公开(公告)号：US09267616B2

公开(公告)日：2016-02-23

申请号：US11665297

申请日：2005-10-14

Applicant: Walter Gumbrecht ,  Peter Paulicka ,  Manfred Stanzel

Inventor： Walter Gumbrecht ,  Peter Paulicka ,  Manfred Stanzel

IPC: C12M1/00 ,  F16K99/00 ,  B01L3/00 ,  B01L7/00

CPC classification number: F16K99/0001 ,  B01L3/502738 ,  B01L7/52 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2400/0633 ,  B01L2400/0661 ,  C08L2201/12 ,  F16K99/0036 ,  F16K99/0038 ,  F16K99/0044 ,  F16K2099/0084

Abstract: At least one embodiment of the invention relates to an arrangement for thermocyclization of a substance. At least one embodiment of the invention also relates to a method for the thermocyclization of a substance, including: the controllable valves automatically close the PCR chamber after the test fluid has been introduced into the PCR-chamber, and the properties for the memory metal or bimetal elements are used for closing the valves when a predetermined temperature has been exceeded. As a result, the mechanical actuator, which is used to actuate the valves, is thermally coupled to the heating/cooling element in order to carry out the thermocyclization.

Abstract translation: 本发明的至少一个实施方案涉及物质热循环的装置。 本发明的至少一个实施方案还涉及一种用于物质热循环的方法，包括：在将测试流体引入PCR室之后，可控阀自动关闭PCR室，以及存储金属或 当超过预定温度时，双金属元件用于关闭阀。 因此，用于致动阀的机械致动器与加热/冷却元件热耦合以便进行热循环。

公开(公告)号：US20160017101A1

公开(公告)日：2016-01-21

申请号：US14441677

申请日：2013-11-02

Applicant: SYRACUSE UNIVERSITY

Inventor： Patrick T. MATHER

IPC: C08G81/00 ,  C08G81/02

CPC classification number: C08G81/00 ,  C08G81/021 ,  C08G81/024 ,  C08G81/027 ,  C08G81/028 ,  C08L53/00 ,  C08L101/12 ,  C08L2201/12

Abstract: Shape memory polymers featuring reversible actuation capability under ambient stimulus for integration with apparel. One approach is to use a multiblock polymer consisting of two (or potentially more) blocks in which the one block is the crystalline switching block with relatively low melting transitions, the other block has a higher thermal transition, and the two blocks are linked together by a linker molecule. Another approach is to use a graft copolymer having high and low melting transitions where the graft copolymer has a first polymer serving as the backbone and a second polymer being grafted to or from the backbone at certain graft locations. A further approach is to use latent crosslinking of a semicrystalline polymer with reactive groups placed on the backbone.

Abstract translation: 形状记忆聚合物在环境刺激下具有可逆的致动能力，与服装集成。 一种方法是使用由两个（或潜在的更多）嵌段组成的多嵌段聚合物，其中一个嵌段是具有相对低的熔融转变的结晶切换嵌段，另一个嵌段具有较高的热转变，并且两个嵌段通过 连接分子。 另一种方法是使用具有高和低熔点转变的接枝共聚物，其中接枝共聚物具有作为主链的第一聚合物，第二聚合物在某些接枝位置处被接枝到骨架上或从主链上接枝。 另一种方法是使用半结晶聚合物与置于骨架上的反应性基团的潜在交联。

公开(公告)号：US20150368406A1

公开(公告)日：2015-12-24

申请号：US14748144

申请日：2015-06-23

Applicant: Agency for Science, Technology and Research

Inventor： Xian Jun Loh ,  Jun Li

IPC: C08G81/00 ,  A61K47/34

CPC classification number: C08G81/00 ,  A61K47/34 ,  A61L27/14 ,  A61L27/50 ,  A61L27/58 ,  A61L29/04 ,  A61L29/14 ,  A61L29/148 ,  A61L31/04 ,  A61L31/14 ,  A61L31/148 ,  A61L2400/16 ,  B29C61/003 ,  C08G18/4277 ,  C08G18/61 ,  C08G18/73 ,  C08G63/08 ,  C08G63/664 ,  C08G77/16 ,  C08G77/458 ,  C08G2230/00 ,  C08G2261/126 ,  C08G2280/00 ,  C08K5/57 ,  C08L87/005 ,  C08L2201/12 ,  C09D187/005

Abstract: This invention relates to shape memory block copolymers comprising: at least one switching segment having a Ttrans from 10 to 70° C.; and at least one soft segment, wherein at least one of the switching segments in linked to at least one of the soft segments by at least one linkage, and wherein the copolymer transforms from a first shape to a second shape by application of a first stimulus and the copolymer transforms back to the first shape from the second shape by application of a second stimulus. The shape memory block copolymers may be biocompatible and biodegradable.

