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    LIQUID-CHROMATOGRAPHY CONDUIT ASSEMBLIES HAVING HIGH-PRESSURE SEALS
    32.
    发明公开
    LIQUID-CHROMATOGRAPHY CONDUIT ASSEMBLIES HAVING HIGH-PRESSURE SEALS 审中-公开
    具有高压密封的液相色谱导管组件

    公开(公告)号：EP2242556A1

    公开(公告)日：2010-10-27

    申请号：EP08870285.7

    申请日：2008-12-16

    Applicant: Waters Technologies Corporation

    Inventor： BENEVIDES, Christopher, C. ,  FADGEN, Keith ,  LAVALLE, Michael ,  JEANNOTTE, Anthony

    IPC: B01D15/08

    CPC classification number: B01D15/14 ,  B01D15/22 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  Y10T29/49826

    Abstract: A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.

    Abstract translation: 用于制造液相色谱装置的方法包括将两个内导管插入中间管，将中间管插入外管中，在中间管和至少一个内导管之间形成近端密封，并形成远端密封 在中间管和至少一个内导管之间。 液相色谱装置包括外管，布置在外管中的中间管，布置在中间管内的两个内导管，介于中间管和至少一个内导管之间的近侧密封件以及位于 中间管和至少一个内导管。

    METHOD TO REMOVE ION INTERFERENCES
    35.
    发明公开
    METHOD TO REMOVE ION INTERFERENCES 审中-公开
    VERFAHREN ZUM ENTFERNEN VON IONENINTERFENENZEN

    公开(公告)号：EP3152778A1

    公开(公告)日：2017-04-12

    申请号：EP15807330.4

    申请日：2015-06-05

    Applicant: Waters Technologies Corporation

    Inventor： GOLICK, Daniel ,  GEROMANOS, Scott ,  GORENSTEIN, Marc, V. ,  CIAVARINI, Steven, J. ,  FADGEN, Keith

    IPC: H01J49/26 ,  G01N30/72 ,  G01N30/86

    CPC classification number: H01J49/0036 ,  G01N30/7233

    Abstract: A method of mass spectrometry is disclosed comprising mass analysing an eluent from a chromatography device and obtaining parent ion data sets and corresponding product ion data sets, and determining whether, in a first product ion data set, one or more product ions are present that are related to one or more parent ions in a corresponding first parent ion data set, based on the mass or mass to charge ratio and/or intensity of the one or more product ions and the one or more parent ions. If it is determined that the one or more product ions are present, the method further comprises removing the one or more product ions from one or more second product ion data sets to produce one or more second modified product ion data sets and/or removing ions other than the one or more product ions from the first product ion data set to produce a first modified product ion data set.

    Abstract translation: 公开了一种质谱方法，其包括从色谱装置中大量分析洗脱液并获得母离子数据集和相应的产物离子数据集，并确定在第一产物离子数据集中是否存在一个或多个产物离子 基于一个或多个产物离子和一个或多个母体离子的质量或质荷比和/或强度，与相应的第一亲本离子数据集中的一个或多个亲本离子相关。 如果确定存在一种或多种产物离子，该方法还包括从一个或多个第二产物离子数据集中去除一个或多个产物离子以产生一个或多个第二修饰产物离子数据集和/或除去离子 除了来自第一产物离子数据集的一个或多个产物离子以产生第一修饰产物离子数据集。

    CHROMATOGRAPHY COLUMN ASSEMBLY
    36.
    发明公开
    CHROMATOGRAPHY COLUMN ASSEMBLY 审中-公开
    色谱柱组件

    公开(公告)号：EP2747861A1

    公开(公告)日：2014-07-02

    申请号：EP12828910.5

    申请日：2012-08-23

    Applicant: Waters Technologies Corporation

    Inventor： MICHIENZI, Joseph D. ,  FADGEN, Keith ,  LEVEILLE, SR., Wade P. ,  FISK, Raymond P. ,  MARZALKOWSKI, JR., Frank John

    IPC: B01D15/08 ,  B23P19/00

    CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

    Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.

    Abstract translation: 描述了色谱柱组件，其包括可永久变形的外管，中间管，内管和设置在内管内的吸附剂床。 吸附剂床可以是填充色谱颗粒或多孔整体结构的形式。 通过在组件上的纵向位置处的一个或多个均匀的径向卷曲提供径向密封。 均匀的径向卷曲将外管和下面的中间管压缩到内管上，以实现三个管之间的高压液密密封。 每个卷边的长度和深度都精确地形成以适应特定应用的要求。 防止沿着管道组件的泄漏并且减少或消除空隙体积。 不需要外部套圈或套圈模锻机构; 因此色谱柱组件很容易适用于各种色谱柱配置。

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