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    ANALYSIS SYSTEM FOR DETERMINING AN ANALYTE IN A BODY FLUID, MAGAZINE FOR AN ANALYSIS SYSTEM, INTEGRATED SAMPLE ACQUISITION AND ANALYZING ELEMENT, AND METHOD FOR ANALYZING A BODY FLUID
    32.
    发明申请
    ANALYSIS SYSTEM FOR DETERMINING AN ANALYTE IN A BODY FLUID, MAGAZINE FOR AN ANALYSIS SYSTEM, INTEGRATED SAMPLE ACQUISITION AND ANALYZING ELEMENT, AND METHOD FOR ANALYZING A BODY FLUID 审中-公开
    用于确定体液中分析物的分析系统，用于分析系统的杂志，集成样品获取和分析单元以及用于分析体液的方法

    公开(公告)号：WO2009027010A2

    公开(公告)日：2009-03-05

    申请号：PCT/EP2008006456

    申请日：2008-08-06

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  LIST HANS ,  FREY STEPHAN-MICHAEL ,  FLUEGGE KAI

    Inventor： LIST HANS ,  FREY STEPHAN-MICHAEL ,  FLUEGGE KAI

    IPC: A61B5/15

    CPC classification number: A61B5/1405 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15115 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15174 ,  A61B5/15176 ,  A61B5/157

    Abstract: Analysis system for determining an analyte in a body fluid, comprising a reusable analysis instrument (2) and a magazine (3) having a plurality of flat, disposable, integrated sample acquisition and analyzing elements, each comprising a puncturing element (23) and an analyzing element (20) and have two major surfaces. The analysis instrument (2) comprises a drive, by which the puncture movement of the puncturing element (23) is driven, to move it on a movement path in the puncturing direction during a propulsion phase and opposite to the puncturing direction after reaching a reversal point of the puncture movement during a retraction phase, a coupling unit (7), which is adapted for coupling an integrated sample acquisition and analyzing element to the drive, a measuring and evaluation unit (8) for measuring a measurement variable characteristic for determining an analyte and for deriving a desired analysis result, and a holder for receiving the magazine (3). The magazine (3) comprises a housing having a plurality of elongate chambers located neighboring one another. The chamber (9) are separated by two side walls (10) running in the longitudinal direction of the chambers (9), and have a height and length greater than the distance of two neighboring side walls (10). The chambers (9) have major sides (11 ) delimited by the side walls (10) and two long and two short minor sides (12, 13) extending between the side walls (10). The chamber (9) contain an integrated sample acquisition and analyzing element, whose puncturing element has a coupling structure (29) and is movable on the movement path of the puncture movement in the puncturing direction. The chambers (9) have an exit opening (14) on one of their minor sides (12, 13) for allowing at least partial exiting out of the chamber of the puncturing element (23) moved on the movement path. The coupling unit (7) has a coupling element (35). The chambers (9) of the magazine (3) are accessible for the coupling element (35) on one of their long minor sides (12) such that the coupling element (35) can be coupled to the coupling structure (29) of the puncturing element (23) in a formfitting way, when the puncturing element (23) is positioned in the chamber (9) of the magazine (3) and the magazine (3) is located in the holder.

