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    Compositions useful for increasing lower esophageal sphincter pressure
    31.
    发明申请
    Compositions useful for increasing lower esophageal sphincter pressure 审中-公开
    用于增加食管下端括约肌压力的组合物

    公开(公告)号：US20060189648A1

    公开(公告)日：2006-08-24

    申请号：US11413857

    申请日：2006-04-28

    Applicant: Steven Landau ,  Theodore Ashburn

    Inventor： Steven Landau ,  Theodore Ashburn

    IPC: A61K31/4743

    CPC classification number: A61K45/06 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4439 ,  A61K2300/00

    Abstract: The present invention relates to a method of increasing the pressure of the lower esophageal sphincter in a subject in need thereof comprising administering to said subject a specified amount of a compound having 5-HT3 receptor agonist activity or a pharmaceutically acceptable salt, hydrate or solvate thereof. The subject in need of treatment is suffering from GERD, including nocturnal GERD.

    Abstract translation: 本发明涉及一种在有需要的受试者中增加下食道括约肌压力的方法，包括向所述受试者施用指定量的具有5-HT 3受体激动剂活性的化合物或 其药学上可接受的盐，水合物或溶剂合物。 需要治疗的患者患有GERD，包括夜间GERD。

    System for guiding visually impaired pedestrian using auditory cues
    32.
    发明授权
    System for guiding visually impaired pedestrian using auditory cues 失效
    使用听觉线索指导视障人士行走系统

    公开(公告)号：US07039522B2

    公开(公告)日：2006-05-02

    申请号：US10706733

    申请日：2003-11-12

    Applicant: Steven Landau

    Inventor： Steven Landau

    IPC: G01C21/00 ,  G08B1/00

    CPC classification number: A61H3/061 ,  G01C21/20 ,  G01S1/725 ,  G01S13/74

    Abstract: A system that provides a means for blind or visually impaired people to navigate through a complex environment using auditory cues. Two-way transceiver devices, held by the person, connect through a communications network to a computer system. The computer system activates appropriate auditory signals that are output from audio beacons located throughout the environment based on input provided through the transceiver. Additional interactivity can be incorporated into the system by means of the computer system.

    Abstract translation: 提供盲人或视障人士通过听觉线索在复杂环境中导航的方法。 由人持有的双向收发器设备通过通信网络连接到计算机系统。 计算机系统基于通过收发器提供的输入，激活从整个环境中的音频信标输出的适当的听觉信号。 额外的交互性可以通过计算机系统并入系统。

    Receptacle cap having aromatic properties
    33.
    发明授权
    Receptacle cap having aromatic properties 失效

    公开(公告)号：US07005152B2

    公开(公告)日：2006-02-28

    申请号：US10211537

    申请日：2002-08-05

    Applicant: Steven Landau

    Inventor： Steven Landau

    IPC: B65D85/72

    CPC classification number: A47G19/2227 ,  B65D2203/12

    Abstract: A device and method for adding the perception of flavoring to a product that is consumed from a receptacle. The device is a cover for a receptacle, wherein a person can drink from a receptacle through the structure of the cover. At least a portion of the receptacle cover is scented with a desired fragrance. Furthermore, the scented portion of the receptacle cover enters the mouth when a person is drinking through the receptacle cover. As the scented portion of the receptacle cover is taken within the mouth, the receptacle cover scents the air contained within the mouth. By scenting the air inside the mouth, the nose is saturated by the desired fragrance and a more effective olfactory sense deception is obtained.

    Method of treating lower urinary tract disorders
    34.
    发明申请
    Method of treating lower urinary tract disorders 审中-公开
    治疗下尿路疾病的方法

    公开(公告)号：US20050282799A1

    公开(公告)日：2005-12-22

    申请号：US11124580

    申请日：2005-05-06

    Applicant: Steven Landau ,  Cheryl Miller ,  Matthew Fraser

    Inventor： Steven Landau ,  Cheryl Miller ,  Matthew Fraser

    IPC: A01N43/54 ,  A61K31/00 ,  A61K31/135 ,  A61K31/519 ,  A61K31/535 ,  A61K31/551 ,  A61K31/5513 ,  A61K45/06

    CPC classification number: A61K31/519 ,  A61K31/00 ,  A61K31/551 ,  A61K31/5513 ,  A61K45/06 ,  A61K2300/00

    Abstract: The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis, comprising coadministering to said subject a first amount of a 5-HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount.

