A porous, molecularly imprinted polymer and a process for the preparation thereof
    31.
    发明公开
    A porous, molecularly imprinted polymer and a process for the preparation thereof 审中-公开
    PorösesmolekulargeprägtesPolymer und Herstellungsverfahrendafür

    公开(公告)号:EP1776949A2

    公开(公告)日:2007-04-25

    申请号:EP07102048.1

    申请日:2000-10-26

    Abstract: A porous, molecularly imprinted polymer and a process for its preparation are described. The porous, molecularly imprinted polymer is characterised in that it is obtainable by providing a porous silica; attaching a molecular template to the surface of the porous silica; filling the pores of the porous silica with a polymer; removing the silica and the molecular template, thereby leaving a porous, molecularly imprinted polymer. The process is characterised by the above defined process steps. Also described are a porous polymer vesicle and its preparation with the same features as defined for the porous, molecularly imprinted polymer and its preparation, except for the lack of the molecular template and thus the lack of the molecular imprint in the porous polymer.

    Abstract translation: 描述了多孔分子印迹聚合物及其制备方法。 多孔分子印迹聚合物的特征在于可通过提供多孔二氧化硅获得; 将分子模板附着到多孔二氧化硅的表面; 用聚合物填充多孔二氧化硅的孔; 除去二氧化硅和分子模板,从而留下多孔的分子印迹聚合物。 该方法的特征在于上述定义的方法步骤。 还描述了多孔聚合物囊泡及其具有与多孔分子印迹聚合物及其制备相同的特征的制剂,不同之处在于缺少分子模板,因此在多孔聚合物中缺少分子印迹。

    Method of Making Nanoporous Structures
    36.
    发明申请
    Method of Making Nanoporous Structures 有权
    制备纳米结构的方法

    公开(公告)号:US20160200632A1

    公开(公告)日:2016-07-14

    申请号:US14912278

    申请日:2014-08-13

    Applicant: LYBRADYN, INC.

    Abstract: A method of making a nanoporous structure comprising a matrix and at least one nanosized pore within the matrix, wherein the method comprises contacting at least a portion of a templated matrix with an acid t solution, wherein the templated matrix comprises a matrix that selected from the group consisting of an organic polymer, a sol-based ceramic, an inorganic salt, an organoaluminate, and combinations thereof, and one or more nanosized templates within the matrix, wherein each nanosized template comprises a core that comprises an inorganic oxide, to dissolve at least a portion of the inorganic oxide of at least one of the cores and form the at least one nanosized pore within the matrix thereby forming the nanoporous structure.

    Abstract translation: 一种制备纳米孔结构的方法,所述纳米多孔结构在基质内包含基质和至少一个纳米孔,其中所述方法包括使模板基质的至少一部分与酸t溶液接触,其中所述模板基质包含选自 由有机聚合物,溶胶基陶瓷,无机盐,有机铝酸盐及其组合组成的组,以及基质内的一个或多个纳米尺寸模板,其中每个纳米尺寸模板包含含有无机氧化物的芯,以溶解于 至少一部分至少一个芯的无机氧化物,并在基质内形成至少一个纳米孔,从而形成纳米多孔结构。

    Biodegradable Inverted-Opal Structure, Method for Manufacturing and Using the Same, and Medical Implant Comprising the Biodegradable Inverted-Opal Structure
    38.
    发明申请
    Biodegradable Inverted-Opal Structure, Method for Manufacturing and Using the Same, and Medical Implant Comprising the Biodegradable Inverted-Opal Structure 审中-公开
    可生物降解的反蛋白石结构,其制造和使用方法以及包括可生物降解的反蛋白石结构的医疗植入物

    公开(公告)号:US20090220426A1

    公开(公告)日:2009-09-03

    申请号:US12223344

    申请日:2007-01-18

    Abstract: (Problems) The object of the present invention is to provide an inverted-opal structure which is excellent in biodegradability, biocompatibility, and pH responsiveness, has specific light reflection property due to three-dimensionally-ordered-pores formed therein, is capable of releasing a drug autonomously and intermittently by responding rapidly to pH change, and is capable of measuring the drug-release associated with its biodegradation by an optical means rapidly in a simple and easy way; a method for manufacturing the inverted-opal structure; a medical implant comprising the inverted-opal structure; a method for enlarging the pore diameter; and a method for measuring the release-amount of a drug held in the inverted-opal structure.(Means for Solving Problems) The present invention provides a biodegradable inverted-opal structure comprising an aliphatic polyester; and a method for manufacturing a biodegradable inverted-opal structure, comprising the steps of: (1) producing a colloidal crystal from a silica particle or a polystyrene particle; (2) immersing the colloidal crystal in a solution including a monomer from which the aliphatic polyester is formed; (3) thermally-polymerizing the monomer under a pressurized condition in order to obtain a composition of the colloidal crystal coated with the aliphatic polyester; and (4) removing the silica particle from said composition by etching, or removing the polystyrene particle from said composition by eluting the polystyrene particle with an organic solvent in order to obtain the biodegradable inverted-opal structure.

