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    PREPARATION OF 1,4-DIHYDROXYBUTENE-2
    35.
    发明专利
    PREPARATION OF 1,4-DIHYDROXYBUTENE-2 失效

    公开(公告)号：JPS5984831A

    公开(公告)日：1984-05-16

    申请号：JP19337182

    申请日：1982-11-05

    Applicant: MITSUI TOATSU CHEMICALS

    Inventor： MATSUHISA TOSHIO ,  MATSUDA FUJIO

    IPC: C07C29/48 ,  B01J23/00 ,  B01J23/40 ,  B01J23/70 ,  B01J27/00 ,  B01J27/06 ,  C07B61/00 ,  C07C27/00 ,  C07C33/035 ,  C07C67/00

    Abstract: PURPOSE:To obtain the titled compound, an industrial useful raw material, by a direct one-stage process advantageously without using a large-sized production device, by oxidizing 1,3-butadiene with molecular oxygen in the presence of iodine, etc. and a transition metal of 8 group as a catalyst in an organic solvent containing water. CONSTITUTION:Two components of iodine or iodine compound and a transition metal of 8 group are used as a catalyst, 1,3-butadiene is reacted with molecular oxygen in an organic solvent containing water at 50-250 deg.C, preferably 70-150 deg.C at 10-200kg/cm , to give the titled compound. The amount of water used in preferably 1-10mol based on 1mol butadiene. The catalyst consists of the two components,the first component is the transition metal of 8 group, its amount used is especially 0.005-0.05 based on 1mol butadiene, and the second component is iodine or iodine compound, its amount used is preferably 0.05-5g atom calculated as iodine atom based on 1g atom of the transition metal of 8 group.

    PREPARATION OF INDOLINE AND INDOLE
    36.
    发明专利
    PREPARATION OF INDOLINE AND INDOLE 失效

    公开(公告)号：JPS56100761A

    公开(公告)日：1981-08-12

    申请号：JP256780

    申请日：1980-01-16

    Applicant: MITSUI TOATSU CHEMICALS

    Inventor： MATSUDA FUJIO ,  KATOU KOUZOU

    IPC: C07D209/08

    Abstract: PURPOSE:To prepare the titled compounds useful as raw materials of perfumery and amino acids, etc., from low-cost raw materials, in one step, in high selectivity, by the gas-phase reaction of benzene with 2-aminoethyl alcohol in the presence of a catalyst containing VIII-group metals, etc. CONSTITUTION:Benzene is made to react with 2-aminoethyl alcohol in the presence of a catalyst containing VIII-group metals, Ib-group metals, zinc salts and/or cadmium salts, pref. at 250-400 deg.C to obtain indoline and/or indole from the low-cost raw materials in one step in high selectivity. The raw materials are fed to the reactor as vapor-phase or liquid-phase at a liquid space velocity to the catalyst of 0.01-5l/l- catalyst/hr and a benzene : ethanolamine molar ratio of 1:(0.05-5). The obtained indoline can be converted easily to indole useful as a raw material of perfumery, amino acids, etc.

    PREPARATION OF INDOLE OR INDOLE DERIVATIVE
    37.
    发明专利
    PREPARATION OF INDOLE OR INDOLE DERIVATIVE 失效

    公开(公告)号：JPS5661353A

    公开(公告)日：1981-05-26

    申请号：JP13594079

    申请日：1979-10-23

    Applicant: MITSUI TOATSU CHEMICALS

    Inventor： MATSUDA FUJIO ,  KATOU KOUZOU

    IPC: C07D209/08 ,  B01J23/40 ,  B01J23/74 ,  B01J27/20

    Abstract: PURPOSE:To prepare the titled compound useful as a raw material of perfumery and amino acids, in one step, easily, in an improved yield, from N-beta-hydroxyethylaniline available at low cost, by carrying out the reaction in the presence of a catalyst containing a VIII-group metal. CONSTITUTION:The titled compound is prepared by the gas phase reaction of N-beta-hydroxyethylaniline or its nucleus-substituted derivative, e.g. N-beta-hydroxyethyl-o-toluidine in the presence of a catalyst comprising a metal of the VIII group of the periodic table, i.e. Fe, Co, Ni, Pd, Pt, etc., a mixture of two or more of the above metals, or a mixture of the metal and other compounds, and pref. in the presence of ethylene glycol and/or aniline. The molar ratio of ethylene glycol to the raw material is 0.01-10 to 1, pref. 0.1-1 to 1.

