公开(公告)号：EP3056894A1

公开(公告)日：2016-08-17

申请号：EP14852972.0

申请日：2014-10-07

Applicant: Universal Bio Research Co., Ltd.

Inventor： TAJIMA Hideji

IPC: G01N21/76 ,  G01N35/10

CPC classification number: G01N21/76 ,  C12Q1/6816 ,  G01N35/0098 ,  G01N35/1002 ,  Y10T436/119163

Abstract: The present invention relates to a device and method for measuring chemiluminescence, and an object is to provide a compact and reliable device and method for measuring chemiluminescence.
The present invention is designed to include a vessel group, a nozzle head having a gas suctioning and discharging mechanism, one or more nozzles, which are in communication with the suctioning and discharging mechanism, and to a front end of which a dispensing tip is attachable, and a magnetic force means capable of causing a magnetic field inside the attached dispensing tip, a nozzle moving mechanism capable of moving the nozzle relative to the vessel group, a linkage part provided to the nozzle head, linkable to the reaction vessel through an opening thereof and capable of forming a confined space shielded from external light by means of linkage with the reaction vessel, a linkage part moving mechanism capable of moving the linkage part relative to the reaction vessel, a photometer, a shutter for bringing into a light guiding state or light shielding state between inside the reaction vessel and the photometer in relation to the linkage of the linkage part to the reaction vessel or release thereof, and a reagent injection flow channel capable of injecting a reagent for chemiluminescence, which is provided to the linkage part, and a front end of which is located in the reaction vessel by means of the linkage.

Abstract translation: 用于测量化学发光的装置和方法技术领域本发明涉及用于测量化学发光的装置和方法，并且本发明的目的是提供用于测量化学发光的紧凑和可靠的装置和方法。 本发明被设计成包括容器组，具有气体抽吸和释放机构的喷嘴头，与该抽吸和释放机构连通的一个或多个喷嘴，并且其前端可连接有分配尖端 以及能够在所安装的分注吸头内部产生磁场的磁力装置，能够使喷嘴相对于容器组移动的喷嘴移动机构，设置在喷嘴头上并能够经由开口与反应容器连结的连结部， 并且能够通过与反应容器的连接形成与外部光屏蔽的封闭空间，能够使连接部相对于反应容器移动的连杆部移动机构，光度计，用于进入导光状态的快门 或反应容器与光度计内部之间的关于连接部分与反应容器或r的连接的遮光状态 以及能够注入用于化学发光的试剂注入流动通道，所述化学发光用试剂被提供给连杆部分，并且其前端通过连杆位于反应容器中。

公开(公告)号：EP3045522A1

公开(公告)日：2016-07-20

申请号：EP14843505.0

申请日：2014-09-02

Applicant: Universal Bio Research Co., Ltd.

Inventor： TAJIMA Hideji

IPC: C12M1/00 ,  C12M3/00

CPC classification number: C12M47/02 ,  C12M21/08 ,  C12M23/00 ,  C12M23/28 ,  C12M23/34 ,  C12M27/16 ,  C12M29/00 ,  C12M35/06 ,  C12M41/48 ,  C12N5/0602

Abstract: A culture system comprises: a preparatory culture vessel and a main culture vessel that accommodate cells and a solution; a main stage that holds the preparatory culture vessel and the main culture vessel; a connecting tube that connects the culture vessels; a valve that opens and closes the connecting tube; and a rotating mechanism that rotates the main stage and imparts a height difference between the culture vessels to transfer the cells and solution by dropping between the culture vessels.

Abstract translation: 培养系统包括：准备培养容器和容纳细胞和溶液的主培养容器; 是准备养殖船和主培养船的主要阶段; 连接培养容器的连接管; 打开和关闭连接管的阀; 以及旋转机构，其旋转主阶段并赋予培养容器之间的高度差，以通过在培养容器之间滴落来转移细胞和溶液。

公开(公告)号：EP2891887A1

公开(公告)日：2015-07-08

申请号：EP13832604.6

申请日：2013-09-02

Applicant: Universal Bio Research Co., Ltd.

