公开(公告)号：US07031845B2

公开(公告)日：2006-04-18

申请号：US10198141

申请日：2002-07-19

Applicant: Ridgway Scott ,  Stephen J. Wright ,  Stuart A. Kurtz ,  Terry Clark ,  Chris (Hristem) Dyanov ,  Richard Quigg

Inventor： Ridgway Scott ,  Stephen J. Wright ,  Stuart A. Kurtz ,  Terry Clark ,  Chris (Hristem) Dyanov ,  Richard Quigg

IPC: G06G7/58 ,  C12Q1/68 ,  G06N7/00

CPC classification number: G06F19/20

Abstract: A method for determining a matrix of expression levels corresponding to a set of biological targets (e.g., genes or gene fragments) and a set of biological samples, including obtaining a matrix of signal values corresponding to the set of biological targets; computing a vector of expression levels for a sample in the set of biological samples using the matrix of signal values; storing the vector of computed expression levels in a storage matrix; repeating the computing and storing steps for each sample in the set of biological samples; and outputting the storage matrix as the matrix of expression levels. The method, based on a linear programming formulation of the problem, works for both “promiscuous” probe array data, in which there may be multiple targets indicated by a single probe, and the “polygamous” case, in which there are multiple probes for a single target. The preferred method can also process data obtained from multiple SAGE analyses using multiple markers. A second embodiment of the method determines optimal expression levels when the available probe data is noisy or uncertain.

Abstract translation: 用于确定对应于一组生物学靶标（例如，基因或基因片段）和一组生物样品的表达水平的基质的方法，包括获得对应于该组生物学靶标的信号值的矩阵; 使用信号值矩阵计算生物样品集合中样本的表达水平向量; 将计算出的表达级别的向量存储在存储矩阵中; 对生物样品集合中的每个样品重复计算和存储步骤; 并输出存储矩阵作为表达式的矩阵。 该方法基于问题的线性规划公式，适用于“混杂”探针阵列数据，其中可能存在由单个探针指示的多个目标和“一夫多妻”情况，其中存在多个探针 一个目标。 优选的方法还可以使用多个标记处理从多个SAGE分析获得的数据。 该方法的第二实施例在可用探测数据有噪声或不确定时确定最佳表达水平。

公开(公告)号：US07026291B1

公开(公告)日：2006-04-11

申请号：US08477983

申请日：1995-06-07

Applicant: Jeffrey S. Rubin ,  Paul W. Finch ,  Stuart A. Aaronson

Inventor： Jeffrey S. Rubin ,  Paul W. Finch ,  Stuart A. Aaronson

IPC: A61K38/18 ,  C07K14/475 ,  C07K14/50

CPC classification number: G01N33/74 ,  A61K38/00 ,  C07K14/50 ,  C07K16/22 ,  C07K2317/73 ,  G01N2333/4742

Abstract: Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as production of antibodies. Means are described for determining the level of expression of genes for the KGF protein, for example, by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

Abstract translation: 揭示了显示重组DNA技术的特定方面的发现可以成功地用于产生迄今为止未知的人角质形成细胞生长因子（KGF）蛋白，而不含其他多肽。 这些蛋白质可以从自发分泌的细胞或引入细胞的DNA片段以各种功能形式产生。 这些形式不同地使得这种新型蛋白质的生物化学和功能研究以及抗体的产生。 描述了用于确定KGF蛋白的基因表达水平的方法，例如通过测量细胞中的mRNA水平或通过测量在细胞外或体液中分泌的抗原。

公开(公告)号：US07004305B2

公开(公告)日：2006-02-28

申请号：US10782343

申请日：2004-02-19

Applicant: Stuart A. Schaefer

Inventor： Stuart A. Schaefer

IPC: B65G33/34

CPC classification number: B65G65/466

Abstract: A grain bin sweep is adapted to be assembled within a grain bin. The sweep comprises an auger assembly including a shield and an auger; and a tractor frame assembly comprising a frame first part and a frame second part. The sweep components are sized to fit through a small access opening to a grain bin and to then be assembled together within the grain bin. Additionally, the assembly of the grain bin sweep is accomplished using simple hand tools, such as wrenches, screwdrivers, etc. No welding, drilling or other fabrication is required to assemble the parts or components together to form the sweep.

Abstract translation: 粮仓扫描器适于组装在谷仓内。 该扫掠装置包括一个包括盾构和螺旋钻的螺旋钻组件; 以及包括框架第一部分和框架第二部分的拖拉机框架组件。 扫掠部件的尺寸适合通过一个小的进入开口到粮仓，然后在谷仓内组装在一起。 另外，使用诸如扳手，螺丝刀等简单的手动工具来实现谷仓扫掠的组装。不需要焊接，钻孔或其它制造来将部件或部件组装在一起以形成扫掠。

公开(公告)号：US06957592B2

公开(公告)日：2005-10-25

申请号：US10419340

申请日：2003-04-21

Applicant: Wayne I. Sternberger ,  Stuart A. Goemmer ,  Rebecca F. Vertes ,  Micah A. Carlson ,  William R. Allmon ,  Alexander E. Dence ,  Stanley G. Reach ,  Adam K. Arabian

Inventor： Wayne I. Sternberger ,  Stuart A. Goemmer ,  Rebecca F. Vertes ,  Micah A. Carlson ,  William R. Allmon ,  Alexander E. Dence ,  Stanley G. Reach ,  Adam K. Arabian

IPC: B01L3/00 ,  G01N1/14 ,  G01N1/40 ,  G01N33/18 ,  G01N1/00

CPC classification number: B01L3/502 ,  B01L2200/18 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2400/086 ,  G01N1/14 ,  G01N1/405 ,  G01N33/18 ,  G01N2001/021

Abstract: The invention comprises a vessel for solid phase micro-extraction chemical sampling. The vessel includes a container having an open end and a cap used to close the open end. The cap has a holder to hold a solid phase coated fiber within an interior of the container. There also is an inlet at a first location of the vessel and an outlet at a second location of the vessel. The inlet and the outlet are adapted to fill the vessel with a material to be exposed to the solid phase coated fiber. The vessel also includes a diffuser plate attached to the container. The plate is adapted to reduce fluid forces exerted on the solid phase coated fiber as material flows from the inlet to the outlet. The purpose of the diffuser plate is both to assure that forces are reduced and to provide laminar flow to assure rapid and complete exchange of the fluid in the vessel.

Abstract translation: 本发明包括用于固相微萃取化学取样的容器。 容器包括具有开口端的容器和用于封闭开口端的盖子。 盖具有用于将固相涂布纤维保持在容器内部的保持器。 在容器的第一位置还有在容器的第二位置处的出口。 入口和出口适于将容器暴露于固相涂覆纤维的材料填充。 容器还包括附接到容器的扩散板。 该板适于当材料从入口流到出口时减少施加在固相涂覆纤维上的流体力。 扩散板的目的是确保力减少并提供层流以确保容器中的流体的快速和完全的更换。

公开(公告)号：US06925807B2

公开(公告)日：2005-08-09

申请号：US10628602

申请日：2003-07-28

Applicant: Franklin B. Jones ,  Stuart A. Jones

Inventor： Franklin B. Jones ,  Stuart A. Jones

IPC: E21B3/02 ,  E21B43/00 ,  F15B9/09 ,  F15B9/17 ,  F15B11/16 ,  F15B15/28 ,  F15B21/08 ,  E21B1/00

CPC classification number: F15B21/087 ,  E21B3/02 ,  F15B9/09 ,  F15B9/17 ,  F15B11/16 ,  F15B15/2815 ,  F15B15/2838 ,  F15B2211/20515 ,  F15B2211/327 ,  F15B2211/6336 ,  F15B2211/6651 ,  F15B2211/6654 ,  F15B2211/7142

Abstract: An apparatus and method for controlling an actuator system having an electrical actuator in hydraulic communication with a hydraulic actuator are described. The apparatus includes a controller module in communication with a source of electrical power and a transceiver. The transceiver is adapted for bi-directional wireless communication with a remote transceiver for the transfer of control data and feedback data. The controller module sends a control signal to the electrical actuator in response to control data received from the remote transceiver. The source of electrical power includes a hydraulic motor and an electrical generator to provide local electrical power from a hydraulic flow. Because the electrical power is generated locally and the control and feedback data are carried over the wireless link, no wires to remote locations are required.

Abstract translation: 描述了一种用于控制具有与液压致动器液压连通的电致动器的致动器系统的装置和方法。 该装置包括与电源和收发器通信的控制器模块。 收发器适用于与远程收发器的双向无线通信，用于传送控制数据和反馈数据。 响应于从远程收发器接收的控制数据，控制器模块向电致动器发送控制信号。 电力源包括液压马达和发电机，以从液压流提供局部电力。 因为电力是本地生成的，并且控制和反馈数据通过无线链路承载，所以不需要到远程位置的电线。

公开(公告)号：US06899339B2

公开(公告)日：2005-05-31

申请号：US09943321

申请日：2001-08-30

Applicant: Stuart A. Sanders ,  Kirk D. Stackhouse ,  Lisa V. O'Connor

Inventor： Stuart A. Sanders ,  Kirk D. Stackhouse ,  Lisa V. O'Connor

IPC: F01D11/02 ,  F01D11/08 ,  F01D11/12 ,  F02C7/00 ,  F02C7/28 ,  F04D29/08 ,  F16J15/16 ,  F16J15/40

CPC classification number: F01D11/122 ,  Y02T50/672

Abstract: An air seal for use in a gas turbine engine provides improved durability, particularly at higher temperatures. The seal includes a seal substrate and an abradable seal layer on the substrate. The abradable seal layer is composed of a densified polyimide foam, preferably a thermomechanically densified foam. The seal is bonded to a stationary engine component such as a stator box or a case.

