-
公开(公告)号：US20160355776A1
公开(公告)日：2016-12-08
申请号：US15238624
申请日：2016-08-16
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
CPC classification number: C12M47/10 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M23/14 , C12M23/22 , C12M27/00 , C12M27/02 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/02 , C12M47/04 , C12P21/02
Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
Abstract translation: 灌注生物反应器包括至少一个可声学地产生多维驻波的超声换能器。 驻波可用于将细胞保留在生物反应器中，并且也可用于从生物反应器中生产的废物中脱水或进一步收获产品。
-
公开(公告)号：US09416344B2
公开(公告)日：2016-08-16
申请号：US14175766
申请日：2014-02-07
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, Jr. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
IPC: C12M1/12 , B06B1/06 , B01D17/04 , B01D17/06 , B01D21/28 , C12M1/00 , C12M1/26 , C12M1/42 , H01L41/09
CPC classification number: C12M25/00 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M29/10 , C12M33/08 , C12M35/04 , C12M47/02 , H01L41/0973
Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
Abstract translation: 灌注生物反应器包括至少一个可声学地产生多维驻波的超声换能器。 驻波可用于将细胞保留在生物反应器中，并且也可用于从生物反应器中生产的废物中脱水或进一步收获产品。
-
公开(公告)号：US11377651B2
公开(公告)日：2022-07-05
申请号：US15916270
申请日：2018-03-08
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Rui Tostoes , Brian Dutra , Rudolf Gilmanshin , Jason Dionne , Walter M. Presz, Jr. , Benjamin Ross-Johnsrud , Goutam Ghoshal , Kedar Chitale
Abstract: A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.
-
公开(公告)号：US20200215109A1
公开(公告)日：2020-07-09
申请号：US16244100
申请日：2019-01-09
Applicant: FLODESIGN SONICS, INC.
Inventor： Bart Lipkens , Rui Tostoes , Walter M. Presz, JR. , Benjamin Ross-Johnsrud , Kedar Chitale , Thomas J. Kennedy, III , Brian Dutra , Brian McCarthy , Jack Saloio
Abstract: A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.
-
公开(公告)号：US10662404B2
公开(公告)日：2020-05-26
申请号：US15475469
申请日：2017-03-31
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, Jr. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
IPC: B01D17/06 , C12M1/00 , C12M1/42 , C12M1/26 , C12M1/02 , B06B1/06 , B01D17/04 , B01D21/28 , C12M1/06 , C12P21/02
Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
-
Patent Agency Ranking
公开(公告)号：US10350514B2
公开(公告)日：2019-07-16
申请号：US15621691
申请日：2017-06-13
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, Jr. , Thomas J. Kennedy, III , Louis Masi
Abstract: An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
-
公开(公告)号：US20180223273A1
公开(公告)日：2018-08-09
申请号：US15942427
申请日：2018-03-30
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Jason Dionne , Walter M. Presz, JR. , Brian Dutra
Abstract: Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.
-
公开(公告)号：US20170321208A1
公开(公告)日：2017-11-09
申请号：US15586116
申请日：2017-05-03
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Walter M. Presz, JR. , Brian Dutra , Rudolf Gilmanshin , Jason Dionne , Chris Leidel , Louis Masi , Goutam Ghoshal
CPC classification number: C12N13/00 , A61J3/00 , C12M23/14 , C12M25/14 , C12M47/02 , C12M47/04 , C12N1/02
Abstract: Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.
-
公开(公告)号：US20170218323A1
公开(公告)日：2017-08-03
申请号：US15417172
申请日：2017-01-26
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Rudolf Gilmanshin , Brian Dutra , Benjamin Ross-Johnsrud
CPC classification number: C12M47/02 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M29/10 , C12M29/18 , C12M33/08 , C12M35/04 , C12M41/12 , C12N13/00 , G10K9/122 , G10K11/28
Abstract: Acoustophoretic devices and methods for separating biological cells (particularly T-cells) from other fluids/materials using multi-dimensional acoustic standing waves are disclosed. The devices include an inlet, at least two outlets, and a flow chamber having an ultrasonic transducer-reflector pair. Specifically, T cells, B cells, or NK cells can be separated from other blood components. A dual-pass acoustophoretic system including two acoustophoretic devices arranged in series and fluidly connected to one another is also illustrated. Means for pre-chilling the mixture prior to separation in the devices or system can be used to improve retention, concentration, and clarification and to prevent outgassing.
-
公开(公告)号：US09675902B2
公开(公告)日：2017-06-13
申请号：US15000573
申请日：2016-01-19
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, Jr. , Thomas J. Kennedy, III , Louis Masi
CPC classification number: B01D17/04 , B01D43/00 , B06B1/0644 , C12M47/02
Abstract: An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
-
-
-
-
-
-
-
-
-
Search Results
43
records
(took 0.037 seconds)