    Abstract translation: (问题)本发明的目的是提供一种生物降解性,生物相容性,pH响应性优异的倒蛋白石结构,由于其中形成有三维有序孔的特定的光反射性,能够释放 通过快速响应pH变化自主地和间歇性地进行药物治疗,并且能够以简单和容易的方式快速地通过光学手段测量与其生物降解有关的药物释放; 一种反蛋白石结构的制造方法; 包括倒蛋白石结构的医用植入物; 扩大孔径的方法; 以及测定保持在倒置蛋白石结构体中的药物释放量的方法。 (解决问题的手段)本发明提供一种包含脂肪族聚酯的生物降解性倒蛋白石结构体, 以及生物降解性倒蛋白石结构体的制造方法,其特征在于,包括以下工序:(1)由二氧化硅粒子或聚苯乙烯粒子制造胶体晶体; (2)将胶体晶体浸渍在包含形成脂肪族聚酯的单体的溶液中; (3)在加压条件下使单体热聚合,得到涂布有脂肪族聚酯的胶体晶体的组成; 和(4)通过蚀刻从所述组合物中除去二氧化硅颗粒,或通过用有机溶剂洗脱聚苯乙烯颗粒从所述组合物中除去聚苯乙烯颗粒,以获得可生物降解的反蛋白石结构。

    Porous, molecularly imprinted polymer and a process for the preparation thereof
    39.
    发明授权
    Porous, molecularly imprinted polymer and a process for the preparation thereof 有权
    多孔分子印迹聚合物及其制备方法

    公开(公告)号:US07393909B2

    公开(公告)日:2008-07-01

    申请号:US11051508

    申请日:2005-02-07

    Abstract: A porous, molecularly imprinted polymer and a process for its preparation are described. The porous, molecularly imprinted polymer is characterized in that it is obtainable by providing a porous silica; attaching a molecular template to the surface of the porous silica; filling the pores of the porous silica with a polymer, removing the silica and the molecular template, thereby leaving a porous, molecularly imprinted polymer. The process is characterized by the above defined process steps. Also described are a porous polymer vesicle and its preparation with the same features as defined for the porous, molecularly imprinted polymer and its preparation, except for the lack of the molecular template and thus the lack of the molecular imprint in the porous polymer.

    Abstract translation: 描述了多孔的分子印迹聚合物及其制备方法。 多孔分子印迹聚合物的特征在于可通过提供多孔二氧化硅获得; 将分子模板附着到多孔二氧化硅的表面; 用聚合物填充多孔二氧化硅的孔,除去二氧化硅和分子模板,从而留下多孔的分子印迹聚合物。 该过程的特征在于上述定义的工艺步骤。 还描述了多孔聚合物囊泡及其具有与多孔分子印迹聚合物及其制备所定义相同特征的制剂,不同之处在于缺少分子模板,因此在多孔聚合物中缺少分子印迹。

    Polymers having ordered, monodisperse pores and their corresponding ordered, monodisperse colloids
    40.
    发明申请
    Polymers having ordered, monodisperse pores and their corresponding ordered, monodisperse colloids 失效
    聚合物已订购,单分散毛孔及其相应的有序单分散胶体

    公开(公告)号:US20020143073A1

    公开(公告)日:2002-10-03

    申请号:US09992084

    申请日:2001-11-19

    Abstract: Ordered, monodisperse macroporous polymers, their corresponding ordered, monodisperse colloids, and methods of preparing them are disclosed. The methods use an ordered, monodisperse colloidal template to define the polymer pore morphology, which in turn acts as a mold for the growth of a new ordered, monodisperse colloid. The macroporous polymer may be prepared with either spherical or ellipsoidal pores from a wide variety of polymeric systems. The new ordered, monodisperse colloid may be grown from a wide variety of materials including ceramics, semiconductors, metals and polymers. These materials are potentially useful in optical, micro-filtering and drug delivery applications.

    Abstract translation: 公开了有序的单分散大孔聚合物,它们相应的有序单分散胶体及其制备方法。 该方法使用有序的单分散胶体模板来定义聚合物孔隙形态,其反过来作为新的有序单分散胶体生长的模具。 大孔聚合物可以用来自各种各样的聚合物体系的球形或椭圆形孔制备。 新的有序单分散胶体可以从各种材料生长,包括陶瓷,半导体,金属和聚合物。 这些材料在光学,微量过滤和药物递送应用中是潜在的。

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