公开(公告)号：EP3240635A4

公开(公告)日：2018-06-27

申请号：EP15875348

申请日：2015-12-29

Applicant: BACTERIOSCAN LTD

Inventor： MARSHALL DANA A ,  BECKMANN ROBERT W

IPC: B01L3/02 ,  G01N35/10

CPC classification number: B01L3/0275 ,  B01L2300/0681 ,  B01L2400/0605

Abstract: The present invention is a pipette-filtration assembly having a main body defining a first channel, a second channel, a first valve, and a second valve. The first valve is associated with the first channel and permits flow in a first direction while substantially hindering flow in a second direction. The second valve is associated with the second channel and permits flow in the second direction while substantially hindering flow in the first direction. At least one filter is used to filter a fluid sample as the fluid sample flows in the first direction and/or the second direction. The pipette-filtration assembly is preferably disposable and includes one or two stages of integral filtration, primarily for use with an air-displacement pipetting or transfer system.

公开(公告)号：EP3250907A1

公开(公告)日：2017-12-06

申请号：EP16742862.2

申请日：2016-01-25

Applicant: Bacterioscan Ltd.

Inventor： MARSHALL, Dana, A. ,  MCMINN, Theodore, S. ,  REGELMAN, Dan, Vadim

IPC: G01N21/47

CPC classification number: G01N21/51 ,  G01N21/0303 ,  G01N2021/513 ,  G01N2201/0231 ,  G01N2201/0415

Abstract: An instrument determines a concentration of bacteria in a plurality of fluid samples, and comprises a housing, a rotatable platform, a plurality of fluid containers, a light source, a sensor, and a motor. The rotatable platform is within the housing. The fluid containers are located on the rotatable platform. Each fluid container holds a corresponding one of the plurality of fluid samples, and has an input window and an output window. The light source provides an input beam for transmission into the input windows of the fluid containers and through the corresponding fluid samples. The input beam creates a forward-scatter signal associated with the concentration of bacteria. The motor rotates the rotatable platform so that the input beam sequentially passes through each fluid sample. A sensor within the housing detects the forward-scatter signal exiting from the output window associated with the fluid sample receiving the input beam.

公开(公告)号：EP3077796A4

公开(公告)日：2017-08-23

申请号：EP14868069

申请日：2014-12-03

Applicant: BACTERIOSCAN LTD

Inventor： REGELMAN DAN VADIM

IPC: G01N21/17 ,  G01N21/49 ,  G01N21/64 ,  G02B21/14

CPC classification number: G01N21/51 ,  E21B47/102 ,  G01N21/0303 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6478 ,  G02B21/14

Abstract: The present invention is an optical measurement system for measuring a liquid sample within a well. The system comprises a light source configured to transmit light though the well, a detector configured to measure optical signals derived from the transmitted light, and a tunable optical element. The tunable optical element is positioned between the light source and the well. The tunable optical element is operable to shape the light to compensate for distortions induced by a surface of the liquid sample. The detector is preferably located below the well for receiving a forward scatter signal indicative of at least one characteristic of the particles within the liquid sample.

Abstract translation: 本发明是一种用于测量井内液体样品的光学测量系统。 该系统包括被配置为通过井传输光的光源，被配置为测量从透射光得到的光信号的检测器以及可调光学元件。 可调谐光学元件位于光源和阱之间。 可调谐光学元件可操作用于成形光以补偿由液体样本的表面引起的失真。 检测器优选位于井下方，用于接收指示液体样品内的颗粒的至少一个特征的前向散射信号。

公开(公告)号：EP2238233B1

公开(公告)日：2020-05-06

申请号：EP08867370.2

申请日：2008-12-24

Applicant: Bacterioscan Ltd.

Inventor： WEICHSELBAUM, Amnon ,  DE LA ZERDA, Jaime ,  REGEV, Issakhar

IPC: C12M1/34 ,  G01N21/03 ,  G01N21/51 ,  G01N33/493 ,  G01N21/47

公开(公告)号：EP3240635A1

公开(公告)日：2017-11-08

申请号：EP15875348.3

申请日：2015-12-29

Applicant: Bacterioscan Ltd.

Inventor： MARSHALL, Dana, A. ,  BECKMANN, Robert, W.

IPC: B01L3/02 ,  G01N35/10

CPC classification number: B01L3/0275 ,  B01L2300/0681 ,  B01L2400/0605

Abstract: The present invention is a pipette-filtration assembly having a main body defining a first channel, a second channel, a first valve, and a second valve. The first valve is associated with the first channel and permits flow in a first direction while substantially hindering flow in a second direction. The second valve is associated with the second channel and permits flow in the second direction while substantially hindering flow in the first direction. At least one filter is used to filter a fluid sample as the fluid sample flows in the first direction and/or the second direction. The pipette-filtration assembly is preferably disposable and includes one or two stages of integral filtration, primarily for use with an air-displacement pipetting or transfer system.

公开(公告)号：EP1960532B1

公开(公告)日：2011-07-27

申请号：EP06821599.5

申请日：2006-11-29

Applicant: Bacterioscan Ltd.

