公开(公告)号：DE69327328D1

公开(公告)日：2000-01-20

申请号：DE69327328

申请日：1993-09-03

Applicant: SEPRACOR INC

Inventor： WOOSLEY RAYMOND L ,  ABERG A K GUNNAR

IPC: C07D401/12 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/454 ,  A61K45/00 ,  A61K45/06 ,  A61P3/08 ,  A61P3/10 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P31/12 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising the compound of formula I: or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for use in a treatment of allergic rhinitis which does not induce any significant cardiac arrhythmia, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient.

公开(公告)号：AU675240B2

公开(公告)日：1997-01-30

申请号：AU4798693

申请日：1993-08-03

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  WOOSLEY RAYMOND L ,  GRAY NANCY M ,  CHEN YIWANG

IPC: C07D211/22 ,  A61K9/48 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：DE4394931T1

公开(公告)日：1995-07-20

申请号：DE4394931

申请日：1993-09-03

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： WOOSLEY RAYMOND L ,  ABERG A K GUNNAR

IPC: C07D401/12 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/454 ,  A61K45/00 ,  A61K45/06 ,  A61P3/08 ,  A61P3/10 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P31/12 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising the compound of formula I: or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for use in a treatment of allergic rhinitis which does not induce any significant cardiac arrhythmia, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient.

公开(公告)号：NO950374L

公开(公告)日：1995-03-29

申请号：NO950374

申请日：1995-02-01

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：AU6098094A

公开(公告)日：1994-08-15

申请号：AU6098094

申请日：1994-01-27

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： GRAY NANCY M ,  WOOSLEY RAYMOND L

IPC: A61K31/495 ,  A61K31/50

公开(公告)号：CA2141572A1

公开(公告)日：1994-02-17

申请号：CA2141572

申请日：1993-08-03

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: C07D211/22 ,  A61K9/48 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: A pharmaceutical composition comprising a compound of formula (I): wherein Z is COOH, COOCH3 or CH2OH, or a pharmaceutically acceptable salt thereof, for use in an anti-histaminic treatment which does not induce any significant cardiac arrhythmia, comprising administering a therapeutically effective amount of a compound of formula (I) to a human patient.

公开(公告)号：AU2005222506B2

公开(公告)日：2008-12-11

申请号：AU2005222506

申请日：2005-10-11

Applicant: SEPRACOR INC

Inventor： WONG JAMES W ,  CHEN YIWANG ,  GRAY NANCY M ,  WOOSLEY RAYMOND L

IPC: A61K31/445

公开(公告)号：DE69334145D1

公开(公告)日：2007-07-12

申请号：DE69334145

申请日：1993-08-03

Applicant: SEPRACOR INC

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K31/445 ,  A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：AU782660B2

公开(公告)日：2005-08-18

申请号：AU9740901

申请日：2001-12-24

Applicant: SEPRACOR INC

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K31/445

公开(公告)号：DK0920865T3

公开(公告)日：2004-04-19

申请号：DK99200247

申请日：1993-09-03

Applicant: SEPRACOR INC

Inventor： WOOSLEY RAYMOND L ,  ABERG A K GUNNAR

IPC: C07D401/12 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/454 ,  A61K45/00 ,  A61K45/06 ,  A61P3/08 ,  A61P3/10 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P31/12 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising the compound of formula I: or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for use in a treatment of allergic rhinitis which does not induce any significant cardiac arrhythmia, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient.