公开(公告)号：JP2015025818A

公开(公告)日：2015-02-05

申请号：JP2014222203

申请日：2014-10-31

Applicant: 日本電気株式会社 ,  Nec Corp

Inventor： ASOGAWA MINORU ,  HAGIWARA HISASHI ,  HIRAMATSU TORU

IPC: G01N35/10 ,  G01N37/00

CPC classification number: B01L3/5027 ,  B01F11/0071 ,  B01F13/0059 ,  B01L3/50273 ,  B01L7/52 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/163 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0666 ,  G01N35/00029 ,  G01N2035/00544

Abstract: 【課題】構造が簡単でしかもコンパクトで、かつ極めて小型・安価で信頼性の高いマイクロチップの試料処理装置を提供する。【解決手段】試料57aを充填するための試料容器52aと、試料容器52aと流路61aで連接されかつ試料57aを順次移送充填して混合・反応せしめる反応容器52dとを有し、試料容器52aと反応容器52dとの間で、流路61aを介して試料57aの送液を繰り返し行うことにより、試料57aを攪拌し混合・反応させるマイクロチップ50の試料処理装置。【選択図】図2

Abstract translation: 要解决的问题：为了提供具有简单紧凑结构的微芯片样品处理装置，具有尺寸非常紧凑的廉价的微芯片样品处理装置，具有高可靠性。微芯片50的样品处理装置包括： ：用于在其中填充样品57a的样品容器52a; 以及反应容器52d，其与通道61a连接到样品容器52a，并顺序地转移和填充样品57a用于混合并使样品反应。 在样品容器52a和反应容器52d之间，重复样品57a通过通道61a的转移，由此样品57a被搅拌，混合和反应。

公开(公告)号：JP2014077806A

公开(公告)日：2014-05-01

申请号：JP2014011196

申请日：2014-01-24

Applicant: Nec Corp ,  日本電気株式会社

Inventor： ASOGAWA MINORU ,  HAGIWARA HISASHI ,  HIRAMATSU TORU

IPC: G01N35/08 ,  B01J19/00 ,  G01N37/00

CPC classification number: B01L3/502738 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0655 ,  G01N35/1095 ,  G01N2035/00158 ,  G01N2035/1034 ,  Y10T137/8593 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

Abstract: PROBLEM TO BE SOLVED: To prevent a sample from remaining on the verge of a transfer destination container, and to prevent the sample from remaining in a channel even in the case of disposing waste liquid in order to prevent mutual contamination in the case of transferring the sample by using a simple mechanism.SOLUTION: A microchip includes: a first layer; a second layer; an intermediate layer containing an elastic member disposed between the first layer and the second layer; a first channel disposed between the first layer and the intermediate layer to link a transfer source tank in which a sample is packed to a transfer destination tank as the transfer destination of the sample; a second channel connected to the transfer destination tank, which is different from the first channel; and a first shutter part disposed between the second layer and the intermediate layer so as to be overlapped with the first channel from the arbitrary position of the first channel to the neighborhood of the transfer destination tank. The first channel is closed by applying a pressure to the first shutter part, and the channel is opened by extracting the pressure to the first shutter. In a state that the first channel is closed by applying the pressure to the first shutter, the sample transferred to the transfer destination tank is pushed out to the second channel.

Abstract translation: 要解决的问题：为了防止样品保持在转移目的地容器的边缘，并且即使在处理废液的情况下也可以防止样品保留在通道中，以防止在转移的情况下相互污染 通过使用简单的机制进行采样。解决方案：微芯片包括：第一层; 第二层; 中间层，其包含布置在所述第一层和所述第二层之间的弹性构件; 第一通道，设置在第一层和中间层之间，以将其中包装样品的转移源罐与样品的转移目的地连接到转移目的地罐; 连接到所述转移目的地箱的与所述第一通道不同的第二通道; 以及第一快门部分，设置在第二层和中间层之间，以便与第一通道重叠，从第一通道的任意位置到转印目的地箱的附近。 通过向第一快门部施加压力来关闭第一通道，并且通过提取到第一快门的压力来打开通道。 在通过向第一快门施加压力来关闭第一通道的状态下，将转移到转移目的地箱的样品推出到第二通道。

