公开(公告)号：EP1945194A2

公开(公告)日：2008-07-23

申请号：EP06817258.4

申请日：2006-10-19

Applicant: ADA FOUNDATION

Inventor： CHOW, Laurence, C. ,  TAKAGI, Shozo

IPC: A61K9/70

CPC classification number: A61C5/50 ,  A61K6/0038 ,  A61K6/0067 ,  A61K6/0606 ,  A61K6/0612 ,  A61K6/0625 ,  A61K6/0643 ,  A61K6/097 ,  C08L31/04 ,  C08L1/284 ,  C08L5/04 ,  C08L29/04 ,  C08L33/08 ,  C08L5/08 ,  C08L5/06

Abstract: Disclosed are endodontic filling materials and methods. A method for filling a dental root canal may include providing a hydrosetting filling material and inserting the hydrosetting filling material into the dental root canal, the material setting in the root canal to form a biocompatible filling. The hydrosetting filling material comprises a hydrogel former and a filler. The hydrogel former is at least one of a reactive organic hydrogel formers, an inorganic hydrogel formers, and a non-reactive organic hydrogel formers, and the filler is at least one of a self-hardening and a non-hardening filler. Plural filling material precursor compositions that collectively contain hydrogel formers and fillers may be provided.

Abstract translation: 公示的是根管填充材料和方法。 用于填充牙根管的方法可以包括提供水合物填充材料并将水合物填充材料插入牙根管中，将根管内的材料置于生根相容的填充物中。 水凝胶填充材料包括水凝胶形成剂和填料。 水凝胶形成剂是反应性有机水凝胶形成剂，无机水凝胶形成剂和非反应性有机水凝胶形成剂中的至少一种，填料是自硬化和非硬化填料中的至少一种。 可以提供集体含有水凝胶形成剂和填料的多种填充材料前体组合物。

公开(公告)号：EP1622843A2

公开(公告)日：2006-02-08

申请号：EP04719777.7

申请日：2004-03-11

Applicant: ADA FOUNDATION

Inventor： CHOW, Laurence, C. ,  TAKAGI, Shozo

IPC: C04B12/02

CPC classification number: C04B28/344 ,  A61K31/19 ,  A61K33/06 ,  A61K33/42 ,  A61L27/12 ,  A61L27/46 ,  A61L2400/06 ,  C04B2111/00836 ,  C04B24/02 ,  C04B24/045 ,  C04B24/06 ,  C04B24/14 ,  C04B24/32 ,  C04B24/38 ,  C04B24/383 ,  C04B40/065 ,  A61K2300/00

Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders, liquid glycerol, organic acid and gelling agent. The paste is stable, resistant to washout and will harden upon exposure to water. Physical characteristics of the paste, including consistency, porosity, and hardening time, are controlled by the choice and ratio of constituents.

公开(公告)号：WO2007050684A3

公开(公告)日：2009-04-30

申请号：PCT/US2006041631

申请日：2006-10-25

Applicant: ADA FOUNDATION ,  CHOW LAURENCE C ,  TAKAGI SHOZO

Inventor： CHOW LAURENCE C ,  TAKAGI SHOZO

IPC: A61K8/21 ,  A61K8/00

CPC classification number: A61Q11/00 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24

Abstract: Disclosed are dental compositions and methods. In accordance with one embodiment, a dental composition includes calcium, fluorine, which is generally present in the form of fluoride, and phosphate or another stabilizing anion. The composition is stable as against precipitation of calcium fluoride during transport and storage, but is unstable against the precipitation of calcium fluoride in the oral cavity of a human. In many embodiments, the amount of fluoride may be less than the amount of fluoride used in a comparable composition intended for a similar purpose. A dental method comprises applying the composition to the oral cavity of a patient, whereupon calcium fluoride precipitates from the composition.

