中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

81 records (took 0.031 seconds)

    METHODS AND SYSTEMS FOR ANALYZING PROTEINS VIA ELECTRON CAPTURE DISSOCIATION
    31.
    发明申请
    METHODS AND SYSTEMS FOR ANALYZING PROTEINS VIA ELECTRON CAPTURE DISSOCIATION 审中-公开
    通过电子捕获离析分析蛋白质的方法和系统

    公开(公告)号：WO2017221151A1

    公开(公告)日：2017-12-28

    申请号：PCT/IB2017/053665

    申请日：2017-06-20

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： BABA, Takashi

    IPC: H01J49/06 ,  H01J49/14

    Abstract: Methods and systems are provided herein for selectively removing product ions resulting from an ECD dissociation event from the interaction region of an ECD reaction cell, while other precursor peptide ions continue to undergo ECD within the interaction region, thereby reducing or preventing the occurrence of multiple electron capture events by the product ions. In some aspects, the preferential extraction of product ions from the interaction region during the ECD reaction can occur without an auxiliary AC field being generated within the interaction region. Additionally, in some aspects, the methods and systems disclosed herein can subject the various product ions to a non-dissociative charge reduction via exposure to reagent ions of the opposite polarity so as to selectively concentrate product ions to a lower charge state.

    Abstract translation: 本文提供了用于从ECD反应细胞的相互作用区域选择性地去除由ECD解离事件产生的产物离子，而其他前体肽离子在相互作用区域内继续经历ECD的方法和系统，由此 减少或防止产物离子发生多重电子俘获事件。 在一些方面，在ECD反应期间优先从交互作用区域提取产物离子可以在交互作用区域内没有产生辅助AC场的情况下发生。 此外，在一些方面，本文公开的方法和系统可以通过暴露于相反极性的试剂离子使各种产物离子经历非解离电荷减少，从而选择性地将产物离子浓缩至较低的电荷状态。

    DEVICE FOR ION SORTING BY M/Z
    32.
    发明申请
    DEVICE FOR ION SORTING BY M/Z 审中-公开
    M / Z离子设备

    公开(公告)号：WO2016087961A1

    公开(公告)日：2016-06-09

    申请号：PCT/IB2015/057880

    申请日：2015-10-14

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： BABA, Takashi

    IPC: H01J49/26

    CPC classification number: H01J49/4225 ,  H01J49/4205 ,  H01J49/4255

    Abstract: An RF voltage is applied across each electrode of a first array of evenly spaced, parallel, and coplanar electrodes and its corresponding electrode of a second array of evenly spaced, parallel, and coplanar electrodes. The RF voltage varies in amplitude according to an RF voltage amplitude gradient. The RF voltage produces an array of different quadrupole RF electric fields in a uniform gap between the first array and the second array. A DC voltage is superimposed on each electrode of the first array and its corresponding electrode of the second array. The DC voltage varies according to a DC voltage gradient in order to produce a DC electric field in the uniform gap. When ions are introduced in the uniform gap, the DC electric field causes the ions to drift toward quadrupole RF electric fields with increasing RF voltage amplitudes where the ions are trapped according to their m/z.

    Abstract translation: 将RF电压施加在均匀间隔的，平行的和共面的电极的第一阵列的每个电极上，并且其对应的电极具有均匀间隔的，平行的和共面的电极的第二阵列。 RF电压根据RF电压幅度梯度而在幅度上变化。 RF电压在第一阵列和第二阵列之间的均匀间隙中产生不同四极RF电场的阵列。 DC电压叠加在第一阵列的每个电极及其对应的第二阵列的电极上。 直流电压根据直流电压梯度而变化，以便产生均匀间隙中的直流电场。 当在均匀间隙中引入离子时，直流电场使离子随着RF电压幅度的升高而向四极RF电场漂移，其中离子根据其m / z被捕获。

    FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY
    33.
    发明申请
    FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY 审中-公开
    傅立叶变换离子共振质谱分析

    公开(公告)号：WO2016084005A1

    公开(公告)日：2016-06-02

    申请号：PCT/IB2015/059103

    申请日：2015-11-24

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： BABA, Takashi ,  BERLYAND, Alex

    IPC: H01J49/26

    CPC classification number: H01J49/063 ,  H01J49/38

    Abstract: Methods and systems for analyzing ions in a magnetic ion trap are provided herein. In accordance with various aspects of the present teachings, the methods and systems described herein enable Fourier transform ion cyclotron resonance mass spectrometry across relatively narrow gap magnetic fields substantially perpendicular to the axis along which the ions are injected into the ion trap. As a result, smaller, less expensive magnets can be used to produce the high-intensity, uniform magnetic fields utilized in high performance FT-ICR/MS applications. Accordingly, the present teachings enable permanent magnets (as well as electromagnets) to generate these magnetic fields, potentially reducing the cost, size, and/or complexity of the systems described herein relative to conventional FT-ICR systems.

