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31.发明申请公开(公告)号：US20100136700A1
公开(公告)日：2010-06-03
申请号：US12620831
申请日：2009-11-18
Applicant: John Bilello , Bo Pi
Inventor： John Bilello , Bo Pi
CPC classification number: G01N33/6893 , G01N2800/304 , G01N2800/52 , G01N2800/60 , G06F19/20 , G06F19/24 , G06F19/34
Abstract: Materials and methods for using combinations of metabolic syndrome and HPA axis biomarkers for monitoring major depressive disorder.
Abstract translation: 使用代谢综合征和HPA轴生物标志物组合监测重症抑郁障碍的材料和方法。
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公开(公告)号：US20100100333A1
公开(公告)日：2010-04-22
申请号：US12579733
申请日：2009-10-15
Applicant: Bo Pi , John Bilello
Inventor： Bo Pi , John Bilello
IPC: G06F19/00
CPC classification number: G01N33/6893 , G01N33/6842 , G01N2800/304 , G16B40/00
Abstract: Materials and Methods related to diagnosing depression disorders, or determining a subject's predisposition to develop a depression disorder, using a multi-parameter hypermapping system and algorithms related thereto.
Abstract translation: 与诊断抑郁症有关的材料和方法，或使用多参数超图系统和与其相关的算法确定受试者发展抑郁症的倾向。
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33.发明授权Fiber optical switches based on optical evanescent coupling between two fibers 有权基于两条光纤之间的光学衰减耦合的光纤开关公开(公告)号：US06571035B1
公开(公告)日：2003-05-27
申请号：US09927095
申请日：2001-08-10
Applicant: Bo Pi , Shulai Zhao
Inventor： Bo Pi , Shulai Zhao
IPC: G02B626
CPC classification number: G02B6/3502 , G02B6/12007 , G02B6/266 , G02B6/2804 , G02B6/2826 , G02B6/2852 , G02B6/29355 , G02B6/30 , G02B6/3536 , G02B6/356 , G02B6/3582 , G02B6/3584 , G02B6/3608 , G02B6/3636 , G02B6/3652 , G02B6/3692
Abstract: Fiber optical devices formed on substrates fabricated with grooves that operate based on evanescent optical coupling through a side-polished fiber surface in each fiber involved. A coupling control layer is formed between two fibers to control the evanescent coupling for optical switching operations.
Abstract translation: 形成在基板上的光纤设备，该基板通过在涉及的每个光纤中通过侧面抛光的光纤表面基于ev逝光耦合而工作的凹槽。 在两个光纤之间形成耦合控制层，以控制光切换操作的渐逝耦合。
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34.发明授权Integrated fiber devices based on Mach-Zehnder interferometers and evanescent optical coupling 有权基于马赫 - 曾德尔干涉仪和ev逝光耦合器的集成光纤器件公开(公告)号：US06556746B1
公开(公告)日：2003-04-29
申请号：US09927099
申请日：2001-08-10
Applicant: Shulai Zhao , Bo Pi
Inventor： Shulai Zhao , Bo Pi
IPC: G02B626
CPC classification number: G02B6/3502 , G02B6/12007 , G02B6/12019 , G02B6/266 , G02B6/2804 , G02B6/2826 , G02B6/2852 , G02B6/29332 , G02B6/29334 , G02B6/29355 , G02B6/30 , G02B6/3536 , G02B6/3556 , G02B6/356 , G02B6/3582 , G02B6/3584 , G02B6/3636 , G02B6/3692
Abstract: Optical Mach-Zehnder interferometers and related devices, systems that have at least one fiber integrated or engaged to a substrate fabricated with one or more grooves. An integrated optical monitoring mechanism may be implemented in such devices.
Abstract translation: 光学马赫 - 策德尔干涉仪和相关装置，具有至少一个光纤集成或接合到用一个或多个凹槽制造的基底的系统。 集成光学监视机构可以在这样的设备中实现。
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公开(公告)号：US06542663B1
公开(公告)日：2003-04-01
申请号：US09949070
申请日：2001-09-07
Applicant: Shulai Zhao , Bo Pi
Inventor： Shulai Zhao , Bo Pi
IPC: G02B626
CPC classification number: G02B6/3536 , G02B6/12007 , G02B6/266 , G02B6/2804 , G02B6/2826 , G02B6/2852 , G02B6/29332 , G02B6/29334 , G02B6/29355 , G02B6/30 , G02B6/3502 , G02B6/356 , G02B6/3582 , G02B6/3584 , G02B6/3636 , G02B6/3692
Abstract: Fiber optical devices formed on substrates fabricated with grooves that operate based on evanescent optical coupling through a side-polished fiber surface in each fiber involved. The fiber cladding under the side-polished fiber surface is designed to support a radial mode profile wider than a radial mode profile supported by adjacent fiber portions.
