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公开(公告)号：US4835110A
公开(公告)日：1989-05-30
申请号：US812827
申请日：1985-12-23
Applicant: Daniel B. Seymour , Paul E. Theobald , John E. Lillig
Inventor： Daniel B. Seymour , Paul E. Theobald , John E. Lillig
IPC: G01N21/75 , G01N21/47 , G01N21/82 , G01N33/536 , G01N33/557
CPC classification number: G01N33/557 , G01N21/82 , G01N21/47 , G01N2201/122 , Y10S436/805 , Y10S436/909
Abstract: The peak verify time for kinetic nephelometric measurements of reactions between antigens and antibodies is adjusted as a function of the magnitude of the peak rate order to reduce the time required for peak verification. The scatter signal is zeroed following the end of the peak verification period and the reaction is tested for antigen excess. Reactions during the antigen excess check having rates that exceed a threshold value are accepted as being valid, and no additional measurements are made for such samples. Reactions during the antigen excess check having rates that are less than the threshold value are rejected as being in antigen excess. Samples found to be in antigen excess are diluted and then reanalyzed.
Abstract translation: 调整抗原和抗体之间反应的动态比浊法测量的峰值验证时间作为峰值速率顺序的大小的函数，以减少峰值验证所需的时间。 在峰值验证期结束后，散射信号为零，测试抗原过量的反应。 在超过阈值的抗原过量检查期间的反应被认为是有效的，并且不对这些样品进行另外的测量。 在具有低于阈值的速率的抗原过量检查期间的反应被拒绝为抗原过量。 发现存在抗原过量的样品被稀释，然后再分析。
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公开(公告)号：US08189189B1
公开(公告)日：2012-05-29
申请号：US12576138
申请日：2009-10-08
Applicant: Robert O. Herendeen , James L. Beck , Larry Perazzo
Inventor： Robert O. Herendeen , James L. Beck , Larry Perazzo
IPC: G01J3/44
CPC classification number: G01J3/501 , G01J3/513 , G01N21/251 , G01N21/31 , G01N21/3563 , G01N21/55 , G01N2201/0625 , G01N2201/0627 , G01N2201/122
Abstract: The invention relates to a device and method for monitoring a chemical reaction proceeding from a first state to a second state by emitting and detecting radiation in ranges of interest for a spectral signature of the material undergoing the chemical reaction. Using the concept of optical spectral detection and identification, it is therefore possible to utilize a combination of specific emitters and detectors, optics and signal processing in order to identify materials and events.
Abstract translation: 本发明涉及用于通过发射和检测经历化学反应的材料的光谱特征的感兴趣范围的辐射来监测从第一状态到第二状态的化学反应的装置和方法。 使用光谱检测和识别的概念，因此可以利用特定发射器和检测器，光学和信号处理的组合来识别材料和事件。
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公开(公告)号：US08119998B2
公开(公告)日：2012-02-21
申请号：US12811666
申请日：2008-12-23
Applicant: Alex Avdeef , Dmytro Voloboy , Deren J. Dohoda , Per E. Nielsen , Michael J. DeMaria
Inventor： Alex Avdeef , Dmytro Voloboy , Deren J. Dohoda , Per E. Nielsen , Michael J. DeMaria
IPC: G01N21/64
CPC classification number: G01N21/253 , G01N21/0332 , G01N21/272 , G01N21/82 , G01N2201/122
Abstract: An apparatus for evaluating physicochemical properties of sample materials contained in an array of vessels includes: a light detector; a light source for transmitting a light beam through the sample material in a vessel to the light detector; an analyzer for processing data from the light detector to determine concentration-related properties of the sample material as a function of time; and a mixing system. The mixing system includes: a plurality of magnetic stirrer elements, each for being placed in a sample material in a different one of the array of vessels; an array of magnetic drive elements, each associated with a different one of the array of vessels and being magnetically coupled with a magnetic stirrer element in an associated vessel; and a drive mechanism coupled to the array of magnetic drive elements for simultaneously moving each of the magnetic drive elements relative to an associated vessel.
