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    Method and device for identification of a substance
    42.
    发明授权
    Method and device for identification of a substance 有权
    物质鉴别方法和装置

    公开(公告)号：US06537499B1

    公开(公告)日：2003-03-25

    申请号：US09315804

    申请日：1999-05-21

    Applicant: Andre Bernard ,  Hans Biebuyck ,  Emmanuel Delamarche ,  Bruno Michel ,  Heinz Schmid

    Inventor： Andre Bernard ,  Hans Biebuyck ,  Emmanuel Delamarche ,  Bruno Michel ,  Heinz Schmid

    IPC: G01N2147

    CPC classification number: G01N13/02 ,  Y10S977/853 ,  Y10T436/11

    Abstract: A method and also a device is proposed for identification of a substance, preferably comprising biochemical molecules. In a first step a probe and said substance will be brought into contact, afterwards in a second step the probe and said substance will be withdrawn from each other, while measuring the value of at least one physical parameter characterizing the interaction between said probe and said substance and comparing said measured value with a reference value for identification.

    Abstract translation: 提出了一种方法和装置，用于鉴定物质，优选包括生化分子。 在第一步骤中，探针和所述物质将被接触，然后在第二步骤中，探针和所述物质将彼此撤回，同时测量表征所述探针和所述物质之间的相互作用的至少一个物理参数的值 物质，并将所述测量值与用于鉴定的参考值进行比较。

    Method for printing a catalyst on substrates for electroless deposition
    43.
    发明授权
    Method for printing a catalyst on substrates for electroless deposition 有权
    用于在基板上印刷催化剂用于无电沉积的方法

    公开(公告)号：US06521285B1

    公开(公告)日：2003-02-18

    申请号：US09763180

    申请日：2001-06-27

    Applicant: Hans Biebuyck ,  Emmanuel Delamarche ,  Matthias Geissler ,  Hannes Kind ,  Bruno Michel

    Inventor： Hans Biebuyck ,  Emmanuel Delamarche ,  Matthias Geissler ,  Hannes Kind ,  Bruno Michel

    IPC: B05D310

    CPC classification number: G03F7/0002 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  C23C18/1608 ,  C23C18/1657 ,  H05K3/182

    Abstract: Methods for electroless deposition of conductive material on a substrate using in both cases a stamp having a patterned surface which is pressed onto the surface of a substrate for printing the substrate and providing a pattern of a catalyst on the substrate on which metal deposition occurs in the course of electroless deposition by immersing the printed substrate in a plating bath are provided. In one case, the stamp is pretreated to render the pattern of the stamp wettable with a catalytic ink which is transformed to the surface of the substrate. In the other case, a catalytic layer is provided on the surface of the substrate which is patterned by the stamp transferring a resist material onto the catalytic layer so that a subsequent etching process lays open the desired pattern of the catalytic layer for electroless deposition.

    Abstract translation: 导电材料在基板上无电沉积的方法，使用两种情况下具有图案化表面的印模，该图案被压在基板的表面上以印刷基板并在基板上提供催化剂图案，在基板上发生金属沉积 提供了将印刷基板浸渍在镀浴中的无电沉积过程。 在一种情况下，对印模进行预处理，以将印模的图案用可转移到基材表面的催化墨水润湿。 在另一种情况下，在衬底的表面上提供催化层，其通过将抗蚀剂材料转移到催化剂层上的印模进行图案化，使得随后的蚀刻工艺打开用于无电沉积的催化剂层的期望图案。

    Detection of an analyte in a sample
    44.
    发明授权
    Detection of an analyte in a sample 有权
    检测样品中的分析物

    公开(公告)号：US09012136B2

    公开(公告)日：2015-04-21

    申请号：US12742996

    申请日：2008-10-30

    Applicant: Emmanuel Delamarche ,  Daniel J. Solis

    Inventor： Emmanuel Delamarche ,  Daniel J. Solis

    IPC: C12Q1/00 ,  C12Q1/70 ,  C12Q1/68 ,  G01N33/53 ,  A61K49/00 ,  G01N33/543 ,  G01N33/536 ,  B01L3/00

    CPC classification number: G01N33/56983 ,  B01L3/502753 ,  B01L3/502761 ,  B01L3/5029 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/086 ,  G01N2333/11

    Abstract: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product.

    Abstract translation: 提供了用于检测样品中的分析物的机制。 这些机构利用至少第一测量通道，其包含对应于待检测分析物的检测反应物，以及至少与第一测量通道相关联的微结构。 当机构使用时，将样品引入第一测量通道并且通过第一测量通道朝向微结构传播。 如果分析物存在于样品中，则分析物与检测反应物相互作用以形成网络产物，并且微结构被配置为过滤网络产物。

    Multilayer microfluidic probe head and method of fabrication thereof
    45.
    发明授权
    Multilayer microfluidic probe head and method of fabrication thereof 有权
    多层微流体探针头及其制造方法

    公开(公告)号：US08695641B2

    公开(公告)日：2014-04-15

    申请号：US13561656

    申请日：2012-07-30

    Applicant: Emmanuel Delamarche ,  Ute Drechsler ,  Robert Lovchik

    Inventor： Emmanuel Delamarche ,  Ute Drechsler ,  Robert Lovchik

    IPC: F15C1/06

    CPC classification number: B01J19/0046 ,  B01J2219/00367 ,  B01J2219/00527 ,  B01J2219/00743 ,  B01L3/0241 ,  B01L3/502707 ,  B01L2300/0874 ,  B01L2300/0887 ,  Y10T29/494 ,  Y10T137/0318 ,  Y10T137/0402 ,  Y10T137/2224 ,  Y10T137/8359 ,  Y10T137/8593 ,  Y10T137/87153 ,  Y10T137/87885

