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    RNAi INHIBITION OF CTGF FOR TREATMENT OF OCULAR DISORDER
    41.
    发明专利
    RNAi INHIBITION OF CTGF FOR TREATMENT OF OCULAR DISORDER 审中-公开
    用于治疗眼部疾病的CTGF的RNAi抑制

    公开(公告)号：JP2012097119A

    公开(公告)日：2012-05-24

    申请号：JP2012029499

    申请日：2012-02-14

    Applicant: Alcon Inc ,  アルコン,インコーポレイテッド

    Inventor： SHEPARD ALLAN R ,  PANG IOK-HOU

    IPC: A61K31/7105 ,  A61K48/00 ,  A61P27/02 ,  A61P27/06 ,  C12N15/113

    CPC classification number: C12N15/1136 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32

    Abstract: PROBLEM TO BE SOLVED: To provide RNA interference for inhibition of connective tissue growth factor mRNA expression in ocular disorders involving CTGF expression.SOLUTION: Ocular disorders involving aberrant CTGF expression include glaucoma, macular degeneration, diabetic retinopathy, choroidal neovascularization, proliferative vitreoretinopathy and wound healing. Such disorders are treated by administering interfering RNAs. There is provided a method of attenuating expression of connective tissue growth factor mRNA in an eye of a subject. The method comprises administering to the eye of the subject a composition comprising an effective amount of interfering RNA such as adouble-stranded (ds) siRNA or single-stranded (ss) siRNA having a lentgh of 19 to 49 nucleotides and a pharmaceutically acceptable carrier.

    Abstract translation: 要解决的问题：提供RNA干扰，用于抑制涉及CTGF表达的眼部疾病中的结缔组织生长因子mRNA表达。 涉及异常CTGF表达的眼部疾病包括青光眼，黄斑变性，糖尿病性视网膜病变，脉络膜新生血管形成，增生性玻璃体视网膜病变和伤口愈合。 通过施用干扰RNA来治疗这些病症。 提供了减弱受试者眼睛中结缔组织生长因子mRNA表达的方法。 该方法包括向受试者的眼睛施用包含有效量的干扰RNA的组合物，所述干扰RNA例如具有19至49个核苷酸的寡核苷酸的双链（ds）siRNA或单链（ss）siRNA和药学上可接受的载体。 版权所有（C）2012，JPO＆INPIT

    Ultrasound apparatus and operating method
    42.
    发明专利
    Ultrasound apparatus and operating method 审中-公开
    超声波设备和操作方法

    公开(公告)号：JP2012081288A

    公开(公告)日：2012-04-26

    申请号：JP2011266973

    申请日：2011-12-06

    Applicant: Alcon Inc ,  アルコン,インコーポレイティド

    Inventor： CHON JAMES Y ,  GORDON RAPHAEL

    IPC: A61B18/00 ,  A61C1/07 ,  A61F9/007

    CPC classification number: A61F9/00745 ,  A61B2017/320098

    Abstract: PROBLEM TO BE SOLVED: To provide a reliable ultrasonic hand piece which vibrates in both of a vertical maneuver and a twisting maneuver simultaneously or separately without using a piezoelectric crystal.SOLUTION: The ultrasonic handpiece includes a magnetorestrictive stack 210, a horn 220 for ultrasonic wave which is attached to the stack while including a plurality of slits 260, and an electric coil 250 which surrounds the stack adapted for receiving a drive signal. The plurality of slits have enough size and space to generate a twisting motion in the horn in response to the drive signal with a first frequency and generate a vertical motion in the horn in response to the drive signal with a second frequency.

    Abstract translation: 要解决的问题：提供一种在不使用压电晶体的情况下同时或分开地在垂直操作和扭转机动两者中振动的可靠的超声波手持件。 解决方案：超声波手持件包括磁阻堆叠210，用于超声波的喇叭220，其附接到堆叠，同时包括多个狭缝260，以及围绕堆叠的电线圈250，其适于接收驱动信号。 多个狭缝具有足够的尺寸和空间，以响应于具有第一频率的驱动信号在喇叭中产生扭转运动，并且响应于具有第二频率的驱动信号而在喇叭中产生垂直运动。 版权所有（C）2012，JPO＆INPIT