Abstract translation: 用于评估包含在容器阵列中的样品材料的物理化学性质的装置包括：光检测器; 用于将光束通过容器中的样品材料传输到光检测器的光源; 用于处理来自光检测器的数据的分析器，以确定作为时间的函数的样品材料的浓度相关性质; 和混合系统。 混合系统包括：多个磁力搅拌器元件，每个磁力搅拌器元件被放置在不同容器阵列中的样品材料中; 一组磁性驱动元件，每个磁性驱动元件与不同的容器阵列相关联并且与相关联的容器中的磁力搅拌器元件磁耦合; 以及耦合到磁驱动元件阵列的驱动机构，用于相对于相关联的容器同时移动每个磁驱动元件。
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公开(公告)号：US20100288944A1
公开(公告)日：2010-11-18
申请号：US12811666
申请日：2008-12-23
Applicant: Alex Avdeef , Dmytro Voloboy , Deren J. Dohoda , Per E. Nielsen , Michael J. DeMaria
Inventor： Alex Avdeef , Dmytro Voloboy , Deren J. Dohoda , Per E. Nielsen , Michael J. DeMaria
CPC classification number: G01N21/253 , G01N21/0332 , G01N21/272 , G01N21/82 , G01N2201/122
Abstract: An apparatus for evaluating physicochemical properties of sample materials contained in an array of vessels includes: a light detector; a light source for transmitting a light beam through the sample material in a vessel to the light detector; an analyzer for processing data from the light detector to determine concentration-related properties of the sample material as a function of time; and a mixing system. The mixing system includes: a plurality of magnetic stirrer elements, each for being placed in a sample material in a different one of the array of vessels; an array of magnetic drive elements, each associated with a different one of the array of vessels and being magnetically coupled with a magnetic stirrer element in an associated vessel; and a drive mechanism coupled to the array of magnetic drive elements for simultaneously moving each of the magnetic drive elements relative to an associated vessel.
Abstract translation: 用于评估包含在容器阵列中的样品材料的物理化学性质的装置包括：光检测器; 用于将光束通过容器中的样品材料传输到光检测器的光源; 用于处理来自光检测器的数据的分析器，以确定作为时间的函数的样品材料的浓度相关性质; 和混合系统。 混合系统包括：多个磁力搅拌器元件，每个磁力搅拌器元件被放置在不同容器阵列中的样品材料中; 一组磁性驱动元件，每个磁性驱动元件与不同的容器阵列相关联并且与相关联的容器中的磁力搅拌器元件磁耦合; 以及耦合到磁驱动元件阵列的驱动机构，用于相对于相关联的容器同时移动每个磁驱动元件。
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公开(公告)号：US5331177A
公开(公告)日：1994-07-19
申请号：US53042
申请日：1993-04-26
Applicant: David Kubisiak , Mark L. Wilson
Inventor： David Kubisiak , Mark L. Wilson
CPC classification number: D06F39/004 , A47L15/4297 , G01N21/532 , G01N2021/054 , G01N2201/122
Abstract: A turbidity sensor is provided with a light source and a plurality of light sensitive components which are disposed proximate a conduit to measure the light intensity directly across the conduit from the light source and at an angle therefrom. The conduit is provided with a plurality of protrusions extending radially inward from the walls of the conduit to discourage the passage of air bubbles through the light beam of the sensor. The direct light beam and scattered light are compared to form a relationship that is indicative of the turbidity of the liquid passing through the conduit. The rate of change of turbidity is provided as a monitored variable.
Abstract translation: 浊度传感器设置有光源和多个光敏部件，这些光敏部件设置在导管附近，以直接从光源穿过导管测量光强度，并且与其成角度。 导管设置有从导管的壁径向向内延伸的多个突起，以阻止气泡通过传感器的光束。 将直接光束和散射光进行比较，以形成指示通过导管的液体的浊度的关系。 浊度变化率作为监测变量提供。
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Patent Agency Ranking
公开(公告)号：US5296195A
公开(公告)日：1994-03-22
申请号：US956049
申请日：1992-10-02
Applicant: Wings S. Pang , Peter Kan , George K. Shibata
Inventor： Wings S. Pang , Peter Kan , George K. Shibata
CPC classification number: G01N21/0332 , G01N35/00 , G01N21/51 , G01N2201/122 , G01N33/53 , Y10S435/808 , Y10S436/808 , Y10S436/909
Abstract: A system for analyzing a chemical reaction provides control of the temperature and volume of the reagents to improve the accuracy and precision in quantitative measurements of specific proteins and other immunochemistries in body fluids. The reaction occurs in a cuvette within a nephelometric optics module. A sensor senses the temperatures of reaction buffer liquids as they flow into the cuvette, and a heat exchanging device increases or decreases the temperatures of the buffer liquids. A control circuit responsive to the temperature sensor controls the heat exchanging device to maintain the temperature of the buffer liquids and the cuvette within a selected temperature range. The system may also include a sample pickup station, a sample probe for withdrawing a selected sample from the sample pickup station, a sample preparation station, and transport device for carrying said sample from the sample preparation station to the reaction cuvette. The system may include an antibody pickup station, an antibody probe for withdrawing an antibody from the antibody pickup station, an antibody preparation station, and antibody transport device for carrying the antibody from the antibody preparation station to the reaction cuvette.
