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    APPARATUS FOR AND METHOD OF SEPARATING POLARIZABLE ANALYTE USING DIELECTROPHORESIS
    31.
    发明申请
    APPARATUS FOR AND METHOD OF SEPARATING POLARIZABLE ANALYTE USING DIELECTROPHORESIS 有权
    使用电子显微镜分离极化分析仪的方法和方法

    公开(公告)号：US20070284254A1

    公开(公告)日：2007-12-13

    申请号：US11754523

    申请日：2007-05-29

    Applicant: Young-kyoung Cho ,  Su-hyeon Kim ,  Chin-sung Park ,  Kyu-sang Lee ,  Jeong-gun Lee

    Inventor： Young-kyoung Cho ,  Su-hyeon Kim ,  Chin-sung Park ,  Kyu-sang Lee ,  Jeong-gun Lee

    IPC: B03C5/02

    CPC classification number: B03C5/005 ,  B03C5/026 ,  B03C2201/26

    Abstract: An apparatus separating a polarizable analyte using dielectrophoresis includes a vessel including a membrane having a plurality of nano- to micro-sized pores, the membrane disposed inside the vessel, electrodes generating spatially non-uniform electric fields in the nano- to micro-sized pores of the membrane when an AC voltage is applied to the electrodes, and a power source applying the AC voltage to the electrodes, wherein a sectional area of the pores varies along a depth of the pores. A method of separating a polarizable material uses the apparatus.

    Abstract translation: 使用介电电泳分离可极化分析物的装置包括容器，其包括具有多个纳米至微米尺寸孔的膜，所述膜设置在容器内部，电极在纳米至微孔中产生空间上不均匀的电场 当向电极施加AC电压时，将膜施加到膜上，并且向电极施加AC电压的电源，其中孔的截面积沿着孔的深度而变化。 分离可极化材料的方法使用该装置。

    FET-type biosensor with surface modification
    32.
    发明申请
    FET-type biosensor with surface modification 有权
    具有表面改性的FET型生物传感器

    公开(公告)号：US20060205013A1

    公开(公告)日：2006-09-14

    申请号：US11336110

    申请日：2006-01-20

    Applicant: Jeo-young Shim ,  Su-hyeon Kim ,  Kyu-tae Yoo ,  Sung-ouk Jung ,  Joon-shik Park

    Inventor： Jeo-young Shim ,  Su-hyeon Kim ,  Kyu-tae Yoo ,  Sung-ouk Jung ,  Joon-shik Park

    IPC: G01N33/53

    CPC classification number: B82Y30/00 ,  B82Y15/00 ,  G01N27/4145

    Abstract: Provided is a field effect transistor (FET) type biosensor including a source electrode, a gate, and a drain electrode. A ligand that can bind to a side of a nucleic acid is added to the surface of the gate. In a conventional FET type biosensor, it is difficult to detect a signal within the debye length because a target nucleic acid is directly fixed to the surface of a gate of the conventional FET. However, in the present invention, this problem can be overcome and the debye length can be increased by treating the surface of a gate of an FET sensor with a ligand that can bind to a side of a nucleic acid. The ligand can be adsorbed onto the surface of the gate. In this case, the nucleic acid is adsorbed parallel to the surface of the gate, not perpendicular to the surface of the gate, thus generating an effective depletion region. In addition, hybridization efficiency can be increased because a hybridized sample can be injected into an FET sensor at high ionic strength.

    Abstract translation: 提供了包括源电极，栅极和漏电极的场效应晶体管（FET）型生物传感器。 可以结合核酸一侧的配体加入到门的表面。 在传统的FET型生物传感器中，由于目标核酸直接固定在常规FET的栅极表面，难以检测德拜长度内的信号。 然而，在本发明中，可以克服这个问题，并且可以通过用可以结合核酸一侧的配体处理FET传感器的栅极的表面来增加德拜长度。 配体可以吸附在栅极的表面上。 在这种情况下，核酸被平行于栅极的表面吸附，而不垂直于栅极的表面，从而产生有效的耗尽区域。 此外，杂交效率可以提高，因为杂化样品可以以高离子强度注入FET传感器。

    Nucleic acid purification method using hydrogen bonding and electric field
    34.
    发明申请
    Nucleic acid purification method using hydrogen bonding and electric field 审中-公开
    使用氢键和电场的核酸纯化方法

    公开(公告)号：US20060118417A1

    公开(公告)日：2006-06-08

    申请号：US11281226

    申请日：2005-11-16

    Applicant: Young-a Kim ,  Jun-hong Min ,  Kui-hyun Kim ,  Myo-yong Lee ,  Su-hyeon Kim ,  Young-nam Kwon ,  Jeong-gun Lee ,  Joon-ho Kim

    Inventor： Young-a Kim ,  Jun-hong Min ,  Kui-hyun Kim ,  Myo-yong Lee ,  Su-hyeon Kim ,  Young-nam Kwon ,  Jeong-gun Lee ,  Joon-ho Kim

    IPC: C07H21/04

    CPC classification number: C07H21/04

    Abstract: Provided is a method of purifying nucleic acids using hydrogen bonding and an electric field, including: bringing a sample containing target nucleic acids into contact with an electrode coated with a material capable of forming hydrogen bonds with the target nucleic acids; applying a positive voltage to the electrode to move the target nucleic acids closer to the electrode so as to form hydrogen bonds with the material on the electrode; washing the electrode; and applying to the electrode a negative voltage to elute the bound target nucleic acids. According to the method, selectivity to nucleic acids and proteins increases due to hydrogen bonding, nucleic acid purification is possible within a short time through an electric field, and the bound nucleic acids can be efficiently eluted.

    Abstract translation: 提供了使用氢键和电场来净化核酸的方法，包括：使含有靶核酸的样品与涂覆有能够与靶核酸形成氢键的材料接触; 向电极施加正电压以使靶核酸更靠近电极以与电极上的材料形成氢键; 清洗电极; 并向电极施加负电压以洗脱结合的靶核酸。 根据该方法，由于氢键，核酸和蛋白质的选择性增加，核酸纯化可以在短时间内通过电场进行，并且结合的核酸可以被有效地洗脱。

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