    PREPARATION OF INDOLE OR INDOLE DERIVATIVE
    38.
    发明专利
    PREPARATION OF INDOLE OR INDOLE DERIVATIVE 失效

    公开(公告)号：JPS5653652A

    公开(公告)日：1981-05-13

    申请号：JP12886579

    申请日：1979-10-08

    Applicant: MITSUI TOATSU CHEMICALS

    Inventor： MATSUDA FUJIO ,  KATOU KOUZOU

    IPC: C07D209/08 ,  B01J27/00 ,  B01J27/02 ,  C07B61/00

    Abstract: PURPOSE:To prepare the titled compound useful as a raw material of perfumery and amino acids, with a single stage process and low production of by-products, in high purity and selectivity, by the gas phase reaction of an aniline available at an extremely low cost with ethylene glycol in the presence of a catalyst. CONSTITUTION:The objective compound id obtained by the gas phase reaction of (A) an aniline such as aniline, o-toluidine, etc. with (B) ethylene glycol in the presence of (C) a catalyst containing cadmium sulfate and/or zinc sulfate. The amount of ethylene glycol is pref. 0.01-5mol, esp. 0.05-2mol per 1mol of the aniline. The cadmium sulfate and zinc sulfate can be used singly or as a mixture. The catalyst may be incorporated with other compounds such as a halide, nitrate, etc. of lithium, sodium, molybdenum, etc.

    NOVEL PENICILLIN* CEPHALOSPORIN* AND THEIR PREPARATION
    39.
    发明专利
    NOVEL PENICILLIN* CEPHALOSPORIN* AND THEIR PREPARATION 失效

    公开(公告)号：JPS55136287A

    公开(公告)日：1980-10-23

    申请号：JP4250879

    申请日：1979-04-10

    Applicant: MITSUI TOATSU CHEMICALS

    Inventor： MATSUDA FUJIO ,  KATOU KOUZOU

    IPC: C07D501/22 ,  A61K31/43 ,  A61K31/545 ,  A61P31/04 ,  C07D499/64 ,  C07D501/34

    Abstract: NEW MATERIAL:A compound of formula I [R is alkyl, cycloalkyl, cycloalkenyl, or cycloalkadienyl group, etc.; R is H, protective group, or cation; X is O or S; Z is formula II or III (Y is H, halogen, OH, or cyano group)], its salt, or ester. EXAMPLE:7-[ D-alpha-Uracil-1-carbonyl-amino )phenylacetamido ]-3-methyl-3-cephem- 4-carboxylic acid. USE:Antibacterials effective against Gram-positive and Gram-negative bacteria. PROCESS:A penicillin of formula IV or its derivative is reacted with a uracil of formula V or its reactive derivative, e.g. uracil-1-carboxylic acid, in the presence or absence of a base in an inert solvent, e.g. methanol, at -50-80 deg.C to give the compound of formula I, its salt, or ester.

    PREPARATION OF POLYCYANOOBENZENE
    40.
    发明专利
    PREPARATION OF POLYCYANOOBENZENE 失效

    公开(公告)号：JPS54138539A

    公开(公告)日：1979-10-27

    申请号：JP4426678

    申请日：1978-04-17

    Applicant: MITSUI TOATSU CHEMICALS

    Inventor： TOYODA TOSHIHIRO ,  MATSUDA FUJIO

    IPC: C07C255/51 ,  C07C67/00 ,  C07C253/00

    Abstract: PURPOSE:To obtain the title compound usable as raw materials for adhesives and heat-resistant resins industrially advantageously, by reacting a polyhalogenated benzene with an inorganic cyano compound in the presence of cupric ions in a polar organic solvent. CONSTITUTION:A polyhalogenated benzene of formula I: (X is Cl, Br, or I; R is H or methyl group; n is an integer 3-6), e.g. 1,2,4,5-tetrachlorobenzene, is reacted with an inorganic cyano compound, e.g. sodium cyanide, in the presence of cupric ions, e.g. cupric sulfate, in a polar organic solvent to give a compound of formula II. An amide solvent, preferably N-methyl-pyrrolidone, may be cited as the polar organic solvent.

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