公开(公告)号：US20170205290A1

公开(公告)日：2017-07-20

申请号：US15418532

申请日：2017-01-27

Applicant: REBELLION PHOTONICS, INC.

Inventor： Robert Timothy Kester ,  Nathan Adrian Hagen

IPC: G01J5/52 ,  G01J3/02 ,  H04N5/33 ,  G01J3/28 ,  G01J5/08 ,  G01J5/00 ,  G01N21/3504 ,  G01J3/12

CPC classification number: G01J5/522 ,  G01J3/0208 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0297 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J5/0014 ,  G01J5/0806 ,  G01J5/0834 ,  G01J5/0862 ,  G01J5/20 ,  G01J2003/2826 ,  G01J2003/283 ,  G01J2005/0048 ,  G01J2005/0077 ,  G01N21/3504 ,  G01N2021/1793 ,  G01N2021/3531 ,  G01N2201/06106 ,  G01N2201/068 ,  G01N2201/127 ,  H04N3/09 ,  H04N5/33 ,  H04N5/332 ,  H04N5/365 ,  H04N5/3651 ,  H04N5/3655

Abstract: Various embodiments disclosed herein describe a divided-aperture infrared spectral imaging (DAISI) system that is adapted to acquire multiple IR images of a scene with a single-shot (also referred to as a snapshot). The plurality of acquired images having different wavelength compositions that are obtained generally simultaneously. The system includes at least two optical channels that are spatially and spectrally different from one another. Each of the at least two optical channels are configured to transfer IR radiation incident on the optical system towards an optical FPA unit comprising at least two detector arrays disposed in the focal plane of two corresponding focusing lenses. The system further comprises at least one temperature reference source or surface that is used to dynamically calibrate the two detector arrays and compensate for a temperature difference between the two detector arrays.

公开(公告)号：US20100172802A1

公开(公告)日：2010-07-08

申请号：US12615723

申请日：2009-11-10

Applicant: STEPHEN P. SHARROCK ,  Andrew P. Phelan

Inventor： STEPHEN P. SHARROCK ,  Andrew P. Phelan

IPC: G01N21/00

CPC classification number: G01N21/55 ,  G01N21/00 ,  G01N21/05 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/78 ,  G01N21/8483 ,  G01N31/22 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: A device for determining an assay result may include a test strip, a light source system, a light detection system, and a processor.

Abstract translation: 用于确定测定结果的装置可以包括测试条，光源系统，光检测系统和处理器。

公开(公告)号：US07616315B2

公开(公告)日：2009-11-10

申请号：US11773325

申请日：2007-07-03

Applicant: Stephen P. Sharrock ,  Andrew P. Phelan

Inventor： Stephen P. Sharrock ,  Andrew P. Phelan

IPC: G01N21/00

CPC classification number: G01N21/55 ,  G01N21/00 ,  G01N21/05 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/78 ,  G01N21/8483 ,  G01N31/22 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: A device for determining an assay result may include a test strip, a light source system, a light detection system, and a processor.

Abstract translation: 用于确定测定结果的装置可以包括测试条，光源系统，光检测系统和处理器。

公开(公告)号：US20050037511A1

公开(公告)日：2005-02-17

申请号：US10742459

申请日：2003-12-19

Applicant: Stephen Sharrock

Inventor： Stephen Sharrock

IPC: G01N21/25 ,  G01N21/27 ,  G01N21/47 ,  G01N21/78 ,  G01N21/86 ,  G01N21/00

CPC classification number: G01N21/8483 ,  G01N21/251 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/78 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: An assay result reading device for reading the result of an assay performed using a liquid transport carrier may include at least one light source capable of emitting light incident upon at least one of two or more spatially separated zones of the carrier, a photodetector so positioned as to be capable of detecting light emanating from each of the two said zones and generating signals representing the presence or absence of a fluid sample in the respective zone, and a computation circuit. The computation circuit may be responsive to the signals to calculate a flow rate for a fluid flowing along the carrier, compare the calculated flow rate to upper and lower limits, and reject the assay result if the calculated flow rate is outside the upper and lower limits.

Abstract translation: 用于读取使用液体输送载体进行的分析结果的测定结果读取装置可以包括能够发射入射到载体的两个或更多个空间上分离的区域中的至少一个的光的至少一个光源， 能够检测从两个所述区域中的每一个发出的光并产生表示各个区域中是否存在流体样本的信号，以及计算电路。 计算电路可以响应于信号来计算沿着载体流动的流体的流量，将计算的流速与上限和下限进行比较，并且如果计算出的流量超出上限和下限，则拒绝测定结果 。