Abstract translation: 用于分析化学反应的系统提供对试剂的温度和体积的控制，以提高体液中特定蛋白质和其他免疫化学的定量测量的准确性和精确度。 反应发生在浊度计光学模块内的比色皿中。 反应缓冲液体流入比色杯时，传感器检测反应缓冲液的温度，热交换装置增加或减少缓冲液的温度。 响应于温度传感器的控制电路控制热交换装置，以将缓冲液和反应杯的温度保持在所选择的温度范围内。 系统还可以包括样品拾取站，用于从样品拾取站取出选定样品的样品探针，样品制备站和用于将样品从样品制备站运送到反应池的输送装置。 该系统可以包括抗体拾取站，用于从抗体拾取站取出抗体的抗体探针，抗体制备站和用于将抗体从抗体制备站携带到反应池的抗体转运装置。
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公开(公告)号：US5246858A
公开(公告)日：1993-09-21
申请号：US661810
申请日：1991-02-27
Applicant: Steven R. Arbuckle , William R. Boyd , Michael E. Grant , Mark A. Gregory , Russell T. Gray , Friedrich Jost , Daniel L. Kennedy , Dino Perin , Richard Riedel , David E. Storvick , John W. Stoughton
Inventor： Steven R. Arbuckle , William R. Boyd , Michael E. Grant , Mark A. Gregory , Russell T. Gray , Friedrich Jost , Daniel L. Kennedy , Dino Perin , Richard Riedel , David E. Storvick , John W. Stoughton
CPC classification number: G01N21/8483 , G01N2021/478 , G01N2201/1214 , G01N2201/122 , G01N2201/12723 , Y10T436/10
Abstract: A method and apparatus (10) for determining the remission of a chemistry (106) which reacts with a medically significant component of a body fluid. The remission of the chemistry (106) changes as it reacts. The method and apparatus (10) include irradiating the chemistry (106) with a radiation source (182), detecting remissions of radiation from the chemistry (106) with a radiation detector (300), providing a radiation pathway (164) between the source (182) and the chemistry (106), providing a remission pathway (164) between the chemistry (106) and the detector (300), and detecting the rate of change of remission of the chemistry (106) with respect to time. The irradiating, detecting and rate detecting steps and apparatus comprise initially irradiating the chemistry (106) at a first time rate and detecting remissions therefrom, comparing remission data from remission readings spaced apart by a first number of intervening remission readings, and determining when the difference between compared readings exceeds a first predetermined limit. The time rate of irradiation of the chemistry is changed once the difference between compared readings exceeds the first limit. Remission data from remission readings spaced apart by a second number of intervening remission readings are then compared. The method and apparatus next determine when the difference between compared readings no longer exceeds a second predetermined limit. The last remission reading is then converted to the concentration of the medically significant component of the body fluid.
Abstract translation: 一种用于确定化学物质（106）的缓解的方法和装置（10），其与体液的医学上重要的组分反应。 化学物质（106）的缓解随着反应而发生变化。 该方法和装置（10）包括用辐射源（182）照射化学物质（106），用辐射检测器（300）检测来自化学物质（106）的辐射的放射，提供源之间的辐射通路（164） （106）和化学物质（106），在化学物质（106）和检测器（300）之间提供缓释途径（164），以及检测化学物质（106）相对于时间的缓解变化率。 照射，检测和速率检测步骤和装置包括首先以第一时间速率辐射化学物质（106）并检测其中的缓解，将缓释数据与间隔开的缓冲读数与第一数量的介入缓解读数进行比较，以及确定何时差异 比较读数超过第一预定极限。 一旦比较读数之间的差超过第一限制，化学物质的照射时间变化就会改变。 然后比较缓冲读数与间隔第二数量的介入缓解读数的缓解数据。 该方法和装置接下来确定比较读数之间的差异何时不再超过第二预定极限。 然后将最后的缓解读数转化为体液的医学重要组分的浓度。
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公开(公告)号：US5098186A
公开(公告)日：1992-03-24
申请号：US596711
申请日：1990-10-12
Applicant: Christopher Bull
Inventor： Christopher Bull
CPC classification number: G01N35/085 , B01F5/0451 , G01N2201/122
Abstract: An improvement in rapid mixers for stopped flow spectrophotometers is disclosed. This improvement involves the dispersion of one solution from the bore of a disperser through notches into a flowing sheath of a second solution. The dispersed mixture is then mixed by passage through a mixer made up of a series of mixing rings with lands and grooves. The lands and grooves of adjoining rings are aligned so grooves are adjacent to lands, thus providing maximum mixing. The ratio of volumes of solutions mixed may vary from 1:1 to 40:1 by varying the number and size of notches in the end of the disperser tube. The viscosity ratio of the solutions mixed may vary from 1:1 to 100:1. Complete (greater than 99%) mixing occurs in less than one millisecond.