Inventor： WEICHSELBAUM, Amnon ,  DE LA ZERDA, Jaime

IPC: C12Q1/68 ,  C12Q1/04

CPC classification number: G01N21/51 ,  B01L3/50 ,  B01L3/508 ,  B01L2300/04 ,  B01L2300/0809 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/10 ,  C12Q1/18 ,  G01N21/03 ,  G01N21/49 ,  G01N33/4875 ,  G01N33/493 ,  G01N2015/0693 ,  G01N2021/0346 ,  G01N2021/0389 ,  G01N2021/513

Abstract: A method for detecting and counting particles suspended in fluids, such as bacteria suspended in urine, utilizing dynamic features of the suspended particles and employing light scattering measurements. The disclosed method is suitable for determining the susceptibility of bacteria to antibiotics. A cuvette for detecting bacteria in fluids, which is especially suited for the light scattering measurements, is provided.

公开(公告)号：EP2238233A2

公开(公告)日：2010-10-13

申请号：EP08867370.2

申请日：2008-12-24

Applicant: Bacterioscan Ltd.

Inventor： WEICHSELBAUM, Amnon ,  DE LA ZERDA, Jaime ,  REGEV, Issakhar

IPC: C12M1/34

CPC classification number: G01N21/51 ,  G01N21/0303 ,  G01N33/493 ,  G01N2021/0382 ,  G01N2021/4769 ,  G01N2021/479 ,  G01N2021/513 ,  G01N2201/064

Abstract: System and method for detecting and counting bacteria suspended in a biological fluid by means of light scattering measurements is provided. In accordance with the method of the invention the level of signal to noise of the measured intensities of light scattered by a sample of the biological fluid is significantly enhanced for forwardly scattered light within a range of scattering angles which are smaller compared to a predefined maximal scattering angle. The system of the invention includes a cuvette adapted to contain a sample of the biological fluid whose sidewalls and windows are suitably constructed and arranged to significantly reduce the level of reflected light obscuring the scattering patterns measured within the range of scattering angles considered.

公开(公告)号：EP3227664A4

公开(公告)日：2018-07-25

申请号：EP15865075

申请日：2015-12-04

Applicant: BACTERIOSCAN LTD

Inventor： MARSHALL DANA A ,  MCMINN THEODORE S ,  REGELMAN DAN VADIM

IPC: G01N21/51 ,  G01N21/03

CPC classification number: G01N21/51 ,  G01N21/0332 ,  G01N2021/4707

Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The light source and sensor are on a bench that is on a translational or rotational mechanical platform such that optical beam can be moved to multiple sample containers. The instrument can be used for taking measurements of organism concentration in multiple samples as a production tool for microbiology. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples during the test. In another aspect, the instrument can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.

公开(公告)号：EP3077794A4

公开(公告)日：2017-12-13

申请号：EP14868105

申请日：2014-12-04

Applicant: BACTERIOSCAN LTD

Inventor： MARSHALL DANA A ,  MCMINN THEODORE S ,  REGELMAN DAN VADIM

IPC: G01N21/03 ,  B01L3/00 ,  G01N21/51

CPC classification number: B01L3/50255 ,  B01L3/50853 ,  B01L2200/0684 ,  B01L2300/022 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/045 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2400/0683 ,  G01N21/51 ,  G01N2021/513

Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly comprises a main body having internal walls and external walls, and a plurality of cuvettes within the main body at least partially being defined by the internal walls. Each of the plurality of cuvettes has a liquid-input chamber for receiving a respective one of the plurality of liquid samples, a filter, and an optical chamber for receiving a respective filtered liquid sample caused by passing the respective one of the plurality of liquid samples through the filter. Each of the optical chambers includes an entry window for allowing transmission of an input light beam through the filtered liquid sample and an exit window for transmitting a forward scatter signal caused by the particles within the filtered liquid sample.

公开(公告)号：EP3227664A1

公开(公告)日：2017-10-11

申请号：EP15865075.4

申请日：2015-12-04

Applicant: Bacterioscan Ltd.

Inventor： MARSHALL, Dana A. ,  MCMINN, Theodore S. ,  REGELMAN, Dan Vadim

IPC: G01N21/00

CPC classification number: G01N21/51 ,  G01N21/0332 ,  G01N2021/4707

Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The light source and sensor are on a bench that is on a translational or rotational mechanical platform such that optical beam can be moved to multiple sample containers. The instrument can be used for taking measurements of organism concentration in multiple samples as a production tool for microbiology. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples during the test. In another aspect, the instrument can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.

Abstract translation: 光学测量仪器是一种集成仪器，其包括具有光源的光腔，样本比色杯和光学传感器。 光源和传感器位于平移或旋转机械平台上的工作台上，使得光束可以移动到多个样品容器。 该仪器可用于测量多个样品中的生物体浓度，作为微生物学的生产工具。 优选地，仪器保持多个独立加载的独立流体样品并通过前向散射信号确定细菌浓度。 该仪器可以结合板载培养以促进试验期间样品中的细菌生长。 在另一方面，仪器可以是用于医学诊断测试数据的网络的一部分，其中数据以固有地由患者可识别信息无法识别的方式存储。