公开(公告)号：JP2011089824A

公开(公告)日：2011-05-06

申请号：JP2009242286

申请日：2009-10-21

Applicant: Nec Corp ,  日本電気株式会社

Inventor： ASOGAWA MINORU

IPC: G01N35/08 ,  B01F3/08 ,  B01F5/00 ,  B01J19/00 ,  G01N35/02 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide a fluid mixer for preventing productivity and maintainability from decreasing and improving operability and reliability even if no precise pressure control is used. SOLUTION: The fluid mixer 10 includes channel selection mechanisms 6a, 6b in mixing tank channels 3a, 3b. As the pressure of liquid 1a is increased gradually, the channel selection mechanism 6a limits the channel to a branch channel 3a at a prescribed pressure or lower, feeds the liquid 1a to a valve 5b, and closes down the mixing tank channel 3b. When the liquid 1a exceeds a prescribed pressure, the channel selection mechanism 6a also permits a channel to a mixing tank 9 and feeds a liquid to the mixing tank 9. The mixing tank channel 3b has been closed down by the valve 5b, thus preventing the liquid from being fed from the mixing tank 9 to a supply tank 2a. Similarly, liquid 1b also does not flow into the supply tank 2a and is fed to the mixing tank 9. In the fluid mixer 10, it is not necessary to operate the valves from the outside, thus preventing a flow from the mixing tank to the supply tank even if the pressure and flow rate of the liquid are not controlled strictly. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：即使没有使用精确的压力控制，也提供一种用于防止生产率和可维护性的流体混合器的降低和改善操作性和可靠性。 解决方案：流体混合器10包括混合槽通道3a，3b中的通道选择机构6a，6b。 当液体1a的压力逐渐增加时，通道选择机构6a将通道限制在规定压力或更低压力下的分支通道3a，将液体1a供给阀5b，并关闭混合罐通道3b。 当液体1a超过规定压力时，通道选择机构6a还允许通向混合槽9的通道并将液体供给到混合槽9.混合槽通道3b被阀5b关闭，从而防止 液体从混合罐9供给到供应罐2a。 类似地，液体1b也不流入供应罐2a并被供给到混合罐9.在流体混合器10中，不需要从外部操作阀，从而防止从混合罐流向 即使液体的压力和流量不受严格控制，供应罐也是如此。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2006309485A

公开(公告)日：2006-11-09

申请号：JP2005130952

申请日：2005-04-28

Applicant: Nec Corp ,  日本電気株式会社

Inventor： YAMASHITA KEIKO ,  OSOUDA TSUTOMU ,  KUROIWA YUKIKO ,  ASOGAWA MINORU

IPC: G06N3/08

CPC classification number: G06N5/025

Abstract: PROBLEM TO BE SOLVED: To generate a temporal positive example, and to advance active learning when any positive example does not exist, or rarely exists. SOLUTION: A learning data storage part 131 stores the group of learning data configured of a plurality of describers and a plurality of labels. When there is not or rarely positive example whose desired label is turned to be a desired value in the learning data storage part 131, a control part 150 generates a temporary positive example by rewriting the value of the desired label with the value of another similar label. An active learning part 140 learns a rule by using the temporary positive example and a negative example, and predicts the positive example likeliness of each candidate data by applying the learned rule to the group of candidate data stored in a candidate data storage part 133 whose desired label is unknown, and selects data to be learnt the next based on the prediction result, and outputs the data form an input/output device 110. Afterwards, the data whose desired label's actual values are inputted from an input/output device 110 are removed from the group of the candidate data, and added to the group of the learning data. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：为了产生时间正面示例，并且当没有任何正面示例或者很少存在时促进主动学习。 解决方案：学习数据存储部分131存储由多个描述符和多个标签配置的学习数据组。 当在学习数据存储部分131中没有或很少正面的示例将其期望的标签变成期望值时，控制部分150通过用另一个类似标签的值重写所需标签的值来生成临时正例 。 主动学习部分140通过使用临时正例和否定例来学习规则，并且通过将学习规则应用于存储在候选数据存储部分133中的候选数据组中来预测每个候选数据的正实例可能性，所述候选数据组的期望 标签未知，并根据预测结果选择要学习的数据，并从输入/输出设备110输出数据。之后，从输入/输出设备110输入其期望标签的实际值的数据被移除 从候选数据组中加入到学习数据组中。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JPH1074189A

