公开(公告)号：EP2525211A1

公开(公告)日：2012-11-21

申请号：EP11166215.1

申请日：2011-05-16

Applicant: F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

Inventor： Furlan, Alan

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  C12Q1/686 ,  G01N21/253 ,  G01N21/255 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2201/0423 ,  G01N2201/0668 ,  G02B7/006

Abstract: The present invention pertains to an instrument for detecting at least one analyte, comprising at least one light
source, capable of generating excitation light for exciting two or more luminescence labels, an excitation beam path extending between said light source and said analyte, at least one detector, capable of detecting light emitted from said luminescence label, an emission beam path extending between said analyte and said detector, one filter carrier carrying two or more pairs of filter portions, each pair being related to one luminescence label and comprising a first filter portion for transmitting excitation light and a second filter portion for transmitting emitted light, wherein said first filter portion of one pair is said second filter portion of another pair, and wherein said filter portions are arranged in a manner that a respective one of said pairs can be brought in an operative condition in which said first filter portion is in said excitation beam path and said second filter portion is in said emission beam path, and wherein said filter carrier and said beam paths are movable with respect to each other by at least one moving mechanism so as to bring a respective one of said pairs in said operative condition. In a method for detecting at least one analyte, one pair of filter portions is moved in said operative condition and another pair of filter portions is moved in said operative condition, wherein the first filter portion of the one pair of filter portions is the second filter portion of the another pair of filter portions.

Abstract translation: 本发明涉及一种用于检测至少一种分析物的仪器，包括至少一个能够产生用于激发两个或更多个发光标记的激发光的光源，在所述光源和所述分析物之间延伸的激发光束路径，至少一个 检测器，能够检测从所述发光标签发射的光，在所述分析物和所述检测器之间延伸的发射光束路径，一个载体两个或更多对滤光器部分的滤光片载体，每对与一个发光标签有关，并且包括第一滤光器部分 用于发射激发光和用于透射发射光的第二滤光器部分，其中一对的所述第一滤光器部分是另一对的所述第二滤光器部分，并且其中所述滤光器部分以所述对中的相应一个可以是 导致操作状态，其中所述第一过滤部分处于所述激发光束路径和所述第二过滤器部分 过滤器部分在所述发射光束路径中，并且其中所述滤光器载体和所述光束路径可通过至少一个移动机构相对于彼此移动，以使所述对中的相应一个处于所述操作状态。 在用于检测至少一种分析物的方法中，一对过滤器部分在所述操作状态下移动，另一对过滤器部分在所述操作状态下移动，其中所述一对过滤器部分的第一过滤器部分是第二过滤器 另一对过滤器部分的一部分。

公开(公告)号：EP0985927A3

公开(公告)日：2000-06-28

申请号：EP99117599.3

申请日：1999-09-07

Applicant: Tosoh Corporation

Inventor： Hayashi, Toshinori ,  Ishiguro, Takahiko

IPC: G01N21/25 ,  G01N21/64

CPC classification number: G01N21/645 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0423

Abstract: An apparatus including a sample holder which fixedly holds sample vessels arranged on a same arc, a partition plate, a light guide which is configured by optical fibers and which transmits fluorescent signals emitted from respective test samples, to an optical sensor, the single optical sensor, and a light source which generates excitation light. Fluorescent signal emission ends of the light guide are opposed to the optical sensor, and fluorescent signal incidence ends of the light guide are respectively opposed to the sample vessels via the partition plate therebetween. The partition plate includes an excitation light optical unit for selectively guiding the excitation light from the light source to only one of the sample vessels arranged on the arc, and a fluorescence optical unit for guiding only the fluorescent signal emitted from a selected one of the sample vessels to the light guide. The partition plate is coupled together with the excitation light optical unit and the fluorescence optical unit to a driving unit, to be rotatable about a center of the arc on which the sample vessels are arranged. Fluorescence is detected while the excitation light is guided sequentially to the sample vessels arranged on the arc, by rotation of the partition plate.

公开(公告)号：EP3312586A1

公开(公告)日：2018-04-25

申请号：EP16811946.9

申请日：2016-06-16

Applicant: Tascom Co., Ltd.

Inventor： LEE, Sung Dong

IPC: G01N21/01 ,  G01N21/03 ,  G01N21/07 ,  G01N1/38 ,  G01N21/31 ,  G01N21/64 ,  G01N21/76 ,  G01N21/82

CPC classification number: G01N1/4077 ,  B04B5/0407 ,  G01N1/38 ,  G01N21/07 ,  G01N21/31 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/76 ,  G01N33/491 ,  G01N2001/4083 ,  G01N2021/0325 ,  G01N2021/0378 ,  G01N2201/0423 ,  G01N2201/08 ,  G01N2201/0846

Abstract: A biological material measuring instrument is disclosed. The biological material measuring instrument comprises: a rotating body including one or more cartridge holders having cuvettes in which a reagent and an analyte in a sample react; and a main body including at least a pair of light-emitting parts and light-receiving parts for optically measuring the analyte in the sample, wherein the rotating body further includes: a light-emitting optical waveguide for guiding the light of the light-emitting parts to a light-irradiated surface, which is one surface, of the cuvette, excluding a sample inflow surface into which the sample flows and a centrifugal force-applied surface to which centrifugal force is applied by the rotation of the rotating body such that particle components in the sample are separated from the sample, and adsorbed thereto or precipitated thereon; and a light-receiving optical waveguide for guiding, to the light-receiving parts, the light penetrating a light-receiving measurement surface, which is one surface excluding the sample inflow surface and the centrifugal force-applied surface.

