公开(公告)号：JP2009096791A

公开(公告)日：2009-05-07

申请号：JP2008038231

申请日：2008-02-20

Applicant: Kaneka Corp ,  株式会社カネカ

Inventor： SUZUKI IKUHIRO ,  SAKA YASUHIRO ,  OGURO KAZUMI

IPC: C07C227/30 ,  C07B53/00 ,  C07B61/00 ,  C07C229/36 ,  C07D277/20 ,  C07D277/30

Abstract: PROBLEM TO BE SOLVED: To provide a method for easily producing an optically active amino acid using an inexpensive reagent suitable to industrial use. SOLUTION: The method comprises making an acid act on an imidazolidinone derivative having a structure represented by chemical formula (1) in a non-aqueous system. Thereby, the 1-arylethyl group of an imidazolidinone derivative having such a catalyst-poisoning functional group can be eliminated, which has been difficult by conventional methods, and furthermore, an N, N-crosslinked substituent constituting an imidazolidinone ring can be deprotected in a single step, thus enabling the objective amino acid or its ester to be easily produced. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 待解决的问题：提供一种使用适合工业用途的廉价试剂容易地制备光学活性氨基酸的方法。 解决方案：该方法包括在非水系统中对具有由化学式（1）表示的结构的咪唑啉酮衍生物进行酸作用。 因此，通过常规方法可以消除具有这样的催化剂中毒官能团的咪唑烷酮衍生物的1-芳基乙基，此外，构成咪唑啉酮环的N，N-交联取代基可以被去保护 单步，从而使客观氨基酸或其酯易于生产。 版权所有（C）2009，JPO＆INPIT