公开(公告)号：US5482842A

公开(公告)日：1996-01-09

申请号：US224054

申请日：1994-04-07

Applicant: Klaus W. Berndt

Inventor： Klaus W. Berndt

IPC: C12M1/34 ,  C12Q1/04 ,  G01N21/27 ,  G01N21/35 ,  G01N21/59 ,  G06Q50/00

CPC classification number: G01N21/274 ,  C12M41/46 ,  G01N2021/5969 ,  G01N21/3504 ,  G01N2201/06106 ,  G01N2201/066 ,  G01N2201/0662 ,  Y10S435/808

Abstract: Methods and apparatus for detecting biological activity within a sample are disclosed. The present invention provides a combination of a first and a second infrared light source arranged on the side of a sample vial, and a first and a second narrow-band infrared detector similarly arranged on the side of the vial approximately opposite the sources. The disclosed arrangement cancels the sources of error while measuring the carbon dioxide content of the headspace gas above the sample. In operation, the present invention sequentially measures the photocurrents generated at each detector with no source turned on, with the first source turned on, and with the second source turned on and the first source turned off. The CO.sub.2 absorption coefficient of the vial headspace gas is then calculated based on the photocurrents measured. This present invention allows compensation for source aging, detector aging, and vial wall thickness changes. Moreover, the present invention permits a determination of the absolute absorption coefficient at a selected wavelength, most preferably about 4.26 .mu.m, which is the CO.sub.2 absorption characteristic wavelength. The determination of the absolute CO.sub.2 concentration within the headspace permits the detection of bacterial growth processes. Additionally, the disclosed source/detector combination can be produced at low cost. Thus, in preferred embodiments, the apparatus of the present invention comprises a plurality of vials that are simultaneously monitored by providing each of the plurality of vials with its own source/detector combination and activating and deactivating the sources and detectors using a multiplexer/demultiplexer arrangement.

Abstract translation: 公开了用于检测样品内生物活性的方法和装置。 本发明提供了布置在样品瓶侧面的第一和第二红外光源的组合，以及类似地布置在大致与源相对的小瓶侧面上的第一和第二窄带红外检测器。 所公开的布置在测量样品上方的顶空气体的二氧化碳含量的同时消除误差源。 在操作中，本发明顺序地测量在每个检测器处产生的光电流，其中第一源被接通，并且第二源被接通，并且第一源被关断。 然后基于测量的光电流计算出瓶顶空气体的CO 2吸收系数。 本发明允许补偿源老化，检测器老化和小瓶壁厚变化。 此外，本发明允许确定选定波长的绝对吸收系数，最优选约4.26μm，这是CO 2吸收特性波长。 顶部空间中绝对二氧化碳浓度的测定允许细菌生长过程的检测。 另外，所公开的源/检测器组合可以以低成本生产。 因此，在优选实施例中，本发明的装置包括多个小瓶，其通过向多个小瓶中的每一个提供自己的源/检测器组合来同时监视，并使用多路复用器/解复用器布置来激活和去激活源和检测器 。

公开(公告)号：EP2128604A1

公开(公告)日：2009-12-02

申请号：EP09151850.6

申请日：2004-05-25

Applicant: Inverness Medical Switzerland GmbH

Inventor： Phelan, Andrew Peter

IPC: G01N21/86 ,  G01N33/487

CPC classification number: G01N21/78 ,  G01N21/274 ,  G01N21/8483 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: Disclosed, in one aspect, is an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: a light source or sources, said light source/s emitting light incident upon at least two, spatially separated zones of the test strip; and a photodetector which detects light emanating from each of the two said zones; in a further aspect is disclosed an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: at least one light source incident upon a zone of the test strip; and at least two photodetectors both of which are able to detect some of the light emanating from the zone of the test strip illuminated by the light source.

Abstract translation: 一方面公开了一种用于读取使用测试条执行的分析结果的测定结果读取装置，该装置包括：光源或光源，所述光源发射入射到至少两个的空间上分离的光 测试带的区域; 以及光电检测器，其检测从所述两个所述区域中的每一个发出的光; 在另一方面公开了一种用于读取使用测试条执行的分析结果的测定结果读取装置，该装置包括：入射到测试条带的至少一个光源; 以及至少两个光电检测器，它们都能够检测从由光源照射的测试条带的区域发出的一些光。

公开(公告)号：EP1484601A3

公开(公告)日：2006-08-23

申请号：EP04253078.2

申请日：2004-05-25

Applicant: Inverness Medical Switzerland GmbH

Inventor： Phelan, Andrew Peter

IPC: G01N21/86 ,  G01N33/487

CPC classification number: G01N21/78 ,  G01N21/274 ,  G01N21/8483 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: Disclosed, in one aspect, is an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: a light source or sources, said light source/s emitting light incident upon at least two, spatially separated zones of the test strip; and a photodetector which detects light emanating from each of the two said zones; in a further aspect is disclosed an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: at least one light source incident upon a zone of the test strip; and at least two photodetectors both of which are able to detect some of the light emanating from the zone of the test strip illuminated by the light source.

