the PCR amplification product is measured. Comparison is made of the signals; and a determination is made of the presence or absence of the at least one genetic variation based i) on the change in signal as determined; and ii) by comparing said change to the change in signal observed upon PCR amplification for a corresponding polynucleotide analyte lacking the at least one genetic variation.
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公开(公告)号：US20180030551A1
公开(公告)日：2018-02-01
申请号：US15675048
申请日：2017-08-11
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
CPC classification number: C12Q1/701 , C12Q1/68 , C12Q1/6851 , C12Q1/703 , Y10T436/143333 , C12Q2561/113 , C12Q2565/101 , C12Q2527/101 , C12Q2565/1015 , C12Q2565/133
Abstract: This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.
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公开(公告)号：US09410887B2
公开(公告)日：2016-08-09
申请号：US14046739
申请日：2013-10-04
Applicant: California Institute of Technology
Inventor： Sameer Sudhir Walavalkar , Andrew Peter Homyk , William Maxwell Jones , Axel Scherer , Scott Fraser , Thai Viet Truong
CPC classification number: G01N21/63 , G01N21/6428 , G01N21/6458 , G01N21/648
Abstract: Devices, systems, and methods for detection of an analyte in a sample are disclosed. In some embodiments, an optical sensor can include a metallic layer and a plurality of dielectric pillars extending through the metallic layer. A plurality of regions of concentrated light can be supported in proximity to the ends of the plurality of dielectric pillars when a surface of the metallic layer is illuminated. Concentrated light within one or more of these regions can interact with an analyte molecule, allowing for detection of the analyte.
Abstract translation: 公开了用于检测样品中分析物的装置，系统和方法。 在一些实施例中，光学传感器可以包括金属层和延伸穿过金属层的多个介电柱。 当金属层的表面被照亮时，多个集中的光的区域可以被支撑在多个介电柱的端部附近。 一个或多个这些区域内的浓缩光可与分析物分子相互作用，从而允许检测分析物。
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公开(公告)号：US09234872B2
公开(公告)日：2016-01-12
申请号：US14673700
申请日：2015-03-30
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Andrew P. Homyk , Michael D. Henry , Axel Scherer , Sameer Walavalkar
IPC: H01L29/772 , H01L29/02 , G01N27/414 , B82Y10/00 , H01L29/06 , H01L29/775 , H01L29/66 , B82Y15/00
CPC classification number: G01N27/4146 , B82Y10/00 , B82Y15/00 , H01L29/0676 , H01L29/66666 , H01L29/775
Abstract: Methods for fabricating silicon nanowire chemical sensing devices, devices thus obtained, and methods for utilizing devices for sensing and measuring chemical concentration of selected species in a fluid are described. Devices may comprise a metal-oxide-semiconductor field-effect transistor (MOSFET) structure.
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公开(公告)号：US09177933B2
公开(公告)日：2015-11-03
申请号：US14656650
申请日：2015-03-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Muhammad Mujeeb-U-Rahman , Axel Scherer
IPC: H01L21/283 , H01L23/00 , H01L21/285 , H01L29/41 , H01L33/38 , H01L31/00 , H01L21/02 , B81C1/00
CPC classification number: H01L21/285 , A61B2562/125 , B81C1/00111 , B81C1/0038 , H01L21/02425 , H01L21/28556 , H01L24/14 , H01L29/41 , H01L31/00 , H01L33/387 , H01L2224/1401 , H01L2924/11
Abstract: Three dimensional high surface electrodes are described. The electrodes are fabricated by methods including the steps: designing the pillars; selecting a material for the formation of the pillars; patterning the material; transferring the pattern to form the pillars; insulating the pillars and providing a metal layer for increased conductivity. Alternative methods for fabrication of the electrodes and fabrication of the electrodes using CMOS are also described.
Abstract translation: 描述三维高表面电极。 电极通过以下方法制造：包括以下步骤：设计支柱; 选择用于形成支柱的材料; 图案化材料; 转移模式形成支柱; 绝缘柱并提供用于增加导电性的金属层。 还描述了用于制造电极和使用CMOS制造电极的替代方法。
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