    Abstract translation: 用于确定体液中的分析物的分析系统，包括可重复使用的分析仪器（2）和具有多个平坦的一次性的一体式样品采集和分析元件的盒（3），每个包括穿刺元件（23）和 分析元件（20）并具有两个主表面。 分析仪器（2）包括驱动器，通过该驱动器，穿刺元件（23）的穿刺运动被驱动，以在推进阶段中在穿刺方向的移动路径上移动，并且在达到反转之后与穿刺方向相反 在退避阶段期间的穿刺运动的点;耦合单元（7），其适于将集成采样和分析元件耦合到驱动器;测量和评估单元（8），用于测量用于确定 分析物和用于获得期望的分析结果，以及用于接收杂志（3）的保持器。 杂志（3）包括具有彼此相邻的多个细长室的壳体。 室（9）由沿着室（9）的纵向延伸的两个侧壁（10）分开，并且具有大于两个相邻侧壁（10）的距离的高度和长度。 室（9）具有由侧壁（10）限定的主侧面（11）和在侧壁（10）之间延伸的两个长的和两个短的短边（12,13）。 腔室（9）包含一个集成的采样和分析元件，其穿刺元件具有耦合结构（29），并且可以在穿刺方向上的穿刺运动的移动路径上移动。 腔室（9）在其小侧（12,13）中的一个上具有出口开口（14），用于允许至少部分地离开在移动路径上移动的穿刺元件（23）的腔室。 联接单元（7）具有联接元件（35）。 盒（3）的腔室（9）可在其长的较小侧面（12）中的一个上接近用于联接元件（35），使得联接元件（35）能够联接到 当穿刺元件（23）位于钉仓（3）的腔室（9）中并且刀库（3）位于保持器中时，穿孔元件（23）以成形方式。

    DEVICE AND METHOD FOR ANALYZING BODY FLUIDS
    33.
    发明申请
    DEVICE AND METHOD FOR ANALYZING BODY FLUIDS 审中-公开
    用于检查身体流体的装置和方法

    公开(公告)号：WO2008068215A2

    公开(公告)日：2008-06-12

    申请号：PCT/EP2007063130

    申请日：2007-12-03

    Applicant: HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS GMBH ,  HAAR HANS-PETER ,  LIST HANS

    Inventor： HAAR HANS-PETER ,  LIST HANS

    IPC: A61B5/00

    CPC classification number: A61B5/14532 ,  A61B5/150022 ,  A61B5/150335 ,  A61B5/150412 ,  A61B5/150511 ,  A61B5/150755 ,  A61B5/15113 ,  A61B5/1513 ,  A61B5/15142 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15176 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B2562/0295

    Abstract: In a device for analyzing body fluids, comprising a piercing element (14) that can be pierced into a body part (22) along a piercing axis (48), the element having a collection volume (44) for collecting of body fluid (52) obtained by means of a puncture, and a receiving element (16) that is configured for verifying the substances of the body fluid (52), wherein the body fluid (52) from the collection volume (44) can be applied to the receiving element, according to the invention the piercing element (14) and the receiving element (16) are disposed in the piercing axis (48) displaceably relative to each other such that the receiving element (16) immerse in the collection volume (44) in the piercing direction during a transfer phase following the puncture.

    Abstract translation: 在用于检查体液具有沿纵向的穿刺轴线（48）插入主体部分具有用于通过穿刺体液（52）收集接收到的收集容器（44）（22）刺穿的穿刺元件（14），和用于检测的装置 体液的（52）形成的接收构件（16），其可从所述收集容器（44）进行体液（52）内容，根据本发明的穿刺轴的穿刺元件（14）和所述接收元件（16）（48）可相对于彼此 布置成使得接收元件（16）在收集容积（44）中的穿刺方向上的穿刺转移阶段之后被浸入。

    ANALYTICAL SYSTEM FOR DETERMINING AN ANALYTE IN A BODY FLUID AND DISPOSABLE INTEGRATED SAMPLE COLLECTION AND ANALYTICAL ELEMENT
    36.
    发明申请
    ANALYTICAL SYSTEM FOR DETERMINING AN ANALYTE IN A BODY FLUID AND DISPOSABLE INTEGRATED SAMPLE COLLECTION AND ANALYTICAL ELEMENT 审中-公开
    分析系统用于测定分析体液和集成DISPOSIBLES PROBENGEWINNUNGS-和分析组件

    公开(公告)号：WO2008110287A2

    公开(公告)日：2008-09-18

    申请号：PCT/EP2008001726

    申请日：2008-03-05

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  LIST HANS ,  ZIMMER VOLKER ,  KEIL MICHAEL

