Abstract:
A scanning photometer and attendant methods are provided. The scanning photometer is generally characterized by first and second fluorophore excitation sources, an objective lens, and a common emission detector for the detection of first and second fluorophore emission originating from the excitation of the fluorophores via passage of excitation energy, via an optical path of the objective lens, from the excitation sources. Excitation energy and emission energy conditioning elements are likewise provided, operatively interposed before or after the objective lens as the case may be.
Abstract:
A controller configured to control one or more of aspiration and dispensing of a primary fluid by an aspirate-dispense apparatus, the aspirate-dispense apparatus comprising a secondary fluid in working communication with the primary fluid, wherein the controller is configured to: receive measurement signalling for a monitored flow parameter of the secondary fluid; determine, using calibration data, a volume of aspirated or dispensed primary fluid based on the received measurement signalling, the calibration data defining a relationship between the volume of aspirated or dispensed primary fluid and the monitored flow parameter of the secondary fluid; and control the flow of primary or secondary fluid based on the determined volume to aspirate or dispense a specific volume of primary fluid.
Abstract:
Some embodiments include a scanning module with an optical reader coupled to a moveable carriage configured to move the optical reader in a first direction. In some embodiments, the optical reader includes excitation sources, emission detectors, emission energy conditioning elements, and a tape drive configured and arranged to selectively advance a tape in a second direction which is substantially perpendicular to the first direction. Further, some embodiments include a bar code reading station positioned adjacent to the moveable carriage. Other embodiments include an objective lens.
Abstract:
Embodiments of the invention provide a filter kit including filters for processing a biological sample. Some embodiments include a filter cap in a tube kit with a first tube containing a buffer solution and a second tube containing a lyophilized master mix. Some embodiments include a method of processing a sample using the kit including mixing a biological sample in a first tube with the buffer solution, positioning the filter cap in the first tube, positioning a second tube on the filter cap, flipping the first tube, the filter cap, and the second cap to filter the biological sample and buffer solution mixture with the filter cap as it flows from the first tube to the second tube. Some embodiments include structure enabling transfer of materials through inline flow between the tubes. Some further embodiments include integrated structure for sample pulverization with integrated buffer and lyophilized master mix.
Abstract:
Some embodiments include a scanning module with an optical reader coupled to a moveable carriage configured to move the optical reader in a first direction. In some embodiments, the optical reader includes excitation sources, emission detectors, emission energy conditioning elements, and a tape drive configured and arranged to selectively advance a tape in a second direction which is substantially perpendicular to the first direction. Further, some embodiments include a bar code reading station positioned adjacent to the moveable carriage. Other embodiments include an objective lens.
Abstract:
A scanning photometer and attendant methods are provided. The scanning photometer is generally characterized by first and second fluorophore excitation sources, an objective lens, and a common emission detector for the detection of first and second fluorophore emission originating from the excitation of the fluorophores via passage of excitation energy, via an optical path of the objective lens, from the excitation sources. Excitation energy and emission energy conditioning elements are likewise provided, operatively interposed before or after the objective lens as the case may be.
Abstract:
A tape adaptor (8) includes a bottom plate (20) and a top plate (60) mounted to the bottom plate (20) with a space (40) defined between an upper side wall (26) of the bottom plate (20) and a lower face (68) of the top plate (60) for receiving a tape segment (100) remaining on or cut from a continuous array tape (10). The tape segment (100) includes an array of wells (54) between two edges (52). A slit (46) is formed between an end (62) of the top plate (60) and an end (22) of the bottom plate (20). The tape segment (100) is slideably extended through the slit (46) into the space (40) with the edges (52) sliding on two ridges (38) on two longitudinal edges (36) of the bottom plate (20). The bottom plate (20) can include at least one groove (30) to receive the array of wells (54) of the tape segment (100). The tape segment (100) is positioned relative to the tape adaptor (8) by the ridges (38) or the groove (30).
Abstract:
A scanning photometer and attendant methods are provided. The scanning photometer is generally characterized by first and second fluorophore excitation sources, an objective lens, and a common emission detector for the detection of first and second fluorophore emission originating from the excitation of the fluorophores via passage of excitation energy, via an optical path of the objective lens, from the excitation sources. Excitation energy and emission energy conditioning elements are likewise provided, operatively interposed before or after the objective lens as the case may be.
Abstract:
An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.
Abstract:
A high throughput biological sample processing system includes a sample carrier with a plurality of wells that progresses through the high throughput biological sample processing system. The system further includes a sample dispensing module, a reagent dispensing module, an accumulation/incubation module, and a detection module. The detection module employs an optical measuring device to encapsulate a biological sample in one of the plurality of wells of the sample carrier and detect energy from the chemistry of the biological sample to determine the amount of an analyte in the biological sample.