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    MUSCLE TREATMENT METHOD USING MYOD MUTANT
    42.
    发明申请
    MUSCLE TREATMENT METHOD USING MYOD MUTANT 审中-公开

    公开(公告)号：US20200338134A1

    公开(公告)日：2020-10-29

    申请号：US16858762

    申请日：2020-04-27

    Applicant: Cleveland State University

    Inventor： Crystal M. Weyman

    IPC: A61K35/34 ,  A61K9/00 ,  C12N15/85

    Abstract: A method for treating a patient with a muscle condition includes transplanting multipotent cells into the patient. A MyoD mutant that has been modified (e.g., to decrease PUMA expression relative to myogenin expression) has been transferred into the multipotent cells. The modification may lead to decreased apoptosis relative to differentiation. The transplantation may be local (i.e., directly to the muscle).

    3D-PRINTED MINIATURE BIOLOGICAL CONSTRUCTS
    43.
    发明申请
    3D-PRINTED MINIATURE BIOLOGICAL CONSTRUCTS 审中-公开

    公开(公告)号：US20170198275A1

    公开(公告)日：2017-07-13

    申请号：US15404291

    申请日：2017-01-12

    Applicant: Cleveland State University

    Inventor： Moo-Yeal Lee

    IPC: C12N11/04 ,  C12Q1/02

    CPC classification number: C12N11/04 ,  C12N5/0671 ,  C12N2513/00 ,  C12N2533/74 ,  C12Q1/02 ,  G01N33/5005

    Abstract: A method of creating a miniature multicellular biological construct and a method for studying cellular environments using the miniature multicellular biological construct is provided. The method for making the miniature multicellular biological construct includes suspending cells in a hydrogel, depositing the cell-suspension into a microwell, gelling the cell-suspension, and incubating the cell-suspension. The method for studying cellular environments includes imaging the miniature multicellular biological construct.

    SCALING AND PARAMETERIZING A CONTROLLER
    44.
    发明申请
    SCALING AND PARAMETERIZING A CONTROLLER 有权
    扩展和参数控制器

    公开(公告)号：US20150261210A1

    公开(公告)日：2015-09-17

    申请号：US14723709

    申请日：2015-05-28

    Applicant: Cleveland State University

    Inventor： Zhiqiang Gao

    IPC: G05B19/416 ,  G05B15/02

    CPC classification number: G05B13/024 ,  G05B5/01 ,  G05B11/42 ,  G05B13/042 ,  G05B15/02 ,  G05B19/416 ,  G05B2219/33347

    Abstract: Controller scaling and parameterization are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also applies to state feedback and state observer based controllers, as well as linear active disturbance rejection controllers. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the application. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

    Abstract translation: 描述控制器缩放和参数化。 可以通过使用缩放和参数化来改进的技术包括但不限于控制器设计，调整和优化。 这里描述的缩放和参数化方法适用于基于传递函数的控制器，包括PID控制器。 参数化方法也适用于状态反馈和基于状态观察器的控制器，以及线性有源扰动抑制控制器。 要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定申请的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

    Secure hierarchical processing using a secure ledger
    46.
    发明授权
    Secure hierarchical processing using a secure ledger 有权

    公开(公告)号：US12045289B2

    公开(公告)日：2024-07-23

    申请号：US17199345

    申请日：2021-03-11

    Applicant: Cleveland State University

    Inventor： Wenbing Zhao

    IPC: G06F16/903 ,  G06F16/18 ,  G06F21/44

    CPC classification number: G06F16/90335 ,  G06F16/1805 ,  G06F21/44

    Abstract: Disclosed is a system and method for processing data using blockchain technology. The system includes a memory having programmable instructions stored thereon that, when executed by a processor, cause the system to: authenticate one or more sensors in anticipation of receiving component data; receive component data, upon successful authentication; store the component data locally or to a cloud-based server and/or calculate a root value for the component data; store or embed the root value with the stored component data; condense the component data and link the condensed component data to the stored component data via the root value. The system further includes instructions to log the condensed data, including the root value, to a ledger, and to identify a tag or transaction id corresponding to the logging event for subsequent retrieval of the condensed data using the tag or transaction id.

    PERFUSION PLATE FOR MICROARRAY 3D BIOPRINTING
    49.
    发明申请
    PERFUSION PLATE FOR MICROARRAY 3D BIOPRINTING 有权

    公开(公告)号：US20210123007A1

    公开(公告)日：2021-04-29

    申请号：US17078742

    申请日：2020-10-23

    Applicant: Cleveland State University

    Inventor： Moo-Yeal Lee

    IPC: C12M3/00 ,  C12M1/12 ,  C12M1/00 ,  G01N33/50 ,  C12M1/32 ,  C12N5/071

    Abstract: A perfusion plate that can be combined with pillar plates containing cell layers is disclosed. The perfusion plate can have an inflow reservoir and an outflow reservoir connected by at least one channel, which fluidly connects the perfusion wells to the reservoirs for the flow of a fluid such as growth media. A perfusion plate can be part of an assembly containing a pillar plate, a lid, and a transparent bottom for visualizing cell growth in the perfusion wells. The perfusion-pillar plate assembly can facilitate perfusion-based tissue culture and tissue communication for high throughput, high-content, drug screening.

    SYSTEM AND METHOD FOR IMPROVING HEALTHCARE THROUGH COMMUNITY ENGAGEMENT
    50.
    发明申请
    SYSTEM AND METHOD FOR IMPROVING HEALTHCARE THROUGH COMMUNITY ENGAGEMENT 有权

    公开(公告)号：US20210118558A1

    公开(公告)日：2021-04-22

    申请号：US17072984

    申请日：2020-10-16

    Applicant: Cleveland State University

    Inventor： William A. MATCHAM

    IPC: G16H40/20 ,  G16H10/20 ,  G16H50/70 ,  G16H10/40 ,  G16H50/80 ,  G16H80/00 ,  G06Q10/10 ,  G16H10/60 ,  G06F21/62 ,  G06F16/9535 ,  A61B5/00 ,  G06F3/0482 ,  H04L29/06

    Abstract: Methods and systems for improving healthcare through community engagement are provided. In one embodiment, a method includes initializing a community health application on a computing device for an engagement session with a candidate patient. A client identification sequence is performed using the application to enroll the candidate patient as a new community health client or lookup the candidate patient as an existing community health client. Certain client information is collected from the community health client via interaction with the computing device by a healthcare facilitator during the engagement session. The community health application controlling the computing device by presenting displays and reading data in relation to the displays. The client information is processed to select a clinical sequence for the engagement session with the community health client based on the client information. In another embodiment, the method is directed to processing and distribution of the client information to third parties.

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