Inventor： TAJIMA Hideji

IPC: G01N35/10 ,  B01J4/00 ,  G01N1/00

CPC classification number: B65D35/30 ,  B01L3/021 ,  B01L3/0275 ,  B01L9/543 ,  B01L2200/0668 ,  B01L2200/0689 ,  B01L2300/0681 ,  B01L2400/0481 ,  B65D35/02 ,  G01N35/0098 ,  G01N35/1016 ,  G01N35/1074 ,  G01N2035/1053

Abstract: It is an object to provide a deforming element-included dispensing tip, a deforming element-included dispensing device, and a deforming element-included dispensing processing method not requiring any cylinder and capable of achieving highly precise position control and enhancing integration of higher density and reducing the burden in the quality control in reaction processing of a biological material for extraction of DNA and the like.
A tip-shaped container formed with a non-deforming wall having an opening portion at an upper side and an inlet unit at a lower side for allowing fluid to flow in and flow out and a sealing plug attached to the opening portion so as to seal the opening portion are provided, and the sealing plug is configured to be provided with a deforming element that has a deforming wall that is formed so as to be able to extend in a lower direction in the tip-shaped container in accordance with pressing from an outside and so as to be urged to shrink or be able to shrink in an upper direction or formed so as to be able to be shrunk.

Abstract translation: 本发明的目的在于提供一种变形元件包括分配尖端，一个变形元件包括分配装置，和一个变形元件包括分配处理方法不需要任何气缸且能够实现高度精确的位置控制和提高更高密度的集成和 减少在用于DNA等的提取的生物材料的加工反应中的质量控制的负担。 与具有在在上侧，并在入口单元在其下侧用于允许流体流入和流出开口部的非变形壁形成的尖状容器和附接到该开口部分以密封的密封塞 设置开口部，并密封塞被构造成设置有变形元件也具有变形壁并形成为以能够在较低的方向在尖端状容器与来自在压制延伸雅舞蹈 外部并且以被推动收缩或能够在向上的方向上收缩或形成为能够被收缩。

公开(公告)号：EP2434284B1

公开(公告)日：2014-11-12

申请号：EP10767047.3

申请日：2010-04-20

Applicant: Universal Bio Research Co., Ltd.

Inventor： TAJIMA Hideji

IPC: G01N33/543 ,  G01N21/64 ,  G01N33/569

CPC classification number: G01N33/54313 ,  G01N21/274 ,  G01N21/6428 ,  G01N2021/0325

公开(公告)号：EP2383575B1

公开(公告)日：2014-08-20

申请号：EP09835061.4

申请日：2009-12-25

Applicant: Universal Bio Research Co., Ltd.

Inventor： TAJIMA Hideji

IPC: G01N33/543 ,  G01N1/28 ,  G01N33/553 ,  G01N30/02 ,  C12Q1/68

CPC classification number: G01N33/54386 ,  B01L3/508 ,  B01L3/52 ,  B01L2200/10 ,  B01L2300/0636 ,  C12Q1/6804 ,  G01N33/54326 ,  G01N33/54393 ,  G01N35/026 ,  G01N35/1009 ,  Y10T436/143333 ,  Y10T436/25125 ,  C12Q2563/143

公开(公告)号：EP2711690A1

公开(公告)日：2014-03-26

申请号：EP12785489.1

申请日：2012-05-16

Applicant: Universal Bio Research Co., Ltd.

Inventor： TAJIMA Hideji

IPC: G01N21/78 ,  G01N21/64 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10

Abstract: The invention relates to an optical measurement device for a reaction vessel, and a method therefor. An object is to measure the optical state within a reaction vessel in an efficient, rapid, and highly reliable manner, without an expansion of the device scale. The configuration includes: a vessel group in which two or more reaction vessels are arranged; a light guide stage having two or more linking portions to which front ends of light guide portions, which have a flexibility, that optically connect with the interior of the linked reaction vessels, are provided; a connecting end arranging body that has an arranging surface that arranges and supports along a predetermined path two or more connecting ends, to which back ends of the light guide portions, in which the front ends thereof are provided to the linking portions, are provided, the connecting ends are provided corresponding to the respective linking portions; a measurement device provided approaching or making contact with the arranging surface that has measuring ends that are successively optically connectable with the respective connecting ends along the predetermined path, and in which light from within the reaction vessels is receivable by means of optical connections between the connecting ends and the measuring ends; and a light guide switching mechanism that relatively moves the respective connecting ends arranged on the connecting end arranging body and the respective measuring ends such that they are successively optically connected.