    Compound with 5-ht1a activity useful for treating disorder of outer retina
    45.
    发明专利
    Compound with 5-ht1a activity useful for treating disorder of outer retina 审中-公开
    具有5-HT1A活性的化合物可用于治疗外周疾病

    公开(公告)号：JP2011153158A

    公开(公告)日：2011-08-11

    申请号：JP2011108785

    申请日：2011-05-13

    Applicant: Alcon Inc ,  アルコン,インコーポレイテッド

    Inventor： COLLIER ROBERT J JR ,  KAPIN MICHAEL A ,  HELLBERG MARK R ,  DEAN THOMAS R

    IPC: A61K45/00 ,  C07D211/70 ,  A61K31/135 ,  A61K31/137 ,  A61K31/36 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5575 ,  A61K45/06 ,  A61P9/10 ,  A61P25/02 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07D209/08 ,  C07D209/16 ,  C07D401/12

    CPC classification number: A61K31/36 ,  A61K31/4045

    Abstract: PROBLEM TO BE SOLVED: To treat disorders of the outer retina resulting from acute or chronic degenerative conditions or diseases of the eye.
    SOLUTION: There are provided compositions and methods for treating disorders of the outer retina using compounds with 5-HT
    1A agonist activity. The invention is directed to 5-HT
    1A agonist which is discovered to be useful in treating disorders of the outer retina, particularly: AMD; RP and other forms of heredodegenerative retinal disease; retinal detachment and tears; macular pucker; ischemia affecting the outer retina; diabetic retinopathy; damage associated with laser therapy (grid, focal, and panretinal) including photodynamic therapy (PDT); trauma; surgical (retinal translocation, subretinal surgery, or vitrectomy); retinopathy or light-induced iatrogenic retinopathy; and preservation of retinal transplants.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 待解决的问题：治疗由急性或慢性退行性疾病或眼睛疾病引起的外部视网膜疾病。 解决方案：提供了使用具有5-HT 1A 激动剂活性的化合物治疗外部视网膜疾病的组合物和方法。 本发明涉及被发现可用于治疗外部视网膜疾病的5-HT 1A激动剂，特别是：AMD; RP和其他形式的遗传性视网膜疾病; 视网膜脱离和眼泪; 黄斑褶皱; 影响外部视网膜的缺血; 糖尿病性视网膜病变; 包括光动力治疗（PDT）在内的激光治疗（网格，焦点和全视网膜）相关的损伤; 外伤; 手术（视网膜易位，视网膜下手术或玻璃体切除术）; 视网膜病变或光诱导的医源性视网膜病变; 并保留视网膜移植物。 版权所有（C）2011，JPO＆INPIT

    Pressure monitor for aerodynamic vitrectomy system
    47.
    发明专利
    Pressure monitor for aerodynamic vitrectomy system 有权
    气动监测系统压力监测仪

    公开(公告)号：JP2010274140A

    公开(公告)日：2010-12-09

    申请号：JP2010206798

    申请日：2010-09-15

    Applicant: Alcon Inc ,  アルコン,インコーポレイティド

    Inventor： OLIVERA ARGELIO ,  HOPKINS MARK A ,  TURNER DENIS P ,  PALINO ROBERT

    IPC: A61F9/007

    CPC classification number: A61F9/00736 ,  A61B2017/00544 ,  F15B19/005 ,  F15B2211/30565 ,  F15B2211/3138 ,  F15B2211/31576 ,  F15B2211/327 ,  F15B2211/6313 ,  F15B2211/87 ,  F15B2211/8755 ,  Y10T137/2544