公开(公告)号：EP1484613A2

公开(公告)日：2004-12-08

申请号：EP04253076.6

申请日：2004-05-25

Applicant: Inverness Medical Switzerland GmbH

Inventor： Sharrock, Stephen Paul ,  Phelan, Andrew Peter

IPC: G01N33/487

CPC classification number: G01N21/55 ,  G01N21/00 ,  G01N21/05 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/78 ,  G01N21/8483 ,  G01N31/22 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: A device for determining the result of an assay may include a computation circuit, responsive to a signal representing the amount of an analyte or the rate of accumulation of an analyte, to: compare the signal to a first threshold; compare the signal to a second threshold, the second threshold being less than the first threshold; generate an output signal if the signal exceeds the first threshold or the signal is less than the second threshold, the output signal indicative of a first result if the signal exceeds the first threshold, or, alternatively, the output signal indicative of a second result if the signal is less than the second threshold; and terminate the assay if the signal exceeds the first threshold or the signal is less than the second threshold.

Abstract translation: 用于确定测定结果的装置可以包括响应于表示分析物的量的信号或分析物的累积速率的计算电路，以将信号与第一阈值进行比较; 将信号与第二阈值进行比较，第二阈值小于第一阈值; 如果信号超过第一阈值或者信号小于第二阈值，则产生输出信号，如果信号超过第一阈值，则输出信号表示第一结果，或者替代地，指示第二结果的输出信号if 信号小于第二阈值; 并且如果信号超过第一阈值或信号小于第二阈值，则终止测定。

公开(公告)号：EP2871452A1

公开(公告)日：2015-05-13

申请号：EP14192862.2

申请日：2014-11-12

Applicant: Rebellion Photonics, Inc.

Inventor： Kester, Robert Timothy ,  Hagan, Nathan Adrian

IPC: G01J3/02 ,  G01J3/36 ,  G01J5/52

CPC classification number: G01J5/522 ,  G01J3/0208 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0297 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J5/0014 ,  G01J5/0806 ,  G01J5/0834 ,  G01J5/0862 ,  G01J5/20 ,  G01J2003/2826 ,  G01J2003/283 ,  G01J2005/0048 ,  G01J2005/0077 ,  G01N21/3504 ,  G01N2021/1793 ,  G01N2021/3531 ,  G01N2201/06106 ,  G01N2201/068 ,  G01N2201/127 ,  H04N3/09 ,  H04N5/33 ,  H04N5/332 ,  H04N5/365 ,  H04N5/3651 ,  H04N5/3655

Abstract: Various embodiments disclosed herein describe a divided-aperture infrared spectral imaging (DAISI) system that is adapted to acquire multiple IR images of a scene with a single-shot (also referred to as a snapshot). The plurality of acquired images having different wavelength compositions that are obtained generally simultaneously. The system includes at least two optical channels that are spatially and spectrally different from one another. Each of the at least two optical channels are configured to transfer IR radiation incident on the optical system towards an optical FPA unit comprising at least two detector arrays disposed in the focal plane of two corresponding focusing lenses. The system further comprises at least one temperature reference source or surface that is used to dynamically calibrate the two detector arrays and compensate for a temperature difference between the two detector arrays.

Abstract translation: 本文公开的各种实施例描述了分光孔径红外光谱成像（DAISI）系统，其适于用单次拍摄（也称为快照）获取场景的多个IR图像。 通常同时获得具有不同波长成分的多个获取图像。 该系统包括在空间上和光谱上彼此不同的至少两个光学通道。 所述至少两个光学通道中的每一个被配置为将入射在所述光学系统上的IR辐射转移到包括设置在两个对应的聚焦透镜的焦平面中的至少两个检测器阵列的光学FPA单元。 该系统还包括用于动态地校准两个检测器阵列并补偿两个检测器阵列之间的温度差的至少一个温度参考源或表面。

公开(公告)号：EP2385363A3

公开(公告)日：2012-05-02

申请号：EP10184102.1

申请日：2004-05-25

Applicant: Alere Switzerland GmbH

Inventor： Phelan, Andrew

IPC: G01N21/84 ,  G01N21/86 ,  G01N33/487 ,  G01N21/27 ,  G01N21/78

CPC classification number: G01N21/78 ,  G01N21/274 ,  G01N21/8483 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2201/06106 ,  G01N2201/062

Abstract: An assay result reading device for reading the result of an assay performed using a test strip, the device comprising: a light source or sources, said light source(s) emitting light incident upon at least two, spatially separated zones of the test strip; and a photodetector which detects light emanating from each of the two said zones; in a further aspect is disclosed an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: at least one light source incident upon a zone of the test strip; and at least two photodetectors both of which are able to detect some of the light emanating from the zone of the test strip illuminated by the light source.