公开(公告)号：AU2012204271B2

公开(公告)日：2015-08-13

申请号：AU2012204271

申请日：2012-01-06

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: A01N1/02 ,  A61M39/00

Abstract: Methods of treating blood, blood products or physiologic fluid maximize shelf life and/or minimize transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent. The blood purification devices comprise: (a) a compliant container suitable for the storage of blood, blood product or physiologic fluid; (b) sorbent comprising hemocompatible material suitable for treating blood, blood product or physiologic fluid, the sorbent performing at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; where the sorbent is contained within the compliant container.

公开(公告)号：AU2013282320A1

公开(公告)日：2015-02-12

申请号：AU2013282320

申请日：2013-06-28

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: A61M1/34 ,  C09K23/38 ,  C09K23/48 ,  C09K23/52

Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50Å to 40,000Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50Å to 40,000Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.

公开(公告)号：MX2012011305A

公开(公告)日：2013-01-29

申请号：MX2012011305

申请日：2011-04-01

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  YOUNG WEI-TAI ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  BARTLETT ROBERT H

IPC: A61K31/74

Abstract: La presente invención es concerniente con métodos de tratamiento de inflamación sistémica, regional o local de un paciente que sufre o está en riesgo de inflamación que comprende la administración de una dosis terapéuticamente efectiva de un sorbente que absorbe un mediador inflamatorio en dicho paciente. En algunas modalidades preferidas, el sorbente es un polímero orgánico biocompartible.

公开(公告)号：CA2795177A1

公开(公告)日：2011-10-06

申请号：CA2795177

申请日：2011-04-01

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  YOUNG WEI-TAI ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  BARLETT ROBERT H

IPC: A61K31/74 ,  A61K31/717 ,  A61P29/00

Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.