    Inventor： LIST HANS ,  ZIMMER VOLKER ,  KEIL MICHAEL

    IPC: A61B5/15

    CPC classification number: A61B5/157 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150511 ,  A61B5/150572 ,  A61B5/15186 ,  A61B2562/0295

    Abstract: The invention relates to an analytical system for determining an analyte in a body fluid, comprising a disposable integrated sample collection and analytical element which includes a lancing element (7) having a tip (15) for lancing the skin of a body part and a flat test strip (6) having a sample receiving zone (10) into which a body fluid sample is transferred to carry out an analysis. The system further comprises a reusable analytical device (2) including a coupling unit adapted to couple an integrated sample collection and analytical element to a drive driving the lancing movement of the lancing element (7). The lancing element is moved on a lancing path in the direction of lancing during an advance phase and, once it has reached a point of return of the lancing movement, it is moved counter to the direction of lancing during a return phase. The measurement and evaluation unit (36) is used to measure a measurement variable which is characteristic for determining the analyte and for determining a desired result of analysis based on said measurement. The sample receiving zone (10) of the test strip (6) is arranged on one of its flat faces (9) that configures a sample contact side (11). The lancing element (7) is arranged in parallel to the test strip (6) and can be moved during at least part of the lancing path relative to the test strip (6) on a movement path. The lancing element (7) is arranged adjacent to the sample contact side (11) of the test strip (6). It has a capillary channel (17) with a sample inlet (23) through which the body fluid can enter the capillary channel (17) after lancing, and a sample outlet (24) through which the body fluid can escape from the capillary channel (17). The movement of the lancing element (7) includes a sample transfer position in which the sample outlet (24) is adjacent to the sample receiving zone (10) of the test strip (6) in such a manner that the body fluid can be transferred from the capillary channel (17) through the sample outlet (24) to the sample receiving zone (10).

    Abstract translation: 用于在包括disposibles体液测定分析物分析系统集成Probengewinnungs-和分析元件包括刺入元件（7）具有用于产生在身体部分的穿刺伤口和平坦测试条的前端（15）（6）配有一个样品接收区（10） 包括，进行分析的体液样品中被提供，并且可重复使用的分析仪器（2），其包括适于连接一个集成Probengewinnungs-和分析元件与一个驱动器，由（穿刺元件的穿刺移动的耦合单元 7）在其被期间在穿刺方向正向相位移动到穿刺路径和，在靠穿刺方向再循环阶段达到刺入运动的反向点被驱动之后。 测量和评估单元（36）用于测量分析物测量变量的确定，并确定基于该测量期望的分析结果的特性。 测试条（6）的（9）上其平坦侧面中的一个样品接收区（10），其形成的样品的接触面（11）设置。 该刺穿构件（7）相对于所述测试条（6）的移动路径上的插入路径的至​​少一部分期间被设置为平行于测试条（6）和可移动的。 该刺穿构件（7）被布置成邻近所述测试条（6）的样品接触侧（11）。 它包括一个毛细管通道（17），包括通过其可以在毛细管通道（17）在穿刺后发生体液样品入口（23），和样品（24），通过它从所述毛细管通道的体液（17）出现 可能有。 该刺穿构件（7）的移动路径包括以这样的方式样本转印位置，其中，所述样本出口（24）的测试条的样品接收区（10）（6）是相邻的，即从毛细管通道（17）通过所述样品（24）与所述主体流体 样品接收区（10）可被发送。

    PIERCING SYSTEM FOR REMOVING A SAMPLE OF BODILY FLUID
    38.
    发明申请
    PIERCING SYSTEM FOR REMOVING A SAMPLE OF BODILY FLUID 审中-公开
    PEG系统去除身体流体测试

    公开(公告)号：WO2007073870A2

    公开(公告)日：2007-07-05

    申请号：PCT/EP2006012016

    申请日：2006-12-13

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  LIST HANS ,  HAAR HANS-PETER ,  MEACHAM GEORGE BEVAN KIRBY ,  EUSEMANN MICHAEL