    Abstract translation: 本发明涉及一种治疗需要治疗的受试者的下尿路疾病的至少一种症状的方法，其中所述症状选自尿频，尿急，尿急迫性尿失禁，夜尿和遗尿。 该方法包括向需要治疗的受试者施用治疗有效量的具有5-HT 3受体拮抗剂活性和NorAdrenaline再摄取抑制剂（NARI）活性的化合物。 本发明还涉及在需要治疗的受试者中治疗下尿路障碍的至少一种症状的方法，其中所述症状选自尿频，尿急，尿急迫性尿失禁，夜尿和遗尿， 包括向所述受试者共同施用第一量的5-HT 3拮抗剂和第二量的NARI，其中第一和第二量一起包含治疗有效量或各自以治疗有效的量存在 量。

    Methods of decreasing intestinal motility
    35.
    发明申请
    Methods of decreasing intestinal motility 审中-公开
    减少肠蠕动的方法

    公开(公告)号：US20050192270A1

    公开(公告)日：2005-09-01

    申请号：US11119357

    申请日：2005-04-29

    Applicant: Steven Landau

    Inventor： Steven Landau

    IPC: A01N43/00 ,  A01N43/54 ,  A61K20060101 ,  A61K31/505 ,  A61K31/519 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06

    CPC classification number: A61K31/505 ,  A61K31/519 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  A61K2300/00

    Abstract: The invention relates to a method of decreasing intestinal motility in a subject in need of treatment. The method comprises administering to the subject a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of decreasing intestinal motility in a subject in need thereof, comprising coadministering to said subject a first amount of a 5-HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount. In addition, the method of the invention comprises administering a NARI alone. In certain embodiments, the subject is a subject with a functional bowel disorder, such as IBS, functional abdominal bloating, or functional diarrhea.

    Abstract translation: 本发明涉及一种减少需要治疗的受试者的肠蠕动的方法。 该方法包括向受试者施用治疗有效量的具有5-HT 3受体拮抗剂活性和NorAdrenaline再摄取抑制剂（NARI）活性的化合物。 本发明还涉及一种降低有需要的受试者的肠蠕动的方法，包括向所述受试者加入第一量的5-HT 3拮抗剂和第二量的NARI，其中 第一和第二量一起包含治疗有效量或各自以治疗有效量存在。 此外，本发明的方法包括单独施用NARI。 在某些实施方案中，受试者是具有功能性肠病，例如IBS，功能性腹部腹胀或功能性腹泻的受试者。

    System for guiding visually impaired pedestrian using auditory cues
    37.
    发明申请
    System for guiding visually impaired pedestrian using auditory cues 失效
    使用听觉线索指导视障人士行走系统

    公开(公告)号：US20050099291A1

    公开(公告)日：2005-05-12

    申请号：US10706733

    申请日：2003-11-12

    Applicant: Steven Landau

    Inventor： Steven Landau

    IPC: A61H3/06 ,  G01C21/20 ,  G01S1/72 ,  G01S13/74 ,  G08B1/08

    CPC classification number: A61H3/061 ,  G01C21/20 ,  G01S1/725 ,  G01S13/74

    Abstract: A system that provides a means for blind or visually impaired people to navigate through a complex environment using auditory cues. Two-way transceiver devices, held by the person, connect through a communications network to a computer system. The computer system activates appropriate auditory signals that are output from audio beacons located throughout the environment based on input provided through the transceiver. Additional interactivity can be incorporated into the system by means of the computer system.

    Abstract translation: 提供盲人或视障人士通过听觉线索在复杂环境中导航的方法。 由人持有的双向收发器设备通过通信网络连接到计算机系统。 计算机系统基于通过收发器提供的输入，激活从整个环境中的音频信标输出的适当的听觉信号。 额外的交互性可以通过计算机系统并入系统。

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