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    OPTICAL DETECTION SYSTEM FOR LIQUID SAMPLES
    36.
    发明申请
    OPTICAL DETECTION SYSTEM FOR LIQUID SAMPLES 有权
    液体样品光学检测系统

    公开(公告)号：US20130330230A1

    公开(公告)日：2013-12-12

    申请号：US13911115

    申请日：2013-06-06

    Applicant: Bio-Rad Laboratories Inc.

    Inventor： Yochanan URI ,  Boaz Ran ,  Ariel G. Notcovich ,  Shay Nimri

    IPC: G01N21/65

    CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

    Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

    Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。

    Resonant cavity photodiode array for rapid DNA microarray readout
    37.
    发明申请
    Resonant cavity photodiode array for rapid DNA microarray readout 审中-公开
    谐振腔光电二极管阵列用于快速DNA微阵列读取

    公开(公告)号：US20040101861A1

    公开(公告)日：2004-05-27

    申请号：US10307219

    申请日：2002-11-27

    Inventor： Roger G. Little ,  Kurt J. Linden

    IPC: C12Q001/68 ,  C12M001/34

    CPC classification number: G01N21/6454 ,  G01N2021/6469 ,  G01N2201/0407 ,  G01N2201/0612

    Abstract: The present invention provides a microarray having a plurality of micro-locations for confining selected photophores, for example, biological molecules exhibiting fluorescence spectra. The microarray can further include an array of optoelectronic photodetectors each of which is optically coupled with at least one of the micro-locations to detect radiation, for example, fluorescence radiation, that is emitted from the photophores confined in that micro-location. Each photodetector includes a resonant cavity that is formed of a front reflector and/or a back reflector having distributed Bragg reflector structures and a photo-detecting element disposed in the resonant cavity. The microarray can utilize either external optical excitation sources, such as lasers, LEDs, or can contain its own excitation sources in an integrated structure containing both optical radiation emitters, such as, vertical cavity surface emitting lasers or resonant cavity LEDs, and resonant cavity photodetectors. The integrated emitters and detectors can be either coaxially or adjacently located. Further, the microarray can include either separate sample array and excitation/detector array plates, or a single sample/excitation/detector array plate in which the photophore-containing sample molecules can be deposited directly on the excitation/detector array.

    Abstract translation: 本发明提供一种微阵列，其具有用于限制所选择的光致抗体的多个微位置，例如表现出荧光光谱的生物分子。 微阵列还可以包括光电子检测器阵列，每个光电检测器与至少一个微位置光学耦合，以检测从限制在该微位置的光电子发射的辐射，例如荧光辐射。 每个光电检测器包括谐振腔，其由具有分布式布拉格反射器结构的前反射器和/或背反射器形成，以及设置在谐振腔中的光检测元件。 微阵列可以利用诸如激光器，LED的外部光学激发源，或者可以在包含光辐射发射器（诸如垂直腔表面发射激光器或谐振腔LED）的集成结构中包含其自身的激发源，以及谐振腔光电探测器 。 集成的发射器和检测器可以同轴或相邻地定位。 此外，微阵列可以包括单独的样品阵列和激发/检测器阵列板，或者单个样品/激发/检测器阵列板，其中含光致抗体的样品分子可以直接沉积在激发/检测器阵列上。

    Method of discriminating particle aggregation pattern
    39.
    发明授权
    Method of discriminating particle aggregation pattern 失效
    鉴别粒子聚集图案的方法

    公开(公告)号：US5265169A

    公开(公告)日：1993-11-23

    申请号：US775809

    申请日：1991-10-11

    Applicant: Masato Ohta ,  Yasuhiko Yokomori ,  Toshiyuki Furuta

    Inventor： Masato Ohta ,  Yasuhiko Yokomori ,  Toshiyuki Furuta

    IPC: G01N21/17 ,  G01N21/75 ,  G01N21/82 ,  G01N33/543 ,  G06K9/00

    CPC classification number: G01N21/82 ,  G01N2021/755 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/127

    Abstract: A method for identifying the presence or absence of an aggregation of particles distributed on a translucent surface includes the steps of providing a light sensing device for sensing light incident thereon and producing an output value which represents the intensity of the incident light, and identifying a first output value which is produced by the light sensing device when there is no light incident thereon. The method also identifies a second output value which is produced by the light sensing means when, with no particles present on the translucent surface, light is directed through the translucent surface onto the light sensing device. With a distribution of particles deposited on the translucent surface, light is directed through the translucent surface and onto the light sensing device, causing the light sensing device to produce a third output value. A final output value is then determined as a function of said first, second and third output values.

    Abstract translation: 用于识别分布在半透明表面上的颗粒的聚集的存在或不存在的方法包括以下步骤：提供用于感测入射在其上的光的光感测装置，并产生表示入射光强度的输出值，并且识别第一 当没有光入射时由光检测装置产生的输出值。 该方法还识别由光感测装置产生的第二输出值，当在半透明表面上没有颗粒存在时，光被引导通过透光表面到光感测装置上。 随着沉积在半透明表面上的颗粒的分布，光被引导通过半透明表面并且到达光感测装置，使光感测装置产生第三输出值。 然后确定最终输出值作为所述第一，第二和第三输出值的函数。

    Photoelectric measuring apparatus for use in automatic analyzer
    40.
    发明授权
    Photoelectric measuring apparatus for use in automatic analyzer 失效
    用于自动分析仪的光电测量仪

    公开(公告)号：US4950077A

    公开(公告)日：1990-08-21

    申请号：US343681

    申请日：1989-04-27

    Applicant: Sugio Manabe

    Inventor： Sugio Manabe

    IPC: G01J3/10 ,  G01J3/18 ,  G01J3/28 ,  G01N21/25 ,  G01N21/27 ,  G01J3/42

    CPC classification number: G01N21/253 ,  G01J3/18 ,  G01J3/2803 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/0826 ,  G01N2201/0833

    Abstract: A photoelectric measuring apparatus for use in an automatic chemical analyzer in which a plurality of test items are analyzed by using light beams having different wavelengths, including a white light source for emitting a polychromatic light beam, a grating for diffracting the polychromatic light beam into a plurality of light beams having predetermined different wavelengths, a plurality of light guides for guiding the light beams emanating from the grating to a plurality of cuvettes containing test liquids to be analyzed, a plurality of light receiving elements for receiving light beams transmitted through the cuvettes, an additional light guide for guiding a polychromatic light beam emanating from the grating as the zero order light beam to a cuvette via an optical filter having a desired transmission wavelength, and an additional light receiving element for receiving a light beam transmitted through the cuvette.

    Abstract translation: 一种用于自动化学分析仪的光电测量装置，其中通过使用具有不同波长的光束来分析多个测试项目，所述光束包括用于发射多色光束的白色光源，用于将多色光束衍射为 具有预定不同波长的多个光束，用于将从光栅发射的光束引导到包含待分析测试液体的多个比色杯的多个光导;多个用于接收透过比色杯的光束的光接收元件， 用于将通过具有期望的透射波长的滤光器将从光栅发出的多色光束作为零级光束引导到比色杯的附加光导，以及用于接收透射通过比色杯的光束的附加光接收元件。

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