    Abstract: A microfluidic probe head includes a first layer, a second layer, and a first tubing port extending from an upper face of the first layer. The first layer has a first via, enabling fluid communication between the first port and a lower face of the first layer. The second layer includes a first aperture on a face, and a first microchannel enabling fluid communication between an upper face of the second layer, facing the lower face of the first layer, and the first aperture. The head enables fluid communication between the first via and the first microchannel. At least a portion of the first microchannel is a groove open on the upper face of the second layer, closed by a portion of a lower face of a layer of the head. The probe head further comprises a second tubing port, a second via, a second aperture and a second microchannel.

    Abstract translation: 微流体探针头包括从第一层的上表面延伸的第一层，第二层和第一管口。 第一层具有第一通孔，使得能够在第一端口和第一层的下表面之间进行流体连通。 第二层包括面上的第一孔，以及第一微通道，其使第二层的上表面与第一层的下表面和第一孔之间能够流体连通。 头部使得第一通孔和第一微通道之间能够流体连通。 第一微通道的至少一部分是在第二层的上表面上开口的凹槽，由头部的一层的下表面的一部分封闭。 探头还包括第二管口，第二通孔，第二孔和第二微通道。

    Method and apparatus for surface treatment
    47.
    发明授权
    Method and apparatus for surface treatment 有权
    表面处理方法和装置

    公开(公告)号：US08268563B2

    公开(公告)日：2012-09-18

    申请号：US10539726

    申请日：2003-11-13

    Applicant: Sergey Amontov ,  Emmanuel Delamarche ,  Bruno Michel

    Inventor： Sergey Amontov ,  Emmanuel Delamarche ,  Bruno Michel

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: G01N33/54366

    Abstract: A method for producing a monolayer of molecules on a surface comprises: loading a stamp with seed molecules; transferring seed molecules from the stamp to the surface; and, amplifying the seed molecules via an amplifying reaction to produce the monolayer. The method permit generation of complete monolayers from incomplete or sparse monolayers initially printed on the surface.

    Abstract translation: 在表面上产生单层分子的方法包括：用种子分子装载印模; 将种子分子从印模转移到表面; 并通过扩增反应扩增种子分子以产生单层。 该方法允许从最初印刷在表面上的不完全或稀疏单层产生完整的单层。

    Detection of an Analyte in a Sample
    48.
    发明申请
    Detection of an Analyte in a Sample 有权
    检测样品中的分析物

    公开(公告)号：US20120214153A1

    公开(公告)日：2012-08-23

    申请号：US13459764

    申请日：2012-04-30

    Applicant: Emmanuel Delamarche ,  Daniel J. Solis

    Inventor： Emmanuel Delamarche ,  Daniel J. Solis

    IPC: C12Q1/70 ,  G01N33/566 ,  C12Q1/02 ,  G01N21/00

    CPC classification number: G01N33/56983 ,  B01L3/502753 ,  B01L3/502761 ,  B01L3/5029 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/086 ,  G01N2333/11

    Abstract: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product.

    Abstract translation: 提供了用于检测样品中的分析物的机制。 这些机构利用至少第一测量通道，其包含对应于待检测分析物的检测反应物，以及至少与第一测量通道相关联的微结构。 当机构使用时，将样品引入第一测量通道并且通过第一测量通道朝向微结构传播。 如果分析物存在于样品中，则分析物与检测反应物相互作用以形成网络产物，并且微结构被配置为过滤网络产物。

    One-step flow control for crossing channels
    49.
    发明授权
    One-step flow control for crossing channels 失效
    跨越通道的一步式流量控制

    公开(公告)号：US08020586B2

    公开(公告)日：2011-09-20

    申请号：US12329550

    申请日：2008-12-06

    Applicant: Emmanuel Delamarche

    Inventor： Emmanuel Delamarche

    IPC: F15C1/04

    CPC classification number: F16K99/0001 ,  F16K31/086 ,  F16K99/0046 ,  F16K2099/0084 ,  Y10T137/2213

    Abstract: In one embodiment of the present invention, an apparatus for one-step flow control at a micro-channel crossing comprises a first micro-channel and a second micro-channel, a plurality of magnetic valves, and a guiding magnet. The guiding magnet produces a proximal magnetic field gradient at a location of each of the plurality of magnetic valves when an operator places the guiding magnet in a vicinity of the chip. The vicinity of the chip comprises a plurality of guiding magnet position ranges. The operator repositions guiding magnet in order to actuate the plurality of magnetic valves simultaneously. Depending on the position of the guiding magnet, the passages are blocked or unblocked to stop or let the fluid flow in a given crossing.

    Abstract translation: 在本发明的一个实施例中，用于微通道交叉的一步流量控制的装置包括第一微通道和第二微通道，多个电磁阀和引导磁体。 当操作者将引导磁体放置在芯片附近时，引导磁体在多个电磁阀的每一个的位置处产生近端磁场梯度。 芯片附近包括多个引导磁体位置范围。 操作者重新引导磁体以同时致动多个电磁阀。 取决于导向磁体的位置，通道被阻塞或不阻挡以停止或使流体在给定的横穿中流动。

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