公开(公告)号：EP2149081A1

公开(公告)日：2010-02-03

申请号：EP08746006.9

申请日：2008-04-16

Applicant: Guava Technologies, Inc.

Inventor： CAPPIONE, Amedeo Joseph ,  LEFEBVRE, Ray ,  KILCOIN, Neil ,  KING, David Andrew ,  DIXON, George J.

IPC: G06F3/048

CPC classification number: G06F19/26 ,  G01N35/00722 ,  G01N2015/1402 ,  G01N2015/1477 ,  G01N2035/0091 ,  G06F3/04817

Abstract: A graphical user interface on a computer provides for the analysis of location specific data and the presentation of analysis results for visual comparison by a user. Results of the analysis are visually presented as icons subdivided into regions and arranged in such a way that the user is able to associate each icon with a data location. A visual presentation of results in the icons and regions allows a user to visually compare the analysis results in two or more data sets according to location. The graphical user interface further provides for the definition and adjustment of an analysis through the interaction of a user with a graphical representation of the analysis. In some cases, the visual presentation of results tracks the analysis adjustments so the user can visually observe the effects that the adjustments have on the results. A method of interacting with the interface to define an analysis and represent results and a method of presenting two or more data sets using the interface are described. The interface can be used to analyze and visually compare the results of location specific data from a number of sources and is illustrated in a flow cytometry application.

公开(公告)号：EP1397666B1

公开(公告)日：2007-11-07

申请号：EP02739288.5

申请日：2002-05-16

Applicant: Guava Technologies, Inc.

Inventor： KOCHY, Thomas, E. ,  O'NEILL, Roger, A. ,  SMILEY, Terah, W. ,  SMITH, Vidal, O.

IPC: G01N15/14 ,  G01N21/64

CPC classification number: G01N15/1459 ,  G01N15/1434 ,  Y10T436/11 ,  Y10T436/117497

Abstract: There is provided a flow cell assembly in which a shuttle supports and positions a capillary with its end extending beyond the shuttle. The flow cell assembly facilitates the replacement of a flow cell which is damaged or with flow cells having capillaries of different size or shape.

公开(公告)号：EP1397666A2

公开(公告)日：2004-03-17

申请号：EP02739288.5

申请日：2002-05-16

Applicant: Guava Technologies, Inc.

Inventor： KOCHY, Thomas, E. ,  O'NEILL, Roger, A. ,  SMILEY, Terah, W. ,  SMITH, Vidal, O.

IPC: G01N15/14 ,  G01N21/64

CPC classification number: G01N15/1459 ,  G01N15/1434 ,  Y10T436/11 ,  Y10T436/117497

Abstract: There is provided a flow cell assembly in which a shuttle supports and positions a capillary with its end extending beyond the shuttle. The flow cell assembly facilitates the replacement of a flow cell which is damaged or with flow cells having capillaries of different size or shape.

公开(公告)号：EP1957982A2

公开(公告)日：2008-08-20

申请号：EP06848541.6

申请日：2006-12-05

Applicant: Guava Technologies, Inc.

Inventor： TYAGARAJAN, Kamala ,  FISHWILD, Dianne, M. ,  KING, David, A.

IPC: G01N33/543 ,  G01N33/58

CPC classification number: G01N33/54346 ,  G01N33/582

Abstract: Methods for assaying a sample for an analyte are provided. In various embodiments, the methods comprise contacting a sample suspected of containing the analyte with a non-uniform particle comprising a capture molecule, and further contacting the particle with a detection moiety comprising a label that permits detection of the analyte when associated with the particle. The methods may be performed to detect and/or quantitate analyte in the sample. In some embodiments, the methods may be performed in an automated manner, and may use an optical and/or cytometric apparatus for performing the method(s). The methods may further be performed with automated vessel-processing apparatus(es), such as plate loaders, plate washers, etc. Also provided are complexes containing the described materials formed by an assay of the invention, including excited state complexes. Kits useful for performing such methods are also provided.

公开(公告)号：EP1664784A1

公开(公告)日：2006-06-07

申请号：EP04784342.0

申请日：2004-09-17

Applicant: Guava Technologies, Inc.