Abstract translation: 本发明涉及形状记忆嵌段共聚物，其包含：至少一个具有10-70℃的Ttrans的切换区段; 和至少一个软链段，其中所述切换段中的至少一个通过至少一个键连接到至少一个所述软链段，并且其中所述共聚物通过施加第一刺激从第一形状转变为第二形状 并且共聚物通过施加第二刺激从第二形状转变回第一形状。 形状记忆嵌段共聚物可以是生物相容的和可生物降解的。

公开(公告)号：US20150305809A1

公开(公告)日：2015-10-29

申请号：US14281264

申请日：2014-05-19

Applicant: COVIDIEN LP

Inventor： MANI N. PRAKASH ,  FRANCESCA ROSSETTO ,  JOSEPH D. BRANNAN

IPC: A61B18/18

CPC classification number: A61B18/1815 ,  A61B5/0422 ,  A61B18/1477 ,  A61B18/16 ,  A61B18/18 ,  A61B2017/00867 ,  A61B2018/00107 ,  A61B2018/00577 ,  A61B2018/00958 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2018/1869 ,  A61B2090/036 ,  C08L2201/12

Abstract: A surgical ablation system employing an ablation probe having a deployable ground plane is disclosed. The disclosed system includes a source of ablation energy and a source of electrosurgical energy, and a switching assembly configured to select between ablation and electrosurgical modes. The probe includes a cannula having a shaft slidably disposed therein. The shaft includes a deployable ground plane electrode assembly and a needle electrode disposed at distal end of the shaft. As the shaft is extended distally from the cannula, the ground plane electrode unfolds, and the needle electrode is exposed. Electrosurgical energy is applied to tissue via the needle electrode to facilitate the insertion thereof into tissue. Ablation energy is applied to tissue via the needle electrode to achieve the desired surgical outcome. The shaft, ground plane electrode and needle electrode are retracted into the cannula, and withdrawn from the surgical site.

Abstract translation: 公开了一种采用具有可展开接地平面的消融探针的手术切除系统。 所公开的系统包括消融能量源和电外科能量源，以及配置成在消融和电外科模式之间进行选择的开关组件。 探针包括具有可滑动地设置在其中的轴的套管。 轴包括可展开的接地平面电极组件和设置在轴的远端处的针状电极。 当轴从套管向远端延伸时，接地平面电极展开，针电极露出。 电外科能量经由针电极施加到组织，以便于将其插入组织中。 通过针电极对组织施加消融能量以达到期望的手术效果。 轴，接地平面电极和针电极缩回到套管中，并从手术部位撤回。

公开(公告)号：US09062141B2

公开(公告)日：2015-06-23

申请号：US13814691

申请日：2011-08-05

Applicant: Stephen Dean Goodrich ,  Michael Lyons ,  Jeffrey Paul Castleberry

Inventor： Stephen Dean Goodrich ,  Michael Lyons ,  Jeffrey Paul Castleberry

IPC: C08F214/16 ,  C08F222/20 ,  C08F263/02 ,  A61K49/04 ,  C08F222/10 ,  C08F222/12

CPC classification number: C08F222/20 ,  A61K49/0442 ,  C08F214/16 ,  C08F222/1006 ,  C08F222/12 ,  C08F263/02 ,  C08F2218/20 ,  C08G2280/00 ,  C08L2201/12

Abstract: Radiopaque polymer compositions and methods for making the compositions are provided. These radiopaque polymer compositions include shape memory polymer compositions comprising a crosslinked polymer network, the network comprising a first repeating unit derived from a monofunctional iodinated monomer and a second repeating unit derived from a multifunctional non-iodinated monomer wherein neither of the two monomers is fluorinated. Devices formed from radiopaque polymer compositions are also provided.

