-
公开(公告)号：CA3062446A1
公开(公告)日：2018-11-08
申请号：CA3062446
申请日：2018-05-03
Applicant: UNIV AKRON
Inventor： BECKER MATTHEW , XU YANYI
Abstract: In various aspects, the present invention is directed to novel bioactive peptide loaded poly(propylene fumarate) (PPF) tissue scaffolds and related methods for their making and use. In various embodiments, these bioactive peptide loaded poly(propylene fumarate) tissue scaffolds are formed by forming a PPF structure or matrix using photochemical 3-D printing techniques and then loading that printed PPF structure or matrix with a bioactive peptides or other bioactive compounds that have, or have been functionalized to have, a thiol functional group at or near its terminus. The thiol groups on the bioactive peptides or other compound will react with exposed alkene functional groups on the PPF polymer matrix via a thiol-ene "click" reaction, thereby binding these bioactive peptides or other compounds to the tissue scaffolds. The bioactive peptide loaded PPF tissue scaffolds of the present invention are particularly useful in repairing bone defects.
-
公开(公告)号：CA2956437A1
公开(公告)日：2016-01-28
申请号：CA2956437
申请日：2015-07-21
Applicant: UNIV AKRON
Inventor： BECKER MATTHEW , ZHOU JINJUN , DEFANTE ADRIAN , DHINOJWALA ALI
IPC: A61K31/765
Abstract: The present invention is directed to a novel group of amino acid-based poly(ester urea)s (PEUs) for use in biodegradable adhesive and related methods for their making and use. These novel amino acid-based PEUs have a wide variation in mechanical properties and degradation behavior that can be tuned by varying the amino acids and polyols used to form the polyester monomers that form the PEUs. Importantly, these novel PEUs have been shown to be non-toxic in vitro and in vivo and may be suitable to a wide variety of biomedical and other uses. In some embodiments, the adhesive properties of these degradable amino acid-based poly(ester urea) adhesives has been further improved by the incorporation of controlled amounts of catechol functional groups into the side chains of the PEU via post-polymerization functionalization chemistry.
-
公开(公告)号：AU2017257659B2
公开(公告)日：2022-05-12
申请号：AU2017257659
申请日：2017-04-25
Applicant: UNIV AKRON
Inventor： BECKER MATTHEW , BHAGAT VRUSHALI DINKAR
Abstract: In various aspects, the present invention provides a degradable and resorbable novel phosphate functionalized amino acid-based poly(ester urea) adhesive and related methods for its synthesis and use. These adhesives are formed from phosphate functionalized PEU polymers and copolymers crosslinked using one or more divalent metal crosslinking agents. The phosphate functionalized amino acid-based poly(ester urea) adhesives of various embodiments of the present invention have been found particularly effective in bonding bone to either bone or metal and have demonstrated adhesive strengths on bone samples that were significant and comparable to commercially available poly(methyl methacrylate) bone cement.
-
公开(公告)号：CA2925758C
公开(公告)日：2022-01-25
申请号：CA2925758
申请日：2014-09-30
Applicant: UNIV AKRON
Inventor： LIN FEI , BECKER MATTHEW
IPC: C08G71/02 , A61L27/18 , C07C227/14 , C07C229/36 , C07C275/24
Abstract: Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent "clickable" groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with Mw exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 30045 MPa; tensile stress: 8.51.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aqueous media.
-
35.发明专利
公开(公告)号：CA2928964C
公开(公告)日：2022-01-11
申请号：CA2928964
申请日：2014-10-29
Applicant: UNIV AKRON
Inventor： BECKER MATTHEW , RENEKER DARRELL , GAO YAOHUA
Abstract: Embodiments relate to amino acid-based poly(ester urea)s with amino acid residues selected L-leucine, L-isoleucine, L-valine or combinations thereof. The amino acid-based poly(ester urea)S may optionally include a second amino acid residue selected from proteinogenic amino acids and non-proteinogenic amino acids. The amino acid-based poly(ester urea)s are particular useful for the preparation of vascular grafts. Due to the biocompatibility of the amino acid-based poly(ester urea)s, vascular grafts prepared from amino acid-based poly(ester urea)s with small internal diameters (i.e. less than 5mm) may be prepared and inserted into a patient or animal, and provide a substantial decrease in the risk of failure compared to conventional polymers used in vascular grafts.