公开(公告)日：1998-03-17

申请号：JP22989896

申请日：1996-08-30

Applicant: NEC CORP

Inventor： ASOGAWA MINORU

IPC: G01N33/48 ,  G01N33/68 ,  G06F15/18 ,  G06F17/00 ,  G06F19/00 ,  G06F19/16 ,  G06N3/00 ,  G06N3/10 ,  G06Q10/04

Abstract: PROBLEM TO BE SOLVED: To predict a natural stereoscopic structure by judging whether or not the stereoscopic structure can be actually obtained, and deciding a pair constituting a pair in an array. SOLUTION: A connecting energy holding part 11 holds the connecting energy of each constituting unit of protein and nucleic acid arrays. A partial array combination generating part 13 generates all the pairs of the two partial arrays of an array 15 in which an inputted stereoscopic structure is unknown. A connecting energy calculating part 12 calculates the connecting energy for all the combination of the two partial arrays by using the connecting energy from the connecting energy holding part 11. A hop field neural network part 14 sets the connecting energy calculated by the connecting energy calculating part 12 as an initial value, and predicts the combination of the partial arrays for generating the minimum connecting energy while fulfilling the constraint of the stereoscopic structure as the arrayed secondary structure of a protein or nucleic acid array in which the inputted stereoscopic structure is unknown.

公开(公告)号：JPH09286796A

公开(公告)日：1997-11-04

申请号：JP10018496

申请日：1996-04-22

Applicant: NEC CORP ,  GIJUTSU KENKYU KUMIAI SHINJOHO

Inventor： ASOGAWA MINORU

IPC: C07B61/00 ,  C07K1/00 ,  G06F17/30 ,  G06F17/50 ,  G06F19/00 ,  G06Q10/04 ,  G06Q50/00 ,  G06Q50/10 ,  G06Q50/22

Abstract: PROBLEM TO BE SOLVED: To enable the application even to a long sequence and prediction even about a β-sheet located at a great distance in prediction about the protein β-sheets. SOLUTION: This protein β-sheet predictor comprises a residue pair predicting part 11 for predicting to what extent optional residue pairs of a protein sequence may form pairs, a virtual distance holding part 12 for holding the virtual distance between the optional residue pairs of the protein sequence, a β-sheet holding part 13 for holding the predicted residue pairs, an energy calculating part 14 for calculating a virtual stable energy of the β-sheets composed of the plural residue pairs and a prediction controlling part 15 for controlling the residue pair predicting part 11, the virtual distance holding part 12, the β-sheet holding part 13 and the energy calculating part 14 and predicting the β-sheets one by one.

公开(公告)号：JPH0668059A

公开(公告)日：1994-03-11

申请号：JP22257692

申请日：1992-08-21

Applicant: NEC CORP

Inventor： ASOGAWA MINORU

IPC: G06F15/18 ,  G06G7/60 ,  G06N99/00

Abstract: PURPOSE:To provide a high-speed neural network learning device by detecting and deleting unnecessary cells in a neural network part after learning a neural network without restrictions. CONSTITUTION:A neural network part 11 consists of links and cells. An example storage part 12 holds examples. A detecting part 13 detects unnecessary cells in the neural network part 11. A learning control part 14 controls learning of the neural network part 11 and restricts erasing of cells.