Abstract translation: 提供不透射线的聚合物组合物和制备组合物的方法。 这些不透射线的聚合物组合物包括包含交联聚合物网络的形状记忆聚合物组合物，该网络包含衍生自单官能碘化单体的第一重复单元和衍生自多官能非碘化单体的第二重复单元，其中两种单体都不是氟化的。 还提供了由不透射线的聚合物组合物形成的装置。

公开(公告)号：US09011430B2

公开(公告)日：2015-04-21

申请号：US13503598

申请日：2010-11-04

Applicant: Nagy Habib

Inventor： Nagy Habib

IPC: A61B18/18 ,  A61B18/04 ,  A61B17/22 ,  A61B18/14 ,  A61B18/08 ,  A61B18/24 ,  A61B19/00 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61F2/01

CPC classification number: A61B17/22 ,  A61B17/2202 ,  A61B18/082 ,  A61B18/14 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/245 ,  A61B90/06 ,  A61B2017/00022 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2017/22061 ,  A61B2017/22079 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00821 ,  A61B2018/00898 ,  A61B2018/126 ,  A61B2018/1861 ,  A61B2090/3782 ,  A61B2090/3788 ,  A61F2/013 ,  C08L2201/12

Abstract: A device and method suitable for remodelling the internal surface of a hollow vessel at least partially occluded by a mass is provided. The device comprises an elongate body having a distal end and a proximal end, the distal end comprising a tip portion located at the distal terminus of the body, and at least one heating element located proximally to the tip portion within the distal end. The at least one heating element is configured to be greater in dimension proximally than distally and thereby tapers towards the distal end. Furthermore, the at least one heating element is arranged so that it can be deployed outwardly from the body of the device and in so doing exert an expansion force on the hollow vessel. The at least one heating element is capable of delivering sufficient energy to remodel the internal surface, and if necessary caused localized ablation, of the hollow vessel without inducing closure of the hollow vessel.

Abstract translation: 提供了一种适于重塑至少部分被块体封闭的中空容器的内表面的装置和方法。 所述装置包括具有远端和近端的细长主体，所述远端包括位于所述主体的远端的尖端部分，以及位于所述远端内的所述尖端部分的近侧的至少一个加热元件。 所述至少一个加热元件被配置为在远端比近端更大的尺寸，从而朝向远端逐渐变细。 此外，至少一个加热元件被布置成使得其可以从装置的主体向外展开，并且这样对中空容器施加膨胀力。 所述至少一个加热元件能够输送足够的能量来重建内表面，并且如果需要引起中空容器的局部消融，而不引起中空容器的封闭。

公开(公告)号：US08979839B2

公开(公告)日：2015-03-17

申请号：US12945982

申请日：2010-11-15

Applicant: Alan De La Rama ,  Cary Hata

Inventor： Alan De La Rama ,  Cary Hata

IPC: A61B18/14 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12

CPC classification number: A61B18/1492 ,  A61B2017/00867 ,  A61B2018/00011 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00654 ,  A61B2018/00797 ,  A61B2018/124 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2018/1497 ,  A61B2218/002 ,  C08L2201/12

Abstract: An ablation catheter comprises a catheter body extending longitudinally between a proximal end and a distal end along a longitudinal axis; and an ablation element assembly comprising ablation elements connected to the catheter body, each ablation element to be energized to produce an ablation zone. The ablation elements are distributed in a staggered configuration such that the ablation zones of the ablation elements span one or more open arc segments around the longitudinal axis, but the ablation zones of all ablation elements projected longitudinally onto any lateral plane which is perpendicular to the longitudinal axis span a substantially closed loop around the longitudinal axis. Since the ablation zones do not form a closed loop, the risk of renal artery/vein stenosis is reduced or eliminated. Since the ablation zones of all ablation elements projected longitudinally onto any lateral plane span a substantially closed loop, substantially complete renal denervation is achieved.

Abstract translation: 消融导管包括沿纵向轴线在近端和远端之间纵向延伸的导管主体; 以及消融元件组件，其包括连接到导管主体的消融元件，每个消融元件被激励以产生消融区域。 消融元件以交错构型分布，使得消融元件的消融区域围绕纵向轴线跨越一个或多个开放弧形段，但是所有消融元件的消融区域纵向投影到垂直于纵向的任何侧向平面 轴线围绕纵向轴线跨越基本上闭合的环路。 由于消融区不形成闭环，所以肾动脉/静脉狭窄的风险降低或消除。 由于所有消融元件的消融区域纵向投影到任何横向平面上跨过基本闭合的环路，所以实现了基本上完全的肾去神经支配。

公开(公告)号：US08945110B2

公开(公告)日：2015-02-03

申请号：US14249188

申请日：2014-04-09

Applicant: St. Jude Medical, Atrial Fibrillation Division, Inc.

