公开(公告)号：AU7165701A

公开(公告)日：2002-01-14

申请号：AU7165701

申请日：2001-06-29

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： WALKER CRAIG S ,  SHETTY RESHMA ,  JIMINEZ ELSIE C ,  MCINTOSH J MICHAEL ,  OLIVERA BALDOMERO M ,  WATKINS MAREN ,  JONES ROBERT M ,  SHEN GREG S

IPC: C07K14/435

公开(公告)号：AU7366000A

公开(公告)日：2001-04-10

申请号：AU7366000

申请日：2000-09-08

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  GARRETT JAMES E ,  WALKER CRAIG S ,  WATKINS MAREN ,  JONES ROBERT M

IPC: C12N15/09 ,  A61K38/00 ,  A61P3/08 ,  A61P9/00 ,  A61P9/10 ,  A61P13/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/36 ,  A61P27/02 ,  A61P31/18 ,  A61P33/00 ,  A61P39/00 ,  C07K7/02 ,  C07K7/08 ,  C07K14/435 ,  C07K5/00 ,  C07H21/02 ,  G01N33/53

Abstract: The invention relates to gamma-carboxyglutamate containing conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

公开(公告)号：CA2385047A1

公开(公告)日：2001-03-29

申请号：CA2385047

申请日：2000-09-21

Applicant: COGNETIX INC

Inventor： JONES ROBERT R ,  MCCABE R TYLER ,  CORNELL-BELL ANN H ,  LAYER RICHARD T ,  TEMPLE DAVIS L JR ,  PEMBERTON KAREN E

IPC: A61K38/00 ,  A61P9/10 ,  A61P11/06 ,  A61P27/02 ,  A61P43/00 ,  C07K14/435 ,  C07K14/00 ,  C07K14/35

Abstract: The invention relates to uses of kappa-conotoxin PVIIA (.kappa.-PVIIA), analogs and derivatives for activating ATP-sensitive K+ channels. The activation of ATP-sensitive K+ channels is useful for opening KATP channels which can be used to treat a wide range of disease and injury states, including cerebral and cardiac ischemia and asthma.

公开(公告)号：AU5474200A

公开(公告)日：2001-01-02

申请号：AU5474200

申请日：2000-06-09

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  MCCABE R TYLER ,  GARRETT JAMES E ,  LAYER RICHARD T ,  WAGSTAFF JOHN D ,  JONES ROBERT M

IPC: C12N15/09 ,  A61K38/00 ,  A61P23/02 ,  A61P25/02 ,  A61P29/00 ,  C07K14/435 ,  C12N15/12 ,  C07K14/00

Abstract: The present invention is directed to the new mu O-conopeptides, their coding sequences and their propeptides and to the use of mu O-conopeptides as a local anesthetic for treating pain. The mu O-conopeptides have long lasting anesthetic activity and are particularly useful for spinal anesthesia, either administered acutely for post-operatively pain or via an intrathecal pump for severe chronic pain situations or for treatment of pain in epithelial tissue.

公开(公告)号：AU727196B2

公开(公告)日：2000-12-07

申请号：AU3886197

申请日：1997-07-21

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC ,  SALK INST

Inventor： ABOGADIE FE C ,  CRUZ LOURDES J ,  OLIVERA BALDOMERO M ,  WALKER CRAIG ,  COLLEDGE CLARK ,  HILLYARD DAVID R ,  JIMENEZ ELSIE ,  LAYER RICHARD T ,  ZHOU LI-MING ,  SHEN GREGORY S ,  MCCABE R TYLER ,  RIVIER JEAN E

IPC: A61P25/04 ,  A61K38/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C12N15/09 ,  C12Q1/68 ,  C07K5/00 ,  C07K14/00 ,  C07H21/02 ,  C07H21/04

Abstract: The present invention is directed to conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more gamma-carboxyglutamic acid residues. The conantokins are useful for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents.