Abstract translation: 公开了一种生物材料测量仪器。 所述生物材料测量仪器包括：旋转体，其包括一个或多个药筒保持器，所述一个或多个药筒保持器具有试剂与样品中的分析物反应的比色杯; 以及主体，其至少具有一对发光部和受光部，该受光部用于对所述试样中的所述分析对象物进行光学测定，所述旋转体还包括：发光光波导，其用于将所述发光光 除了样本流入的样本流入面和通过旋转体的旋转施加了离心力的离心力施加面以外，还包括除了样本流入的样本流入面以外的部分到作为一个表面的光照射面， 样品中的组分与样品分离，并吸附或沉淀在其上; 以及光接收光波导，其用于将穿过作为除样本流入表面和离心力施加表面之外的一个表面的光接收测量表面的光引导至光接收部分。

公开(公告)号：EP2309251A1

公开(公告)日：2011-04-13

申请号：EP10009248.5

申请日：2010-09-06

Applicant: Siemens Healthcare Diagnostics Products GmbH

Inventor： Meller, Paul, Dr. ,  Pufahl, Holger, Dr.

IPC: G01N21/25 ,  G01N35/00 ,  G01N1/38

CPC classification number: G01N21/253 ,  G01N21/0332 ,  G01N21/255 ,  G01N35/02 ,  G01N2021/0325 ,  G01N2021/825 ,  G01N2035/00534 ,  G01N2201/0407 ,  G01N2201/0423 ,  G01N2201/0453 ,  G01N2201/0627

Abstract: Die vorliegende Erfindung bezieht sich auf eine Vorrichtung (10,30,40,50,60) zur photometrischen Untersuchung von Proben. Sie weist eine Probenhalterungseinrichtung (11,31,41,51,61) für mindestens zwei Probengefäße sowie eine Messeinrichtung und eine bewegbare Einrichtung (14,34,44,54) auf. Die Probenhalterungseinrichtung ist dabei stationär ausgebildet, und die Messeinrichtung ist an der bewegbaren Einrichtung angeordnet, so dass sie mittels der bewegbaren Einrichtung verfahrbar ist.

Abstract translation: 装置（10）具有固定的样品保持器装置（11），其包括用于容纳两个样品容器的保持单元（15）。 测量装置布置在可移动装置（14）上并由可移动装置移位。 保持单元以弧形的方式设置在样品保持器装置上，并且测量装置以旋转的方式围绕弧形布置移位。 测量装置包括光源（12） LED或激光二极管，以及光电检测器（13）。 磁力搅拌器设置在样品架上。 还包括以下独立权利要求：（1）样品的光度检测方法（2）用于自动检查液体样品的分析仪器，包括样品的光度检测装置。

公开(公告)号：EP1024355B1

公开(公告)日：2008-03-26

申请号：EP00101404.2

申请日：2000-01-25

Applicant: TOSOH CORPORATION

Inventor： Hayashi, Toshinori ,  Ishiguro, Takahiko

IPC: G01N21/25 ,  G01N21/64

CPC classification number: G01N21/645 ,  G01N21/253 ,  G01N35/025 ,  G01N2201/0231 ,  G01N2201/0423 ,  G01N2201/043 ,  G01N2201/0806 ,  G01N2201/0853

公开(公告)号：EP0985927A2

公开(公告)日：2000-03-15

申请号：EP99117599.3

申请日：1999-09-07

Applicant: Tosoh Corporation

Inventor： Hayashi, Toshinori ,  Ishiguro, Takahiko

IPC: G01N23/223

CPC classification number: G01N21/645 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0423

Abstract: An apparatus including a sample holder which fixedly holds sample vessels arranged on a same arc, a partition plate, a light guide which is configured by optical fibers and which transmits fluorescent signals emitted from respective test samples, to an optical sensor, the single optical sensor, and a light source which generates excitation light. Fluorescent signal emission ends of the light guide are opposed to the optical sensor, and fluorescent signal incidence ends of the light guide are respectively opposed to the sample vessels via the partition plate therebetween. The partition plate includes an excitation light optical unit for selectively guiding the excitation light from the light source to only one of the sample vessels arranged on the arc, and a fluorescence optical unit for guiding only the fluorescent signal emitted from a selected one of the sample vessels to the light guide. The partition plate is coupled together with the excitation light optical unit and the fluorescence optical unit to a driving unit, to be rotatable about a center of the arc on which the sample vessels are arranged. Fluorescence is detected while the excitation light is guided sequentially to the sample vessels arranged on the arc, by rotation of the partition plate.