Abstract translation: 形成在基板上的光纤设备，该基板通过在涉及的每个光纤中通过侧面抛光的光纤表面基于ev逝光耦合而工作的凹槽。 在侧面抛光的纤维表面下方的纤维包层被设计成支持比由相邻纤维部分支撑的径向模式轮廓更宽的径向模式轮廓。
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Patent Agency Ranking
公开(公告)号：US08673650B2
公开(公告)日：2014-03-18
申请号：US12305950
申请日：2006-12-11
Applicant: Bo Pi
Inventor： Bo Pi
IPC: G01N21/00
CPC classification number: G01N21/253 , G01N21/274 , G06F19/00
Abstract: Optical detection of molecules using a biochip having at least one reagent immobilizing area designed to receive one or more reagents and at least one calibration structure with a predetermined height to provide a height reference for optical measurement is disclosed. When the calibration structure is illuminated by a probe beam of light, a first reflected beam of light is reflected off the calibration structure, and a second reflected beam of light is reflected off the reagent immobilizing area. The first reflected beam and the second reflected beam are compared to determine a height at the reagent immobilizing area.
Abstract translation: 公开了使用具有设计成接收一种或多种试剂的至少一个试剂固定区域和具有预定高度的至少一个校准结构以提供用于光学测量的高度参考的生物芯片的分子的光学检测。 当校准结构被探测光束照射时，第一反射光束从校准结构反射，第二反射光束从试剂固定区域反射出来。 比较第一反射光束和第二反射光束以确定试剂固定区域的高度。
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公开(公告)号：US20110269633A1
公开(公告)日：2011-11-03
申请号：US12922365
申请日：2009-03-11
Applicant: John Bilello , Yiwu He , Bo Pi
Inventor： John Bilello , Yiwu He , Bo Pi
CPC classification number: G06Q30/02 , G01N33/6869 , G01N2800/304 , G16B20/00 , G16B40/00 , G16H50/20
Abstract: Materials and Methods related to developing a unipolar depression (MDD) disease score in a subject using a multi-parameter system to measure a plurality of parameters, and an algorithm to calculate a score.
Abstract translation: 与使用多参数系统测量多个参数的受试者中发展单极抑郁症（MDD）疾病评分相关的材料和方法以及计算得分的算法。
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38.发明申请DIAGNOSING AND MONITORING DEPRESSION DISORDERS BASED ON MULTIPLE SERUM BIOMARKER PANELS 审中-公开基于多个血清生物标志物面板的诊断和监测抑郁症公开(公告)号：US20110245092A1
公开(公告)日：2011-10-06
申请号：US12921349
申请日：2009-03-04
Applicant: John Bilello , Yiwu He , Bo Pi
Inventor： John Bilello , Yiwu He , Bo Pi
CPC classification number: G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N2800/304 , G01N2800/60 , G16H10/40 , G16H50/30
Abstract: Materials and Methods related to developing a unipolar depression (MDD) disease score in a subject using a multi-parameter system to measure a plurality of parameters, and an algorithm to calculate a score.
Abstract translation: 与使用多参数系统测量多个参数的受试者中发展单极抑郁症（MDD）疾病评分相关的材料和方法以及计算得分的算法。
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公开(公告)号：US20100280562A1
公开(公告)日：2010-11-04
申请号：US12754770
申请日：2010-04-06
Applicant: Bo Pi , John Bilello
Inventor： Bo Pi , John Bilello
CPC classification number: C12Q1/6883 , C12Q2600/158 , G16B40/00
Abstract: Methods for identifying and measuring pharmacodynamic biomarkers of neuropsychiatric disease, and for monitoring a subject's response to treatment. For example, materials and methods for monitoring the effectiveness of vagus nerve stimulation in a subject having a neuropsychiatric disease are provided.
Abstract translation: 用于鉴定和测量神经精神疾病的药效学生物标志物并监测受试者对治疗反应的方法。 例如，提供了用于监测具有神经精神疾病的受试者中的迷走神经刺激的有效性的材料和方法。
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公开(公告)号：US20100144052A1
公开(公告)日：2010-06-10
申请号：US12305950
申请日：2006-12-11
Applicant: Bo Pi
Inventor： Bo Pi
CPC classification number: G01N21/253 , G01N21/274 , G06F19/00
Abstract: Optical detection of molecules using a biochip having at least one reagent immobilizing area designed to receive one or more reagents and at least one calibration structure with a predetermined height to provide a height reference for optical measurement is disclosed. When the calibration structure is illuminated by a probe beam of light, a first reflected beam of light is reflected off the calibration structure, and a second reflected beam of light is reflected off the reagent immobilizing area. The first reflected beam and the second reflected beam are compared to determine a height at the reagent immobilizing area.
Abstract translation: 公开了使用具有设计成接收一种或多种试剂的至少一个试剂固定区域和具有预定高度的至少一个校准结构以提供用于光学测量的高度参考的生物芯片的分子的光学检测。 当校准结构被探测光束照射时，第一反射光束从校准结构反射，第二反射光束从试剂固定区域反射出来。 比较第一反射光束和第二反射光束以确定试剂固定区域的高度。
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