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公开(公告)号：ZA200405456B
公开(公告)日：2005-06-22
申请号：ZA200405456
申请日：2004-07-08
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： WILLEMSEN PETRUS THEODORUS JOH , BAKKER DOUWE , RUDOLFUS THOLE JELLE EGBERTUS , WESTERVEEN SJOUKJE FETSJE , SIJDERVELD FRED GOVERT VAN
IPC: A61K39/00 , A61K39/005 , A61K39/02 , A61K39/04 , A61K39/085 , G01N33/53 , A61K39/09 , A61K39/108 , A61K39/135 , A61K39/145 , A61K39/155 , A61K39/215 , A61K39/245 , A61P31/04 , A61P31/06 , A61P31/12 , C07K14/35 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12Q1/02 , C12Q1/04 , C12Q1/68 , G01N33/569 , G01N , C12N , C07K , C12Q , A61K
Abstract: The present invention relates to nucleic acid sequences encoding Mycobacterium avium subspecies paratuberculosis proteins, to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to Mycobacterium avium subspecies paratuberculosis proteins and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins or immunogenic parts thereof. Also, the invention relates to the use of said proteins in vaccines and for the manufacture of vaccines. Moreover, the inventions relates to the use of said nucleic acid sequences, proteins, or antibodies for diagnostic or vaccination purposes. Also, the invention relates to methods for the preparation of such vaccines. Finally the invention relates to diagnostic kits comprising such nucleic acids, proteins or antibodies against such proteins.
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公开(公告)号：NZ508982A
公开(公告)日：2003-07-25
申请号：NZ50898299
申请日：1999-06-17
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： PEETERS BERNARDUS PETRUS HUBER , DE LEEUW OLAV SVEN , KOCH GUUS , GIELKENS ARNOUD LEONARD JOSEF
IPC: C12N15/09 , A61K39/17 , A61K48/00 , A61P31/12 , C07K14/125 , C12N7/00 , C12N7/01 , C12N15/45 , C12N15/86 , C12Q1/70
Abstract: The invention relates to the process for generating infectious Newcastle disease virus (NDV) entirely from cloned full-length cDNA and to the use of vaccines and diagnostic assays generated with and derived from said process. The process offers the possibility to modify the NDV genome by means of genetic modification and allows the introduction of mutations, deletions, and/or insertions. The process can be used to modify the virulence of NDV, thereby generating new attenuated live vaccines with enhanced properties. The process can be used to modify the antigenic make-up of NDV, thus allowing the generation of live NDV marker vaccines which can be serologically distinguished from NDV field strains.
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公开(公告)号：CA2473226A1
公开(公告)日：2003-07-17
申请号：CA2473226
申请日：2003-01-13
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： BAKKER DOUWE , THOLE JELLE EGBERTUS RUDOLFUS , VAN ZIJDERVELD FRED GOVERT , WILLEMSEN PETRUS THEODORUS JOH , WESTERVEEN SJOUKJE FETSJE
IPC: G01N33/53 , A61K39/00 , A61K39/005 , A61K39/02 , A61K39/04 , A61K39/085 , A61K39/09 , A61K39/108 , A61K39/135 , A61K39/145 , A61K39/155 , A61K39/215 , A61K39/245 , A61P31/04 , A61P31/06 , A61P31/12 , C07K14/35 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12Q1/02 , C12Q1/04 , C12Q1/68 , G01N33/569 , C12N15/63
Abstract: The present invention relates to nucleic acid sequences encoding Mycobacteri um avium subspecies paratuberculosis proteins, to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cel ls comprising such nucleic acid sequences or such parts thereof. The invention also relates to Mycobacterium avium subspecies paratuberculosis proteins and immunogenic parts thereof encoded by such sequences. Furthermore, the presen t invention relates to vaccines comprising such nucleic acid sequences and par ts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins o r immunogenic parts thereof. Also, the invention relates to the use of said proteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, proteins or antibodies for diagnostic or vaccination purposes. Also, the invention relat es to methods for the preparation of such vaccines. Finally the invention relat es to diagnostic kits comprising such nucleic acids, proteins or antibodies against such proteins.
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公开(公告)号：IL153600D0
公开(公告)日：2003-07-06
申请号：IL15360001
申请日：2001-06-28
Applicant: ID LELYSTAD INST DIERHOUDERIJ
IPC: A61K38/00 , C12N15/09 , A61K39/00 , A61K39/12 , A61P31/04 , C07K14/135 , C07K14/18 , C07K14/185 , C07K16/10 , C12N15/40 , G01N33/569 , C12N
Abstract: The invention relates to peptides derived from or similar to the E protein of pestiviruses for type -specific diagnosis of infection, for eliciting antibiotic activity and for transport of substances into a cell. For among others these purposes the invention provides an isolated, synthetic or recombinant protein module or functional equivalent thereof comprising an amino acid sequence that is at least 75% identical to an amino acid sequence of a peptide located from at about amino acid position 194 to 220 in a pestiviral E protein.