公开(公告)号：CA2361138A1

公开(公告)日：2000-07-27

申请号：CA2361138

申请日：2000-01-21

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： MCINTOSH J MICHAEL ,  HILLYARD DAVID R ,  JONES ROBERT M ,  OLIVERA BALDOMERO M ,  WATKINS MAREN ,  LAYER RICHARD T ,  SCHOENFELD ROBERT

IPC: C12N15/09 ,  A61K38/00 ,  A61P21/02 ,  A61P27/02 ,  C07K7/08 ,  C07K14/435 ,  C07K14/46 ,  C12N15/12 ,  A61P21/00 ,  C07K7/06 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16

Abstract: The invention relates to relatively short peptides (termed .alpha.-conotoxin s herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The .alpha.-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.

公开(公告)号：AU3886197A

公开(公告)日：1998-02-10

申请号：AU3886197

申请日：1997-07-21

Applicant: COGNETIX INC ,  SALK INSTITUTE THE ,  UNIV UTAH RES FOUND

Inventor： ABOGADIE FE C ,  CRUZ LOURDES J ,  OLIVERA BALDOMERO M ,  WALKER CRAIG ,  COLLEDGE CLARK ,  HILLYARD DAVID R ,  JIMENEZ ELSIE ,  LAYER RICHARD T ,  ZHOU LI-MING ,  SHEN GREGORY S ,  MCCABE R TYLER ,  RIVIER JEAN E

IPC: A61P25/04 ,  A61K38/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C12N15/09 ,  C12Q1/68 ,  C07K5/00 ,  C07K14/00 ,  C07H21/02 ,  C07H21/04

Abstract: The present invention is directed to conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more gamma-carboxyglutamic acid residues. The conantokins are useful for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents.

公开(公告)号：CA2527317A1

公开(公告)日：2004-12-16

申请号：CA2527317

申请日：2004-06-04

Applicant: COGNETIX INC

Inventor： OLIVERA BALDOMERO M ,  BULAJ GRZEGORZ

IPC: C07K14/435 ,  C12N20060101 ,  C40B40/10 ,  C40B50/02 ,  C40B50/06 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68 ,  G06F19/00

Abstract: The invention includes a method of assaying phylogenetically related sequenc es and generating a set of possible nucleic acid or amino acid sequence combinations. Sequences are analyzed to create an alignment and a set of phylogenetically related sequences are selected. The observed residue(s) or indel(s) occupying each position in the alignment of the selected phylogenetically related sequences are identified and this information is us ed to generate a set of sequence combinations, wherein the set of possible sequence combinations (nucleic acid or polypeptide) is composed of the union of the observed residues or indels identified at each position.

公开(公告)号：AU778353B2

公开(公告)日：2004-12-02

申请号：AU2732700

申请日：2000-01-21

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： OLIVERA BALDOMERO M ,  LAYER RICHARD T ,  WATKINS MAREN ,  HILLYARD DAVID R ,  MCINTOSH J MICHAEL ,  JONES ROBERT M ,  SCHOENFELD ROBERT

IPC: C12N15/09 ,  A61K38/00 ,  A61P21/02 ,  A61P27/02 ,  C07K7/08 ,  C07K14/435 ,  C07K14/46 ,  C12N15/12

Abstract: The invention relates to relatively short peptides (termed alpha-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The alpha-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.

公开(公告)号：AU778182B2

公开(公告)日：2004-11-18

申请号：AU7596800

申请日：2000-09-21

Applicant: COGNETIX INC

Inventor： CORNELL-BELL ANN H ,  PEMBERTON KAREN E ,  TEMPLE DAVIS L JR ,  LAYER RICHARD T ,  MCCABE R TYLER ,  JONES ROBERT R

IPC: A61K38/00 ,  A61P9/10 ,  A61P11/06 ,  A61P27/02 ,  A61P43/00 ,  C07K14/435 ,  C07K14/00 ,  C07K14/35