公开(公告)号：US20180230105A1

公开(公告)日：2018-08-16

申请号：US15872776

申请日：2018-01-16

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Swati S. More ,  Robert Vince

IPC: C07D233/44 ,  C07D239/22 ,  C07D239/47 ,  C07C279/06 ,  C07C335/12 ,  A61P35/00 ,  A61P5/48 ,  A61P25/16

CPC classification number: C07D233/44 ,  A61K31/167 ,  A61P5/48 ,  A61P25/16 ,  A61P35/00 ,  C07C279/06 ,  C07C279/08 ,  C07C279/18 ,  C07C279/22 ,  C07C281/14 ,  C07C281/16 ,  C07C281/18 ,  C07C335/04 ,  C07C335/12 ,  C07C335/40 ,  C07D213/61 ,  C07D231/38 ,  C07D233/50 ,  C07D233/52 ,  C07D233/64 ,  C07D239/06 ,  C07D239/18 ,  C07D239/22 ,  C07D239/47

Abstract: The invention provides compounds of formula Ia′, Ib′, Ic′, and Id′: and pharmaceutically acceptable salts thereof, wherein the variables A, R6, R7, R8, R9, Rx, L, X, Y, and Z have the meaning as described herein. The compounds are useful for reducing endoplasmic reticulum stress and for producing analgesia in an animal.

公开(公告)号：US09757354B2

公开(公告)日：2017-09-12

申请号：US15177150

申请日：2016-06-08

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Steven Earl Patterson ,  Herbert Tsukasa Nagasawa ,  Robert Vince ,  Alexandre Monteil

IPC: A61K31/385 ,  A61K31/198 ,  A61K9/16 ,  A61K9/00

CPC classification number: A61K31/385 ,  A61K9/0019 ,  A61K9/16 ,  A61K9/19 ,  A61K31/198 ,  A61K2300/00

Abstract: The invention provides compositions and methods for treating cyanide poisoning.

公开(公告)号：US09585558B2

公开(公告)日：2017-03-07

申请号：US14363953

申请日：2012-12-10

Applicant: Regents of the University of Minnesota

Inventor： Robert Vince ,  Swati Sudhakar More

IPC: A61B3/12 ,  A61B5/04 ,  G01J3/30 ,  G01J3/40 ,  G01J3/443 ,  G01J9/00 ,  G01N21/31 ,  A61B3/14 ,  A61K38/06 ,  G01N33/50

CPC classification number: A61B3/12 ,  A61B3/14 ,  A61B5/4848 ,  A61K38/063 ,  G01N21/31 ,  G01N33/5038

Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.

Abstract translation: 这里描述的是使用可见近红外（VNIR）高光谱成像系统作为早期检测阿尔茨海默病（AD）的非侵入性诊断工具。 本文还描述了在针对AD的潜在治疗剂的高通量筛选中使用VNIR高光谱成像系统。