    Inventor： LIST HANS ,  HAAR HANS-PETER ,  MEACHAM GEORGE BEVAN KIRBY ,  EUSEMANN MICHAEL

    IPC: A61B5/15 ,  A61B10/00

    CPC classification number: A61B5/15196 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150175 ,  A61B5/15019 ,  A61B5/150419 ,  A61B5/150519 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15119 ,  A61B5/15128 ,  A61B5/1519 ,  A61B5/15194

    Abstract: The invention relates to a microsampler piercing system for removing a sample of bodily fluid from a body part. Said system comprises: a sampling unit with a piercing element and a piercing device with a drive, which is used to displace a sampling unit along a displacement path, in order to allow the piercing element to penetrate and be withdrawn from the skin of the body part by means of a piercing and retraction displacement; an adjusting device for adjusting the piercing depth of the wound that is to be pierced; and a control unit for controlling the piercing and retraction displacement with the following sequential displacement phases: a propulsion phase (V), in which the piercing element (5) penetrates the skin to a defined pierced depth (dm); a withdrawal phase (R1), in which the piercing element (5) is partially withdrawn over a withdrawal distance (?d), slowing down towards the end of the withdrawal phase (R1) so that it is lodged in the skin at a defined pierced remainder depth (dr); and a collection phase (S), in which the piercing element remains lodged in the skin and the sampling unit takes a sample of bodily fluid. The adjusting device is configured in such a way that the defined pierced depth can be adjusted independently of the defined pierced remainder depth that is defined by temporal means , in relation to the collection phase.

    Abstract translation: 本发明涉及一种微采样穿刺系统用于与穿刺元件从一个身体部分收集体液样品，包括采样单元，并用一驱动器中的柳叶刀切开装置，借助于该采样单元是一个移动路径在与穿刺的穿刺元件和返回运动对可动 刺身体部分的皮肤，并再次拉出，调节装置，用于调节所加工的穿刺伤口的穿刺深度，以及控制装置，用于控制与以下顺序移动相位的穿刺和收回运动：一个推进阶段（V），其中穿刺元件（5），以 限定的穿刺深度（DM）被插入时，一个缩回阶段（R1），其中穿刺元件（5）绕一个缩回距离（？d）被部分地抽出并缩回阶段（R1）的端部被制动，使得它（具有规定的残余穿刺深度 博士） 突出皮肤和积累阶段（S），其中穿刺元件渗入皮肤和体液样品通过样品接收单元接收。 所述设定装置适于使得所限定的穿刺深度独立于时间平均<博士>规定的残余穿刺深度（DR），相对于所述收集阶段，可调节的。

    PIERCING SYSTEM FOR REMOVING A BODILY FLUID
    39.
    发明申请
    PIERCING SYSTEM FOR REMOVING A BODILY FLUID 审中-公开
    用于去除身体流体的PEG系统

    公开(公告)号：WO2006092309A3

    公开(公告)日：2006-12-21

    申请号：PCT/EP2006001922

    申请日：2006-03-02

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  DECK FRANK ,  QUARDER ORTRUD ,  WEISS THOMAS ,  HOERAUF CHRISTIAN ,  KISTNER MICHAEL ,  KONYA AHMET ,  HARTTIG HERBERT ,  BAADER FELIX ,  LIST HANS ,  EBERT KARL-PETER

    Inventor： DECK FRANK ,  QUARDER ORTRUD ,  WEISS THOMAS ,  HOERAUF CHRISTIAN ,  KISTNER MICHAEL ,  KONYA AHMET ,  HARTTIG HERBERT ,  BAADER FELIX ,  LIST HANS ,  EBERT KARL-PETER

    IPC: A61B5/151

    CPC classification number: A61B5/15148 ,  A61B5/150022 ,  A61B5/15019 ,  A61B5/150198 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150832 ,  A61B5/150916 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/15196