    Abstract: PROBLEM TO BE SOLVED: To provide an aerodynamic module for supplying power to a vitrectomy apparatus, attaining the high speed operation of the vitrectomy apparatus with the minimum number of components. SOLUTION: A system for supplying aerodynamic power to the vitrectomy apparatus includes the first (A) and second (B) output ports, an output valve (210), an exhaust valve (205), and three manifolds. The output valve supplies compressed gas to the first and second output ports alternately, and the exhaust valve (205) supplies pressurized gas to the output valve. Two manifolds fluidly connect the output valve to the first and second output ports, and the third manifold (250) fluidly connects the exhaust valve to the output valve. When the exhaust valve supplies pressurized gas to the output valve, the output valve supplies the pressurized gas to the first and second output ports alternately at high speed to supply power to the apparatus. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种用于向玻璃体切割装置供电的空气动力学模块，以最少数量的部件实现玻璃体切割装置的高速操作。 解决方案：用于向玻璃体切割设备供应空气动力的系统包括第一（A）和第二（B）输出端口，输出阀（210），排气阀（205）和三个歧管。 输出阀将压缩气体交替地供应到第一和第二输出端口，并且排气阀（205）向输出阀供应加压气体。 两个歧管将输出阀流体地连接到第一和第二输出端口，并且第三歧管（250）将排气阀流体地连接到输出阀。 当排气阀向输出阀供给加压气体时，输出阀将加压气体以高速交替地供给到第一和第二输出端口，以向设备供电。 版权所有（C）2011，JPO＆INPIT

    Method of priming surgical system
    48.
    发明专利
    Method of priming surgical system 有权
    引导手术系统的方法

    公开(公告)号：JP2009011811A

    公开(公告)日：2009-01-22

    申请号：JP2008095212

    申请日：2008-04-01

    Applicant: Alcon Inc ,  アルコン,インコーポレイティド

    Inventor： DAVIS SHERMAN G ,  SORENSEN GARY P

    IPC: A61F9/007

    CPC classification number: A61M1/0058 ,  A61F9/00745

    Abstract: PROBLEM TO BE SOLVED: To provide a method of priming a surgical system by which residual entrained air inside a surgical instrument can be securely removed. SOLUTION: The method of priming a surgical system includes a step to pull a very high vacuum and then cycling fluid through the system as a fluid pulse. These steps can be repeated a number of times to help ensure that residual entrained air is removed from the system. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种引导手术系统的方法，通过该方法可以可靠地去除手术器械内的残留夹带空气。 引发手术系统的方法包括拉动非常高的真空并随后以流体脉冲循环流体通过系统的步骤。 这些步骤可以重复多次以帮助确保从系统中除去残留的夹带空气。 版权所有（C）2009，JPO＆INPIT

    Method of operating ultrasonic handpiece
    50.
    发明专利
    Method of operating ultrasonic handpiece 有权
    超声波手术操作方法

    公开(公告)号：JP2008289874A

    公开(公告)日：2008-12-04

    申请号：JP2008123693

    申请日：2008-05-09

    Applicant: Alcon Inc ,  アルコン,インコーポレイティド

    Inventor： INJEV VALENTINE P ,  ROBERT J CIONNI

    IPC: A61F9/007

    CPC classification number: A61F9/00745 ,  A61B2017/320098 ,  A61M2205/3344 ,  B06B1/0261 ,  B06B3/00

    Abstract: PROBLEM TO BE SOLVED: To provide a reliable ultrasonic handpiece vibrating in longitudinal movement and torsional movement simultaneously or separately. SOLUTION: A method employing a handpiece having at least a set of piezoelectric elements polarized to produce a longitudinal movement when excited at the relevant resonant frequency. The piezoelectric crystals are connected to an ultrasonic horn to which a cutting tip 20 is attached. The horn and/or the cutting tip contains a plurality of diagonal slits or grooves. The slits or grooves produce optimized torsional movement in the cutting tip when the piezoelectric crystals are excited at a second resonant frequency. When in torsional mode, material may clog the cutting tip. The present method includes the step of providing a pulse of longitudinal movement of the cutting tip when clogging is detected. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供可靠的超声波手持件，以便在纵向运动和扭转运动中同时或分开地振动。 解决方案：一种使用具有至少一组压电元件的手持件的方法，所述压电元件在相关谐振频率下被激发时被极化以产生纵向移动。 压电晶体连接到安装切割尖端20的超声波喇叭。 喇叭和/或切割尖端包含多个对角狭缝或凹槽。 当压电晶体以第二谐振频率被激发时，狭槽或凹槽在切割尖端中产生优化的扭转运动。 当处于扭转模式时，材料可能堵塞切割尖端。 本方法包括当检测到堵塞时提供切割尖端的纵向运动的脉冲的步骤。 版权所有（C）2009，JPO＆INPIT

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