Inventor： DANIELZADEH, Robert ,  OLSON, Keith R.

IPC: G01N33/566

CPC classification number: G01N33/54306 ,  G01N33/54366 ,  G01N33/569 ,  G01N33/56983 ,  G01N33/582 ,  G01N33/585 ,  G01N33/6863 ,  G01N33/74

Abstract: Compositions and methods are provided for analyzing a sample for the presence or absence of one or more target analytes.

公开(公告)号：EP1334346A2

公开(公告)日：2003-08-13

申请号：EP01968506.4

申请日：2001-09-05

Applicant: Guava Technologies, Inc.

Inventor： GOIX, Philippe, J. ,  LINGANE, Paul, J. ,  PHI-WILSON, Janette, T.

IPC: G01N15/14 ,  B01L3/02 ,  G01N1/14

CPC classification number: G01N15/1404 ,  G01N21/64

Abstract: A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.

公开(公告)号：EP2005141A2

公开(公告)日：2008-12-24

申请号：EP07760400.7

申请日：2007-04-10

Applicant: Guava Technologies, Inc.

Inventor： ILKOV, Fedor, A.

IPC: G01N21/00

CPC classification number: G01N15/1404 ,  G01N2015/0053 ,  G01N2015/1415

Abstract: The present invention provides improved capillaries that lead to increased resolution in conventional capillary-flow cytometers. The cross-sectional shape of capillaries made according to the present invention lack a center of symmetry. In some embodiments, capillaries have inner side walls that are tilted at angles with respect to the collection-system optical axis so that the widest dimension of the inner bore is closest to the collection optical system and have an outer wall closest to the collection optical system with a dimension large enough to minimize the contribution of outer-wall refraction to the collected light signal. Exemplary capillary embodiments include tubes with a rectangular outer wall and a trapezoidal inner wall, a rectangular outer wall and a triangular inner wall, triangular outer and inner walls, a triangular outer wall with a trapezoidal inner wall, and a hemispherical or rhomboid outer wall and trapezoidal or triangular inner wall.

公开(公告)号：EP0988523A1

公开(公告)日：2000-03-29

申请号：EP98926490.8

申请日：1998-06-09

Applicant: Guava Technologies, Inc.

Inventor： GOIX, Philippe

IPC: G01N21/64

CPC classification number: G01N15/1484 ,  G01N15/1456 ,  G01N21/64 ,  G01N2021/0346

Abstract: A method and apparatus for detecting a fluorescent substance tagged to a microparticle are described. The device comprises a single capillary flow carrier system for transporting the microparticle past a a selected location, a source of electromagnetic radiation for irradiating the substance tagged to the microparticle, and a detection system for measuring fluorescent light emitted from the substance at the selected location. The method comprises transporting the microparticle to a selected location, irradiating a fluorescent substance tagged to the microparticle, and measuring the fluorescent light emitted from the fluorescent substance at the selected location.

公开(公告)号：EP2062056A2

公开(公告)日：2009-05-27

申请号：EP07843384.4

申请日：2007-09-27

Applicant: Guava Technologies, Inc.

Inventor： PITTARO, Richard ,  GOLDMAN, Bruce ,  LEFEBVRE, Ray ,  KING, David, A.

IPC: G01P3/36 ,  G01F1/36

CPC classification number: G01N15/14 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1486

Abstract: A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.

公开(公告)号：EP1539728A2

公开(公告)日：2005-06-15

申请号：EP03742373.8

申请日：2003-07-01

Applicant: Guava Technologies, Inc.

Inventor： O'NEILL, Roger ,  FISHER, Peter, V.

IPC: C07D311/80 ,  A61P43/00 ,  A61K31/35

CPC classification number: C09B11/08 ,  C09B11/06 ,  C09B11/24 ,  C09B11/28 ,  C09B23/083 ,  G01N33/542

Abstract: Fluorescent dyes, fluorescence energy transfer dye couples, multi-color dye sets, can be employed in art-recognized assays and certain novel methods, such as in proximity assays.