Abstract translation: 公开了牙科用组合物和方法。 根据一个实施方案，牙科用组合物包括通常以氟化物形式存在的钙，氟，磷酸盐或其它稳定阴离子。 该组合物在运输和储存期间对于氟化钙的沉淀是稳定的，但是对于人体口腔中氟化钙的沉淀是不稳定的。 在许多实施方案中，氟化物的量可以小于用于类似目的的类似组合物中使用的氟化物的量。 牙科方法包括将组合物施用于患者的口腔，于是氟化钙从组合物中沉淀出来。

公开(公告)号：WO2008147997A1

公开(公告)日：2008-12-04

申请号：PCT/US2008/064707

申请日：2008-05-23

Applicant: ADA FOUNDATION ,  TUNG, Ming

Inventor： TUNG, Ming

IPC: A61C5/04

CPC classification number: A61K8/24 ,  A61K8/19 ,  A61K8/20 ,  A61K8/22 ,  A61Q11/00 ,  A61Q17/005

Abstract: Compositions and methods for forming, in an aqueous environment, a nanoaggregate of calcium fluoride and amorphous calcium phosphate-containing compound, such as amorphous calcium phosphate fluoride or amorphous calcium carbonate phosphate fluoride are described. The nanoaggregate (or nanocomposite) can release calcium, phosphate, and fluoride, and ultimately convert to the tooth mineral, fluorapatite. One method for forming such a nanoaggregate involves applying a non-aqueous {e.g., varnish-based) composition (e.g., a suspension), containing solid particles of water soluble salts of calcium, phosphate, and fluoride, to the aqueous environment of the mouth. This results in rapid solubilization of the salts, precipitation of the nanoaggregate, and tooth remineralization. Tooth fluoridation and remineralization may also be carried out by applying to the tooth a non-aqueous carrier containing the nanoaggregate. Whitening agents can also be added to these compositions and methods.

Abstract translation: 描述了在水性环境中形成氟化钙和无定形含磷酸钙化合物的纳米聚集体如无定形磷酸钙氟化物或无定形碳酸钙磷酸氟化物的组合物和方法。 纳米聚集体（或纳米复合材料）可以释放钙，磷酸盐和氟化物，并最终转化为矿物质的氟磷灰石。 用于形成这种纳米聚集体的一种方法包括将含有钙，磷酸盐和氟化物的水溶性盐的固体颗粒的非水（例如，基于清漆的）组合物（例如悬浮液）施加到口腔的水性环境中 。 这导致盐的快速溶解，纳米聚集体的沉淀和牙齿再矿化。 牙齿氟化和再矿化也可以通过向牙齿施用含有纳米聚集体的非水载体来进行。 美白剂也可以添加到这些组合物和方法中。

公开(公告)号：WO2007050684A2

公开(公告)日：2007-05-03

申请号：PCT/US2006/041631

申请日：2006-10-25

Applicant: ADA FOUNDATION ,  CHOW, Laurence, C. ,  TAKAGI, Shozo

Inventor： CHOW, Laurence, C. ,  TAKAGI, Shozo

IPC: A61K8/30 ,  A61K8/21

CPC classification number: A61Q11/00 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24

Abstract: Disclosed are dental compositions and methods. In accordance with one embodiment, a dental composition includes calcium, fluorine, which is generally present in the form of fluoride, and phosphate or another stabilizing anion. The composition is stable as against precipitation of calcium fluoride during transport and storage, but is unstable against the precipitation of calcium fluoride in the oral cavity of a human. In many embodiments, the amount of fluoride may be less than the amount of fluoride used in a comparable composition intended for a similar purpose. A dental method comprises applying the composition to the oral cavity of a patient, whereupon calcium fluoride precipitates from the composition.