Inventor： Jeffrey M. Fish ,  Sacha C. Hall ,  Theodore A. Johnson

IPC: A61B18/18 ,  A61B5/042 ,  A61B5/04

CPC classification number: A61B5/042 ,  A61B5/0422 ,  A61B5/6857 ,  A61B18/1492 ,  A61B2017/00867 ,  A61B2018/1435 ,  A61B2562/125 ,  C08L2201/12 ,  Y10T29/49002

Abstract: An electrophysiology catheter includes an elongate catheter body having an elastically-deformable distal region predisposed to assume a spiral shape and a first plurality of electrodes disposed thereon. Each of the first plurality of electrodes includes an electrically active region limited to the inner surface of the spiral shape for use in non-contact electrophysiology studies. A second plurality of electrodes may also be disposed on the distal region interspersed (e.g., alternating) with the first plurality of electrodes, with each of the second plurality of electrodes having an electrically active region extending into the outer surface of the spiral shape for use in contact electrophysiology studies. The distal region may be deformed into a straight configuration for insertion into and navigation through the patient's vasculature, for example via use of a tubular introducer. As the distal region deploys beyond the distal end of the introducer, it resumes the spiral shape.

Abstract translation: 电生理导管包括细长的导管主体，其具有倾向于呈现螺旋形状的可弹性变形的远端区域和设置在其上的第一多个电极。 第一多个电极中的每一个包括限于用于非接触电生理学研究的螺旋形状的内表面的电活性区域。 第二多个电极也可以设置在与第一多个电极分散（例如交替）的远端区域上，第二多个电极中的每一个具有延伸到螺旋形状的外表面的电活性区域以供使用 接触电生理学研究。 远侧区域可以变形成直的构造，用于插入和导航通过患者的脉管系统，例如通过使用管状导引器。 当远端区域展开超过导引器的远端时，它恢复螺旋形状。

公开(公告)号：US08940041B2

公开(公告)日：2015-01-27

申请号：US13453630

申请日：2012-04-23

Applicant: James M. Carlson ,  Shyam S.V. Kuppurathanam ,  Fred T. Parker ,  Rebecca Sue Todd

Inventor： James M. Carlson ,  Shyam S.V. Kuppurathanam ,  Fred T. Parker ,  Rebecca Sue Todd

IPC: A61F2/06 ,  A61L31/14 ,  A61F2/07 ,  A61L31/02 ,  A61L31/04 ,  D02G3/12 ,  D02G3/44 ,  D03D3/02 ,  D03D13/00 ,  D03D15/00 ,  D03D15/08 ,  A61F2/90

CPC classification number: A61F2/90 ,  A61F2/06 ,  A61F2/07 ,  A61F2002/075 ,  A61F2210/0014 ,  A61L31/022 ,  A61L31/041 ,  A61L31/14 ,  A61L2400/16 ,  C08L2201/12 ,  D02G3/12 ,  D02G3/448 ,  D03D3/02 ,  D03D13/004 ,  D03D13/008 ,  D03D15/00 ,  D03D15/08 ,  D10B2101/20 ,  D10B2321/021 ,  D10B2321/022 ,  D10B2321/042 ,  D10B2331/04 ,  D10B2331/10 ,  D10B2401/046 ,  D10B2401/061 ,  D10B2509/06

Abstract: The disclosure relates to a woven fabric for use in an implantable medical device. The woven fabric has shape memory element strands woven with textile strands. At least one of the shape memory element strands has at least one float of at least five textile strands between binding points.

Abstract translation: 本公开涉及用于可植入医疗装置的机织织物。 机织织物具有用织物股线编织的形状记忆元件股。 形状记忆元件股线中的至少一个在结合点之间具有至少一个至少五个纺织股线的浮子。

公开(公告)号：US08926589B2

公开(公告)日：2015-01-06

申请号：US13765044

申请日：2013-02-12

Applicant: Biosense Webster (Israel), Ltd.

Inventor： Assaf Govari

IPC: A61M25/01 ,  A61B18/18 ,  A61B18/14 ,  A61B17/00 ,  A61B19/00

CPC classification number: A61B18/18 ,  A61B18/1492 ,  A61B2017/00867 ,  A61B2034/2051 ,  A61B2090/067 ,  C08L2201/12

Abstract: A medical device includes an insertion tube, having a longitudinal axis and having a distal end adapted for insertion through a body passage into a cavity within a body of a patient. An electrode is located on the distal end of the insertion tube and is configured to contact tissue in the cavity. A resilient member is contained within the distal end of the insertion tube and is configured, when unconstrained, to cause the distal end to bend away from the longitudinal axis in a curved shape and to straighten toward the longitudinal axis when subjected to a force.

Abstract translation: 医疗装置包括插入管，其具有纵向轴线并且具有适于插入通过身体通道进入患者体内空腔的远端。 电极位于插入管的远端，并且构造成接触空腔中的组织。 弹性构件容纳在插入管的远端内，并且当不受约束时被构造成使远端远离纵向轴线弯曲成弯曲形状并且当受到力时朝向纵向轴线拉直。