    Abstract translation: 本文提供了用于分析磁离子阱中的离子的方法和系统。 根据本教导的各个方面，本文描述的方法和系统使得能够跨越基本上垂直于离子注入离子阱的轴的相对窄的间隙磁场进行傅里叶变换离子回旋共振质谱。 因此，可以使用更小，更便宜的磁体来产生在高性能FT-ICR / MS应用中使用的高强度，均匀的磁场。 因此，本教导使得永磁体（以及电磁体）能够产生这些磁场，相对于传统的FT-ICR系统潜在地降低了本文所描述的系统的成本，尺寸和/或复杂性。

    BAND PASS EXTRACTION FROM AN ION TRAPPING DEVICE AND TOF MASS SPECTROMETER SENSITIVITY ENHANCEMENT
    34.
    发明申请
    BAND PASS EXTRACTION FROM AN ION TRAPPING DEVICE AND TOF MASS SPECTROMETER SENSITIVITY ENHANCEMENT 审中-公开
    离子捕获装置的带式提取和TOF质谱仪灵敏度增强

    公开(公告)号：WO2016020789A1

    公开(公告)日：2016-02-11

    申请号：PCT/IB2015/055625

    申请日：2015-07-24

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： BABA, Takashi

    IPC: H01J49/40

    CPC classification number: H01J49/403 ,  H01J49/063 ,  H01J49/067 ,  H01J49/429

    Abstract: A multipole rod set of an ion guide is adapted to receive a radial RF trapping voltage and a radial dipole direct current DC voltage. A lens electrode of the ion guide is positioned at one end of the multipole rod set to extract ions from the multipole rod set and adapted to receive an axial trapping AC voltage and a DC voltage. A radial dipole DC voltage is applied to the multipole rod set and an axial trapping AC voltage is simultaneously applied to a lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set. Alternatively, a radial RF trapping voltage amplitude is applied to the multipole rod set and an axial trapping AC voltage is simultaneously applied to the lens electrode in order to extract a bandpass mass range of ions trapped in the multipole rod set.

    Abstract translation: 离子导向器的多极杆组适于接收径向RF捕获电压和径向偶极直流DC电压。 离子导向器的透镜电极位于多极棒组的一端，以从多极棒组中提取离子并适于接收轴向捕获AC电压和DC电压。 将径向偶极直流电压施加到多极杆组，并且轴向捕获AC电压同时施加到透镜电极，以便提取捕获在多极棒组中的离子的带通质量范围。 或者，将径向RF捕获电压振幅施加到多极棒组，并且轴向捕获AC电压同时施加到透镜电极，以便提取捕获在多极棒组中的离子的带通质量范围。

    METHODS FOR ANALYSIS OF LIPIDS USING MASS SPECTROMETRY
    35.
    发明申请
    METHODS FOR ANALYSIS OF LIPIDS USING MASS SPECTROMETRY 审中-公开
    使用大量光谱分析脂肪的方法

    公开(公告)号：WO2015189749A1

    公开(公告)日：2015-12-17

    申请号：PCT/IB2015/054236

    申请日：2015-06-04

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： BABA, Takashi ,  CAMPBELL, John Lawrence

    IPC: G01N27/62 ,  H01J49/26

    CPC classification number: H01J49/0054 ,  H01J49/0072 ,  H01J49/4225

    Abstract: A method and apparatus for analyzing samples using mass spectrometry are disclosed. The apparatus includes a reaction device configured to dissociate sample ions into fragments by reacting the sample ions with a charged species (e.g., electrons) such as through ECD, EID, or EIEIO. The kinetic energy of the charged species is such that the fragments may be detected and produce spectra that allow for the determination of isomeric species in the sample and the location of double bonds of sample molecules. The fragments may include radical fragments and non-radical fragments. The apparatus may also include an oxygen gas source configured to react with the radical fragments to produce oxygen-radical fragments. Spectra resulting from analysis of the fragments may allow for the determination of the oxygen-radical fragments resulting from the dissociation of the sample molecules.

    Abstract translation: 公开了使用质谱分析样品的方法和装置。 该装置包括反应装置，其被配置为通过使样品离子与带电物质（例如电子）例如通过ECD，EID或EIEIO反应来将样品离子分离成片段。 带电物质的动能使得可以检测碎片并产生允许测定样品中异构物质和样品分子双键位置的光谱。 片段可以包括自由基片段和非自由基片段。 该装置还可以包括配置成与自由基片段反应以产生氧自由基碎片的氧气源。 由片段分析产生的光谱可以允许测定样品分子解离产生的氧自由基片段。

    MULTIPLEXED PRECURSOR ISOLATION FOR MASS SPECTROMETRY
    36.
    发明申请
    MULTIPLEXED PRECURSOR ISOLATION FOR MASS SPECTROMETRY 审中-公开
    多重前置分离器用于质谱分析

    公开(公告)号：WO2015056067A1

    公开(公告)日：2015-04-23

    申请号：PCT/IB2014/002040

    申请日：2014-10-07

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： BABA, Takashi

    IPC: H01J49/26

    CPC classification number: H01J49/0036 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/04 ,  H01J49/067 ,  H01J49/4285

    Abstract: Systems and methods for multiplexed precursor ion selection are provided. A mass isolator includes a selection region of rods, a transmission region of rods, and a barrier electrode lens separating the selection and transmission regions. Two or more different precursor ions are selected by applying two or more different AC voltage frequencies to rods of a selection region in order to resonate the two or more different precursor ions from a continuous beam of ions. The two or more different precursor ions are transmitted by applying a DC voltage to the barrier electrode lens, creating an electric field potential barrier over which only the resonating ions are transmitted. Precursor ions of product ions from combined product ion spectra produced by multiplexed precursor ion selection are identified by grouping the target precursor ions.

    Abstract translation: 提供了多路前体离子选择的系统和方法。 质量隔离器包括杆的选择区域，杆的透射区域和分离选择和透射区域的阻挡电极透镜。 通过对选择区域的棒施加两个或更多个不同的AC电压频率来选择两个或更多个不同的前体离子，以便使两个或更多个不同的前体离子与连续离子束共振。 通过向阻挡电极透镜施加DC电压来传输两种或更多种不同的前体离子，产生仅在其上传播谐振离子的电场势垒。 通过将目标前体离子分组来鉴定由多重前体离子选择产生的组合产物离子光谱的产物离子的前体离子。

Patent Agency Ranking