Abstract translation: 公开了牙科用组合物和方法。 根据一个实施方案，牙科用组合物包括通常以氟化物形式存在的钙，氟，磷酸盐或其它稳定阴离子。 该组合物在运输和储存期间对于氟化钙的沉淀是稳定的，但是对于人体口腔中氟化钙的沉淀是不稳定的。 在许多实施方案中，氟化物的量可以小于用于类似目的的类似组合物中使用的氟化物的量。 牙科方法包括将组合物施用于患者的口腔，由此氟化钙从组合物中沉淀出来。

公开(公告)号：WO2018071262A1

公开(公告)日：2018-04-19

申请号：PCT/US2017/055283

申请日：2017-10-05

Applicant: ADA FOUNDATION ,  SUN, Jirun

Inventor： SUN, Jirun

IPC: C07C245/06 ,  A61K31/655

Abstract: A new azo-type quaternary pyridinium salt (Azo-QPS) shows enhanced activity at acidic conditions (e.g., pH = 5); in neutral or basic conditions, this new Azo-QPS shows a much lower level (2 - 50 times lower) anti-bacterial activity. The use of such a "stimulus- enhance" antibiotic can response to the proliferation of bacteria directly. It helps reduce or prevent the build-up of potent antibacterial agents in the oral environment. The antibacterial properties of Azo-QPS are "activated" when the environmental pH becomes acidic; this acidic pH may be indicative of the accumulation of Streptococcus mutans , or the initiation of tooth decay.

Abstract translation: 新的偶氮型季吡啶鎓盐（Azo-QPS）在酸性条件下（例如，pH = 5）显示增强的活性; 在中性或碱性条件下，这种新的偶氮-QPS显示出低得多的水平（2-50倍）的抗菌活性。 使用这种“刺激 - 增强” 抗生素可以直接响应细菌的增殖。 它有助于减少或防止在口腔环境中积聚有效的抗菌剂。 偶氮-QPS的抗菌性能被“活化” 当环境pH值变为酸性时; 该酸性pH值可能表明变形链球菌的积聚或蛀牙的发生。

公开(公告)号：WO2017058852A1

公开(公告)日：2017-04-06

申请号：PCT/US2016/054079

申请日：2016-09-28

Applicant: ADA FOUNDATION ,  SUN, Jirun

Inventor： SUN, Jirun

IPC: C08F20/56

CPC classification number: C08F220/68 ,  A61K6/0023 ,  A61K6/0052 ,  A61K6/083 ,  B33Y70/00 ,  C08F216/125 ,  C08F222/1006 ,  C08K3/36 ,  C09D11/101 ,  C09D11/107 ,  C09D129/10 ,  C09D133/14 ,  C09J129/10 ,  C09J133/14

Abstract: A composition of matter includes a mixture of styrene derivative monomers and methacrylate/acrylate derivative monomers, which have one or more urethane, carbamate, amide, and/or amine functional groups, and initiators, and the compositions are used to achieve composition control of the forming polymer, with the mole fraction of acrylate/methacrylate and styrene moieties in the forming polymer determined preferably by the chemistry and composition of the feeding monomers rather than the viscosity of the monomers.

Abstract translation: 物质组合物包括具有一个或多个氨基甲酸酯，氨基甲酸酯，酰胺和/或胺官能团的苯乙烯衍生物单体和甲基丙烯酸酯/丙烯酸酯衍生物单体的混合物和引发剂，并且组合物用于实现 形成聚合物，其中成型聚合物中丙烯酸酯/甲基丙烯酸酯和苯乙烯部分的摩尔分数优选通过进料单体的化学和组成而不是单体的粘度来确定。

公开(公告)号：WO2012148557A1

公开(公告)日：2012-11-01

申请号：PCT/US2012/026770

申请日：2012-02-27

Applicant: ADA FOUNDATION ,  CHOW, Laurence, C. ,  SUN, Limin

Inventor： CHOW, Laurence, C. ,  SUN, Limin

IPC: C01B15/16

CPC classification number: B82Y40/00 ,  B01J2/04 ,  B82Y30/00

Abstract: A method for preparing uniquely sized nanoparticles of CaF 2 by simultaneously spray drying a first NH 4 F and a biocompatible salt solution and a second Ca(OH) 2 and biocompatible salt solution to form CaF 2 solid particles in a soluble salt matrix wherein the salt is more soluble than CaF 2 . The salt matrix may then be dissolved and the separate CaF 2 nanosized particles collected for use as a dental therapeutic material. The technique is useful in the preparation of other discrete, nanoparticle sized compounds and combinations by carefully choosing the solvents and solutes of the two spray dried solutions.