-
Patent Agency Ranking
公开(公告)号：AU2018313107A1
公开(公告)日：2020-02-20
申请号：AU2018313107
申请日：2018-08-07
Applicant: UNIV AKRON
Inventor： BECKER MATTHEW , PETERSON GREGORY ISAAC , ABEL ALEXANDRA
Abstract: In one or more embodiments, the present invention provide a novel drug loaded amino acid based poly(ester urea) polymers for use in drug delivery having shape memory properties and without the shortcomings of the polymers for drug delivery known in the art, as well as related methods for their synthesis and use.
-
公开(公告)号：AU2017257659A1
公开(公告)日：2018-11-15
申请号：AU2017257659
申请日：2017-04-25
Applicant: UNIV AKRON
Inventor： BECKER MATTHEW , BHAGAT VRUSHALI DINKAR
Abstract: In various aspects, the present invention provides a degradable and resorbable novel phosphate functionalized amino acid-based poly(ester urea) adhesive and related methods for its synthesis and use. These adhesives are formed from phosphate functionalized PEU polymers and copolymers crosslinked using one or more divalent metal crosslinking agents. The phosphate functionalized amino acid-based poly(ester urea) adhesives of various embodiments of the present invention have been found particularly effective in bonding bone to either bone or metal and have demonstrated adhesive strengths on bone samples that were significant and comparable to commercially available poly(methyl methacrylate) bone cement.
-
公开(公告)号：CA2948154C
公开(公告)日：2017-09-26
申请号：CA2948154
申请日：2015-05-07
Applicant: UNIV AKRON
Inventor： BECKER MATTHEW , LI SHAN
Abstract: In one or more embodiments, the present invention provides iodine-functionalized phenylalanine-based poly(ester urea)s (PEUs) (and related methods for their synthesis and use) that are metal free, degradable, radiopaque and suitable for use in surgical implants and other medical devices used within a patient. In one or more embodiment of the present invention 4-Iodo-L-phenylalanine and L-phenylalanine are separately reacted with 1,6-hexanediol to produce two monomers, bis-4-I-L-phenylalanine-1,6-hexanediol-diester (1-IPHE-6 monomer) and bis-L-phenylalanine-1,6-hexanediol-diester (1-PHE-6 monomer). It has been found that by varying the feed ratio of the 1-IPHE-6 and 1-PHE-6 monomers, the copolymer composition may be modulated to predictably create phenylalanine-based PEUs having a wide variation in thermal, mechanical and radiopacity properties. As most medical device procedures require placement verification via fluoroscopic imaging, materials that possess inherent X-ray contrast are valuable for a number of applications.
-
39.发明专利
公开(公告)号：AU2015349988A1
公开(公告)日：2017-05-25
申请号：AU2015349988
申请日：2015-11-18
Applicant: UNIV AKRON , UNIV OHIO STATE
Inventor： BECKER MATTHEW , DEAN HOWARD , LUO YUANYUAN
Abstract: The present invention provides a low molecular mass PPF polymer (and related methods) that is suitable for 3D printing and other polymer device fabrication modalities and can be made inexpensively in commercially reasonable quantities. These novel low molecular mass PPF polymers have a low molecular mass distribution (Đm) and a wide variety of potential uses, particularly as a component in resins for 3D printing of medical devices. The ability to produce low Đm PPF creates a new opportunity for reliable GMP production of PPF. It provides low cost synthesis and scalability of synthesis, blending of well-defined mass and viscosity PPF, and reduced reliance on solvents or heat to (a) achieve mixing of 3D printable resins or (b) and flowability during 3D printing. These PPF polymers are non-toxic, degradable, and resorbable and can be used in tissue scaffolds and medical devices that are implanted within a living organism.
-
公开(公告)号：CA2837087A1
公开(公告)日：2012-12-06
申请号：CA2837087
申请日：2012-05-25
Applicant: UNIV AKRON
Inventor： BECKER MATTHEW , GRAHAM MATTHEW , HARRIS FRANK , LIN FEI
IPC: C07K14/00
Abstract: A method for creating a peptide crosslinked bioactive polymeric material includes reacting a hydroxy-functionalized small molecule with a amino acid to form an amino acid functionalized monomer, reacting the amino acid functionalized monomer with a urea bond former to form a amino acid-based poly(ester urea), and reacting the amino acid-based poly(ester urea) with a peptide based crosslinker to form the peptide crosslinked bioactive polymeric material.
-
-
-
-
-
-
-
-
-
Search Results
40
records
(took 0.025 seconds)