Abstract translation: 用于燃气涡轮发动机的空气密封件提供改善的耐久性，特别是在较高的温度下。 密封件包括密封基底和基底上可磨损的密封层。 耐磨密封层由致密的聚酰亚胺泡沫，优选热机械致密化泡沫构成。 密封件结合到诸如定子箱或壳体的固定发动机部件。

公开(公告)号：US06852760B1

公开(公告)日：2005-02-08

申请号：US09787325

申请日：1999-09-17

Applicant: Stuart A. Fine ,  Kevin J. Kinsella

Inventor： Stuart A. Fine ,  Kevin J. Kinsella

IPC: A61K33/24 ,  A61K31/175 ,  A61K31/17 ,  A61K33/26

CPC classification number: A61K33/24 ,  A61K2300/00

Abstract: Compositions and methods of using the same for the treatment of diabetes and other disorders of glucose metabolism are provided. Compositions may include an anti-diabetic agent and one or more of a bioavailable source of chromium and vanadium.

Abstract translation: 提供了使用它们用于治疗糖尿病和其他糖代谢障碍的组合物和方法。 组合物可以包括抗糖尿病剂和一种或多种生物可利用的铬和钒源。

公开(公告)号：US06834260B2

公开(公告)日：2004-12-21

申请号：US10040602

申请日：2001-12-28

Applicant: Stuart A. Golden ,  Naiel K. Askar

Inventor： Stuart A. Golden ,  Naiel K. Askar

IPC: H04B1500

CPC classification number: H04L25/061

Abstract: Correcting a signal offset may include observing a finite duration signal yn that comprises a representation of a mixture of a desired signal that may include data of interest, and an undesired signal based on interference of an external interference source. The undesired signal may include an offset component which may be modeled as comprising a step function u defined by unknown step function parameters. The unknown step function parameters may be estimated using, for example, a maximum likelihood method. Thereafter, yn may be corrected based on the estimated step function parameters.

Abstract translation: 校正信号偏移可以包括观察包括可包括感兴趣的数据的期望信号的混合的表示的有限持续时间信号yn和基于外部干扰源的干扰的不期望的信号。 不期望的信号可以包括偏移分量，该偏移分量可以被建模为包括由未知步长函数参数定义的阶跃函数u。 可以使用例如最大似然法来估计未知的步骤功能参数。 此后，可以基于估计的步骤功能参数来校正yn。

公开(公告)号：US06803231B1

公开(公告)日：2004-10-12

申请号：US09355793

申请日：1999-09-21

Applicant: Martin Blaser ,  Joel Dworkin ,  Stuart A. Thompson

Inventor： Martin Blaser ,  Joel Dworkin ,  Stuart A. Thompson

IPC: A01N6300

CPC classification number: C07K14/205 ,  A61K2039/523

Abstract: The present invention provides a mutant C. fetus strain in which one or more sapA homologs are altered by an inserted DNA cassette so that the encoded S-layer proteins represent a chimera between the native S-layer proteins and a heterologous peptide encoded by the inserted cassette. Preferably, the heterologous peptide is an immunogen of a pathogen and the mutant strain can be used to immunize a host to develop mucosal and systemic immune responses to such immunogen.

Abstract translation: 本发明提供了一种突变体C.胎儿菌株，其中一个或多个sapA同系物被插入的DNA盒改变，使得编码的S层蛋白质代表天然S层蛋白质与由插入的编码的异源肽之间的嵌合体 盒式磁带 优选地，异源肽是病原体的免疫原，并且突变株可用于免疫宿主以产生对这种免疫原的粘膜和全身免疫应答。

公开(公告)号：US06760140B1

公开(公告)日：2004-07-06

申请号：US10086355

申请日：2002-03-01

Applicant: Victor Argueta-Diaz ,  Betty Lise Anderson ,  Stuart A. Collins, Jr.

Inventor： Victor Argueta-Diaz ,  Betty Lise Anderson ,  Stuart A. Collins, Jr.

IPC: G02F103

CPC classification number: G02B6/3542 ,  G02B6/352 ,  G02B6/3526 ,  G02B6/3528

Abstract: An optical interconnection device and a spot displacement device are presented. In optical interconnection device of the present invention, a spot displacement device is employed to cause a light beam to shift positions, thereby making available output positions not previously available for a light beam having bounced so few times.

Abstract translation: 提出了光互连装置和光斑位移装置。 在本发明的光学互连装置中，使用光斑位移装置使光束移动位置，从而使弹簧几次的光束以前不可用的可用输出位置。