公开(公告)号：JPH03218730A

公开(公告)日：1991-09-26

申请号：JP1519290

申请日：1990-01-24

Applicant: NEC CORP

Inventor： ASOGAWA MINORU

IPC: A61B5/0452

Abstract: PURPOSE:To improve the recognition accuracy and the maximum likelihood of a partition point by using two kinds of neural networks, and executing the recognition of a partition by taking notice of an electrocardiogram waveform of that time and a timewise structure of the partition. CONSTITUTION:At the time of recognizing a partition at the time point (t), a value of an electrocardiogram waveform to be recognized and a prediction Ft of the partition of the time point (t) of a partition buffer 14 are inputted to a pattern associative type neural network 12. Consequently, a recognition result Kt of the partition of the time point (t) is obtained as the output of the pattern associative type neural network 12. This recognition result Kt becomes the input of a recurrent neural network 13. Thus, the prediction Ft+1 of the partition of a time point (t+1) is obtained as the output of the recurrent neural network 13. This prediction Ft+1 is stored in the partition buffer 14, and used for recognizing the partition at the time point (t+1). The partition buffer for holding the prediction of the partition of the next time point is initialized prior to the recognition.

公开(公告)号：JP2013007760A

公开(公告)日：2013-01-10

申请号：JP2012227066

申请日：2012-10-12

Applicant: Nec Corp ,  日本電気株式会社

Inventor： ASOGAWA MINORU ,  HAGIWARA HISASHI ,  HIRAMATSU TORU

IPC: G01N35/08 ,  G01N37/00

CPC classification number: G01N35/08

Abstract: PROBLEM TO BE SOLVED: To provide a fluid control mechanism with simple, inexpensive structure and high reliability in transfer means of a microchip for reacting a plurality of samples to perform reaction, mixture, separation, analysis, and gene analysis of chemical samples.SOLUTION: A fluid control mechanism of a microchip performs predetermined processing to samples, and includes; a sample part for filling the samples; first and second reaction parts for mixing and reacting the samples; a disposal part for disposing the samples or gas; a first flow channel which connects the sample part with the first reaction part; a second flow channel which connects the first reaction part with the second reaction part; and a third flow channel which connects the first reaction part with the disposal part. The first and second flow channels are provided at a lower part of the sample part, the first and second reaction parts, and the third flow channel is provided at an upper part of the first reaction part and the disposal part.

Abstract translation: 要解决的问题：提供一种用于使多个样品反应以进行化学样品的反应，混合，分离，分析和基因分析的微芯片的转移装置中具有简单，便宜的结构和高可靠性的流体控制机制 。 解决方案：微芯片的流体控制机构对样品进行预定处理，并包括： 用于填充样品的样品部分; 用于混合和反应样品的第一和第二反应部分; 处置样品或气体的处置部分; 将样品部与第一反应部连接的第一流路; 将第一反应部与第二反应部连接的第二流路; 以及将第一反应部与处置部连接的第三流路。 第一和第二流动通道设置在样品部分的下部，第一和第二反应部分，第三流动通道设置在第一反应部分和处理部分的上部。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2009069050A

公开(公告)日：2009-04-02

申请号：JP2007239228

申请日：2007-09-14

Applicant: Nec Corp ,  日本電気株式会社

Inventor： ASOGAWA MINORU ,  MATSUMOTO TATSU

IPC: G01N30/88

CPC classification number: C07C303/06 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3253 ,  C07B2200/11 ,  C07C303/38 ,  C07C303/40 ,  C07C309/40 ,  C07C311/19

Abstract: PROBLEM TO BE SOLVED: To provide a method for fixing a compound, having a sulfo group or a compound to which a sulfo group can be added to a column carrier.
SOLUTION: The method uses a linker having a sulfo group bonded group which can form bonding to the sulfo group in the compound and a carrier bonded group which can form bonding to a group that exists on the surface of the column carrier, the compound is fixed to the column carrier.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供一种固定化合物的方法，该化合物具有磺基或可以加入磺基的化合物到塔载体中。 解决方案：该方法使用具有磺基键合基团的接头，其可以与化合物中的磺基形成键合，以及可以与存在于载体的表面上的基团形成键合的载体键合基团， 化合物固定在柱载体上。 版权所有（C）2009，JPO＆INPIT