    Abstract: The invention relates to a piercing system for removing bodily fluid from the skin of a human or animal. Said system comprises a disposable piercing unit (1), which contains a needle element (6) for puncturing the skin, a piercing device (2), which encompasses a piercing drive (4), said drive propelling a piercing displacement of the piercing unit (1), which is coupled to the piercing drive (4) by means of a coupling mechanism (3), a predefined value of the piercing depth being guaranteed using a piercing depth reference element (10), which comprises a skin contact surface (11) and the predefined value of the piercing depth being determined by the distance in the piercing direction between the skin contact surface (11) and the position of the needle tip at the inversion point of the piercing displacement. The piercing depth reference element (10) is connected to the needle element (6) and coupled to the drive in such a way that it is displaced together with the needle element (1) during at least one part of the propulsion phase and has a defined longitudinal position in the piercing direction in relation to the needle element (6), at least at the inverse point of the piercing displacement.

    Abstract translation: 用于收集体液从人或动物的皮肤上，用一次性采血部的柳叶刀切开系统（1）具有针构件（6），用于刺穿皮肤，穿刺装置（2），其包括穿刺驱动器（4），由 通过联接机构的装置连接到所述切缝驱动件的穿刺单元（1）的穿刺移动（3）（4）耦合，被驱动，由此，穿刺深度的由穿刺深度参考元件的装置的预定值（10）得到保证，其具有皮肤接触面（11）， 和穿刺深度的预定值.The通过在皮肤接触表面（11），并且在刺入运动穿刺深度参考元件的反转点的针尖（10）被连接在与所述针元件（6）这样的方式以及与所述驱动器的位置之间的穿刺方向的距离来确定， 在推进阶段的至少一部分期间它至少与针元件（1）一起移动 s在刺穿运动的反向点处具有相对于针元件（6）在穿刺方向上限定的纵向位置。

    TEST SYSTEM FOR MEASURING THE CONCENTRATION OF AN ANALYTE IN A BODY FLUID
    40.
    发明申请
    TEST SYSTEM FOR MEASURING THE CONCENTRATION OF AN ANALYTE IN A BODY FLUID 审中-公开
    用于测量体液中分析物浓度的测试系统

    公开(公告)号：WO2008145625A3

    公开(公告)日：2009-02-12

    申请号：PCT/EP2008056404

    申请日：2008-05-26

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  LIST HANS ,  HAAR HANS-PETER ,  MEACHAM GEORGE BEVAN KIRBY

    Inventor： LIST HANS ,  HAAR HANS-PETER ,  MEACHAM GEORGE BEVAN KIRBY

    IPC: A61B5/151

    CPC classification number: A61B5/150198 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150511 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15176

    Abstract: An actuator for driving a test element is proposed. The test element comprises a lancet for perforating a skin portion of a living organism. The actuator comprises an engaging part for engaging and driving the test element to perform a lancing motion. The actuator further comprises a lancing actuator and a lancing spring, wherein the lancing actuator is adapted for biasing the lancing spring by executing a forward movement and thereby exerting a biasing force on the engaging part. The actuator further comprises a latch element, wherein the latch element is a force-sensitive latch element, wherein the latch element is adapted for exerting a retention force holding back the engaging part, The retention force counteracts the biasing force. The latch element is adapted for releasing the engaging part when the biasing force exerted by the lancing actuator exceeds the retention force exerted by the latch element, thereby allowing for the test element to perform the lancing motion.

    Abstract translation: 提出了用于驱动测试元件的致动器。 测试元件包括用于穿孔活体的皮肤部分的刺血针。 致动器包括用于接合和驱动测试元件以执行穿刺运动的接合部分。 所述致动器还包括穿刺致动器和采血弹簧，其中所述采血执行器适于通过执行向前运动来偏置所述穿刺弹簧，从而对所述接合部施加偏置力。 所述致动器还包括闩锁元件，其中所述闩锁元件是力敏锁定元件，其中所述闩锁元件适于施加阻止所述接合部分的保持力。所述保持力抵消所述偏置力。 当由穿刺致动器施加的偏压力超过由闩锁元件施加的保持力时，闩锁元件适于释放接合部件，从而允许测试元件执行穿刺运动。

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