Abstract translation: 通过同时喷雾干燥第一NH 4 F和生物相容性盐溶液和第二种Ca（OH）2和生物相容性盐溶液以在可溶性盐基质中形成CaF 2固体颗粒，其中所述盐的溶解度比 氟化钙。 然后可以将盐基质溶解并收集单独的CaF 2纳米尺寸颗粒以用作牙科治疗材料。 该技术通过仔细选择两种喷雾干燥溶液的溶剂和溶质来制备其它离散的纳米颗粒大小的化合物和组合是有用的。

公开(公告)号：WO2009099824A1

公开(公告)日：2009-08-13

申请号：PCT/US2009/032200

申请日：2009-01-28

Applicant: ADA FOUNDATION ,  BOWEN, Rafael, L.

Inventor： BOWEN, Rafael, L.

IPC: C08B37/00

CPC classification number: C08B37/0012 ,  A61K6/08 ,  C08B11/18 ,  C08B37/0009 ,  C08F224/00 ,  C08L5/16 ,  C09J4/00 ,  C09J101/30

Abstract: Disclosed are compositions that comprise vinylarylalkylene ethers of cyclodextrins optionally containing ether-linked adhesion-promoting groups, in combination with copolymerizable monomer or monomers. The copolymerizable monomer or monomers may include vinylarylalkylene ethers of oligohydroxy compounds (for example, sorbitol divinylbenzyl ether and others). The composition further may include stabilizers (for example, 1,3,5-trimethyl-2,4,6-tris(3,5-di-(tert)-butyl-4-hydroxybenzyl)benzene and others), and polymerization initiators (for example, phenylbis[2,4,6-trimethylbenzoyl]phosphine oxide and others) and reinforcing materials (for example, imogolite). Methods of preparing the compositions as well as the components of compositions and methods for their use in dental and other applications are also disclosed.

Abstract translation: 公开了包含任选含有醚连接的粘附促进基团的环糊精的乙烯基芳基亚烷基醚与可共聚单体或单体组合的组合物。 可共聚的单体或单体可以包括低聚羟基化合物的乙烯基芳基亚烷基醚（例如，山梨醇二乙烯基苄基醚等）。 组合物还可以包括稳定剂（例如1,3,5-三甲基-2,4,6-三（3,5-二（叔）丁基-4-羟基苄基）苯等）和聚合引发剂 （例如苯基双[2,4,6-三甲基苯甲酰基]氧化膦等）和增强材料（例如，imogolite）。 还公开了制备组合物的方法以及其用于牙齿和其它应用的组合物和方法的组分。

公开(公告)号：WO2006127989B1

公开(公告)日：2007-02-15

申请号：PCT/US2006020409

申请日：2006-05-25

Applicant: ADA FOUNDATION ,  XU HUAKUN ,  SUN LIMIN ,  TAKAGI SHOZO ,  CHOW LAWRENCE C

Inventor： XU HUAKUN ,  SUN LIMIN ,  TAKAGI SHOZO ,  CHOW LAWRENCE C

IPC: A61K6/08 ,  A61L27/14 ,  C08K3/04 ,  C08K3/32 ,  C08K3/34 ,  C08K3/40

CPC classification number: A61L27/54 ,  A61L27/44 ,  A61L2300/112 ,  A61L2300/624 ,  A61L2400/12

Abstract: Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results.

Abstract translation: 将所需牙科修复剂，修复或治疗材料源的纳米尺寸颗粒与各种通常纳米尺寸形式的增强剂（例如晶须，纤维，颗粒等）在树脂基质中组合提供了高度耐应变的复合材料，其更有效地释放治疗剂 。 联合使用治疗剂的纳米尺寸颗粒可以观察到明显改善的治疗结果。