Abstract translation: 公开了用于停止流动分光光度计的快速混合器的改进。 这种改进涉及将一种溶液从分散器的孔通过凹口分散到第二溶液的流动护套中。 然后将分散的混合物通过由一系列具有焊盘和凹槽的混合环组成的混合器混合。 相邻环的平台和凹槽对齐，因此凹槽与平台相邻，从而提供最大的混合。 通过改变分散管末端的切口的数量和尺寸，混合溶液的体积比可以从1:1至40:1变化。 混合溶液的粘度比可以从1:1到100:1变化。 完成（大于99％）混合发生在不到一毫秒。
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公开(公告)号：US4767600A
公开(公告)日：1988-08-30
申请号：US746583
申请日：1985-06-19
Applicant: Guido Vicario
Inventor： Guido Vicario
CPC classification number: G01N21/253 , G01N35/026 , B01J2219/00468 , G01N2201/122 , Y10S435/807 , Y10S435/809
Abstract: A detecting device is fitted so as to span a row of adjoining receptacles which are set in a reciprocating continuous motion, so that each receptacle passes within the scanning field of the detecting device. The latter sends the signals sequentially to a processor for elaboration into point curves showing the courses of each reaction through time. The row of receptacles may be set in a reciprocating motion by a rack, a stepping motor, a cam-type control or a coupling device, etc.
Abstract translation: 检测装置被装配成跨越一排毗邻的容纳件，其被设置为往复连续运动，使得每个容器在检测装置的扫描场内通过。 后者将信号顺序地发送到处理器，以详细阐述显示每个反应的时间过程的点曲线。 插座的排可以通过机架，步进电机，凸轮型控制器或联接装置等进行往复运动。
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40.发明授权Procedure for photometric measurement of liquids in reaction vessels, and reaction vessel 失效反应容器和反应容器中液体的光度测量程序
公开(公告)号：US4690900A
公开(公告)日：1987-09-01
申请号：US462046
申请日：1983-01-28
Applicant: Kayhko Kimmo , Kari H. Helenius
Inventor： Kayhko Kimmo , Kari H. Helenius
CPC classification number: G01N21/251 , G01N21/03 , G01N21/59 , G01N2021/0357 , G01N2021/0378 , G01N2021/0392 , G01N21/0303 , G01N21/76 , G01N2201/0415 , G01N2201/0438 , G01N2201/122 , G01N2201/1242 , Y10T436/113332
Abstract: A procedure for photometric measurement of liquids in a reaction vessel in an automatic analyser, with a radiation flow having its course perpendicular to a row of the reaction vessel, so as to provide a reliable and positively operating measuring method for the photometric measurement of the liquids. The procedure is characterized in that the radiation flow and the reaction vessel are in movement relative to each other during the measurement. The invention affords the advantage of improved accuracy of measurement and improved reliability since it becomes possible, by measuring a moving object and at the same time calculating the mean of the radiant flux over accepted portions of the signal, to eliminate the error of measurement introduced by a dirt particle or by a scratch. The invention also concerns a row of reaction vessels employed in the procedure, wherein each reaction vessel is contiguous to the next and separated by a wall. The row of reaction vessels is characterized in that the bottom of each reaction vessel consists of a lens focussing luminescence radiation. This affords the advantage that the lens enables a luminiscence measurement to be performed simultaneously with the photometric measurement.
Abstract translation: 一种自动分析仪中的反应容器中的液体的光度测量程序，其辐射流程垂直于反应容器的一排，以便提供可靠和积极的测量方法，用于液体的光度测量 。 该过程的特征在于在测量期间辐射流和反应容器相对于彼此运动。 本发明提供了提高测量精度和提高可靠性的优点，因为通过测量移动物体并同时计算辐射通量超过信号接收部分的平均值，可消除由 污垢颗粒或划痕。 本发明还涉及在该方法中使用的一排反应容器，其中每个反应容器与下一个连续并由壁隔开。 反应容器的一排的特征在于每个反应容器的底部由聚焦发光辐射的透镜组成。 这提供了这样的优点，即透镜使得能够与光度测量同时进行亮度测量。
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