Abstract translation: 本发明提供一种装置，该装置包括：将样品容器固定地保持在同一圆弧上的分隔板;由光纤构成并将从各测试样品发出的荧光信号发送到光学传感器的光导; 以及产生激励光的光源。 光导的荧光信号发射端与光学传感器相对，并且光导的荧光信号入射端经由其间的隔板分别与样品容器相对。 分隔板包括：激发光光学单元，用于选择性地将来自光源的激发光引导至排列在圆弧上的样品器皿中的一个;以及荧光光学单元，用于仅引导从样品中选定的一个发射的荧光信号 船只的光导。 分隔板与激励光光学单元和荧光光学单元一起连接到驱动单元，以围绕其上布置有样品器皿的弧的中心可旋转。 当通过隔板的旋转将激发光顺序引导至布置在电弧上的样品容器时检测荧光。

公开(公告)号：EP0985927B1

公开(公告)日：2006-03-08

申请号：EP99117599.3

申请日：1999-09-07

Applicant: TOSOH CORPORATION

Inventor： Hayashi, Toshinori ,  Ishiguro, Takahiko

IPC: G01N21/25 ,  G01N21/64

CPC classification number: G01N21/645 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0423

公开(公告)号：EP1087222B1

公开(公告)日：2005-01-26

申请号：EP00120650.7

申请日：2000-09-21

Applicant: Tosoh Corporation

Inventor： Hayashi, Toshinori ,  Kurihara, Yoshifumi ,  Ishiguro, Takahiko

IPC: G01N21/64 ,  G01N21/25

CPC classification number: G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0423

公开(公告)号：EP1087222A3

公开(公告)日：2001-12-05

申请号：EP00120650.7

申请日：2000-09-21

Applicant: Tosoh Corporation

Inventor： Hayashi, Toshinori ,  Kurihara, Yoshifumi ,  Ishiguro, Takahiko

IPC: G01N21/64 ,  G01N21/25

CPC classification number: G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0423

Abstract: A fluorescence detection apparatus comprising: a sample holder for fixing and holding sample vessels on a circular arc; a partition plate being joined to drive means for rotation on the center of the circular arc; an excitation light source; excitation light optical means; and fluorescence optical means containing a light guide being fixed on the partition plate for rotation integrally and a photosensor. The photosensor is mechanically discontinued from the drive means and fixedly placed. The fluorescence signal emission end of the light guide is placed facing the photosensor on the rotation center axis and the partition plate and the parts fixed thereto are rotated integrally, whereby fluorescence detection of the samples arranged on the circular arc is repeated in order.

公开(公告)号：EP1024355A1

公开(公告)日：2000-08-02

申请号：EP00101404.2

申请日：2000-01-25

Applicant: Tosoh Corporation

Inventor： Hayashi, Toshinori ,  Ishiguro, Takahiko

IPC: G01N21/25 ,  G01N21/64

CPC classification number: G01N21/645 ,  G01N21/253 ,  G01N35/025 ,  G01N2201/0231 ,  G01N2201/0423 ,  G01N2201/043 ,  G01N2201/0806 ,  G01N2201/0853

Abstract: A fluorescence detection apparatus is provided which comprises a sample holder (4) for holding stationarily sample vessels deployed along a circle line or concentric circle lines having different radiuses, a partition plate (3) connected to a driving means (7) to be rotatable around the center of the circle line or concentric circle lines, optical means (5) for excitation light and optical means (6) for fluorescence light fixed respectively to the partition plate to be rotatable in integration therewith, a first light guide (1) constituted of numerous optical fibers, a photosensor (2), and a light source (8) for generating the excitation light, wherein the partition plate, the optical means for excitation light, and the optical means for fluorescence are integrally rotated, and thereby the fluorescence of the sample arranged along the circle line is successively detected and the detected fluorescence is transmitted to the photosensor. This fluorescence detection apparatus is useful in real-time monitoring of fluorescence signals, and satisfies the requirements of precise temperature control, quick treatment of many samples, high sensitivity, high reliability, low cost, and small size of the apparatus.

Abstract translation: 提供了一种荧光检测装置，其包括用于保持沿着圆线展开的固定样品容器的样本保持器（4）或具有不同半径的同心圆线;连接到驱动装置（7）以可旋转的分隔板（3） 圆线或同心圆线的中心，用于激发光的光学装置（5）和用于荧光的光学装置（6），分别固定在分隔板上以与其一体旋转;第一光导（1），由 多个光纤，光电传感器（2）和用于产生激发光的光源（8），其中分隔板，用于激发光的光学装置和用于荧光的光学装置一体地旋转，由此荧光 连续检测沿圆线排列的样品，并将检测到的荧光传输到光电传感器。 该荧光检测装置可以实时监测荧光信号，满足精密温度控制，快速处理多种样品，高灵敏度，高可靠性，低成本，小尺寸等要求。