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公开(公告)号：AU2002314610A1
公开(公告)日：2002-12-09
申请号：AU2002314610
申请日：2002-05-31
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： BOOT HENDRIK JOHANNIS
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Patent Agency Ranking
公开(公告)号：AU754844B2
公开(公告)日：2002-11-28
申请号：AU4399199
申请日：1999-06-17
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： PEETERS BERNARDUS PETRUS HUBER , LEEUW OLAV SVEN DE , KOCH GUUS , GIELKENS ARNOUD LEONARD JOSEF
IPC: C12N15/09 , A61K39/17 , A61K48/00 , A61P31/12 , C07K14/125 , C12N7/00 , C12N7/01 , C12N15/45 , C12N15/86 , C12Q1/70
Abstract: The invention relates to the process for generating infectious Newcastle disease virus (NDV) entirely from cloned full-length cDNA and to the use of vaccines and diagnostic assays generated with and derived from said process. The process offers the possibility to modify the NDV genome by means of genetic modification and allows the introduction of mutations, deletions, and/or insertions. The process can be used to modify the virulence of NDV, thereby generating new attenuated live vaccines with enhanced properties. The process can be used to modify the antigenic make-up of NDV, thus allowing the generation of live NDV marker vaccines which can be serologically distinguished from NDV field strains.
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公开(公告)号：CA2436530A1
公开(公告)日：2002-08-08
申请号：CA2436530
申请日：2002-01-31
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： SMITH HILDA ELIZABETH
IPC: C12N15/09 , A61K39/00 , A61K39/09 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/21 , C12Q1/68 , C12N15/31 , A61K48/00 , G01N33/569 , A61K35/74
Abstract: The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention provides a method for modulating virulence of a Streptococcus comprising modifying a genomic fragment of said Streptococcus wherein said genomic fragment comprises at least a functional part of a fragment identifiable by hybridisation in Streptococcus suis to a nucleic ac id or fragment thereof.
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公开(公告)号：BR0012433A
公开(公告)日：2002-05-21
申请号：BR0012433
申请日：2000-07-13
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Abstract: The invention relates to recombinant Infectious Bursal Disease Virus (IBDV) and vaccines derived thereof. The invention provides infectious recombinant Infectious Bursal Disease Virus (rIBDV) essentially incapable of growing in a cell that is not derived from a bursa cell, or an infectious rIBDV having retained at least part of the very virulent characteristics of a very virulent Infectious Bursal Disease Virus (vvIBDV).
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公开(公告)号：AU6961601A
公开(公告)日：2002-01-08
申请号：AU6961601
申请日：2001-06-28
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： LANGEDIJK JOHANNES PETRUS MARI
IPC: C12N15/09 , A61K38/00 , A61K39/00 , A61K39/12 , A61P31/04 , C07K14/135 , C07K14/18 , C07K14/185 , C07K16/10 , C12N15/40 , G01N33/569
Abstract: The invention relates to peptides derived from or similar to the E protein of pestiviruses for type -specific diagnosis of infection, for eliciting antibiotic activity and for transport of substances into a cell. For among others these purposes the invention provides an isolated, synthetic or recombinant protein module or functional equivalent thereof comprising an amino acid sequence that is at least 75% identical to an amino acid sequence of a peptide located from at about amino acid position 194 to 220 in a pestiviral E protein.
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公开(公告)号：TR200100350T2
公开(公告)日：2001-06-21
申请号：TR200100350
申请日：1999-06-17
Applicant: ID LELYSTAD INST DIERHOUDERIJ , B V
Inventor： PEETERS BERNARDUS PETRUS HUBER , LEEUW OLAV SVEN DE , KOCH GUUS , GIELKENS ARNOUD LEONARD JOSEF
IPC: C12N15/09 , A61K39/17 , A61K48/00 , A61P31/12 , C07K14/125 , C12N7/00 , C12N7/01 , C12N15/45 , C12N15/86 , C12Q1/70
Abstract: The invention relates to the process for generating infectious Newcastle disease virus (NDV) entirely from cloned full-length cDNA and to the use of vaccines and diagnostic assays generated with and derived from said process. The process offers the possibility to modify the NDV genome by means of genetic modification and allows the introduction of mutations, deletions, and/or insertions. The process can be used to modify the virulence of NDV, thereby generating new attenuated live vaccines with enhanced properties. The process can be used to modify the antigenic make-up of NDV, thus allowing the generation of live NDV marker vaccines which can be serologically distinguished from NDV field strains.
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