Abstract translation: 反应容器的光学测量装置及其方法 一个目的是以有效，快速和高度可靠的方式测量反应容器内的光学状态，而不扩大装置规模。 该构造包括：其中布置有两个或更多个反应容器的容器组; 具有两个或更多个连接部分的导光台，具有柔性的导光部分的前端与连接的反应容器的内部光学连接; 连接端排列体，其具有布置表面，所述布置表面沿着预定路径布置和支撑两个或更多个连接端，所述导光部分的后端在所述连接端处设置有前端，所述后端设置到所述连接部分， 连接端对应于相应的连接部分设置; 测量装置，所述测量装置设置成接近或接触所述布置表面，所述布置表面具有沿着所述预定路径与各个连接端顺序光学连接的测量端，并且来自所述反应容器内的光可通过所述连接器 结束和测量结束; 以及导光切换机构，其使配置在上述连接端配置体上的各连接端和各测量端相对移动，以使它们依次光学连接。

公开(公告)号：EP2383575A1

公开(公告)日：2011-11-02

申请号：EP09835061.4

申请日：2009-12-25

Applicant: Universal Bio Research Co., Ltd.

Inventor： TAJIMA Hideji

IPC: G01N33/543 ,  G01N1/28 ,  G01N33/553

CPC classification number: G01N33/54386 ,  B01L3/508 ,  B01L3/52 ,  B01L2200/10 ,  B01L2300/0636 ,  C12Q1/6804 ,  G01N33/54326 ,  G01N33/54393 ,  G01N35/026 ,  G01N35/1009 ,  Y10T436/143333 ,  Y10T436/25125 ,  C12Q2563/143

Abstract: On magnetic particles serving as a first support, an antibody against a nonspecific reaction factor is immobilized. These magnetic particles are mixed with a specimen and suspended therein. After suspending, the suspension is sucked up into a pipette chip and a magnet comes close to the pipette chip. While remotely constraining with the magnet the magnetic particles carrying the nonspecific reaction factor bonded thereto, the residual liquid is discharged into a well. Thus, the removal of a contaminant contained in the specimen is completed. The thus treated specimen discharged into the well is subjected to an immunoassay. The magnetic particles carrying the antibody immobilized thereon are mixed with the treated specimen and suspended therein. The suspension is sucked up into a pipette chip and the magnetic particles carrying an antigen bonded thereto are separated by use of the magnet. The magnetic particles carrying the antigen bonded thereto are washed, mixed with an enzyme-labeling solution, which contains a second support, and suspended therein. After suspending, the magnetic particles being labeled and carrying the antigen bonded thereto are mixed with a substrate solution and subjected to the measurement of emission intensity, etc.

Abstract translation: 在用作第一载体的磁性颗粒上，固定抗非特异性反应因子的抗体。 这些磁性颗粒与样品混合并悬浮在其中。 悬挂后，将悬浮液吸入移液管芯片，磁铁靠近移液器芯片。 当与磁体远程约束时，携带非特异性反应因子的磁性颗粒与其结合，残留的液体被排出到井中。 因此，完成了包含在样品中的污染物的去除。 将经排出的经处理的样品进行免疫测定。 将固定有抗体的磁性颗粒与经处理的样品混合并悬浮在其中。 悬浮液被吸入移液管芯片中，并且携带与其结合的抗原的磁性颗粒通过使用磁体分离。 将携带与其结合的抗原的磁性颗粒洗涤，与含有第二载体的酶标记溶液混合并悬浮在其中。 悬浮后，将标记的磁性颗粒与其结合的抗原与底物溶液混合并进行发射强度等的测定。